脉∶瘟脉无名，随见诸经，未汗宜强，虚缓伤生。众人病一般者，乃天行时疫也。
辟邪丹 虎头骨（二两） 朱砂 雄黄 雌黄 鬼臼 芜荑 鬼箭 藜芦（各一两）
上为末，炼蜜为丸，如弹子大。囊盛一丸，男左女右，系于背上。或常病者，户内烧之，一切邪鬼不敢进。
兼治妇人与鬼魅交通。
五瘟丹 治四时瘟疫流行、伤寒发热并诸疟热病。
黄连（属火，戊癸之年为君） 黄柏（属水，丙辛之年为君） 黄芩（属金，乙庚之年为君） 甘草（属土，
甲己之年为君） 紫苏，香附（以上各一两，以直年药为君者倍一两）
上七味皆生用，于冬至日制为末，用锦纹大黄三两浓煎汤，去滓熬成膏，和前药为丸，如弹子大，朱砂、
雄黄末为衣，再贴金箔。每服一丸，冷水磨服，神效。
普济消毒散 治大头瘟病。
黄连（二两） 黄芩（酒炒，二两） 陈皮 玄参 生甘草 川芎 鼠粘子 白僵蚕 升麻 柴胡 葛根
薄荷 当归 大黄 人参（三钱） 连翘（各五钱） 大兰根（如无加靛花亦可）
上为细末，炼蜜为丸，每丸重二钱，每服一丸，细嚼，白熟水送下，发汗。如不及丸，用末药一钱二分，
照前服。如未愈，再进一服，以汗为度，不可透风。若透风复肿，再服药，只是去皮一层方愈。忌酸冷羊鸡鱼之
物并房事。
冬应寒而反暖者，春发瘟疫也，人参败毒散主之。
二圣救苦丸 治伤寒瘟疫，不论传经过经可服。
锦纹大黄（四两，酒拌，蒸，晒干） 牙皂（二两，如猪牙者）
上二味俱为末，水打稀糊为丸，绿豆大。每服五七十丸，冷绿豆汤送下，以汗为度。
人参败毒散 治四时瘟疫通用。
羌活 独活 前胡 柴胡 川芎 枳壳（去穣） 桔梗（去芦） 茯苓 人参（各等分） 甘草（减半）
上锉剂，每服一两，生姜三片、水盏半煎八分温服。或
为末，沸汤点服亦可。此药治伤寒瘟疫、风温风眩、四肢疼痛、憎寒壮热、项强睛疼，不问老人小儿，皆可服。
或岭南烟瘴之地，或瘟疫时行，或人多风痰，或处卑湿之地、香港脚痿弱，此药不可缺也。连进三五服，以止为
度。一方加薄荷少许。
春应温而反清凉者，夏发燥郁也，大柴胡汤。（方见伤寒。）
夏应热而反寒者，秋发寒郁也，五积散主之。（方见中寒。）
秋应凉而反淫雨者，冬发湿郁也，五苓散主之。（方见中暑。）
大头病者，湿热在高巅之上也。
牛蒡芩连汤 治积热在上，头顶肿起，或面肿，或从耳根上起，俗曰大头瘟，并治烟瘴。
黄芩（酒炒，二钱半） 黄连（酒炒，一钱半） 桔梗（一钱半） 连翘 牛蒡子（另研） 玄参（各一钱）
大黄 荆芥 防风 羌活（各三分） 石膏（一钱半） 甘草（一钱）
上锉一剂，生姜一片，水煎，食后细细呷温服。每一盏做二十次服，常令药在上，勿令饮食在后也。
内府仙方 治肿项大头病、虾蟆瘟病。
僵蚕（二两） 姜黄（二钱半） 蝉蜕（二钱半） 大黄（四两）
上共为细末，姜汁打糊为丸，重一钱一枚，大人服一丸，小儿半丸，蜜水调服，立愈。
又方 治大头瘟病，肿脸颈项者。
用福建靛花三钱、烧酒一钟、鸡子清一个，入内打匀吃。不时而愈，肿即消，神方也。
虾蟆瘟者，属风热也，防风通圣散。（方见中风。）凡入病家，须避其邪气，不受染着，亦医者之惠不可
不知。以雄黄末涂鼻孔中，或香油涂鼻孔亦妙，然后入病家行动从容。在位而入，男子病秽气出于口，女子秽气
出于阴户，其相对坐立之间，必须识其向背，既出自以纸条探鼻深入，喷嚏为佳。
太仓公辟瘟丹 凡宫舍久无人到，积湿容易侵人，预制此烧之，可远此害。极宜于暑月烧之，以却瘟
疫，并散邪气。
茅术（一斤） 台乌 黄连 白术（各半斤） 羌活（半斤） 川芎 草乌 细辛 紫草 防风 独活
本 白芷 香附 当归 荆芥 天麻 官桂 甘松 三柰 干姜 麻黄 牙皂 芍药 甘草（各四两） 麝香（三分）
上为末，枣肉为丸，如弹子大，每丸烧之。
万历丙戌春，余寓大梁属瘟疫大作，士民多毙其症，闾巷相染，甚至灭门。其症头疼身痛、憎寒壮热、头面
颈项赤肿、咽喉肿痛、昏愦等症，此乃冬应寒而反热，人受不正之气，至春发为瘟疫，至夏发为热病，名曰大头
瘟，大热之症也。余发一秘方，名二圣救苦丸，用牙皂以开关窍而发其表，大黄以泻诸火而通其里。一服即汗，
一汗即愈，真仙方也。日夜塞户填门，应酬不暇，全活者不能胜数矣。但人禀之稍壮者，百发百中；其虚弱者，
余先以人参败毒散，轻者即愈，如未愈，用牛蒡芩连汤可收全效。
补遗方
清凉救苦散 治头面耳目鼻肿痛。
芙蓉叶 桑叶 白芨 白蔹 车前 大黄 黄连 黄柏 白芷 雄黄 赤小豆 芒硝
上各等分，为细末，用蜜水调敷于肿痛处，频频扫之。
脉象：瘟疫的脉象没有固定名称，随所见各经病证而变化。若未经发汗而脉象强盛，或脉象虚缓，均会损伤生命。众人患相同病症的，乃是天行时疫（流行性传染病）。
辟邪丹：虎头骨（二两）、朱砂、雄黄、雌黄、鬼臼、芜荑、鬼箭、藜芦（各一两）。
以上药物研为细末，用炼蜜制成丸剂，大小如弹子。将一丸装入囊中，男性系于左背，女性系于右背。或者对于经常患病的人，可在室内焚烧此药，一切邪气鬼魅不敢侵入。
兼治妇女与鬼魅交合之症。
五瘟丹：治疗四时瘟疫流行、伤寒发热以及各类疟疾热病。
黄连（属火，在戊癸之年作为君药）、黄柏（属水，在丙辛之年作为君药）、黄芩（属金，在乙庚之年作为君药）、甘草（属土，在甲己之年作为君药）、紫苏、香附（以上各一两，以当年五行对应的君药剂量加倍一两）。
以上七味药均生用，在冬至日制作成粉末，用锦纹大黄三两浓煎取汤，去渣后熬成膏状，与前药混合制成丸剂，大小如弹子，外披朱砂、雄黄粉末，再贴上金箔。每次服用一丸，用冷水磨化后服下，效果神妙。
普济消毒散：治疗大头瘟病。
黄连（二两）、黄芩（酒炒，二两）、陈皮、玄参、生甘草、川芎、鼠粘子（牛蒡子）、白僵蚕、升麻、柴胡、葛根、薄荷、当归、大黄、人参（三钱）、连翘（各五钱）、大兰根（若无可用靛花代替）。
以上药物研为细末，用炼蜜制成丸剂，每丸重二钱。每次服用一丸，细细咀嚼，用白开水送下，以发汗为度。如果来不及做丸剂，可用药末一钱二分，按前述方法服用。如果未痊愈，再服一次，以出汗为标准，注意不可受风。如果受风导致再次肿胀，再服药，只是表皮脱落一层即可痊愈。忌食酸冷及羊、鸡、鱼等食物，并禁止房事。
二圣救苦丸：治疗伤寒瘟疫，不论是否传经均可服用。
锦纹大黄（四两，用酒拌，蒸熟，晒干）、牙皂（二两，选用像猪牙形状的）。
以上两味药均研为细末，用水调成稀糊状制成丸剂，大小如绿豆。每次服用五七十丸，用冷绿豆汤送下，以出汗为标准。
人参败毒散：治疗四时瘟疫通用。
羌活、独活、前胡、柴胡、川芎、枳壳（去瓤）、桔梗（去芦）、茯苓、人参（各等分）、甘草（减半）。
以上药物切碎，每次服用一两，加生姜三片、水一盏半，煎至八分，温服。或者研为细末，用沸水冲服亦可。此药治疗伤寒瘟疫、风温风眩、四肢疼痛、憎寒壮热、项强睛疼，不问老人小儿，皆可服用。或者岭南烟瘴之地，或瘟疫流行时，或人多风痰，或处于卑湿之地、患有香港脚痿弱，此药不可缺。连续服用三五次，以症状停止为度。一方加少许薄荷。
春季应当温暖却反而清凉，夏季会爆发燥郁证，用大柴胡汤主治。（方剂见伤寒篇。）
夏季应当炎热却反而寒冷，秋季会爆发寒郁证，用五积散主治。（方剂见中寒篇。）
秋季应当凉爽却反而多雨，冬季会爆发湿郁证，用五苓散主治。（方剂见中暑篇。）
大头病，是湿热位于高巅之上所致。
牛蒡芩连汤：治疗积热在上部，头顶肿起，或面部肿胀，或从耳根向上肿起，俗称大头瘟，并治疗烟瘴。
黄芩（酒炒，二钱半）、黄连（酒炒，一钱半）、桔梗（一钱半）、连翘、牛蒡子（另研）、玄参（各一钱）、大黄、荆芥、防风、羌活（各三分）、石膏（一钱半）、甘草（一钱）。
以上药物切碎一剂，加生姜一片，水煎，饭后细细呷服温药。每一盏药液分二十次服用，常使药力停留在上部，不要让饮食紧随其后。
内府仙方：治疗肿项大头病、虾蟆瘟病。
僵蚕（二两）、姜黄（二钱半）、蝉蜕（二钱半）、大黄（四两）。
以上共同研为细末，用姜汁调糊制成丸剂，每丸重一钱。成人服用一丸，小儿服用半丸，用蜜水调服，立即痊愈。
又一方：治疗大头瘟病，脸部颈部肿胀者。
用福建靛花三钱、烧酒一杯、鸡蛋清一个，放入内打匀服下。不久即愈，肿胀消退，这是神方。
虾蟆瘟，属于风热证，用防风通圣散主治。（方剂见中风篇。）凡是进入病人家，必须避开其邪气，避免被感染，这也是医者不可不知的恩惠。用雄黄末涂抹鼻孔中，或用香油涂抹鼻孔也很好，然后从容进入病家。如果是男性病人，秽气从口出；女性病人，秽气从阴户出。相对坐立之间，必须识别其方向背向，既然秽气出自某处，就用纸条探入鼻孔深处，打喷嚏为佳。
太仓公辟瘟丹：凡是宫舍长久无人居住，积聚湿气容易侵袭人，预先制备此药焚烧，可远离此害。极适宜在暑月焚烧，以驱除瘟疫，并散发邪气。
茅术（一斤）、台乌、黄连、白术（各半斤）、羌活（半斤）、川芎、草乌、细辛、紫草、防风、独活、本（藁本）、白芷、香附、当归、荆芥、天麻、官桂、甘松、三柰、干姜、麻黄、牙皂、芍药、甘草（各四两）、麝香（三分）。
以上药物研为细末，用枣肉制成丸剂，大小如弹子，每丸焚烧使用。
万历丙戌年春天，我寓居大梁，当时瘟疫大作，士民多死于该症，街巷相互传染，甚至灭门。其症状有头疼身痛、憎寒壮热、头面颈项赤肿、咽喉肿痛、昏愦等症，这是冬季应当寒冷却反而发热，人感受不正之气，到春季爆发为瘟疫，到夏季爆发为热病，名为大头瘟，是大热之症。我发布一个秘方，名为二圣救苦丸，用牙皂来开通窍道而发散表邪，用大黄来泻诸火而通利里实。服用一次即出汗，一出汗即痊愈，真是仙方啊。日夜堵塞门户填塞街道，应酬不暇，保全性命者不胜枚举。但人体质稍强壮者，百发百中；体质虚弱者，我先用人参败毒散，轻者即愈，如果未愈，用牛蒡芩连汤可收全效。
补遗方
清凉救苦散：治疗头面耳目鼻肿痛。
芙蓉叶、桑叶、白芨、白蔹、车前、大黄、黄连、黄柏、白芷、雄黄、赤小豆、芒硝。
以上各等分，研为细末，用蜜水调敷于肿痛处，频频扫涂。
Pulse: The pulse of plague (Wen Bing, epidemic febrile diseases) has no fixed name; it varies according to the meridians involved. If the pulse is forceful before sweating, or if it is deficient and slow, life will be endangered. When everyone suffers from similar symptoms, it is Tian Xing Shi Yi (seasonal epidemic infectious disease).
Bixie Dan (Evil-Expelling Pill): Tiger skull bone (2 liang), Cinnabar (Zhusha), Realgar (Xionghuang), Orpiment (Cihuang), Aristolochia debilis (Guijiu), Elaeagnus multiflora seed (Wuyi), Aralia cordata branch (Guijian), Veratrum nigrum root (Lilu) (each 1 liang).
Grind the above into powder, mix with refined honey to make pills the size of a bullet. Place one pill in a pouch, tie it on the back—left side for men, right side for women. Alternatively, for those prone to illness, burn it indoors; all evil spirits and pathogens will dare not enter.
Also treats women having sexual intercourse with ghosts/spirits.
Wuwen Dan (Five Plagues Pill): Treats seasonal epidemics, Shanghan fever, and various malaria fevers.
Scutellaria baicalensis root (Huangqin, associated with Fire, becomes the Sovereign herb in Wu-Gui years), Phellodendron bark (Huangbai, associated with Water, becomes the Sovereign herb in Bing-Xin years), Scutellaria baicalensis root (Huangqin, associated with Metal, becomes the Sovereign herb in Yi-Geng years), Licorice root (Gancao, associated with Earth, becomes the Sovereign herb in Jia-Ji years), Perilla leaf (Zisu), Cyperus rotundus rhizome (Xiangfu) (above each 1 liang; double the amount by 1 liang for the Sovereign herb corresponding to the current year).
All seven ingredients are used raw. Process them into powder on the Winter Solstice. Decoct 3 liang of Polygonum multiflorum stem (Jinwen Dahuang) in thick water, remove dregs, and boil down to a paste. Mix with the herbal powder to form pills the size of a bullet. Coat with Cinnabar and Realgar powder, then apply gold foil. Take one pill per dose, ground in cold water and swallowed. It is extremely effective.
Puji Xiaodu San (Great Benefit Detoxification Powder): Treats Da Tou Wen (Big Head Plague).
Scutellaria baicalensis root (Huangqin, 2 liang), Scutellaria baicalensis root fried with wine (Huangqin, 2 liang), Tangerine peel (Chenpi), Polygala root (Xuanshen), Raw Licorice root (Sheng Gancao), Szechuan lovage rhizome (Chuanxiong), Burdock fruit (Shuniuzi), White silkworm (Bai Jiangcan), Cimicifuga rhizome (Shengma), Bupleurum root (Chaihu), Kudzu root (Gegen), Mint (Bohe), Angelica sinensis root (Danggui), Rhubarb (Dahuang), Ginseng (Renshen, 3 qian), Forsythia fruit (Lianqiao) (each 5 qian), Isatis root (Dalan Gen) (if unavailable, use Indigofera tinctoria leaf/Dianhua).
Grind all into fine powder, mix with refined honey to make pills weighing 2 qian each. Take one pill per dose, chew thoroughly, and swallow with plain cooked water to induce sweating. If pills are unavailable, take 1.2 qian of powder and administer as above. If not cured, take another dose. The goal is sweating; avoid exposure to wind. If swelling recurs due to wind exposure, take medicine again; healing occurs when the outer skin layer peels off. Avoid sour, cold foods, and lamb, chicken, fish. Also avoid sexual intercourse.
If winter should be cold but is instead warm, plague will erupt in spring; treat with Renshen Baidu San (Ginseng Rescue the Damaged Powder).
Ersheng Jiuku Wan (Two Sages Saving Pain Pills): Treats Shanghan and plague; usable regardless of whether the disease has transmitted through meridians.
Polygonum multiflorum stem (Jinwen Dahuang, 4 liang, mixed with wine, steamed, dried), Ziziphus jujuba seed pod (Yazao, 2 liang, preferably pig-tooth shaped).
Grind both into powder, mix with water to form a thin paste, and make pills the size of mung beans. Take 50-70 pills per dose, swallow with cold mung bean soup. The goal is sweating.
Renshen Baidu San (Ginseng Rescue the Damaged Powder): Universally treats seasonal plagues.
Notopterygium rhizome (Qianghuo), Angelica pubescens root (Duhuo), Peucedanum root (Qianhu), Bupleurum root (Chaihu), Szechuan lovage rhizome (Chuanxiong), Aurantium fruit (Zhike, pith removed), Platycodon root (Jiegeng, radix removed), Poria (Fuling), Ginseng (Renshen) (all equal parts), Licorice root (Gancao, half dose).
Cut into pieces. Take 1 liang per dose, add 3 slices of ginger and 1.5 cups of water, decoct until 0.8 cup remains, and take warm. Alternatively, grind into powder and take with boiling water. This medicine treats Shanghan plague, Fengwen (wind-warmth), Fengxuan (wind-dizziness), limb pain, aversion to cold with high fever, stiff neck, and painful eyes. It can be taken by both elderly and children. It is indispensable in Lingnan smog-miasma regions, during plague outbreaks, for people with much wind-phlegm, or those living in damp lowlands suffering from Hong Kong foot (gout/paralysis). Take continuously for 3-5 doses until symptoms cease. One variation adds a small amount of Mint.
If spring should be warm but is instead cool, dryness stagnation will erupt in summer; treat with Da Chaihu Tang (Major Bupleurum Decoction). (Formula see Shanghan.)
If summer should be hot but is instead cold, cold stagnation will erupt in autumn; treat with Wuji San (Five Accumulations Powder). (Formula see Zhonghan.)
If autumn should be cool but is instead rainy, dampness stagnation will erupt in winter; treat with Wuling San (Five-Ling Powder). (Formula see Zhongshu.)
Da Tou Bing (Big Head Disease) is caused by damp-heat located at the highest peak (head).
Niubang Qinlian Tang (Burdock Scutellaria Coptis Decoction): Treats accumulated heat in the upper body, causing swelling of the top of the head, face, or rising from behind the ears. Commonly known as Da Tou Wen (Big Head Plague); also treats smog-miasma.
Scutellaria baicalensis root fried with wine (Huangqin, 2.5 qian), Coptis chinensis rhizome fried with wine (Huanglian, 1.5 qian), Platycodon root (Jiegeng, 1.5 qian), Forsythia fruit (Lianqiao), Burdock fruit (Niubangzi, separately ground), Polygala root (Xuanshen) (each 1 qian), Rhubarb (Dahuang), Schizonepeta spike (Jingjie), Saposhnikovia root (Fangfeng), Notopterygium rhizome (Qianghuo) (each 3 fen), Gypsum (Shigao, 1.5 qian), Licorice root (Gancao, 1 qian).
Cut one dose, add one slice of ginger, decoct in water. Sip warm liquid slowly after meals. Divide one cup into 20 doses. Keep the medicinal effect in the upper body; do not let food follow immediately.
Neifu Xianfang (Internal Palace Immortal Formula): Treats swollen neck Big Head Disease and Hamawen (Toad Plague).
White silkworm (Jiangcan, 2 liang), Turmeric rhizome (Jianghuang, 2.5 qian), Cicada slough (Chantui, 2.5 qian), Rhubarb (Dahuang, 4 liang).
Grind all into fine powder, mix with ginger juice to form a paste, and make pills weighing 1 qian each. Adults take one pill, children take half a pill, mixed with honey water. Cure is immediate.
Another Formula: Treats Big Head Plague with swelling of the face, neck, and nape.
Use 3 qian of Fujian Indigofera tinctoria leaf (Dianhua), one cup of distilled liquor (Baijiu), and one egg white. Mix well and drink. Cured shortly thereafter; swelling subsides. This is a divine formula.
Hamawen (Toad Plague) belongs to Wind-Heat; treat with Fangfeng Tongsheng San (Saposhnikovia Unblocking Supreme Powder). (Formula see Fengzhong.)
When entering a patient's home, one must avoid their pathogenic qi to prevent infection. This is a benefit physicians must know. Apply Realgar powder inside the nostrils, or sesame oil, which is also excellent. Then enter the home calmly. For male patients, foul qi exits from the mouth; for female patients, from the vagina. When sitting or standing opposite, identify the direction. Since the qi comes from a specific source, insert a paper strip deep into the nose to induce sneezing, which is ideal.
Taicanggong Bixie Dan (Grand Master Tai Gong's Evil-Expelling Pill): In palaces or houses long unoccupied, accumulated dampness easily invades humans. Prepare this in advance and burn it to avoid harm. It is especially suitable to burn during summer months to dispel plague and scatter pathogenic qi.
Atractylodes lancea rhizome (Maozhu, 1 jin), Curcuma phaeocaulis rhizome (Taiwu), Coptis chinensis rhizome (Huanglian), Atractylodes macrocephala rhizome (Baizhu) (each 0.5 jin), Notopterygium rhizome (Qianghuo, 0.5 jin), Szechuan lovage rhizome (Chuanxiong), Aconitum carmichaelii lateral root (Caowu), Asarum root (Xixin), Lithospermum root (Zicao), Saposhnikovia root (Fangfeng), Angelica pubescens root (Duhuo), Ligusticum wallichii rhizome (Ben), Angelica dahurica root (Baizhi), Cyperus rotundus rhizome (Xiangfu), Angelica sinensis root (Danggui), Schizonepeta spike (Jingjie), Gastrodia elata tuber (Tianma), Cinnamon twig (Guangui), Nardostachys root (Gansong), Kaempferia galanga rhizome (Sansha), Dried ginger (Ganjiang), Ephedra stem (Mahuang), Ziziphus jujuba seed pod (Yazao), Peony root (Shaoyao), Licorice root (Gancao) (each 4 liang), Musk (Shexiang, 3 fen).
Grind all into powder, mix with date flesh to make pills the size of bullets. Burn one pill per use.
In the spring of Bingxu year of the Wanli era, I resided in Daliang where plague erupted severely. Scholars and commoners died frequently, spreading through neighborhoods, even wiping out families. Symptoms included headache, body pain, aversion to cold with high fever, red and swollen head/face/neck, sore throat, and confusion. This occurred because winter should have been cold but was hot; people contracted abnormal qi, which erupted as plague in spring and heat disease in summer. Named Da Tou Wen (Big Head Plague), it is a severe heat syndrome. I released a secret formula named Ersheng Jiuku Wan. Yazao opens orifices and releases the exterior; Dahuang purges fire and unblocks the interior. One dose induces sweating; one sweat brings cure. Truly an immortal formula. Day and night, doors were blocked and streets filled; I had no time for social calls. Countless lives were saved. Those with strong constitutions responded perfectly; for the weak, I first used Renshen Baidu San. Mild cases cured immediately; if not, Niubang Qinlian Tang achieved full recovery.
Supplementary Formulas
Qingliang Jiuku San (Cooling Rescue Pain Powder): Treats swelling and pain of head, face, ears, eyes, and nose.
Hibiscus mutabilis leaf (Furongye), Mulberry leaf (Sangye), Bletilla striata rhizome (Baiji), Ampelopsis japonica rhizome (Bailian), Plantago seed/herb (Cheqian), Rhubarb (Dahuang), Coptis chinensis rhizome (Huanglian), Phellodendron bark (Huangbai), Angelica dahurica root (Baizhi), Realgar (Xionghuang), Adzuki bean (Chixiaodou), Mirabilite (Mangxiao).
Equal parts, grind into fine powder. Mix with honey water and apply to swollen/painful areas, sweeping repeatedly.