太阳（足膀胱手小肠）上羌活，下黄柏。少阴（足肾手心）上黄连，下知母。少阳（足
胆手三焦）上柴胡，下青皮。厥阴（足肝手包络）上青皮，下柴胡。阳明（足胃手大肠）上
升麻白芷，下石膏。太
黄连泻心火。栀子、黄芩泻肺火。白芍泻脾火。柴胡、黄连泻肝胆火。知母泻肾火。木
通泻小肠火。黄芩泻大肠火。柴胡、黄芩泻三焦火。黄柏泻膀胱火。
甘草反大戟、芫花、甘遂、海藻；乌头反半夏、瓜蒌、白蔹、白芨；藜芦反细辛、芍药
、人参、沙参、苦参、丹参、元参。
本草名言十八反，半蒌贝蔹芨攻乌，藻戟遂芫俱战草，诸参辛芍叛藜芦。
硫黄原是火中精，朴硝一见便相争。水银莫与砒霜见，野狼毒最怕密佗僧。巴豆性烈最为
上，偏与牵牛不顺情。丁香莫与郁金见，牙硝难合京三棱。川乌草乌不顺犀，人参最怕五灵
脂。官桂善能调冷气，若逢石脂便相欺。大凡修合看顺逆，炮 炙爆莫相依。
枳壳陈皮半夏齐，麻黄野狼毒及茱萸。六般之药宜陈久，入药方知奏效奇。
肝虚者，陈皮、干姜之类补之。虚者补其母，肾者肝之母也。熟地、地黄、黄柏补之，
如无他症，钱氏地黄丸主之。实则白芍药泻之，如无他症，钱氏泻青丸主之。实则泻其子，
以甘草泻心。心者肝之子也。心虚者炒盐补之。虚则补其母，肝者心之母也。以生姜补肝，
如无他症，钱氏安神丸主之。实则甘草泻之，如无他症，钱氏方中重则泻心汤，轻则导赤散。
脾虚者甘草、大枣之类补之。实则黄连、枳实泻之，如无他症，钱氏益元散主之。虚则补
其母，心乃脾之母，以炒盐补心。实则泻其子，肺乃脾之子，以桑白皮泻肺。肺虚者，五味
子补之，实则桑白皮泻之。如无他症，钱氏阿胶散主之。虚则补其母，脾乃肺之母。以甘草、
大枣补脾。实则泻其子，肾者肺之子，以泽泻泻肾。肾虚者，熟地黄、黄柏补之。肾无实
不可泻。钱氏只有补肾地黄丸，无泻肾药。虚则补其母，肺乃肾之母，以五味子补肺。
以上五脏补泻，素问脏气法时论备有之矣。欲究其祥，再着本论。
太阳经（足太阳膀胱经与手太阳小肠经）在上部引经药为羌活，在下部引经药为黄柏。少阴经（足少阴肾经与手少阴心经）在上部引经药为黄连，在下部引经药为知母。少阳经（足少阳胆经与手少阳三焦经）在上部引经药为柴胡，在下部引经药为青皮。厥阴经（足厥阴肝经与手厥阴心包经）在上部引经药为青皮，在下部引经药为柴胡。阳明经（足阳明胃经与手阳明大肠经）在上部引经药为升麻、白芷，在下部引经药为石膏。
黄连用于清泻心火。栀子、黄芩用于清泻肺火。白芍用于清泻脾火。柴胡、黄连用于清泻肝胆之火。知母用于清泻肾火。木通用于清泻小肠之火。黄芩用于清泻大肠之火。柴胡、黄芩用于清泻三焦之火。黄柏用于清泻膀胱之火。
甘草与大戟、芫花、甘遂、海藻相反；乌头与半夏、瓜蒌、白蔹、白及相反；藜芦与细辛、芍药、人参、沙参、苦参、丹参、玄参相反。
本草中有十八反的名言：“半蒌贝蔹芨攻乌，藻戟遂芫俱战草，诸参辛芍叛藜芦。”
硫黄本是火中的精华，但遇到朴硝便会相互争斗。水银绝不能与砒霜相见，野狼毒最害怕密佗僧。巴豆药性猛烈最为上乘，偏偏与牵牛子性情不合。丁香不能与郁金同用，牙硝难以与京三棱合用。川乌、草乌不与犀角相顺，人参最怕五灵脂。官桂善于调理冷气，但如果遇到赤石脂就会受到欺侮。大凡药物配伍要看顺逆关系，炮制加工时不要互相依赖或冲突。
枳壳、陈皮、半夏、麻黄、野狼毒、吴茱萸这六味药适宜陈久存放，入药后才知道其疗效奇特。
肝虚证，用陈皮、干姜之类来补益。根据“虚则补其母”的原则，肾是肝之母，所以用熟地黄、生地黄、黄柏来补益；如果没有其他症状，以钱乙的地黄丸为主方。肝实证，用白芍药来清泻。如果没有其他症状，以钱乙的泻青丸为主方。根据“实则泻其子”的原则，用甘草清泻心火，因为心是肝之子。心虚证，用炒盐来补益。根据“虚则补其母”的原则，肝是心之母，所以用生姜补肝；如果没有其他症状，以钱乙的安神丸为主方。心实证，用甘草来清泻；如果没有其他症状，钱氏方中重证用泻心汤，轻证用导赤散。脾虚证，用甘草、大枣之类来补益。脾实证，用黄连、枳实来清泻；如果没有其他症状，以钱乙的益元散为主方。根据“虚则补其母”的原则，心是脾之母，所以用炒盐补心。根据“实则泻其子”的原则，肺是脾之子，所以用桑白皮清泻肺。肺虚证，用五味子来补益；肺实证，用桑白皮来清泻。如果没有其他症状，以钱乙的阿胶散为主方。根据“虚则补其母”的原则，脾是肺之母，所以用甘草、大枣补脾。根据“实则泻其子”的原则，肾是肺之子，所以用泽泻清泻肾。肾虚证，用熟地黄、黄柏来补益。肾没有实证，不可清泻。钱乙只有补肾的地黄丸，没有泻肾的药方。根据“虚则补其母”的原则，肺是肾之母，所以用五味子补肺。以上五脏的补泻方法，《素问·脏气法时论》中已有完备记载。想要探究详细情况，请参阅本论。
The Sun Taiyang (Foot Bladder and Hand Small Intestine) channel uses Qianghuo (Notopterygii Rhizoma et Radix) as the guiding herb for the upper part, and Huangbai (Phellodendri Cortex) for the lower part. The Shao Yin (Foot Kidney and Hand Heart) channel uses Huanglian (Coptidis Rhizoma) for the upper part, and Zhimu (Anemarrhenae Rhizoma) for the lower part. The Shao Yang (Foot Gallbladder and Hand Sanjiao) channel uses Chaihu (Bupleuri Radix) for the upper part, and Qingpi (Citri Reticulatae Pericarpium Viride) for the lower part. The Jue Yin (Foot Liver and Hand Pericardium) channel uses Qingpi for the upper part, and Chaihu for the lower part. The Yang Ming (Foot Stomach and Hand Large Intestine) channel uses Shengma (Cimicifugae Rhizoma) and Baizhi (Angelicae Dahuricae Radix) for the upper part, and Shigao (Gypsum Fibrosum) for the lower part.
Huanglian clears and drains Heart Fire. Zhizi (Gardeniae Fructus) and Huangqin (Scutellariae Radix) clear and drain Lung Fire. Baishao (Paeoniae Radix Alba) clears and drains Spleen Fire. Chaihu and Huanglian clear and drain Liver and Gallbladder Fire. Zhimu clears and drains Kidney Fire. Mutong (Akebiae Caulis) clears and drains Small Intestine Fire. Huangqin clears and drains Large Intestine Fire. Chaihu and Huangqin clear and drain Sanjiao Fire. Huangbai clears and drains Bladder Fire.
Gancao (Glycyrrhizae Radix et Rhizoma) is incompatible with Daji (Euphorbiae Pekinensis Radix), Yuanhua (Genkwa Flos), Gansui (Kansui Radix), and Haizao (Sargassum). Wutou (Aconiti Radix) is incompatible with Banxia (Pinelliae Tuber), Gualou (Trichosanthis Fructus), Bailian (Liriopes Bulbus), and Baiji (Bletillae Rhizoma). Lilu (Veratri Rhizoma) is incompatible with Xixin (Asari Radix et Rhizoma), Shaoyao, Renshen (Ginseng Radix), Shashen (Glehniae Radix), Kushen (Sophorae Flavescentis Radix), Danshen (Salviae Miltiorrhizae Radix), and Xuanshen (Scrophulariae Radix).
There are eighteen incompatibilities in Materia Medica: "Banxia, Gualou, Beimu, Bailian, and Baiji attack Wutou; Zaocys, Daji, Gansui, and Yuanhua all war against Gancao; various Shen, Xixin, and Shaoyao rebel against Lilu."
Liuhuang (Sulfur) is originally the essence of fire, but it conflicts immediately upon meeting Puxiao (Natrii Sulfas). Shuiyin (Mercurius) must never meet Pishuang (Arsenici Trioxidum); Yelangdu (Daphnes Genkwei Cortex) fears Mituoseng (Calamina) most. Badou (Crotonis Fructus) has a fierce nature and is supreme, yet it disagrees with Qianniu (Pharbitidis Semen). Dingxiang (Caryophylli Flos) must not be seen with Yujin (Curcumae Longae Radix); Yanxiao (Natrii Sulfas) is difficult to combine with Jing Sanleng (Sparganii Rhizoma). Chuanwu (Aconiti Radix Preparata) and Caowu (Aconiti Kusnezoffii Radix) do not accord with Xijiao (Rhinocerotis Cornu); Renshen fears Wulingzhi (Trogopterori Faeces) most. Guanzi (Cinnamomi Cortex) is good at regulating cold qi, but if it meets Shizhi (Haematitum), it will be deceived. Generally, when compounding medicines, one must observe compatibility and incompatibility; during processing (pao zhi), they should not rely on or conflict with each other.
Zhike (Citri Reticulatae Pericarpium), Chenpi (Citri Reticulatae Pericarpium), Banxia, Mahuang (Ephedrae Herba), Yelangdu, and Zhuyu (Euodiae Fructus)—these six herbs are suitable for long-term storage; only then does one realize their miraculous efficacy in medicine.
For Liver deficiency, use Chenpi and Ganjiang (Zingiberis Rhizoma) to tonify. According to the principle "tonify the mother in deficiency," the Kidney is the mother of the Liver; therefore, use Shudihuang (Rehmanniae Radix Preparata), Dihuang (Rehmanniae Radix), and Huangbai to tonify. If there are no other symptoms, Qian Shi's Dihuang Wan (Rehmannia Pill) is the primary formula. For Liver excess, use Baishao to drain. If there are no other symptoms, Qian Shi's Xieqing Wan (Drain Green Pill) is the primary formula. According to the principle "drain the child in excess," use Gancao to drain Heart Fire, because the Heart is the child of the Liver. For Heart deficiency, use Chao Yan (Fried Salt) to tonify. According to the principle "tonify the mother in deficiency," the Liver is the mother of the Heart; therefore, use Shengjiang (Zingiberis Rhizoma Recens) to tonify the Liver. If there are no other symptoms, Qian Shi's Anshen Wan (Calm Spirit Pill) is the primary formula. For Heart excess, use Gancao to drain. If there are no other symptoms, in Qian Shi's formulas, severe cases use Xiexin Tang (Drain Heart Decoction), and mild cases use Daochi San (Guide Out Red Powder). For Spleen deficiency, use Gancao and Dazao (Jujubae Fructus) to tonify. For Spleen excess, use Huanglian and Zhishi (Aurantii Fructus Immaturus) to drain. If there are no other symptoms, Qian Shi's Yiyuan San (Benefit Origin Powder) is the primary formula. According to the principle "tonify the mother in deficiency," the Heart is the mother of the Spleen; therefore, use Chao Yan to tonify the Heart. According to the principle "drain the child in excess," the Lung is the child of the Spleen; therefore, use Sangbaipi (Morus Cortex) to drain the Lung. For Lung deficiency, use Wuweizi (Schisandrae Chinensis Fructus) to tonify; for Lung excess, use Sangbaipi to drain. If there are no other symptoms, Qian Shi's Ejiao San (Donkey-Hide Gelatin Powder) is the primary formula. According to the principle "tonify the mother in deficiency," the Spleen is the mother of the Lung; therefore, use Gancao and Dazao to tonify the Spleen. According to the principle "drain the child in excess," the Kidney is the child of the Lung; therefore, use Zexie (Alismatis Rhizoma) to drain the Kidney. For Kidney deficiency, use Shudihuang and Huangbai to tonify. The Kidney has no excess conditions and cannot be drained. Qian Shi only has Bushen Dihuang Wan (Tonify Kidney Rehmannia Pill) and has no Kidney-draining formulas. According to the principle "tonify the mother in deficiency," the Lung is the mother of the Kidney; therefore, use Wuweizi to tonify the Lung. The above methods for tonifying and draining the five Zang organs are fully recorded in the *Suwen* chapter "Organ Qi Laws and Times." To investigate the details further, refer to this treatise.