小儿面色青白，或黧黑痿黄，无喜色无精采，两目黑多白少，白睛带青色，视瞻
歪斜，暗昧无神，囟陷囟填，解颅，囟不合，五软，五鞮，龟胸，龟背，鹤膝，鼻孔
小，气浊，声音不亮不长，肉不束，骨松如发面样，身体瘦无胭肉，身有廒敛疥疮，
腹有疳积，项有结核，病后元气未复，素有惊痫之证，失乳之后，气血不足，脾胃虚
弱，精神倦怠，脉不和平，以上皆不可种。
凡小儿父母，行事疏忽，不知调摄，不听禁忌，不信医药，过于溺爱娇纵者，亦
断不可与种。
种痘之时，要细阅小儿气血冲和，脏腑均平，内无痰热食积所伤，外无六淫之气
相侵，方可用上好痘痂种之，一岁者用二十余粒，三四岁者用三十余粒，置于净磁钟
内，以柳木作杵，碾为细末，以净水滴三五点入钟内，春温用，冬热用，干则再加水
几点，总以调匀为度，不燥不湿，用新棉些须摊极薄片，裹所调痘屑在内，捏成枣核
样，以红线拴定，仍留寸许，长则剪去，将苖纳入鼻孔，分男左女右，不可离人，时
时看守，倘小儿用手指拈弄，急禁止之，或被嚏出，急将苗塞鼻内，不可稍缓，恐泄
苗气，下苖后必以六个时辰为度，然后取出，如遇天气严寒，多留数刻，若遇时令和
暖，早取数刻亦可，要在临时斟酌，痘苗取出之后，其苗气渐次而入，传遍五藏，至
七日始发热，发热三日而苗见，见苖三日而出齐，出齐三日而灌浆，灌足三日而回水
结痂，大功成矣。
小儿面色青白，或黧黑痿黄，无喜色无精采，两目黑多白少，白睛带青色，视瞻歪斜，暗昧无神，囟陷囟填，解颅，囟不合，五软，五鞮，龟胸，龟背，鹤膝，鼻孔小，气浊，声音不亮不长，肉不束，骨松如发面样，身体瘦无胭肉，身有廒敛疥疮，腹有疳积，项有结核，病后元气未复，素有惊痫之证，失乳之后，气血不足，脾胃虚弱，精神倦怠，脉不和平，以上皆不可种。
译文：如果小儿面色呈现青白色，或者黧黑、萎黄，没有喜悦的神色和神采，双眼黑色多于白色，眼白部分带有青色，视线和目光歪斜昏暗、没有神采，囟门凹陷或隆起，解颅（囟门迟闭），囟门不合拢，出现五软（头项、口、手、足、肌肉软弱无力），五鞮（指手足拘挛僵硬等症，此处通“疳”或指肢体畸形），龟胸（胸廓前凸如龟背），龟背（脊柱弯曲如龟背），鹤膝（膝关节肿大，小腿纤细如鹤膝），鼻孔狭小，气息浑浊，声音不响亮且不悠长，肌肉不能收束紧致，骨骼松软如同发酵的面团一样，身体消瘦且臀部无肉，身上有瘰疬、疥疮，腹部有疳积（小儿慢性营养不良综合征），颈部有结核（淋巴结肿大），大病之后元气尚未恢复，平素就有惊风、癫痫的病症，断奶之后，气血不足，脾胃虚弱，精神疲倦懈怠，脉搏不调和，以上这些情况都不可进行种痘。
凡小儿父母，行事疏忽，不知调摄，不听禁忌，不信医药，过于溺爱娇纵者，亦断不可与种。
译文：凡是小儿的父母，行为疏忽大意，不懂得调理护理，不听从医疗禁忌，不相信医药治疗，过度溺爱和娇惯孩子的，也绝对不可以给孩子种痘。
种痘之时，要细阅小儿气血冲和，脏腑均平，内无痰热食积所伤，外无六淫之气相侵，方可用上好痘痂种之，一岁者用二十余粒，三四岁者用三十余余粒，置于净磁钟内，以柳木作杵，碾为细末，以净水滴三五点入钟内，春温用，冬热用，干则再加水几点，总以调匀为度，不燥不湿，用新棉些须摊极薄片，裹所调痘屑在内，捏成枣核样，以红线拴定，仍留寸许，长则剪去，将苖纳入鼻孔，分男左女右，不可离人，时时看守，倘小儿用手指拈弄，急禁止之，或被嚏出，急将苗塞鼻内，不可稍缓，恐泄苗气，下苖后必以六个时辰为度，然后取出，如遇天气严寒，多留数刻，若遇时令和暖，早取数刻亦可，要在临时斟酌，痘苗取出之后，其苗气渐次而入，传遍五藏，至七日始发热，发热三日而苗见，见苖三日而出齐，出齐三日而灌浆，灌足三日而回水结痂，大功成矣。
译文：在种痘的时候，必须仔细审视小儿是否气血调和，脏腑平衡，体内没有受到痰热、食积的伤害，体外没有被风、寒、暑、湿、燥、火这六淫邪气侵袭，才可以选用上好的痘痂进行接种。一岁的儿童使用二十多粒，三到四岁的儿童使用三十多粒，放入干净的瓷钵中，用柳木做成药杵，研磨成细粉末，滴入三五滴纯净水在瓷钵内，春季温暖时用水，冬季寒冷时用热水（注：原文“春温用，冬热用”通常理解为根据季节调整水温，或指用药引/介质，此处直译为根据季节使用温水或热水，结合语境多为调节温度以适应体质或操作需求，古籍中常指水温或介质性质，此处依字面意译并保留原意逻辑，即春用常温/温水，冬用热水以助发散或适应寒冷），如果变干了就再滴几滴水，总之以调配均匀为标准，不干也不湿。取少许新棉花摊成极薄的片状，包裹住调制好的痘屑，捏成枣核形状，用红线系紧，留出约一寸长的线头，如果太长就剪掉。将痘苗插入鼻孔，男孩插左边鼻孔，女孩插右边鼻孔，过程中不能离开人，要时刻看护，如果小儿用手指拨弄，急忙制止；如果被喷嚏打出，急忙将痘苗塞回鼻内，不能稍有迟缓，恐怕泄露了痘苗的气机。植入痘苗后，必须以六个时辰（12小时）为限度，然后再取出。如果遇到天气严寒，可以多停留一会儿；如果遇到气候温和暖和，可以提前几个时辰取出，这要根据当时的情况酌情处理。痘苗取出之后，痘苗的气机逐渐进入体内，传播遍及五脏，到了第七天开始发热，发热三天后痘疹显现，痘疹显现三天后出齐，出齐三天后开始灌浆，浆液灌满三天后回水结痂，这项大功就完成了。
When a child's complexion is cyanotic and pale, or dark/blackish with sallow atrophy, lacking joyous expression and vitality; when the eyes show more black than white, the sclera has a bluish tint, gaze is slanted or dim and spiritless; when the fontanelle is sunken or bulging, there is delayed closure of the fontanelle (Jie Lu), the five softnesses (Wu Ruan - weakness of head, neck, mouth, hands, feet, and muscles), five rigidity/deformities (Wu Di), turtle chest (Gu Xiong), turtle back (Gu Bei), crane knee (He Xi); when nostrils are small, breath is turbid, voice is not resonant or long, muscles are lax, bones are loose like dough, body is emaciated without gluteal flesh, skin has scrofula or scabies, abdomen has infantile malnutrition (Gan Ji), neck has tubercles, post-illness Yuan Qi has not recovered, there is a history of fright convulsions or epilepsy, after weaning Qi and Blood are insufficient, Spleen and Stomach are weak, spirit is fatigued, pulse is unharmonious. All the above conditions contraindicate vaccination.
For children whose parents are negligent in conduct, unaware of proper care, disregard taboos, distrust medicine, or are overly doting and spoiling, vaccination must absolutely be avoided.
At the time of vaccination, one must carefully examine whether the child's Qi and Blood are harmonious, Zang-Fu organs are balanced, internally free from damage by phlegm-heat or food retention, and externally free from invasion by the Six Exogenous Pathogens (Liu Yin). Only then can high-quality variolae crusts be used for inoculation. For a one-year-old, use over twenty grains; for three to four years old, use over thirty grains. Place them in a clean porcelain mortar, grind into fine powder using a willow wood pestle. Add three to five drops of pure water to the mortar. In warm spring weather, use room temperature water; in cold winter weather, use warm/hot water. If it dries out, add a few more drops. The mixture should always be uniform, neither too dry nor too wet. Take a small amount of new cotton, spread it into an extremely thin sheet, wrap the prepared variolae powder inside, and pinch it into a date-pit shape. Secure it with a red thread, leaving about one cun of thread length; if longer, trim it off. Insert the seed into the nostril: left nostril for boys, right nostril for girls. Do not leave the child unattended; watch constantly. If the child fiddles with it using fingers, stop them immediately. If sneezed out, reinsert the seed into the nose immediately without delay, lest the efficacy of the seed be lost. After inserting the seed, keep it in place for six shichen (twelve hours) before removal. If the weather is severely cold, leave it for a bit longer; if the season is mild and warm, remove it a few ke (quarters of an hour) earlier. This requires discretion based on the situation. After removing the variolae seed, its qi gradually enters the body and spreads through the Five Zang Organs. Fever begins on the seventh day. After three days of fever, the rash appears. Three days after appearance, the lesions fully erupt. Three days after full eruption, they begin to suppurate (fill with pus). Three days after being fully filled, the fluid recedes and scabs form. The great task is accomplished.