四十三难曰∶人不食饮，七日而死者，何也？然∶人胃中当有留谷二斗，水一斗五升。故平人日再
至圊，一行二升半，日中五升，七日五七三斗五升，而水谷尽矣。故平人不食饮七日而死者，水
谷津液俱尽，即死矣。
四十四难曰∶七冲门何在？然∶唇为飞门，齿为户门，会厌为吸门，胃为贲门，
太仓下口为幽门，大肠、小肠会为阑门，下极为魄门，故曰七冲门也。
四十五难曰∶经言八会者，何也？然∶腑会太仓、脏会季胁，筋会阳陵泉，髓会绝骨，血会膈
俞，骨会大杼，脉会太渊，气会三焦，外一筋直两乳内也。热病在内者，取其会之气穴也。
四十六难曰∶老人卧而不寐，少壮寐而不寤者，何也？然∶经言少壮者，血气盛，肌肉滑，气道
通，荣卫之行不失于常，故昼日精，夜不寤也。老人血气衰，肌肉不滑，荣卫之道涩，故昼
日不能精，夜不得寐也，故知老人不得寐也。
四十七难曰∶人面独能耐寒者，何也？然∶人头者，诸阳之会也。诸阴脉皆至颈、胸中而
还，独诸阳脉皆上至头耳，故令面耐寒也。
四十八难曰∶人有三虚三实，何谓也？然∶有脉之虚实，有病之虚实，有诊之虚实也。脉之虚
实者，濡者为虚，紧牢者为实。病之虚实者，出者为虚，入者为实；言者为虚，不言者为
实；缓者为虚，急者为实。诊之虚实者，濡者为虚，牢者为实；痒者为虚，痛者为实；外痛内快，
为外实内虚；内痛外快，为内实外虚，故曰虚实也。
第四十三难问：人不进食饮水，七天就死亡的，是什么原因呢？回答：人的胃中通常存留有谷物二斗，水一斗五升。所以正常的人每天两次去厕所排便，每次排出二升半，一天共排出五升，七天共排出三斗五升，体内的水和谷物就排尽了。所以正常人如果不进食饮水七天就会死亡，这是因为水谷和津液都耗竭了，人也就死了。
第四十四难问：七冲门在哪里？回答：嘴唇是飞门，牙齿是户门，会厌是吸门，胃的上口是贲门，太仓（胃）的下口是幽门，大肠和小肠交接处是阑门，肛门是魄门，所以称为七冲门。
第四十五难问：医经说八会穴，是指什么？回答：腑的会穴是太仓（中脘），脏的会穴在季胁（章门），筋的会穴是阳陵泉，髓的会穴是绝骨（悬钟），血的会穴是膈俞，骨的会穴是大杼，脉的会穴是太渊，气的会穴是三焦（此处指气街或相关部位，原文注“外一筋直两乳内也”）。热病邪气在体内的，取用会的穴位来治疗。
第四十六难问：老人躺着不能入睡，年轻人睡着后不易醒来的，是什么原因呢？回答：医经说，年轻人血气旺盛，肌肉滑利，气道通畅，营卫之气的运行不失常度，所以白天精神饱满，夜晚安睡不醒。老人血气衰弱，肌肉不滑利，营卫之道涩滞，所以白天精神不振，夜晚不能入睡，因此知道老人难以入睡。
第四十七难问：唯独人脸能够耐寒，是什么原因呢？回答：人的头部，是诸阳经汇聚的地方。所有的阴经都只到达颈部、胸部就返回去了，只有诸阳经都上行至头耳部，所以使面部能够耐寒。
第四十八难问：人有三种虚证和三种实证，是什么意思？回答：有脉象的虚实，有病证的虚实，有诊察表现的虚实。脉象的虚实，脉濡软无力的是虚，脉紧而坚实的是实。病证的虚实，病势向外发散的是虚，病势向内深入的是实；能言语的是虚，不能言语的是实；脉势缓的是虚，脉势急的是实。诊察表现的虚实，感觉濡软的是虚，感觉坚硬的是实；发痒的是虚，疼痛的是实；体表疼痛但体内舒适，是外实内虚；体内疼痛但体表舒适，是内实外虚，所以称为虚实。
Difficulty 43 asks: Why does a person who consumes no food or drink die after seven days? The answer is: Normally, the stomach contains two dou of retained grain and one dan five sheng of water. Therefore, a healthy person defecates twice daily, with each bowel movement discharging two and a half sheng, totaling five sheng per day. Over seven days, this amounts to three dan five sheng (3.5 dan), exhausting the water and grain. Thus, a healthy person dies after seven days without food or drink because both water, grain, and Jin-Ye (body fluids) are exhausted.
Difficulty 44 asks: Where are the Seven Rush Gates located? The answer is: The lips are the Flying Gate (Feimen), the teeth are the Household Gate (Humen), the epiglottis is the Inhaling Gate (Ximen), the upper opening of the stomach is the Receiving Gate (Benmen), the lower opening of the Tai Cang (Stomach) is the Secluded Gate (Youmen), the junction of the large and small intestines is the Curtain Gate (Lanmen), and the anus is the Corporeal Spirit Gate (Pomen). Hence, they are called the Seven Rush Gates.
Difficulty 45 asks: What are the Eight Hui (Meeting) Points mentioned in the classics? The answer is: The Hui Point of the Fu organs is Zhongwan (CV12, located in the Tai Cang); the Hui Point of the Zang organs is Zhangmen (LR13, located in the costal region); the Hui Point of the tendons is Yanglingquan (GB34); the Hui Point of the marrow is Xuanzhong (GB39, also known as Juegu); the Hui Point of the blood is Geshu (BL17); the Hui Point of the bones is Dazhu (BL11); the Hui Point of the vessels is Taiyuan (LU9); and the Hui Point of Qi is the Sanjiao (Triple Burner), specifically referring to the area between the sternum and the nipples. For heat diseases with pathogens inside, the Hui points are selected for treatment.
Difficulty 46 asks: Why do the elderly lie down but fail to sleep, while the young sleep soundly and do not wake easily? The answer is: The classics state that the young have abundant Qi and Blood, smooth muscles, unobstructed Qi pathways, and normal circulation of Ying (Nutrient) and Wei (Defensive) Qi; thus, they are energetic during the day and sleep peacefully at night. The elderly have declining Qi and Blood, rough muscles, and sluggish Ying-Wei circulation; thus, they lack energy during the day and cannot sleep at night. This explains why the elderly suffer from insomnia.
Difficulty 47 asks: Why is the face uniquely capable of resisting cold? The answer is: The head is the convergence point of all Yang meridians. All Yin meridians ascend only to the neck and chest before returning, whereas all Yang meridians ascend to the head and ears. This distribution allows the face to resist cold.
Difficulty 48 asks: What are the three types of Deficiency (Xu) and Excess (Shi) in humans? The answer is: There are pulse Deficiency/Excess, disease Deficiency/Excess, and diagnostic symptom Deficiency/Excess. Regarding pulse: a soft (Ru) pulse indicates Deficiency, while a tight (Jin) or firm (Lao) pulse indicates Excess. Regarding disease nature: outward progression indicates Deficiency, inward progression indicates Excess; ability to speak indicates Deficiency, inability to speak indicates Excess; a slow pulse rhythm indicates Deficiency, a rapid/tense rhythm indicates Excess. Regarding diagnostic symptoms: softness indicates Deficiency, hardness indicates Excess; itching indicates Deficiency, pain indicates Excess; pain on the exterior with comfort inside indicates Exterior Excess and Interior Deficiency; pain on the interior with comfort outside indicates Interior Excess and Exterior Deficiency. These constitute the concepts of Deficiency and Excess.