夫禀气实者，夏不畏热，冬不畏寒；禀气怯者，天寒阴雨，感寒湿而濡泻，天气
炎热，则伏热而中 。阳盛人耐冬而不耐夏，阴盛人耐夏不耐冬，此又禀受之不同
也。故自立夏则气变纯阳，治药者用热远热，如自立冬则气合纯阴，治药者用寒远
寒。兼天气大寒，则盖覆宜暖，勿使毒瓦斯为寒所触而不得出，如天气大热，却宜清
凉，不可重为盖覆，以至客热与毒相并，乃至烦躁而疮溃烂。至于时有迅雷烈风之变，
则宜谨帏帐节盖覆，多烧辟秽之物，以辟一时不正之气。卧处最要无风，又要通明
忌暗，时常亲人看守。夜中灯火莫离，以便供奉饮食，防御搔破痘疮。及宜切避秽
气，否则未出者不出，已出者斑烂，甚或疮黑陷伏臭烂，恶痛如刀剜，闷乱而死。并
不可少使饥馁寒冷，即在乳母，皆所当然。盖痘赖谷气乳哺以助其内，避风寒以护其
外，苟谷气一亏，风寒乘袭，为害殊甚。但勿过为饱暖及啖煎 五辛，否则热毒熏膈，
眼目必伤。至于既愈，则肌肉重新，洗澡固禁太早，风寒尤切谨防，勿视为浅淡之言，实卫生之大要也。
痘之为证，五脏百骸无不振动，血气无不虚弱，故有杂证相仍，最宜戒其峻治。
盖杂证痊日无定，痘疮靥日有期。若治杂
证一寸，则痘疹落后一丈，杂证未痊而痘已先毙矣。故治痘不可违限，而急治其标，
缓治其本。痘之毒不解，则一病不去，痘之毒一解，则百病自痊，正在乎本上用力，
固何在乎一标哉！但有紧要杂证，则痘证亦为其所害，医者知其本末轻重，以为治
之缓急，斯得之矣。痘证重而杂证轻，则杂证之药加于痘证药内，是缓则治其本也；
杂证重者先逐杂证，而后调其痘证，是急则治其标也。然用药固其宜，当调理尤善
为良。若酷暑而不加以凉，严冬不施以暖，则溃烂者溃烂，冰伏者冰伏矣。故凡用剂
及诸调理，并宜顺四时，得天和令其和暖如春，使气血调畅，而毒自释矣。至于久
雨阴湿，天之气厄塞，人之气亦厄塞者，久晴旱 天之气散逸，人之气亦散逸者，久
雨亢阳，久旱亢阴，而气血自病，并须因时制宜也。
凡是先天禀赋充实的人，夏天不畏惧炎热，冬天不畏惧寒冷；先天禀赋虚弱的人，遇到天寒阴雨天气，容易感受寒湿之邪而患濡泻（因寒湿导致的泄泻），遇到天气炎热，则体内潜伏的热邪发作而中暑。阳气偏盛的人耐寒但不耐热，阴气偏盛的人耐热但不耐寒，这又是由于先天禀受不同所致。因此，从立夏开始，气候转变为纯阳之气，用药者应当避开热性药物（用热远热）；从立冬开始，气候合于纯阴之气，用药者应当避开寒性药物（用寒远寒）。如果遇到天气极度寒冷，覆盖保暖应该适宜温暖，不要使毒邪被寒气所遏制而不能透发出来；如果遇到天气极度炎热，却宜保持清凉，不可过度覆盖保暖，以免外来的热邪与体内的毒邪相结合，导致烦躁不安甚至疮疡溃烂。至于遇到突然的雷暴大风等气候变化，应当谨慎调节帷帐和覆盖物，多焚烧驱除秽浊之气的物品，以辟除一时不正的邪气。卧处最重要的是无风，又要明亮通风忌讳阴暗，时常需要亲人看守。夜间灯火不能离开，以便供给饮食，防御抓破痘疮。并且必须切近避免秽浊之气，否则未发出的痘疹发不出来，已发出的痘疹会斑烂，严重时甚至出现疮色黑陷、伏匿、恶臭溃烂，疼痛剧烈如刀割，神志昏乱而死。也不可让患儿感到饥饿寒冷，即使是乳母的饮食起居也应当如此。因为痘疹依赖谷气和乳汁来资助内在正气，依靠避风寒来保护外在肌表，如果谷气一旦亏损，风寒乘虚侵袭，危害非常严重。但是不要过分使其过饱过暖以及食用煎炸食品和五辛（葱、蒜、韭、薤、兴渠），否则热毒熏蒸胸膈，眼睛必定受伤。至于痘疹痊愈之后，肌肉重新生长，洗澡固然禁止过早，防范风寒尤其要警惕，不要把这话看作浅显平淡之言，这实际上是养生保健的大要领。
痘疮这种病证，五脏六腑和全身骨骼没有不受到震动的，气血没有不虚弱的，所以常有其他杂病相继出现，最应当戒除使用峻猛的治疗方法。因为杂病的痊愈日期没有定数，而痘疮结痂脱落的日期是有期限的。如果治疗杂病花费一寸功夫，就会导致痘疹病程落后一丈，杂病还没好而痘疹患者已经先死去了。所以治疗痘疮不可以违背时限，而要急治其标症，缓治其本原。痘疮的毒邪不解散，则一种病根去不掉；痘疮的毒邪一旦解散，则百种病症自然痊愈，关键在于在本原上用力，何必在乎某一个标症呢！但是如果有紧要的杂病，那么痘疮病证也会受到它的损害，医生知道本末轻重的关系，从而决定治疗的缓急，这样就对了。痘疮病证重而杂病轻，就把治疗杂病的药加在治疗痘疮的药里面，这是缓则治其本的方法；杂病重的先驱逐杂病，然后调理痘疮病证，这是急则治其标的方法。然而用药固然适宜，当注重调理更是善举。如果在酷暑季节不加以清凉措施，在严冬季节不施以温暖措施，那么该溃烂的就溃烂，该冰伏的就冰伏了。所以凡是用药剂量以及各种调理方法，都应当顺应四季变化，得到天地之和气使其和暖如春，使气血调畅，而毒邪自然释放了。至于久雨阴湿天气，天的气机闭塞，人的气机也闭塞；久晴干旱天气，天的气机散逸，人的气机也散逸；久雨后出现亢盛的阳气，久旱后出现亢盛的阴气，从而导致气血自病，都必须根据时令情况制宜处理。
Those with a robust innate constitution do not fear heat in summer or cold in winter; those with a deficient innate constitution, when exposed to cold and rainy weather, are susceptible to damp-cold pathogenic factors leading to loose stools (Ruxie), and when the weather is hot, latent heat within may flare up causing heatstroke. Individuals with predominant Yang can tolerate cold but not heat, while those with predominant Yin can tolerate heat but not cold; this further illustrates differences in innate endowment. Therefore, from Lixia (Start of Summer) onwards, when the climate shifts to pure Yang, physicians should avoid using hot-natured medicines (Yong Re Yuan Re); from Lidong (Start of Winter) onwards, when the climate aligns with pure Yin, physicians should avoid using cold-natured medicines (Yong Han Yuan Han). If the weather is extremely cold, covering and warming should be appropriate to prevent toxic pathogens from being constrained by cold and unable to erupt; if the weather is extremely hot, one should maintain coolness and avoid excessive covering, so as not to allow external heat to combine with internal toxins, leading to restlessness and ulceration of sores. During sudden changes such as thunderstorms and strong winds, one should carefully adjust curtains and coverings, and burn substances that dispel foul odors to ward off transient abnormal Qi. The sleeping area must be free from drafts, well-lit and ventilated, avoiding darkness, with constant supervision by relatives. Lights should not be extinguished at night to facilitate feeding and prevent scratching of the smallpox lesions. One must strictly avoid foul odors; otherwise, un-erupted lesions will fail to emerge, erupted lesions will become necrotic, or worse, lesions may turn black, sink inward, emit a foul odor, cause severe pain like knife wounds, lead to delirium, and result in death. One must also prevent hunger and cold; even the wet nurse's regimen should adhere to these principles. Smallpox relies on grain Qi and milk to support internal righteousness, and avoidance of wind-cold to protect the exterior. If grain Qi is depleted and wind-cold invades, the harm is significant. However, one should not overfeed or over-warm, nor consume fried foods or the "Five Pungent Spices" (Wu Xin: garlic, chives, leeks, scallions, and alliums), as this may cause heat-toxicity to harass the chest and diaphragm, inevitably injuring the eyes. After recovery, as muscles regenerate, bathing is prohibited too early, and vigilance against wind-cold is crucial; do not dismiss this as trivial advice, for it is a major principle of health preservation.
Smallpox is a condition where the five Zang organs and hundred bones are all shaken, and Qi and Blood are all weakened; thus, miscellaneous diseases often follow, making it essential to abstain from harsh treatments. The duration for curing miscellaneous diseases is indefinite, whereas the date for smallpox crusts to fall off is fixed. If one spends effort treating miscellaneous diseases, the smallpox progression lags significantly, and the patient may die from smallpox before the miscellaneous disease is cured. Therefore, in treating smallpox, one must not violate time limits but should urgently treat the branch symptoms and slowly address the root. If the smallpox toxin is not resolved, one pathological basis remains; once the smallpox toxin is resolved, hundreds of ailments heal spontaneously. Effort should be focused on the root, not merely on individual branch symptoms. However, if critical miscellaneous diseases occur, they can harm the smallpox condition. Physicians must understand the priority and severity of root versus branch to determine the urgency of treatment. If smallpox is severe and miscellaneous diseases are mild, add miscellaneous disease medications to smallpox medications; this is "treating the root in slow cases." If miscellaneous diseases are severe, first eliminate them, then regulate the smallpox condition; this is "treating the branch in urgent cases." While medication is necessary, regulation is even more beneficial. In intense summer heat, cooling measures are required; in severe winter cold, warming measures are needed; otherwise, ulcers will worsen, and frozen conditions will persist. Thus, all dosages and regulatory methods should conform to the four seasons, harmonizing with Heaven's Qi to create a spring-like warmth, ensuring smooth flow of Qi and Blood so that toxins are naturally released. During prolonged rainy and humid weather, both heavenly and human Qi are obstructed; during prolonged sunny and dry weather, both heavenly and human Qi are dispersed; after long rains followed by extreme Yang, or long droughts followed by extreme Yin, Qi and Blood become diseased. All such situations require adaptation to the specific timing.