夫间日疟者。此由邪气与卫气。俱行于六腑。而有时相失不相得。故邪气内搏于五脏。
则道远气深。故其气行迟。不能与卫气皆出。是以间三两日而作也。
治间日疟。身体壮热。时发增寒。大便秘涩。鳖甲散方。
鳖甲（一两涂醋炙令黄去裙 ） 赤芍药（一两） 当归（一两锉微炒） 大青（一两）
知母
（一两）
炒） 天
灵盖（
上件药。捣粗罗为散。每服五钱。用水一大盏。煎至五分。去滓。调天灵盖末
前服之。
治间日疟。或隔日。或三五日。发动无时。知母散方。
知母（一分） 恒山（半分） 鳖甲（一分涂醋炙令黄去裙 ） 桃仁〔二（一）分汤
浸去皮尖
双仁麸炒微黄〕 附子（一分炮裂去皮脐） 糯米（五十粒） 乌梅肉（一枚） 野狼牙（半
分）
上件药。都细锉。用酒一大盏半。浸一宿。五更初煎取八分。去滓。分为二服。空心热
服。将欲发时再服。
治间日疟。发作无时。寒热不止方。
恒山（一两） 鳖甲（一两涂醋炙令黄去裙 ） 川升麻（一两） 栀子仁（半两）
上件药。捣细罗为散。空腹。以温水调二钱。服以微吐为度。未吐再服。
治间日疟。寒热不止。乌梅丸方。
乌梅肉（一两微炒） 桃仁〔二（三）十枚汤浸去皮尖双仁麸炒微黄〕 地骨皮（一两）
豉
心
（一两炒干）
升麻
（一两） 人参（
上件药。捣罗为末。炼蜜和捣三二百杵。丸如梧桐子大。空腹。以暖浆水下二十丸。晚
再服之。
治间日疟。或夜发者方。
恒山（二两） 秫米（一百粒） 竹叶（一两） 石膏（二两）
上件药。都细锉。以水二大盏浸药。露经一宿。明旦煎取一盏二分。去滓。分为二服。
空心一服。未发前一服。当日勿洗手面及漱口。勿食。并用药汁涂五心。及胸前头面。药滓
置于头边。极妙。
又方。
川大黄（半两锉碎微炒） 甘草（一分炙微赤） 恒山（三分） 桂心（一分）
上件药。都细锉。以水二大盏。煮取一盏。去滓。分为二服。空心热服。临发前再服。
治间日疟。或每日发者。雄黄丸方。
雄黄（一两细研） 腊月野狐肝（一两） 阿魏（一分） 朱砂（半两细研） 猢狲头
骨（一两）
天灵盖（半两） 麝香（一分细研）
上件药。生捣罗为末。入研药末令匀。于五月五日午时。炼蜜和丸。如豇豆大。每发时
前。男左女右。以绯帛系一丸于中指上。时时嗅之。后更以醋汤下一丸。
又方。
小麦（一合） 砒黄（一两细研）
上件药。于腊月。以醋浸四十九日。取出焙干。每有患者。取小麦七粒。发前。以冷醋
汤下之。
所谓间日疟，是由于邪气与卫气共同运行于六腑，但有时两者失去协调、不能同步。因此邪气内迫于五脏，导致病位深远、气机深伏，所以邪气运行迟缓，无法与卫气同时外出。这就是为什么病症每隔两三天才发作一次的原因。
治疗间日疟，症见身体高热，时而发冷加重，大便秘结不通，使用鳖甲散方。
药材：鳖甲（一两，涂醋炙至黄色，去除裙边）、赤芍药（一两）、当归（一两，切碎微炒）、大青（一两）、知母（一两）、天灵盖（半两）。
以上药物，捣碎过粗筛制成散剂。每次服用五钱，用水一大盏，煎至五分，去渣，调入天灵盖粉末，饭前服用。
治疗间日疟，或隔日发作，或三五日发作，发病时间不固定，使用知母散方。
药材：知母（一分）、恒山（半分）、鳖甲（一分，涂醋炙至黄色，去除裙边）、桃仁（一分，汤浸去皮尖，双仁者用麸炒微黄）、附子（一分，炮裂去皮脐）、糯米（五十粒）、乌梅肉（一枚）、野狼牙（半分）。
以上药物，都细细切碎，用酒一大盏半，浸泡一夜，五更初煎取八分，去渣，分为两次服用。空腹热服，在即将发作时再服一次。
治疗间日疟，发作时间不固定，寒热症状不止，使用以下方剂。
药材：恒山（一两）、鳖甲（一两，涂醋炙至黄色，去除裙边）、川升麻（一两）、栀子仁（半两）。
以上药物，捣细过筛制成散剂。空腹时，用温水调服二钱，以微微呕吐为限度，未吐则再服。
治疗间日疟，寒热症状不止，使用乌梅丸方。
药材：乌梅肉（一两，微炒）、桃仁（三十枚，汤浸去皮尖，双仁者用麸炒微黄）、地骨皮（一两）、豉心（一两，炒干）、升麻（一两）、人参（一两）。
以上药物，捣罗成末，炼蜜调和并捣三二百杵，制成梧桐子大小的丸剂。空腹时，用暖浆水送服二十丸，晚上再服一次。
治疗间日疟，或在夜间发作的方剂。
药材：恒山（二两）、秫米（一百粒）、竹叶（一两）、石膏（二两）。
以上药物，都细细切碎，用两大盏水浸泡药物，露天放置一夜，第二天早晨煎取一盏二分，去渣，分为两次服用。空腹服一次，在发作前服一次。当天不要洗手脸及漱口，也不要进食。并将药汁涂抹在两手心、两脚心和心口（五心），以及胸前、头部和面部。药渣放置在枕头边，效果极佳。
又一方。
药材：川大黄（半两，切碎微炒）、甘草（一分，炙微赤）、恒山（三分）、桂心（一分）。
以上药物，都细细切碎，用两大盏水，煮取一盏，去渣，分为两次服用。空腹热服，临发作前再服一次。
治疗间日疟，或每日发作的，使用雄黄丸方。
药材：雄黄（一两，细研）、腊月野狐肝（一两）、阿魏（一分）、朱砂（半两，细研）、猢狲头骨（一两）、天灵盖（半两）、麝香（一分，细研）。
以上药物，生捣罗成末，加入研好的药末混合均匀，在五月五日午时，用炼蜜和丸，如豇豆大小。每次发作前，男性系于左手，女性系于右手的中指上，用红布包裹，不时嗅闻。之后再用醋汤送服一丸。
又一方。
药材：小麦（一合）、砒黄（一两，细研）。
以上药物，在腊月，用醋浸泡四十九天，取出焙干。每当有患者，取小麦七粒，在发作前，用冷醋汤送服。
Intermittent malaria (Jianri Nue) is caused by pathogenic factors (Xieqi) and defensive qi (Weiqi) traveling together through the six fu organs, but occasionally losing synchronization. Consequently, the pathogenic factors press inward upon the five zang organs. Since the disease site is distant and the qi is deep-seated, the qi movement is sluggish and cannot exit simultaneously with the defensive qi. This is why the symptoms manifest every two or three days.
For treating intermittent malaria characterized by high fever, alternating chills and fever, and constipation, use Biejia San (Turtle Shell Powder).
Ingredients: Bie Jia (Testudinis Carapax et Plastrum, 1 liang, prepared with vinegar until yellow, remove skirt edges); Chi Shao Yao (Paeoniae Radix Rubra, 1 liang); Dang Gui (Angelicae Sinensis Radix, 1 liang, sliced and lightly stir-fried); Da Qing (Isatidis Folium, 1 liang); Zhi Mu (Anemarrhenae Rhizoma, 1 liang); Tian Ling Gai (Cranii Humanis Os, 0.5 liang).
Process the above ingredients into a coarse powder. Take 5 qian per dose, decoct with one large cup of water until reduced to 0.5 cup, strain, and mix in the Tian Ling Gai powder. Administer before meals.
For treating intermittent malaria where attacks occur every other day or every three to five days at irregular intervals, use Zhi Mu San (Anemarrhena Powder).
Ingredients: Zhi Mu (Anemarrhenae Rhizoma, 1 fen); Heng Shan (Dichroae Radix, 0.5 fen); Bie Jia (Testudinis Carapax et Plastrum, 1 fen, prepared with vinegar until yellow, remove skirt edges); Tao Ren (Persicae Semen, 1 fen, soaked in water, skin and pointed ends removed, use double-kernel seeds stir-fried with bran until slightly yellow); Fu Zi (Aconiti Lateralis Radix Praeparata, 1 fen, processed until cracked, skin and navel removed); Nuomi (Oryza Sativa Var. Glutinosa, 50 grains); Wu Mei Rou (Mume Fructus Carnosus, 1 piece); Ye Lang Ya (Sarcandrae Herba, 0.5 fen).
Finely chop all ingredients. Soak in 1.5 large cups of wine overnight. At dawn (Wugeng), decoct to obtain 0.8 cup, strain, and divide into two doses. Take warm on an empty stomach, and administer again just before the attack begins.
For treating intermittent malaria with irregular onset and persistent chills and fever, use the following prescription.
Ingredients: Heng Shan (Dichroae Radix, 1 liang); Bie Jia (Testudinis Carapax et Plastrum, 1 liang, prepared with vinegar until yellow, remove skirt edges); Chuan Sheng Ma (Bupleuri Radix, 1 liang); Zhi Zi Ren (Gardeniae Fructus, 0.5 liang).
Grind into a fine powder. On an empty stomach, take 2 qian mixed with warm water. The goal is mild vomiting; if vomiting does not occur, take another dose.
For treating intermittent malaria with persistent chills and fever, use Wumei Wan (Dark Plum Pill).
Ingredients: Wu Mei Rou (Mume Fructus Carnosus, 1 liang, lightly stir-fried); Tao Ren (Persicae Semen, 30 kernels, soaked in water, skin and pointed ends removed, use double-kernel seeds stir-fried with bran until slightly yellow); Di Gu Pi (Lycii Cortex, 1 liang); Chi (Zizyphi Fructus, specifically the heart/core, 1 liang, dried by stir-frying); Sheng Ma (Bupleuri Radix, 1 liang); Ren Shen (Ginseng Radix et Rhizoma, 1 liang).
Grind into powder. Mix with refined honey and pound for 200-300 strokes to form pills the size of paulownia seeds. Take 20 pills on an empty stomach with warm grain water, and repeat in the evening.
For treating intermittent malaria that occurs at night, use the following formula.
Ingredients: Heng Shan (Dichroae Radix, 2 liang); Shumi (Milii Glucini Semen, 100 grains); Zhu Ye (Bambusae Folium, 1 liang); Shi Gao (Gypsum Fibrosum, 2 liang).
Finely chop all ingredients. Soak in 2 large cups of water and leave exposed to the air overnight. Decoct the next morning to obtain 1.2 cups, strain, and divide into two doses. Take one dose on an empty stomach and the other dose before the anticipated attack. On the day of treatment, do not wash hands/face or rinse the mouth, and do not eat. Apply the medicinal juice to the "five centers" (palms, soles, and chest) as well as the chest, head, and face. Place the medicinal dregs near the pillow for optimal effect.
Another formula.
Ingredients: Chuan Da Huang (Rhei Radix et Rhizoma, 0.5 liang, chopped and lightly stir-fried); Gan Cao (Glycyrrhizae Radix et Rhizoma, 1 fen, stir-fried until slightly red); Heng Shan (Dichroae Radix, 3 fen); Gui Xin (Cinnamomi Ramulus Cortex, 1 fen).
Finely chop all ingredients. Decoct in 2 large cups of water until reduced to 1 cup, strain, and divide into two doses. Take warm on an empty stomach, and administer again just before the attack.
For treating intermittent malaria that may occur daily, use Xionghuang Wan (Realgar Pill).
Ingredients: Xiong Huang (Realgar, 1 liang, finely ground); Yehuogan (Vulpis Liver, collected in the twelfth lunar month, 1 liang); Awei (Ferulae Resina, 1 fen); Zhusha (Cinnabar, 0.5 liang, finely ground); Hunsun Tougu (Simiae Cranii Os, 1 liang); Tian Ling Gai (Cranii Humanis Os, 0.5 liang); She Xiang (Moschus, 1 fen, finely ground).
Grind raw ingredients into powder, mix thoroughly with the ground minerals. On the noon hour of the fifth day of the fifth lunar month, mix with refined honey to form pills the size of cowpeas. Before each attack, males tie one pill to the left middle finger and females to the right middle finger using red silk. Sniff the pill intermittently. Subsequently, swallow one pill with vinegar-infused water.
Another formula.
Ingredients: Xiaomai (Tritici Fructus, 1 he); Pi Huang (Arsenicum, 1 liang, finely ground).
In the twelfth lunar month, soak these ingredients in vinegar for 49 days. Remove and dry by baking. When a patient presents, take 7 grains of wheat and administer with cold vinegar-infused water just before the attack.