丹溪曰。附骨疽者。皆因久食浓味及劳役。与酒后涉水得此。阳滞于阴之症也。又曰。
环跳
空痛不止。生附骨疽。以苍术为君。佐以黄柏之辛。行以青皮。冬加桂枝。夏加条芩。体虚
者加杜仲、牛膝。以生甘草为佐。作大料煎。入姜汁。食前饮之。
痛甚者。恐前药十数剂发不动。少加麻黄。一二剂又不动者。恐疽将成。急掘地坑。以
火
坑通红。沃以小便。令患者赤体坐于坑中。以席或棉衣围抱下体。使热气熏蒸。腠理开。气
血通畅而愈。
一论疮生腿外侧。或因寒湿。得附骨疽于足少阳经分。微侵足阳明经。坚硬漫肿。行步
作痛。或不能行。
内托黄 汤
柴胡 连翘 肉桂 大力子 黄 当归尾 黄柏 升麻 白芷 甘草（各八分）
上锉。水酒各一盏。煎至一盏。食前。温服。
一治附骨疽。
黄连消毒饮
黄连 羌活（各一钱） 黄柏 黄芩 本 防己 桔梗 归尾（各五分） 生地黄 知母
独活 防风 连翘（各四分） 黄 人参 甘草 陈皮 苏木 泽泻（各二分）
上十九味。切作一剂。水煎服。
一老人年七十。因寒湿地气。得附骨疽于左腿外侧。少阳胆经之分。微侵足阳明经分。
阔
六七寸。长一小尺。坚硬漫肿。不辨肉色皮泽。但行步作痛。以指按至骨内大痛。与此药一
服即止。次日坚硬肿消而愈。
一论顽疮恶毒。年久不愈。以有附骨在内。先用贝母煎浓汤洗净。刮去腐肉。用刀拨去
附骨
或用蜣螂脑子五六个。捣烂敷上。其骨即出。然后用人言五厘。研细末。入黄铜灯盏内。
用好醋一小盏。慢火熬干。收起。过三日。即生出铜绿来。研极细。用鸡翎蘸药扫疮上。即
痛出水。腐肉去净。然后用后药。
珍珠象牙膏 楚黄宾江传。
珍珠（用豆腐一块切两片将珠铺在内两片合住缚定入水煮三炷香为度研细末一钱） 象牙
末（一钱） 天花粉（末五分） 宫粉（末一钱） 白蜡（一钱） 香油（五钱）
上共合一处。入碗内。重汤煮化澄成膏。纸摊贴患处。神效。
一治诸疮大疼痛。不辨肉色。漫肿光色。名曰附骨痈。又治疮口久不合。酒调服。
三生散
露蜂房 蛇蜕 乱发（洗净各等分）
上三味。烧灰存性研末。酒调服一钱七分。
朱丹溪说：附骨疽（生于骨骼深处的化脓性疾患），都是由于长期食用肥甘厚味以及过度劳累，或在酒后涉水受寒而引发的。这是阳气郁滞于阴分的病证。他又说：环跳穴处疼痛不止，会生出附骨疽。治疗时以苍术为君药，佐以黄柏的辛味，配合青皮行气，冬季加桂枝，夏季加条芩。体质虚弱者加杜仲、牛膝，以生甘草为佐使药。将药物大料煎煮，加入姜汁，饭前服用。
疼痛剧烈的，恐怕前面药物的十几剂无法发散邪气，可少量加入麻黄；一二剂后仍无效果的，恐怕疽毒即将成形，应紧急挖掘地坑，用火将地坑烧得通红，浇上小便，让患者赤身坐在地坑中，用席子或棉衣围抱住下半身，使热气熏蒸，腠理开泄，气血通畅即可痊愈。
另一种论述：疮疡生在腿部外侧，可能是因为寒湿之邪，导致足少阳经发生附骨疽，轻微侵犯足阳明经分。表现为坚硬且漫肿，行走时疼痛，或者不能行走。
内托黄芪汤：柴胡、连翘、肉桂、大力子（牛蒡子）、黄芪、当归尾、黄柏、升麻、白芷、甘草（各八分）。以上药物切碎，用水和酒各一盏，煎至一盏，饭前温服。
一种治疗附骨疽的方法：黄连消毒饮。黄连、羌活（各一钱）；黄柏、黄芩、藁本、防己、桔梗、归尾（各五分）；生地黄、知母、独活、防风、连翘（各四分）；黄芪、人参、甘草、陈皮、苏木、泽泻（各二分）。以上十九味药，切制成一剂，水煎服用。
一位七十岁的老人，因寒湿地气侵袭，左腿外侧足少阳胆经部位患上附骨疽，轻微侵犯足阳明经分。肿块宽六七寸，长一尺左右，坚硬漫肿，看不出肌肉颜色和皮肤光泽，只是行走时疼痛，用手指按压直到骨头内部感到剧烈疼痛。服用此药一次即止痛，第二天坚硬肿胀消退而痊愈。
另一种论述：顽固恶毒的疮疡，多年不愈，是因为有死骨附着在内部。先用贝母煎浓汤清洗患处，刮去腐肉，用刀拨出附着的死骨；或者用五六个屎壳郎的脑子捣烂敷在上面，死骨就会排出。然后取人言（信石/砒霜）五厘，研成细末，放入黄铜灯盏内，用好醋一小盏，慢火熬干，收集起来。过三天，表面会长出铜绿，将其研成极细粉末，用鸡毛蘸药涂抹在疮口上，立即疼痛并流出液体，腐肉去除干净。然后用下面的药方：
珍珠象牙膏（由楚黄宾江传授）：珍珠（用一块豆腐切两片，将珍珠铺在其中一片上，盖上另一片绑紧，入水煮三炷香的时间为度，研成细末一钱）；象牙末（一钱）；天花粉末（五分）；宫粉（一钱）；白蜡（一钱）；香油（五钱）。以上药物混合在一起，放入碗内，隔水加热融化澄清成膏状，用纸摊涂贴在患处，效果神奇。
一种治疗各种疮疡剧烈疼痛、看不清肌肉颜色、漫肿发亮的病症，名为附骨痈。也可治疗疮口久不愈合，用酒调服。三生散：露蜂房、蛇蜕、乱发（洗净，各等分）。以上三味药，烧成灰保留药性，研成末，用酒调服一钱七分。
Zhu Danxi stated: Fugu Ju (bone-abscess, a suppurative disease deep in the bone) is caused by long-term consumption of rich and greasy foods, overexertion, or wading in water after drinking alcohol. It is a syndrome where Yang Qi stagnates in Yin. He further stated that persistent pain at the Huantiao (GB30) acupoint can lead to Fugu Ju. Treatment should use Cangzhu (Atractylodis Rhizoma) as the sovereign herb, assisted by the pungency of Huangbai (Phellodendri Cortex), combined with Qingpi (Citri Reticulatae Pericarpium Viride) to move Qi. In winter, add Guizhi (Cinnamomi Ramulus); in summer, add Tiaoqin (Scutellariae Radix). For those with deficient constitution, add Duzhong (Eucommiae Cortex) and Niuxi (Achyranthis Bidentatae Radix), with Sheng Gancao (Glycyrrhizae Radix et Rhizoma) as an assistant herb. Decoct these herbs in large quantities, add Jiangzhi (Zingiberis Recens Juice), and drink before meals.
If the pain is severe, fearing that ten to twelve doses of the previous prescription may not induce dispersal, add a small amount of Mahuang (Ephedrae Herba). If there is no effect after one or two doses, fearing the abscess is about to form, urgently dig a pit in the ground, heat it red-hot with fire, pour urine into it, and have the patient sit naked in the pit. Surround the lower body with mats or cotton clothes so that the heat steams the body, opening the Couli (pores/skin texture), allowing Qi and Blood to flow freely, leading to recovery.
Another discussion: Sores appearing on the lateral side of the leg may be due to Cold-Dampness, resulting in Fugu Ju in the Foot-Shaoyang channel, slightly invading the Foot-Yangming channel. The presentation involves hardness and diffuse swelling, pain upon walking, or inability to walk.
Neituo Huangqi Tang (Internal Supportive Decoction with Astragalus): Chaihu (Bupleuri Radix), Lianqiao (Forsythiae Fructus), Rougui (Cinnamomi Cortex), Dalizi (Arctii Fructus), Huangqi (Astragali Radix), Dangguiwei (Angelicae Sinensis Radix), Huangbai (Phellodendri Cortex), Shengma ( Cimicifugae Rhizoma), Baizhi (Angelicae Dahuricae Radix), Gancao (Glycyrrhizae Radix et Rhizoma) (each 8 fen). Chop the above ingredients. Decoct with one cup of water and one cup of wine until reduced to one cup. Take warm before meals.
A treatment for Fugu Ju: Huanglian Xiaodu Yin (Coptis Detoxification Decoction). Huanglian (Coptidis Rhizoma), Qianghuo (Notopterygii Rhizoma et Radix) (each 1 qian); Huangbai (Phellodendri Cortex), Huangqin (Scutellariae Radix), Ben (Ligustici Rhizoma et Radix), Fangji (Stephaniae Tetrandrae Radix), Jiegeng (Platycodonis Radix), Guiwei (Angelicae Sinensis Radix) (each 5 fen); Sheng Dihuang (Rehmanniae Radix), Zhimu (Anemarrhenae Rhizoma), Duhuo (Angelicae Pubescentis Radix), Fangfeng (Saposhnikoviae Radix), Lianqiao (Forsythiae Fructus) (each 4 fen); Huangqi (Astragali Radix), Renshen (Ginseng Radix), Gancao (Glycyrrhizae Radix et Rhizoma), Chenpi (Citri Reticulatae Pericarpium), Sumu (Pterocarpi Santalinus Lignum), Zexie (Alismatis Rhizoma) (each 2 fen). Cut the above nineteen herbs into one dose, decoct with water, and take orally.
An elderly man aged seventy contracted Fugu Ju on the lateral aspect of his left leg, in the region of the Foot-Shaoyang Gallbladder channel, slightly invading the Foot-Yangming channel, due to Cold-Damp earthy qi. The mass was six to seven cun wide and one chi long, hard and diffusely swollen, with unclear muscle color and skin luster. He experienced pain upon walking and severe pain when pressing with fingers down to the bone. One dose of this medicine stopped the pain immediately; the next day, the hardness and swelling subsided, and he recovered.
Another discussion: Stubborn and malignant sores that do not heal for years are due to necrotic bone attached inside. First, wash the area with a thick decoction of Beimu (Fritillariae Bulbus), scrape off the putrid flesh, and use a knife to dislodge the attached necrotic bone. Alternatively, mash five or six dung beetle brains and apply them topically; the bone will then extrude. Then, take Wuyan (Realgar/Arsenic compound, specifically refined arsenic trioxide here referred to as 'human speech/mineral'), 5 li, grind into fine powder, place in a brass lamp basin, add one small cup of good vinegar, and slowly boil dry. Collect the residue. After three days, verdigris (copper acetate) will form on the surface. Grind this into an extremely fine powder, dip a chicken feather in the medicine, and sweep it onto the sore. This will immediately cause pain and discharge fluid, removing all putrid flesh. Then use the following prescription:
Zhenzhu Xiangya Gao (Pearl and Ivory Paste) (Transmitted by Bin Jiang from Chuhuang): Zhenzhu (Pearl) (Place pearls between two slices of tofu, bind tightly, boil in water for the time it takes to burn three incense sticks, then grind into fine powder, 1 qian); Xiangya Mo (Ivory Powder) (1 qian); Tianhuafen Powder (Trichosanthis Radix Powder) (5 fen); Gongfen (Lead White) (1 qian); Bala (Beeswax) (1 qian); Xiangyou (Sesame Oil) (5 qian). Mix all together, place in a bowl, melt and clarify over a double boiler into a paste. Spread on paper and apply to the affected area. Miraculous effect.
A treatment for severe pain in various sores, where muscle color is indistinguishable, presenting with diffuse swelling and brightness, named Fugu Yong (Bone-Abscess). Also treats sores that fail to close for a long time. Take mixed with wine. Sansheng San (Three Lives Powder): Lufengfang (Vespa Nidus), Shetui (Ophiopogonis Molt/Shed Snake Skin), Luankou (Tangle of Human Hair) (wash clean, equal parts). Burn the above three ingredients to ash while preserving their medicinal properties, grind into powder, and take 1.7 qian mixed with wine.