夫痘疮始终贵于安静，然烦躁之因，始终迥别。如在初起之时者，此因热毒在内攻
击而脏腑燔灼所致也，则痘出热解而自己。如当起胀行浆之时，身复发热烦躁者，此为
蒸浆，必浆足痛止，热退而后已，至于脓成之后，则毒当尽解，脏腑平和，神宇爽快，
尤宜安静矣。若忽烦躁不得眠者，宜于痘上辨之。如脓多清淡，尚不满足者，此毒犹在
里，未得尽出而然也，治宜托里助脓。如脓成饱满，适因发热浆干而然者，并为烧瘢而
欲成实，此应候也，治宜清热滋阴。如痘子太密，是以脓成之后，心血亏损，故乃虚烦
不得眠者，此阴不能敛阳也，治宜清心补血。然此证似轻而重，苟服药而久不愈，则
心脾二经，皆为热毒所伤，故烦则必渴，渴则必泻，泻则必切牙寒战，而痒塌内攻之患
立至矣。
按是太阴脾经，主失气。足阳明胃经，主腹胀。贲响失气者，脾败而谷气下脱也。
肠鸣者，胃败而中气下陷也。以病痘之人，不宜有此与泄泻皆系死症，故曰∶肠鸣失气
者，是泄肠胃生养之气也。大宜补中，佐以升提。
头乃诸阳之会，因毒瓦斯上蒸，故温也。足之六经，属水土木，盖足之三阳，太阳膀
胱水、阳明胃经土、少阳胆经木，足之三阴，太阴脾经土、少阴肾经水、厥阴肝经
木，水寒则冰，土寒则坼，木寒则枝叶枯落。足冷者，阳气绝也。故足冷过膝者，不
治。然有火郁于上而足寒者，实者清上，则火自降，下虚者温下，则火自归源而足温
矣，不可以概泥前说不治也。
痘疮在整个病程中，最宝贵的是保持安静状态。然而，导致烦躁的原因，在病程的不同阶段截然不同。如果在痘疮初起的时候出现烦躁，这是因为热毒在体内攻击，导致脏腑被火热灼烧所致，那么随着痘疹发出，热邪解除，症状就会自然消失。如果在痘疮起胀、行浆的阶段，身体再次发热并出现烦躁，这是蒸化脓浆的正常过程，必须等到脓浆充盈、疼痛停止、热退之后才会结束。到了脓液形成之后，毒邪应当已经全部解除，脏腑功能平和，精神清爽，尤其应该保持安静。如果突然烦躁无法入睡，应当在痘疮的形态上进行辨别。如果脓液多而清淡，尚不饱满，这是毒邪仍在体内，未能完全透发所致，治疗宜用托里法以助脓液生成。如果脓液已形成且饱满，恰好因为发热导致浆液干燥，进而结成痂皮欲要结实，这是顺应病势的正常现象，治疗宜清热滋阴。如果痘子过于密集，因此在脓成之后，心血亏损，导致虚烦无法入睡，这是阴液不能敛摄阳气所致，治疗宜清心补血。然而，这种病症看似轻微实则严重，如果服药后长久不愈，则心经和脾经都会受到热毒的伤害，所以烦躁必然伴随口渴，口渴必然导致腹泻，腹泻必然导致咬牙寒战，那么瘙痒塌陷及毒邪内攻的危害就会立刻到来。
按：太阴脾经主管放屁（失气）。足阳明胃经主管腹胀。腹部作响且放屁，是脾气败坏，谷气下脱的表现。肠鸣，是胃气败坏，中气下陷的表现。对于患痘疮的人来说，不应该出现这些症状，它们与泄泻一样都属于死症，所以说：肠鸣失气，是耗泄肠胃赖以生存的气机。治疗大宜补益中气，佐以升提之法。
头部是诸阳经汇聚的地方，因为毒气上蒸，所以头部感觉温热。足部的六条经脉，分别归属于水、土、木五行。其中足之三阳经：太阳膀胱经属水，阳明胃经属土，少阳胆经属木；足之三阴经：太阴脾经属土，少阴肾经属水，厥阴肝经属木。水寒冷则结冰，土寒冷则开裂，木寒冷则枝叶枯落。足部发冷，意味着阳气断绝。所以足冷超过膝盖的，属于不治之症。但是，也有火邪郁结在上部而导致足部寒冷的情况，实证者清解上部热邪，火气自然下降；下焦虚损者温补下部，火气自然回归本源，足部就会温暖了，不可以一概拘泥于前面所说的“不治”之说。
In the entire course of smallpox (Dou Chuang), tranquility is most prized. However, the causes of restlessness (Fan Zao) differ significantly throughout the stages. If restlessness occurs at the initial stage, it is caused by heat-toxin attacking internally and scorching the Zang-Fu organs; thus, as the rash emerges and heat resolves, the condition will resolve spontaneously. During the stage of swelling and pus formation, if fever and restlessness recur, this indicates the steaming process for pus formation; it must continue until the pustules are full, pain ceases, and fever subsides. After pus formation, toxins should be fully resolved, Zang-Fu functions harmonious, and spirit refreshed, making tranquility especially appropriate. If sudden restlessness and insomnia occur, one must examine the appearance of the pustules. If there is abundant but clear, thin pus that is not yet full, this indicates toxin remaining inside, unable to fully emerge; treatment should employ methods to support the interior and assist pus formation. If pus is formed and full, and dryness results from fever leading to scabbing and hardening, this is a normal progression; treatment should clear heat and nourish Yin. If the pustules are too dense, causing blood and heart deficiency after pus formation, leading to empty restlessness and insomnia, this is due to Yin failing to contain Yang; treatment should clear the Heart and nourish Blood. Although this condition appears mild but is actually severe, if it persists despite medication, both the Heart and Spleen meridians will be damaged by heat-toxin. Consequently, restlessness leads to thirst, thirst leads to diarrhea, and diarrhea leads to teeth chattering and shivering, immediately bringing about the dangers of itching, collapse, and internal invasion of toxins.
According to theory: The Taiyin Spleen Meridian governs flatus (Shi Qi). The Foot-Yangming Stomach Meridian governs abdominal distension. Abdominal borborygmi accompanied by flatus indicates Spleen failure and the downward escape of Grain Qi. Intestinal rumbling indicates Stomach failure and the sinking of Middle Qi. For patients with smallpox, these symptoms are inappropriate; along with diarrhea, they are considered fatal signs. Thus, it is said: intestinal rumbling and flatus indicate the depletion of the vital Qi of the intestines and stomach. Treatment greatly benefits from tonifying the Middle Jiao, assisted by lifting methods.
The head is the convergence point of all Yang meridians; due to the upward steaming of toxic vapors, it feels warm. The six meridians of the feet belong to Water, Earth, and Wood elements. Specifically, the Three Yang Meridians of the Foot: Taiyang Bladder Meridian belongs to Water, Yangming Stomach Meridian belongs to Earth, Shaoyang Gallbladder Meridian belongs to Wood. The Three Yin Meridians of the Foot: Taiyin Spleen Meridian belongs to Earth, Shaoyin Kidney Meridian belongs to Water, Jueyin Liver Meridian belongs to Wood. When Water is cold, it freezes; when Earth is cold, it cracks; when Wood is cold, its branches and leaves wither. Coldness in the feet indicates the extinction of Yang Qi. Therefore, coldness extending above the knees is considered incurable. However, there are cases where Fire is constrained in the upper body causing cold feet. In excess patterns, clearing the upper Heat allows Fire to descend naturally; in deficiency patterns of the lower Jiao, warming the lower region allows Fire to return to its source, warming the feet. One cannot rigidly adhere to the previous assertion that such cases are incurable.