发。此缘劳役过度，寒热往来，医认为疟，发散寒凉，重虚其虚，非峻补气血，何由得生？○方虎病三阴疟四年，
服过人参几十斤，年久病深，形肉尽脱，饮食不进，每觉气从左胁上冲，烦乱欲脱，重用桂、附、芍药、地黄，
养营逐翳。冬至日，正发期，遂不至。（《己任编》）
陈眉公三日疟，浃岁未瘥，素畏人参。诊其脉，浮濡沉弱，此营卫俱衰，故延久不已。谓曰∶素不服参
者，天畀之丰也。今不可缺者，病魔之久也。试服钱许，口有津生，腹无烦满，遂以人参一两，首乌一两，煎
成入姜汁少许，一剂势减，再剂遂截。（李士材）
有二男子，各得 疟三年，俱发于寅申巳亥日。一人昼发，发于巳而退于申；一人夜发，发于亥而退于
寅。昼发者乃阴中之阳病，宜补气解表，与小柴胡汤倍人参加白术、川芎、陈皮。夜发者为阴中之阴病，宜补
血疏肝，用小柴胡汤合四物汤，加青皮。
各与十帖，加姜枣煎，于未发前二时，每日一帖，服至八帖，同日得大汗而愈。（《医学正传》）
及门鲍北山患三日疟，经九十日未脱，因思左传齐候 遂 ，注云∶自三日一发至十日一发皆名 。考本
草专治 疟，莫如葳蕤（俗名玉竹），每日浓煎三两，分三次服，半月断根。此方传治多人，志之以俾济世。（《医参》）
附方
燮理丸 日蚀之时，用灰面若干，清水和成，对日为丸，晒干收贮听用。此阳中有阴，阴阳既分，疟有不
愈者乎？试剖丸中则空，是其验也。
五方丸 疟来多发，邪势已衰，用此截之。青黛五钱、辰砂一钱、桂心五钱、白凡五钱、白芷三钱、巴霜
三钱、黑附子三钱、麝香一钱、硫黄五钱、雄黄三钱。各研为末，用五色纸分包，端阳午时，按方位摆就，焚
香一炷，取五姓粽捣丸如桐子大，辰砂为衣，日中晒干。疟发之日，早一、二时用新绵裹塞鼻内，男左
女右，勿经妇人手。
发作。这是因为过度劳累，出现寒热往来的症状，医生误认为是疟疾，使用了发散和寒凉的药物，导致正气更加虚弱，如果不使用峻补气血的方法，怎么能存活呢？○方虎患有三阴疟四年，服用了人参几十斤，因病程长久且病势深重，形体肌肉完全脱失，饮食无法进入，每次感觉气从左胁向上冲逆，心烦意乱几乎要昏厥，重用桂枝、附子、芍药、地黄，以滋养营血、驱除病邪。在冬至日，正值疟疾发作的时期，病情却没有发作。（《己任编》）
陈眉公患三日疟，整整一年没有痊愈，平时畏惧服用的人参。诊察他的脉象，浮取濡软，沉取微弱，这是营卫之气都衰弱，所以拖延日久不能停止。我对他说：“平时不服用人参，是因为你天赋体质丰盈。现在不可缺少的，是因为病魔缠身太久。”试着让他服用一钱，口中生津液，腹部没有烦闷胀满的感觉，于是用人参一两、首乌一两，煎煮后加入少许姜汁，服用一剂后症状减轻，服用两剂后疟疾便截断停止了。（李士材）
有两个男子，各自患疟疾三年，都在寅、申、巳、亥日发作。一人白天发作，在巳时发作而在申时退去；一人夜晚发作，在亥时发作而在寅时退去。白天发作的是阴中之阳的病，应当补气解表，给予小柴胡汤，加倍人参并加入白术、川芎、陈皮。夜晚发作的是阴中之阴的病，应当补血疏肝，给予小柴胡汤合四物汤，加入青皮。
各给予十帖，加入生姜、大枣煎煮，在未发作前两小时，每日一帖，服用至第八帖，在同一天出大汗而痊愈。（《医学正传》）
弟子鲍北山患三日疟，经过九十天仍未脱离病苦，因此思考《左传》中齐侯“遂”的注解，说：“从三天一发到十天一发都名为‘遂’（指疟疾迁延不愈）。考察本草，专门治疗这种迁延性疟疾的，没有比葳蕤（俗名玉竹）更好的了。”每天浓煎三两，分三次服用，半个月断根。这个方子传授给多人治疗过，记录下来以便救济世人。（《医参》）
附方
燮理丸 在日蚀的时候，用面粉若干，清水调和成团，对着太阳做成丸药，晒干收藏备用。这是阳中有阴，阴阳既已分开，疟疾有不痊愈的吗？剖开丸药中间则是空的，这就是验证。
五方丸 疟疾发作次数多，邪气势力已经衰退，用此法截断疟疾。青黛五钱、辰砂一钱、桂心五钱、白矾五钱、白芷三钱、巴豆霜三钱、黑附子三钱、麝香一钱、硫黄五钱、雄黄三钱。各研为细末，用五色纸分包，端午节午时，按照方位摆放好，焚香一炷的时间，取五种姓氏的粽子捣碎做成如梧桐子大小的丸药，用辰砂做衣，在阳光下晒干。疟疾发作的那天，早晨一、两个时辰用新棉包裹塞入鼻孔内，男性左鼻，女性右鼻，不要经过妇女的手触碰。
Paroxysm occurs. This is due to excessive labor, presenting with alternating chills and fever. The physician mistakenly diagnosed it as malaria (Nüe Ji) and administered diaphoretic and cold-natured drugs, further depleting the already deficient healthy qi. Without vigorous tonification of Qi and Blood, how could life be preserved? ○ Fang Hu suffered from San Yin Malaria for four years, having consumed dozens of jin of Renshen (Ginseng Root). Due to the prolonged duration and deep-seated nature of the disease, his flesh and muscles were completely wasted, and he could not take food. He felt Qi rushing upward from the left hypochondrium, causing severe restlessness and a sensation of impending collapse. Heavy doses of Guizhi (Cinnamon Twig), Fuzi (Prepared Aconite Root), Shaoyao (Peony Root), and Dihuang (Rehmannia Root) were used to nourish Ying (Nutritive Qi) and dispel pathogenic factors. On the day of the Winter Solstice, which was the expected time of paroxysm, the attack did not occur. (from *Jiren Bian*)
Chen McGong suffered from Triennial Malaria (San Ri Nüe) for a full year without recovery. He had a long-standing aversion to taking Renshen (Ginseng Root). Upon palpation, his pulse was floating and soggy on the superficial level, and weak on the deep level. This indicates that both Ying (Nutritive Qi) and Wei (Defensive Qi) are depleted, hence the persistence of the disease. I told him: "Your previous refusal to take Renshen was because your innate constitution was robust. However, now it is indispensable because the pathogenic factor has lingered for too long." He tried taking one qian, and saliva was produced in the mouth, with no abdominal distension or discomfort. Subsequently, one liang of Renshen (Ginseng Root) and one liang of Shouwu (Polygonum Multiflorum Root) were decocted with a little Jiangzhi (Ginger Juice). After one dose, the condition improved; after two doses, the malaria was arrested. (Li Shicai)
Two men each suffered from Malaria for three years, with paroxysms occurring on days corresponding to Yin, Shen, Si, and Hai. One man's paroxysms occurred during the day, starting at Si hour and subsiding at Shen hour; the other's occurred at night, starting at Hai hour and subsiding at Yin hour. The daytime paroxysm represents a disease of Yang within Yin, suitable for tonifying Qi and releasing the exterior. Xiao Chaihu Tang (Minor Bupleurum Decoction) was prescribed with doubled Renshen (Ginseng Root), plus Baizhu (Atractylodes Macrocephala Rhizome), Chuanyiong (Szechuan Lovage Rhizome), and Chenpi (Tangerine Peel). The nighttime paroxysm represents a disease of Yin within Yin, suitable for nourishing Blood and soothing the Liver. Xiao Chaihu Tang (Minor Bupleurum Decoction) was combined with Siwu Tang (Four Substance Decoction), plus Qingpi (Green Tangerine Peel).
Ten doses were given to each, decocted with Shengjiang (Fresh Ginger) and Dazao (Jujube Fruit). One dose was taken daily two hours before the expected paroxysm. After eight doses, they both experienced profuse sweating on the same day and recovered. (from *Yixue Zhengzhuan*)
Student Bao Beishan suffered from Triennial Malaria for ninety days without relief. Recalling the commentary in *Zuo Zhuan* regarding Duke Huan of Qi's "Sui" (protracted illness), which states that paroxysms ranging from every three days to every ten days are all termed "Sui" (referring to protracted malaria), he consulted materia medica. It was found that Zhebeimu (Fritillaria Thunbergii Bulb) [Note: Text says Weirui/Yuzhu, but context implies specific herb for this case, sticking to text: Weirui] (commonly known as Yuzhu / Polygonatum Odoratum Rhizome) is best for treating such protracted malaria. Three liang were decocted strongly daily, divided into three doses. The root cause was eliminated in half a month. This prescription has been successfully used on many people; it is recorded here to benefit the world. (from *Yican*)
Appendix Formulas
Xieli Wan (Harmonizing Pill) At the time of a solar eclipse, use an appropriate amount of flour, mix with clear water to form a dough, shape into pills while facing the sun, dry them in the sun, and store for use. This embodies 'Yang containing Yin'. Once Yin and Yang are separated, can Malaria fail to heal? If you cut open the pill, it is hollow inside, which serves as verification.
Wufang Wan (Five Directions Pill) Used when Malaria attacks frequently, indicating the pathogenic force has weakened, to arrest the disease. Qingdai (Indigo Naturalis) 5 qian, Chensha (Cinnabar) 1 qian, Guixin (Cinnamon Heartwood) 5 qian, Bai Fan (Alumen) 5 qian, Baizhi (Angelica Dahurica Root) 3 qian, Bashuang (Croton Seed Pulp) 3 qian, Hei Fuzi (Black Prepared Aconite Root) 3 qian, Shexiang (Musk) 1 qian, Liuhuang (Sulfur) 5 qian, Xionghuang (Realgar) 3 qian. Each ingredient is ground into fine powder, separately wrapped in five-colored paper. On the Dragon Boat Festival at Wu hour (noon), arrange them according to directions, burn one stick of incense, then take Zongzi (sticky rice dumplings) from five different surnames, pound them together, and shape into pills the size of paulownia seeds. Coat with Chensha (Cinnabar), and dry in the sun. On the day of the Malaria paroxysm, early morning (one or two shichen), wrap the pill in new cotton and insert it into the nostril. For males, the left nostril; for females, the right nostril. Do not let women touch it.