张景岳曰∶二阳，阳明也，为胃与大肠二经。然大小肠皆属于胃，胃与心，子母也。人之情欲，本以伤心，
母伤则害及其子。胃与脾，表里也。人之劳倦，本以伤脾，脏病则连于腑。故凡内而伤精，外而伤形，皆能
病及于胃。此二阳之病，所以发于心脾也。不得隐曲，阳道病也。夫胃为水谷气血之海，主化荣卫而润宗筋。
阴阳总宗筋之会，会于气街，而阳明为之长。然则精血下行，生化之本，唯阳明为最。今化源既病，则阳道外
衰，故为不得隐曲。其在女子，当为不月也。
李太素曰∶经云二阳之病发心脾，二阳指阳明经胃与大肠也。此经乃水谷传化之地，
而心与脾实系之。盖胃之下口通于小肠上口，胃不病，而小肠传化，则心气流通，而邪不归心。大肠不病而传
化，则饮食营运而脾不劳力。今二阳既病，则传化不行，心脾乌得不病？故曰病发心脾则精血不充。盖精、血，
一物也，主于心而生于脾。在男子言精不言血，故曰少精而不得隐曲。在女子言血不言精，故曰少血而不月。
此心脾受病而然，是月经不调之一端也。
武叔卿曰∶洁古云泻心火，养脾血，是从本文之义也，愚谓当从隐曲推解。人有隐情曲意，难以舒其衷，则
气郁而不畅，不畅则心气不开，脾气不化，水谷日少，不能变化气血，以入二阳之血海。血海无余，所以不月也。
传为风消者，阳明主肌肉，血不足则肌肉不荣，有不消瘦乎？风之名，火之化也。故当根不得隐曲上看，乃有本。
张景岳说：所谓“二阳”，指的是阳明经，即胃与大肠两条经脉。然而大小肠都隶属于胃，胃与心之间是母子关系（心为母，胃为子）。人的情欲过度，原本就会损伤心脏，母亲受损则祸害波及儿子。胃与脾互为表里。人的劳累倦怠，原本就会损伤脾脏，内脏患病则会牵连腑器。所以凡是内部损伤精气，外部损伤形体，都能导致胃病。这就是二阳的病变，之所以发源于心脾的原因。所谓“不得隐曲”，是指性功能方面的疾病。胃是水谷和气血汇聚的海洋，主要化生营卫之气并滋润宗筋（男性外生殖器及周围组织）。阴阳总汇于宗筋，交会于气街穴，而阳明经在其中起主导作用。既然精血下行、生化之源的根本在于阳明，如今化源已经生病，那么性功能就会在外表现衰弱，所以出现“不得隐曲”的症状。对于女子来说，这应当表现为月经不来潮。
李太素说：医经中说“二阳之病发心脾”，这里的二阳指阳明经的胃与大肠。这条经脉是水谷传化的场所，而心与脾实际上与之密切相关。因为胃的下口连接小肠的上口，如果胃不生病，小肠就能正常传化，心气就能流通，邪气就不会归聚于心。如果大肠不生病并能正常传化，饮食营运顺畅，脾脏就不会劳损。如今二阳既已生病，传化功能就不能运行，心脾怎么能不生病呢？所以说病变发于心脾就会导致精血不充盈。精和血，本质上是同一类物质，由心主宰并由脾生成。在男子身上谈论精而不谈论血，所以说精少而导致性功能障碍。在女子身上谈论血而不谈论精，所以说血少而导致月经闭止。这是心脾受病所致，这是月经不调的一种情况。
武叔卿说：洁古（张元素）说泻心火、养脾血，是从本文的原意出发的，我认为应当从“隐曲”二字推演解释。人如果有隐秘的情感和委屈的心意，难以抒发内心的苦衷，就会导致气机郁结而不通畅，气机不畅则心气不能开通，脾气不能运化，水谷摄入日渐减少，不能变化生成气血，从而无法注入二阳的血海（冲脉）。血海没有余血，所以导致月经不来潮。病情发展为“风消”（因虚热耗伤肌肉导致的消瘦），是因为阳明经主司肌肉，血不足则肌肉得不到滋养，能不消瘦吗？“风”的名称，源于火的转化。所以应当从“不得隐曲”这个根源上去寻找病因，这样才有根本依据。
Zhang Jingyue stated: "Er Yang" (Two Yangs) refers to the Yangming channel, which comprises the Stomach and Large Intestine meridians. However, both the Small and Large Intestines are subordinated to the Stomach. The Stomach and Heart share a mother-son relationship (with the Heart as the Mother and the Stomach as the Son). Excessive emotional desires originally damage the Heart; when the Mother is damaged, the harm extends to the Son. The Stomach and Spleen are exterior-interior partners. Laborious fatigue originally damages the Spleen; when Zang organs are diseased, they affect the Fu organs. Therefore, whether internally damaging Essence or externally damaging the Form, all can lead to disease in the Stomach. This is why diseases of Er Yang originate from the Heart and Spleen. "Bu De Yin Qu" (Inability to conceal or resolve hidden matters/sexual dysfunction) refers to pathology of the Yang pathway. The Stomach is the sea of water and grain and Qi and Blood, primarily transforming Ying and Wei (Nutritive and Defensive Qi) and moistening the Zong Jin (Tendon Sheath/Male Genitals). Yin and Yang converge at the Zong Jin, meeting at the Qichuan acupoint, with the Yangming channel acting as their leader. Since the root of descending Essence and Blood and biological transformation lies most heavily in Yangming, now that the source of transformation is diseased, the Yang pathway declines externally, thus resulting in "Bu De Yin Qu." In women, this manifests as amenorrhea (absence of menstruation).
Li Taisu stated: The medical classic says "Diseases of Er Yang originate from the Heart and Spleen." Here, Er Yang refers to the Yangming channels of the Stomach and Large Intestine. This channel is the site of water and grain transmission and transformation, while the Heart and Spleen are intrinsically linked to it. The lower opening of the Stomach connects to the upper opening of the Small Intestine; if the Stomach is not diseased and the Small Intestine transmits normally, Heart Qi flows freely, and pathogens do not gather in the Heart. If the Large Intestine is not diseased and transmits normally, dietary operation proceeds smoothly, and the Spleen does not labor. Now that Er Yang is diseased, transmission and transformation cease; how can the Heart and Spleen not become diseased? Thus, it is said that disease originating in the Heart and Spleen results in insufficient Essence and Blood. Essence and Blood are essentially one substance, governed by the Heart and generated by the Spleen. In men, discussion focuses on Essence rather than Blood, hence "scanty Essence leading to sexual dysfunction." In women, discussion focuses on Blood rather than Essence, hence "scanty Blood leading to amenorrhea." This is caused by disease affecting the Heart and Spleen and represents one aspect of irregular menstruation.
Wu Shuqing stated: Jiegu (Zhang Yuansu) said that draining Heart Fire and nourishing Spleen Blood aligns with the original meaning of the text. I believe, however, that interpretation should be deduced from "Yin Qu." When a person harbors hidden feelings and grievous intentions that cannot be expressed, Qi stagnates and fails to flow smoothly. If Qi flow is unsmooth, Heart Qi fails to open, and Spleen Qi fails to transform. Daily intake of water and grain decreases, preventing the transformation into Qi and Blood to fill the Xue Hai (Sea of Blood/Chong Mai) of Er Yang. With no surplus in the Sea of Blood, menstruation ceases. If the condition progresses to "Feng Xiao" (wasting-thirst due to wind/fire causing emaciation), it is because the Yangming channel governs muscles; without sufficient Blood, muscles lose nourishment, and emaciation inevitably occurs. The term "Wind" derives from the transformation of Fire. Therefore, one must trace back to "Bu De Yin Qu" to find the fundamental cause.