以发热之时适因经水方断，是以血分空虚者，须早服柴胡四物汤，以防毒邪乘虚而
入。若已憎寒壮热，神识不清，见闻狂妄，言语错乱，寻衣撮空者，此因血室空虚而热
邪已入血室。血室者，动脉是也。而肝主之，治宜四物汤，合导赤散，加麦门冬与安
神丸，相间服之。更凡女子经闭者，谓之居经。满而不泻，病在心脾，疮疹之毒，本属
于心。又脾为主者，心脾先病，则血室不行，冲任之间，已多积垢，势必至于疮疹之
火，郁于命门胞户之中，当出不出，毒邪留伏，致虚乘戾者，理所必矣。是故发热之
初，当即消除停垢，宜桃仁承气汤主之，后以四物汤，合匀气散加红花、木通治之，固
不可使其有盈，更不可使其有亏也。倘虽居经而痘起胀如常，饮食如故而无腹痛他苦者，
亦不必过于治也。复有血海干涸。经水不通而适逢出痘者，治法亦宜调其心脾、使里气
既和，邪无留伏而日外出，否则。毒郁卫任之间，二热并发，互为攻声，则血妄行
不止，或毒不出而为喘息，为腹胀为陷伏矣。
凡女子出痘，经水忽行，乃暴音不语者，盖心主血。舌乃心之苗，血去则心虚，
心虚则少阴之脉不能上荣于血，故卒失音不语也。宜先以当归养心汤、养心血，利心
窍，待其能言，则以十全大补汤调之。更有因值月事大行，是以疮不起发，不光壮，不
饱满，不红活，顶平陷，色灰白，或青干黑陷者，此皆里虚之候，疮复陷入也，治宜十
全大补汤，夺命丹相间服之。如疮胖胀红缇，或疮空中再出一番者，俱为大吉之兆。
若加胀喘促，谵妄闷乱，寒战切牙，手足厥逆者，必死之症也。
当发热之时，恰逢月经刚刚结束，此时血分空虚，应当尽早服用柴胡四物汤，以防止毒邪趁虚而入。如果已经出现怕冷且高热、神志不清、看见或听到不存在的事物而狂妄、言语错乱、手在空中摸索抓东西的症状，这是因为血室（子宫）空虚，热邪已经进入血室。血室，指的是动脉（此处指代与血液运行密切相关的生理结构/部位），由肝脏所主，治疗适宜用四物汤，配合导赤散，加入麦门冬和安神丸，交替服用。另外，凡是女子月经闭止不行的，称为居经（每三个月来一次月经）。如果满三个月而不排泄经血，病位在心脾，疮疹的毒邪本属于心。又因为脾是气血生化之源，心脾先生病，则血室不通畅，冲脉和任脉之间，已经积聚了污垢，势必导致疮疹的火毒，郁结在命门和胞宫之中，该排出却排不出来，毒邪留滞潜伏，致使正气虚弱而邪气乖戾，这是理所当然的。因此在发热的初期，就应当消除停积的污垢，适宜用桃仁承气汤为主方治疗，随后用四物汤，配合匀气散，加入红花、木通进行治疗，既不可以让气血充盈过度，也不可以让气血亏损。倘若虽然是居经，但痘疹起胀如常，饮食正常而没有腹痛等其他痛苦，也不必过于治疗。又有血海干涸，月经不通畅而恰好遇到出痘的情况，治疗方法也适宜调理心脾，使里气调和，邪气没有留滞潜伏而每日向外透发，否则，毒邪郁结在卫分和任脉之间，两种热邪并发，互相攻伐，就会导致血液妄行不止，或者毒邪不能透出而出现喘息、腹胀、痘疹内陷等症状。
凡是女子出痘，月经突然来潮，随即失音不能说话的，是因为心主血，舌是心的苗窍，血液流失则心气虚弱，心气虚弱则少阴经脉不能向上滋养，所以突然失音不能说话。适宜先用当归养心汤，滋养心血，开通心窍，等到能够说话后，再用十全大补汤进行调理。更有因为正值月经量多，导致痘疹不起发、不光泽壮实、不饱满、不红活，痘顶平陷、颜色灰白，或者青紫干枯黑陷的，这都是里气虚弱的征候，痘疹再次陷入体内，治疗适宜用十全大补汤，与夺命丹交替服用。如果痘疹胖胀红活，或者痘疮中间再发出一番新的，都大吉大利的征兆。如果加上腹胀气喘急促、说胡话烦躁闷乱、寒战咬牙、手脚冰凉的症状，则是必死的病症。
When fever occurs and coincides with the cessation of menstruation, the blood aspect is empty; therefore, Chaihu Siwu Tang (Bupleurum Four Substances Decoction) should be taken early to prevent pathogenic toxins from entering due to deficiency. If there are already symptoms of aversion to cold with high fever, unclear consciousness, hallucinations (seeing or hearing things that are not there), delirious speech, and picking at empty air, this is because the Blood Chamber (uterus) is empty and heat pathogens have entered it. The Blood Chamber refers to the arterial vessels (here referring to the physiological structures/areas closely related to blood circulation), which is governed by the Liver. Treatment should utilize Siwu Tang (Four Substances Decoction) combined with Daochi San (Guide Out Red Powder), added with Ophiopogonis Radix (Maidong) and Anshen Wan (Calming Spirit Pill), administered alternately. Furthermore, any woman whose menstruation ceases is termed Ju Jing (menstruation occurring once every three months). If the cycle completes without discharge, the pathology lies in the Heart and Spleen; the toxin of carbuncles and rashes originally belongs to the Heart. Moreover, since the Spleen is the source of Qi and Blood, if the Heart and Spleen are diseased first, the Blood Chamber will not flow smoothly, and impurities will accumulate between the Chong Mai (Penetrating Vessel) and Ren Mai (Conception Vessel). Consequently, the fire toxin of carbuncles and rashes will stagnate within the Ming Men (Gate of Life) and Bao Hu (Uterus); when it should be expelled but is not, toxic pathogens remain latent, causing deficiency to prevail and pathogenic factors to become perverse, which is inevitable. Therefore, at the initial stage of fever, one should eliminate accumulated impurities, preferably using Tao Ren Cheng Qi Tang (Peach Kernel and Rhubarb Decoction to Order the Qi) as the main formula, followed by treatment with Siwu Tang combined with Yunqi San (Harmonizing Qi Powder) added with Carthami Flos (Honghua) and Akebiae Caulis (Mutong). One must ensure neither excessive fullness nor deficiency. Even if it is Ju Jing, provided the smallpox/rash rises and swells normally, diet remains normal, and there is no abdominal pain or other distress, over-treatment is unnecessary. In cases where the Sea of Blood is dry, menstruation does not flow, yet smallpox/rash erupts simultaneously, the treatment method should also focus on regulating the Heart and Spleen, harmonizing the interior so that pathogens do not remain latent but emerge daily; otherwise, toxins stagnate between the Wei Qi (Defensive Qi) and Ren Mai, two heats merge and attack each other, leading to uncontrolled bleeding, or failure of toxins to exit resulting in panting, abdominal distension, or rash sinking inward.
In women suffering from smallpox/rash, if menstruation suddenly starts followed by sudden loss of voice and inability to speak, it is because the Heart governs Blood, and the tongue is the sprout of the Heart. Loss of blood leads to Heart deficiency; Heart deficiency causes the Shaoyin Meridian (Heart-Kidney channel) to fail to nourish upwards, resulting in sudden aphonia. Initially, Danggui Yangxin Tang (Angelica Tonifying Heart Decoction) should be used to nourish Heart Blood and open the Heart orifices. Once speech returns, Shiquan Dabu Tang (Ten Substance Great Tonic Decoction) should be used for regulation. Additionally, if menstruation is heavy during the eruption phase, causing the rash to fail to rise, lacking luster and vigor, not plump, not red and vibrant, with flat tops, gray-white color, or turning cyan, dry, and black-sunken, these are signs of interior deficiency and rash sinking back inward. Treatment should involve alternating administration of Shiquan Dabu Tang and Duoming Dan (Life-Snatching Pill). If the rash becomes plump, swollen, and red-vibrant, or if a new batch emerges from within the existing lesions, these are auspicious omens. However, if accompanied by abdominal distension, rapid panting, delirium, restlessness, severe chills with teeth grinding, and cold extremities, it is a fatal condition.