《准绳》秘方
射干 甘草 枳实 升麻 干地黄 黄芩（各二两） 犀角（六分） 前胡（三分）
水五升，煎三分，入大黄一钱，一沸去滓，入麝香二分，分三服，瘥止，不限剂数，神效。
浙有士人，指忽隐痛不可忍，其中指甲间，生一珊瑚，高二寸，血色气缕成海
市，人士战马，城廓戈矛，人与自己皆见。嗜饮烧酒，医谓火所吐幻景，服以大黄稍
减，久服遂绝，火何得成此异者。（《异识资谐》）
王肯堂曰∶五指丫处，结毒 肿者，俗名鸦叉，又名病蟹叉。（《准绳》）
申斗垣曰∶手丫毒俱是手经，手背丫是手三阳经，手掌心丫是手三阴经。受证
当分何经，加引经药治之。（《启玄》）
汪省之曰∶手三阴、三阳经，亦有气血多少不同，生于指丫，当分经络治之（《理例》）
朱丹溪曰∶手丫发生于手丫岐骨缝间，
除大指合谷穴名合谷疽。其余指丫生毒，皆名手丫发。初起如粟色红，渐大如豆，
热，溃后疼痛不止者。俟脓塞提出，其痛方止。
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王肯堂曰∶虎口疽，一名虎丫毒，又名合谷疽，又名丫刺毒，又名臂蟹毒，又
名手丫发，又名病蟹叉。此手阳明大肠经风热积毒之所致也。（《准绳》）
陈实功曰∶合谷疔，俗名虎口百丫是也。此患多系疙瘩泡起，亦有红丝走上，故
有疔名。此足阳明胃经湿毒攻注作痒。初起挑破，蟾酥饼膏盖，金黄散敷之，必须
内外消托为主。（《正宗》）
胡公弼曰∶虎口毒即丫刺毒，最能烂手，毒归肝脾，亦能杀人。（《青囊》）
又曰∶赤 热痛，更有虎口胀裂者。
薛氏曰∶此患多生大指次指连界处，忽生肿毒，痛不可忍。若不早治，必烂人手，
名曰拍蟹毒。
朱丹溪曰∶虎口疽生（合谷穴）在手大指次指岐骨间，属大肠经湿热凝结而成。一名
丫叉毒。初起如豆，漫肿色青，木痛坚硬。若初起黄粟小泡，痒热 痛，根深有红线
上攻腋内，即名合谷疔。
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《准绳》中的秘方：
射干、甘草、枳实、升麻、干地黄、黄芩（各二两），犀角（六分），前胡（三分）。
用水五升，煎煮至剩余三分之一的药液，加入大黄一钱，煮沸一次后滤去药渣，再加入麝香二分，分三次服用。病愈即停药，不限服药次数，疗效神奇。
浙江有一位读书人，手指突然发生剧烈疼痛，无法忍受，指甲缝隙间长出一个珊瑚状的肿物，高二寸，呈现出血色气缕形成的海市蜃楼景象，其中有战士骑马、城墙房屋、戈矛兵器，连他自己也能看见这些幻象。他嗜好饮用烧酒，医生认为是火邪导致的幻觉，给他服用大黄后症状稍减，长期服用后症状消失，但火邪为何能形成这种奇异的现象呢？（出自《异识资谐》）
王肯堂说：五指指缝处结毒肿胀的，俗名叫鸦叉，又叫做病蟹叉。（出自《准绳》）
申斗垣说：手丫毒都属于手经病变，手背指缝是手三阳经，手掌心指缝是手三阴经。发病时应当辨别属于哪条经络，加入引经药进行治疗。（出自《启玄》）
汪省之说：手三阴经和手三阳经的气血多少各不相同，生于指缝处的毒疮，应当根据经络进行辨证治疗（出自《理例》）
朱丹溪说：手丫发发生在手指歧骨缝隙之间，除了大拇指合谷穴处的称为合谷疽外，其余指缝生毒，都叫手丫发。初起时像粟米大小，颜色发红，逐渐增大如豆粒，伴有发热，溃破后疼痛不止。等到脓液排出并被清除后，疼痛才会停止。
王肯堂说：虎口疽，一名虎丫毒，又名合谷疽，又名丫刺毒，又名臂蟹毒，又名手丫发，又名病蟹叉。这是由手阳明大肠经的风热积毒所致。（出自《准绳》）
陈实功说：合谷疔，俗名虎口百丫。这个病症多是由疙瘩泡发起，也有红丝向上蔓延，所以称为疔。这是足阳明胃经的湿毒攻注引起的瘙痒。初起时挑破，用蟾酥饼膏覆盖，敷上金黄散，必须以内外消托为主。（出自《正宗》）
胡公弼说：虎口毒就是丫刺毒，最能导致手部腐烂，毒气归入肝脾，也能致人死亡。（出自《青囊》）
又说：出现赤色、发热、疼痛，更有虎口部位胀裂的情况。
薛氏说：这个病症多生在大拇指和食指连接交界处，突然发生肿毒，疼痛难忍。如果不及时治疗，必然会导致人手腐烂，名叫拍蟹毒。
朱丹溪说：虎口疽生在（合谷穴）位于大拇指和食指之间的歧骨处，属于大肠经湿热凝结而成。一名丫叉毒。初起时像豆粒大，漫肿呈青色，麻木疼痛且坚硬。如果初起时有黄粟米小泡，痒、热、痛，根部有红线向上攻入腋窝内，就叫做合谷疔。
Secret Formula from *Zhunsheng*:
*Radix Belamcandae* (Shegan), *Radix Glycyrrhizae* (Gancao), *Pericarpium Citri Reticulatae Viride* (Zhishi), *Rhizoma Cimicifugae* (Shengma), *Radix Rehmanniae Preparata* (Shengdihuang), *Cortex Scutellariae* (Huangqin) (each 2 liang), *Cornu Rhinocerotis* (Xijiao) (6 fen), *Radix Peucedani* (Qianhu) (3 fen).
Add five sheng of water, decoct until one-third remains. Add *Radix et Rhizoma Rhei* (Dahuang) 1 qian, boil once, remove dregs, add *Moschus* (Shexiang) 2 fen. Divide into three doses. Stop medication when cured; the number of doses is not limited. It is extremely effective.
A scholar in Zhejiang experienced sudden, unbearable pain in his finger. Between the fingernails, a coral-like swelling grew two cun high, presenting a mirage-like appearance with blood-colored vapor streams forming scenes of warriors on horseback, city walls, and spears, which he could see himself. He had a fondness for drinking distilled liquor. Physicians attributed these hallucinations to fire pathogenic factors and prescribed *Radix et Rhizoma Rhei* (Dahuang), which provided slight relief. Long-term use led to the cessation of symptoms. However, how can fire pathogenic factors create such anomalies? (From *Yishi Zixie*)
Wang Kentang stated: Swelling and toxic accumulation at the web spaces of the five fingers are commonly known as "Yacha" or "Bingxiecha." (*Zhunsheng*)
Shen Douyuan stated: Web space toxins of the hand all involve the Hand meridians. The dorsal web spaces correspond to the Three Yang Meridians of the Hand, while the palmar web spaces correspond to the Three Yin Meridians of the Hand. In diagnosis, it is necessary to distinguish the affected meridian and administer guiding herbs accordingly. (*Qixuan*)
Wang Shengzhi stated: The Three Yin and Three Yang Meridians of the Hand differ in their abundance and deficiency of Qi and Blood. Toxems arising in the web spaces should be treated according to the specific meridians involved. (*Lili*)
Zhu Danxi stated: Web space sores occur in the interosseous spaces between the phalanges. Except for the sore at the Hegu acupoint of the thumb, which is called Hegu Ju, sores in other web spaces are collectively called Hand Web Space Fa. Initially, they resemble millet grains, red in color, gradually enlarging to the size of a bean, accompanied by heat. Pain persists after ulceration until the pus is drained and cleared.
Wang Kentang stated: Tiger Mouth Ju, also known as Tiger Web Space Du, Hegu Ju, Yaci Du, Bi Xie Du, Hand Web Space Fa, and Bing Xie Cha. This condition is caused by the accumulation of wind-heat toxicity in the Large Intestine Meridian of Hand-Yangming. (*Zhunsheng*)
Chen Shigong stated: Hegu Ding, commonly known as "Tiger Mouth Baiya," often originates from nodular blisters or spreading red threads, hence the name "Ding." This itching is caused by damp-toxicity attacking from the Stomach Meridian of Foot-Yangming. Upon onset, puncture the lesion, cover with Chansu Paste, and apply Jinhual San. Treatment must focus on internal and external resolution and expulsion. (*Zhengzong*)
Hu Gongbi stated: Tiger Mouth Du, also known as Yaci Du, is highly destructive to the hand tissue. If the toxicity enters the Liver and Spleen, it can be fatal. (*Qingnang*)
He further stated: Symptoms include redness, heat, and pain, with possible cracking and swelling of the tiger mouth area.
Xue stated: This condition often arises at the junction of the thumb and index finger, presenting as sudden swelling and toxicity with unbearable pain. If not treated early, it will cause severe tissue necrosis of the hand, known as Pai Xie Du.
Zhu Danxi stated: Tiger Mouth Ju occurs in the interosseous space between the thumb and index finger (at the Hegu acupoint), resulting from the coagulation of damp-heat in the Large Intestine Meridian. Also known as Yacha Du. Initially, it resembles a bean, with diffuse swelling, cyanotic color, numbness, pain, and hardness. If small yellow millet-like blisters appear initially with itching, heat, and pain, and red lines spread upward toward the axilla, it is named Hegu Ding.