痘症之出，热邪内外蒸发者也。若热毒方运而为暴寒折之，则外寒与内热相拒而不
得入内，热与外寒相阻而不得出，故毒瓦斯壅于肌腠，痘如痣点，或青、或紫、俗所谓鬼
捻青是也。治宜发散寒邪，温肌匀气，则毒瓦斯复行而痘疮乃出矣。不特年小禀弱者有
之，年壮而肌肉浓者，亦多此症。
夫面为诸阳之会，故无论何病何时，其色白兼红黄者，皆无阳一气之所化，况痘疹
属火，故面色赤者，顺也。如面反青色者，是色病不相应，且为阴惨肃杀之气，逆也。
然有因肝木克制脾土者；有因吐泻脾胃受伤者；有因痘出遇寒相搏凝滞遍身青色者；更
有因身热烦燥不去而欲生风者。盖热者必生风；虚者必下利，随所因而治之，大抵不外
先天阳气不足，后天脾元有亏、故为凶多吉少者也。
痘有阴囊肿痛如瓠瓜者，是膀胱热甚，毒瓦斯流入于小肠也，宜解毒清热利水为主。
若在痘后者，是余热余毒湿热下注也，亦宜解毒清利湿热，外以石燕醋磨浓汁搽之
夫目者，心之所使，神所寓焉。然目得血而能视，兼之诸脉及五脏六腑之精气，皆
上注于目，故阴阳合德而为之精。凡痘毒发于脏腑，其热毒之甚者，火走空窍，肝肾虚
者，目必受之。然若发热之初，观其两目，神倦不欲开者，痘也；目中汪汪若水者，疹
也。盖诸疮皆属于心，故候见于目也。至若痘疮入眼者，此不在于初，多在收靥之时，
满面破烂，重复充灌，脓血胶固，是以热毒熏蒸，内攻于目者，或有痘毒太盛，成就迟
缓，过用辛热之药以致者，在白珠子者，此不必治，久当自去，惟在黑轮上者，急宜治
之，治法惟宜活血解毒而已。活血不致于热，解毒不致于冷，用药得宜，其症渐退。
至于虚弱者，尤忌凉剂，恐致变症百出。非徒无益矣。但调脏腑平和而再不愈，乃专治
之。如至靥后，目涩不开，明暗皆然者，是肝热也。如见明则合，暗处则开者，谓之羞
明，此余热在于心肝，或肾虚所致也。若眼目昏暗，时多热泪者，是肝脏实热也。更有
风热上攻而赤肿流血者；更有疮毒入目，血热不散，两目皆赤痛楚难忍者；更有翳膜生
中者。若翳生四边散漫者，易治。如暴遮黑睛者，多致失明，至如瞳人破损，及睛突出
或陷下者，此皆不可治也，然切不可用点洗之药，以致反生大害，故最宜调理于未成，
有于将痘之际，用胭脂浸水涂眼四傍，及诸护眼之方，皆良法也。痘后忌食鸡、鸭、蛋
者，盖卵性寒多滞，滞则毒不化，流入于肝，乃目病也。
痘疹的发出，是热邪在体内内外蒸腾发散的结果。如果热毒正在运行之时，突然受到暴寒的遏制，那么外来的寒邪与体内的热邪相互抗拒，导致毒气既不能内入，又因外寒阻滞而不能外发。因此，毒气壅塞在肌肤腠理之间，痘疮呈现出如痣点般的形态，颜色或青或紫，这就是俗称的“鬼捻青”。治疗应当以发散寒邪、温通肌表、调和气血为主，使毒气重新运行，痘疮才能顺利发出。这不仅见于年幼体质虚弱者，年壮且肌肉丰厚的人，也常出现这种病症。
面部是诸阳经汇聚之处，所以无论患什么病、在什么时期，面色白中兼带红黄的，都是阳气化生的正常表现。何况痘疹属火性，所以面色红润是顺证。如果面色反而发青，这是色与病不相符合，且带有阴冷肃杀之气，属于逆证。然而，这种情况有的因为肝木克制脾土所致；有的因为呕吐腹泻损伤脾胃所致；有的因为痘疮发出时遭遇寒邪相搏，凝滞导致遍身青色；更有因为身体发热烦躁不退而欲生风动惊者。大概热盛必生风，虚损必致下利，根据病因进行治疗，大抵都不外乎先天阳气不足，后天脾胃元气亏损，所以预后多为凶险少吉。
痘疮患者若出现阴囊肿痛像瓠瓜一样大的，这是膀胱热毒炽盛，毒气流入小肠的表现，治疗应以解毒、清热、利水为主。如果是痘疮消退后出现这种情况，则是余热余毒导致的湿热下注，也宜用解毒清利湿热的方法治疗，外用石燕醋磨成的浓汁涂抹患处。
眼睛是心神所驱使，也是精神寄居的地方。然而眼睛得到血液的滋养才能视物，加上各条经脉以及五脏六腑的精气都上注于目，所以阴阳和谐交融才形成眼的精气。凡是痘毒发于脏腑，其中热毒严重的，火热之邪会走窜空窍，肝肾虚弱的人，眼睛必然受累。如果在发热初期，观察其双眼，神情疲倦不想睁开的，是痘疮；眼中汪汪如水样的，是麻疹。大概各种疮疡都归属于心，所以征候反映在眼睛上。至于痘疮长在眼睛上的，这并不在于发病初期，多在结痂收靥的时候，满脸破烂，反复充灌，脓血胶结固着，因此热毒熏蒸，向内攻冲于眼睛。或者是因为痘毒太盛，成痘迟缓，过度使用辛热药物所导致。长在白珠（巩膜）上的，不必治疗，时间久了自然会消退；只有长在黑轮（角膜/瞳孔区域）上的，急需治疗，治疗方法只宜活血解毒而已。活血而不致过热，解毒而不致过冷，用药得当，症状会逐渐消退。对于虚弱的人，尤其忌讳凉药，恐怕导致变症百出，不仅无益反而有害。只是调理脏腑平和之后仍然不愈，才专门针对眼睛治疗。比如到结痂后，眼睛干涩无法睁开，无论明暗都一样，这是肝热。如果见光亮就闭合，在暗处就睁开，称为羞明，这是余热在心肝，或是肾虚所致。如果眼目昏暗，时常流出热泪，这是肝脏实热。更有风热上攻导致红肿流血者；更有疮毒入目，血热不散，两眼皆赤痛难忍者；更有翳膜生在中央者。如果翳膜生在四边散漫的，容易治疗。如果突然遮蔽黑睛的，多会导致失明。至于瞳人破损，以及眼球突出或凹陷的，这些都属于不可治之症。然而切不可使用点洗的眼药，以免反而造成大害，所以最适宜在未形成之前进行调理，比如在即将出痘之际，用胭脂浸水涂在眼睛四周，以及使用各种护眼的方法，都是很好的办法。痘疮痊愈后忌食鸡、鸭、蛋，因为蛋类性质寒凉且多滞腻，滞腻则毒气不能化解，流入肝脏，从而导致眼病。
The eruption of smallpox (Douzhen) is the result of pathogenic heat steaming and diffusing from within to outside. If, while the heat-toxin is in motion, it is abruptly constrained by violent cold, the external cold and internal heat repel each other, preventing the toxin from entering inward or exiting outward due to the obstruction by external cold. Consequently, toxic vapors become congested in the muscle and interstitial spaces, causing the pustules to appear like mole spots, either blue or purple, commonly known as "Ghost Pinching Blue" (Guinianning Qing). The treatment should focus on dispersing cold pathogens, warming the muscles, and harmonizing Qi, so that toxic vapors can resume their circulation and the pustules can erupt properly. This condition occurs not only in young individuals with weak constitutions but also frequently in robust adults with thick flesh.
The face is the convergence point of all Yang meridians. Therefore, regardless of the disease or stage, a complexion that is white with hints of red and yellow indicates the transformation of Yang Qi. Since smallpox belongs to the Fire element, a reddish facial color is a favorable sign (Shun). Conversely, a bluish-green complexion indicates a mismatch between color and disease, carrying an Yin, cold, and desolate Qi, which is an unfavorable sign (Ni). However, this may arise from Liver Wood overacting on Spleen Earth; from vomiting and diarrhea injuring the Spleen and Stomach; from cold pathogens clashing during eruption causing stagnation and generalized cyanosis; or from persistent fever and restlessness leading to wind-stirring. Generally, excess heat generates wind, while deficiency leads to diarrhea. Treatment depends on the cause, but fundamentally, it usually stems from insufficient congenital Yang Qi and deficient postnatal Spleen Yuan, resulting in more misfortune than fortune.
If a patient presents with swelling and pain in the scrotum resembling a gourd, it indicates excessive heat in the Bladder and toxic vapors flowing into the Small Intestine. The treatment should prioritize detoxification, clearing heat, and promoting diuresis. If this occurs after the resolution of pustules, it is due to residual heat and toxins causing damp-heat to flow downward. It should also be treated with detoxification and clearing/drainage of damp-heat. Externally, apply a thick paste made from grinding Shiyan (Swallow Stone) in vinegar.
The eyes are directed by the Heart Spirit and house the Shen (Spirit). However, the eyes require blood nourishment to see, and the essence-Qi of all meridians and Zang-Fu organs flows upward into them. Thus, the harmonious interaction of Yin and Yang forms the essence of vision. When smallpox toxins affect the Zang-Fu organs, severe heat-toxins tend to travel through hollow orifices; thus, those with Liver and Kidney deficiency will inevitably suffer eye involvement. During the initial fever, if the eyes appear weary and reluctant to open, it indicates smallpox; if they appear watery, it indicates measles (Zhen). Since all sores belong to the Heart, signs manifest in the eyes. Pustules growing on the eyes typically do not occur at the onset but rather during the crusting phase (Shouye), when the face is ulcerated, repeatedly filling with pus and blood. Heat-toxins steam and attack inwardly. Alternatively, excessive use of acrid-warm herbs due to slow progression of severe toxins may cause this. Lesions on the Bai Zhu Zi (white part of the eye/sclera) need no treatment and will resolve spontaneously; however, lesions on the Hei Lun (black part/cornea/pupil area) require urgent treatment using methods to invigorate blood and detoxify. Blood-invigorating agents should not be too hot, and detoxifying agents should not be too cold. With appropriate medication, symptoms will gradually subside. For weak patients, cold-natured formulas are strictly contraindicated to avoid inducing various complications, which would be futile and harmful. Only after regulating the Zang-Fu to harmony, if the condition persists, should specific eye treatment be pursued. For instance, after crusting, if eyes are dry and cannot open regardless of light, it indicates Liver Heat. If eyes close in bright light but open in darkness, it is called photophobia (Xiuming), caused by residual heat in the Heart and Liver or Kidney deficiency. Dim vision with frequent hot tears indicates Liver Excess Heat. Other presentations include redness, swelling, and bleeding from attacking Wind-Heat; unbearable redness and pain from blood-heat stagnation due to sore toxins entering the eyes; or the formation of nebulae (Yi Mo). Nebulae spreading at the periphery are easy to treat; sudden obscuration of the black pupil often leads to blindness. Damage to the pupil, protrusion, or sinking of the eyeball are incurable. Crucially, avoid using eye drops or washes, which may cause greater harm. Prevention is best: before eruption, applying water-infused rouge around the eyes or using other eye-protection formulas are effective methods. After recovery, avoid chicken, duck, and eggs, as egg whites are cold and cloying; stagnation prevents toxin resolution, allowing toxins to enter the Liver and cause eye diseases.