愚按诸家本草。皆称常山苦寒有毒。为截疟要药。但此最败真气。疟邪未解。遽用止截
虽顿
愈一时。转息复发。或变生他症。肿胀为患。往往大命殉之。目击多矣。然必惟元气壮实。
山野顽夫。或可暂用也。汪石山曰本草于知母草果乌梅穿山甲皆言治疟。然知母性寒入治足
阳明独盛之火。使其退就太阳也。草果性温燥。治足太阴独盛之寒。使其退就阳明也。二味
合和。则无阴阳交作之变。故为君药。常山主寒热疟吐胸中痰结。故用为臣。甘草和诸药。
乌梅去痰。槟榔除痰癖。破滞气。故用为佐。穿山甲以其穿山而居。遇水而入。则是出阴入
阳。穿其经络于荣分。以破暑结之邪。故用为使。若脾胃郁伏痰涎。用之必效。苟或无痰。
只是暑结荣分。独应足太阴血分热者。当发唇疮。此方无效。丹溪曰常山性暴悍。善驱逐。
能伤真气。病患稍近虚怯不可用也。张通一曰余阅疟门方剂。多不分表里先后。俱用芩连知
母及大黄石膏之类夫以表邪不解而得此寒凉则寒邪愈陷或任用常山草果。及劫截峻厉等剂。
若正为邪伤而受此克伐。则元气愈虚。故多致绵延不已。轻者变重。重者至危。是皆不得其
本耳。得则易如反掌。在察所由而已。愚以为治疟之法。当操其要无越新久虚实标本六者而
已若新病标多元气实者。即用仲景法。察昼夜迟速治之。刘宗浓云从卯至午发者宜大柴汤下
之。从午至酉发者宜大承气汤下之。从酉至子或至寅发者宜桃仁承气汤下之。更以小柴胡汤
彻其余邪。其脉实长者。先以大柴胡下之。余热不尽再用白芷汤。或甚寒微热。或但寒不热
名曰牝疟。用柴胡桂枝以解表凡此皆治实之道也若病久而标少元气虚者。或间日一发则用补
中汤气血俱虚三四日一发者此人里之深也用十全大补汤或因饮食所伤。则以六君为主。或劳
伤中气。亦以补中为主。至其日久不愈。只用人参一二两。生姜减半。煎浓汤于将发之先一
二时。不数剂顿止。亦有病久而标尚在。元气未虚者。又须攻补兼施又有新病暴虚。急宜救
本。不得以病邪正炽。难用峻补而论也。大意有汗要无汗。以扶正为主腠理开泄阳不能固必
补敛之无汗要有汗以散邪为主腠理密致邪不能解必发散之虽曰有汗宜补。亦当兼散。无汗宜
散
。亦当兼补。盖邪气盛则实不可不攻精气夺则虚不可不补也故在阳分者浅而易治在阴分者深
则难治在春夏易在秋冬难在上体易在下体难在少壮易在衰老难至妇人在胎前产后尤难其治也
务必由阴而阳由晏及早。由下及上。或寒多热少。或隔日转成一日一发此由脏及腑也汗必由
顶至足为易愈。立斋云凡病大热燥渴以姜汤乘热饮之。此亦截疟之良法也。每见发时饮啖生
冷物者。病或少愈。多致脾虚胃损。往往不治。又云余常以参术各一两。生姜四两。煨熟煎
服即止。或以大剂补中益气汤加煨姜尤效。生姜一味亦效。吁此法极妥何必别寻妄剂至清脾
截疟二饮断不宜轻服盖养正则邪自除。可侥速效而丧生乎。又有如疟之症夫真疟病在风寒暑
湿之感而如疟则为脏腑气血之衰一由营卫之出入以为止作一由水火之争胜以为盛衰一责在表
一责在里一攻在邪一扶在正有阳虚而寒热如疟有阴虚而寒热如疟盖如疟而非真疟也是非之间
便有邪正虚实之分治一少差生死反掌学人尤不可不知。
我考察各家本草著作,都称常山味苦、性寒、有毒,是治疗疟疾的要药。但是此药最易败坏人体真气。若疟邪尚未解除,就急于使用截疟药物,虽然能暂时顿然痊愈,但转瞬间又会复发,或者变生其他病症,出现肿胀等祸患,往往因此丧命,我亲眼目睹过很多这样的案例。然而,只有那些元气壮实、山野粗鄙之人,或许可以暂时使用。
汪石山说:本草书中对于知母、草果、乌梅、穿山甲都记载能治疟疾。其中,知母性寒,入足阳明经,专门清泻独盛的火热,使其退回到太阳经;草果性温燥,治足太阴经独盛的寒邪,使其退回到阳明经。这两味药配合调和,就不会出现阴阳交争的变故,所以作为君药。常山主治寒热疟疾、呕吐及胸中痰结,所以用作臣药。甘草调和诸药,乌梅祛痰,槟榔消除痰癖、破滞气,所以用作佐药。穿山甲因为穿山而居,遇水而入,这意味着从阴出阳,穿透经络进入营分,以破除暑邪凝结,所以用作使药。如果是脾胃郁伏的痰涎,使用此方必定有效。但如果体内无痰,只是暑邪凝结在营分,且仅对应足太阴血分有热的情况,应当出现唇疮,此方无效。
丹溪说:常山性质暴烈悍猛,善于驱逐病邪,但能损伤真气。病患如果稍微接近虚弱怯弱的状态,不可使用。
张通一说:我阅读疟疾门的方剂,大多不区分表里和先后顺序,一律使用黄芩、黄连、知母以及大黄、石膏之类的寒凉药。既然表邪未解,再用这些寒凉药,则寒邪会更加深陷;或者任意使用常山、草果及劫截峻厉等药剂。如果正气已经被邪气所伤,再受到这种克伐,则元气更加虚弱,所以多导致病情绵延不断,轻者变重,重者至危。这都是因为没有抓住根本的缘故。抓住了根本,治疗就容易得像翻手掌一样简单,关键在于考察病因罢了。
我认为治疗疟疾的方法,应当掌握要领,不外乎新久、虚实、标本这六个方面而已。如果是新病、标证多、元气实的人,就使用张仲景的方法,观察昼夜发作的快慢来治疗。刘宗浓说:从卯时到午时发作的,宜用大柴胡汤攻下;从午时到酉时发作的,宜用大承气汤攻下;从酉时到子时或寅时发作的,宜用桃仁承气汤攻下。再用小柴胡汤彻除其余邪。脉象实而长的,先用大柴胡汤攻下,余热不尽再用白芷汤。或者恶寒重发热轻,或者只寒不热,名叫牝疟,用柴胡桂枝汤解表。这些都是治疗实证的方法。
如果是病久、标证少、元气虚的人,或者间日一发,则用补中益气汤;气血俱虚、三四日一发的人,说明病位深入,用十全大补汤。或者因饮食所伤,则以六君子汤为主;或者劳伤中气,也以补中益气汤为主。至于日久不愈的,只用一二两人参,生姜减半,煎成浓汤,在即将发作前一两个小时服用,不需几剂就能顿止。也有病久但标证仍在、元气未虚的,又须攻补兼施。又有新病却突然虚弱的,急宜救本,不能因为病邪正炽盛,就认为难以使用峻补之剂。
大意是:有汗要转为无汗,以扶正为主,腠理开泄,阳气不能固守,必须补益收敛;无汗要转为有汗,以散邪为主,腠理密致,邪气不能解散,必须发散。虽然说有汗宜补,也应当兼用发散;无汗宜散,也应当兼用补益。大概是因为邪气盛则表现为实证,不可不攻伐;精气夺则表现为虚证,不可不补益。所以在阳分的病浅而易治,在阴分的病深则难治;在春夏季易治,在秋冬季难治;在上半身的病易治,在下半身的病难治;在少年壮年易治,在衰老难治。至于妇女在胎前产后尤其难治。务必使病情由阴转阳,由晚发转早发,由下部转上部,或者由寒多热少,或由隔日发作转成一日一发,这是由脏传腑的表现。汗出必须由头顶至足部,才容易痊愈。
立斋说:凡是生病出现大热、燥渴,用姜汤趁热饮用,这也是截断疟疾的良好方法。我常见患者在发作时饮用生冷食物,病可能稍有好转,但多导致脾虚胃损,往往无法治愈。他又说:我常用人参、白术各一两,生姜四两,煨熟后煎服,疟疾即止。或者用大剂量的补中益气汤加煨姜,尤其有效。单用生姜一味也有效。唉,这种方法极妥当,何必另外寻找妄乱的药剂?至于清脾饮、截疟饮,绝对不宜轻易服用。大概养护正气则邪气自然除去,岂可侥幸追求速效而丧生呢?
又有类似疟疾的症状。真正的疟疾病因在于风寒暑湿的外感,而类似疟疾则是由于脏腑气血的衰弱。一种是由营卫之气的出入来决定发作与停止,一种是由水火之争胜来决定盛衰。一种责之于表,一种责之于里;一种攻伐邪气,一种扶持正气。有阳虚而寒热如疟的,有阴虚而寒热如疟的。大概类似疟疾而非真疟疾,在这之间便有邪正、虚实的区别。治疗只要稍有差错,生死就在反掌之间,学习中医的人尤其不可不知道。
I have examined various Materia Medica texts, all of which state that Changshan (Dichroa Radix) is bitter, cold, and toxic, serving as a key herb for treating malaria. However, this herb most easily damages the body's True Qi (vital energy). If the malaria pathogen has not yet been resolved, and one hastily uses antimalarial drugs to stop the attack, although it may bring temporary relief, the condition will recur shortly thereafter, or other symptoms may develop, such as swelling, often leading to death. I have witnessed many such cases with my own eyes. Nevertheless, it might be used temporarily only in those with robust Yuan Qi (original qi) and sturdy constitutions, such as rough laborers in rural areas.
Wang Shishan stated: The Materia Medica records that Zhi Mu (Anemarrhenae Rhizoma), Caoguo (Tsaoko Fructus), Wumei (Mume Fructus), and Chuanshanjia (Pangolin Scales) can all treat malaria. Among them, Zhi Mu is cold in nature and enters the Foot-Yangming channel, specifically clearing excessive fire, causing it to retreat to the Taiyang channel. Caoguo is warm and drying, treating excessive cold in the Foot-Taiyin channel, causing it to retreat to the Yangming channel. When these two herbs are combined and harmonized, there will be no adverse changes from the interaction of Yin and Yang; thus, they serve as the Sovereign (Jun) herbs. Changshan primarily treats chills and fever in malaria, vomiting, and phlegm accumulation in the chest, so it is used as the Minister (Chen) herb. Gancao (Licorice Root) harmonizes the various herbs, Wumei removes phlegm, and Binglang (Areca Seed) eliminates phlegm-related stagnation and breaks stagnant Qi, so they are used as the Assistant (Zuo) herbs. Chuanshanjia, because it lives by burrowing through mountains and entering water, symbolizes moving out of Yin into Yang, penetrating the meridians to enter the Ying (Nutritive) level, thereby breaking the congealed summer-heat pathogen; thus, it serves as the Envoy (Shi) herb. This formula is certainly effective if the cause is phlegm-fluid retention due to depression in the Spleen and Stomach. However, if there is no phlegm, but only summer-heat congealing in the Ying level, corresponding solely to heat in the Blood level of the Foot-Taiyin, where lip sores should appear, this formula will be ineffective.
Danxi stated: Changshan has a violent and aggressive nature, good at expelling pathogens, but it can damage True Qi. It should not be used for patients who are slightly deficient or frail.
Zhang Tongyi said: In reviewing prescriptions for malaria, many do not distinguish between exterior/interior conditions or the sequence of treatment, indiscriminately using cold and cooling herbs like Huangqin (Scutellariae Radix), Lianzi (Coptidis Rhizoma), Zhi Mu, Dahuang (Rhei Radix et Rhizoma), and Shigao (Gypsum Fibrosum). Since the exterior pathogen is unresolved, using these cold herbs causes the cold pathogen to sink deeper. Alternatively, arbitrarily using harsh and drastic antimalarial agents like Changshan and Caoguo, or strong purgatives, when the healthy Qi is already injured by the pathogen, further depletes the Yuan Qi. Consequently, the disease often becomes chronic, light cases become severe, and severe cases become critical. All these errors stem from failing to grasp the root cause. Grasping the root makes treatment as easy as turning over a hand; it lies merely in investigating the origin.
I believe that the method for treating malaria should focus on the essentials, covering only six aspects: new vs. old, deficiency vs. excess, and root vs. branch. For new-onset malaria with prominent branch symptoms and robust Yuan Qi, one should use Zhang Zhongjing’s methods, observing the speed of onset during day and night to guide treatment. Liu Zongnong stated: Attacks occurring from Mao hour to Wu hour should be treated with Da Chai Hu Tang (Major Bupleurum Decoction) to purge; attacks from Wu hour to You hour should be treated with Da Cheng Qi Tang (Major Order the Qi Decoction) to purge; attacks from You hour to Zi hour or Yin hour should be treated with Tao Ren Cheng Qi Tang (Peach Kernel Order the Qi Decoction) to purge. Subsequently, Xiao Chai Hu Tang (Minor Bupleurum Decoction) should be used to eliminate residual pathogens. If the pulse is excess and long, start with Da Chai Hu Tang to purge; if residual heat remains, use Baizhi Tang (Angelica Dahurica Decoction). If chills are heavy and fever is slight, or if there is only chills without fever, it is called Pin Malaria (Female Malaria); treat with Chaihu Guizhi Tang (Bupleurum and Cinnamon Twig Decoction) to release the exterior. These are all methods for treating excess patterns.
For chronic malaria with few branch symptoms and deficient Yuan Qi, if attacks occur every other day, use Buzhong Yiqi Tang (Tonify the Middle and Augment the Qi Decoction). If Qi and Blood are both deficient and attacks occur every three to four days, indicating deep internal involvement, use Shiquan Dabu Tang (Ten Substance Great Tonifying Decoction). If caused by dietary injury, base the treatment on Liujunzi Tang (Six Gentlemen Decoction). If caused by overwork injuring Middle Qi, also base the treatment on Buzhong Yiqi Tang. For cases persisting for a long time, use 1–2 liang of Renshen (Ginseng Radix et Rhizoma) and half the amount of Shengjiang (Zingiberis Rhizoma Recens), decocted into a concentrated soup, administered one to two hours before the anticipated onset. A few doses will bring immediate cessation. There are also cases where the disease is chronic but branch symptoms remain and Yuan Qi is not yet depleted, requiring simultaneous tonification and purging. Furthermore, in new-onset cases presenting with sudden deficiency, urgent rescue of the root is required; one must not refrain from using strong tonics simply because the pathogenic factor is currently vigorous.
The general principle is: If there is sweating, aim to stop it by supporting the righteous Qi; since the Couli (pores) are open and Yang cannot consolidate, tonification and astringency are necessary. If there is no sweating, aim to induce it by dispersing the pathogen; since the Couli are tight and the pathogen cannot resolve, dispersion is necessary. Although sweating indicates a need for tonification, dispersion should also be considered; although lack of sweating indicates a need for dispersion, tonification should also be considered. This is because when pathogenic factors are abundant, it manifests as excess and must be attacked; when essence and Qi are depleted, it manifests as deficiency and must be tonified. Therefore, diseases in the Yang levels are superficial and easier to treat; diseases in the Yin levels are deep and harder to treat. Treatments in Spring and Summer are easier; in Autumn and Winter, harder. Diseases in the upper body are easier; in the lower body, harder. In youth and prime, easier; in old age, harder. Especially difficult are women during pregnancy and postpartum. Treatment must strive to transform Yin to Yang, late onset to early onset, lower body to upper body, or change from more chills than fever to alternating daily, indicating transmission from Zang (organs) to Fu (bowels). Sweating from the head down to the feet indicates ease of recovery.
Lizhai stated: Whenever a patient presents with high fever, dryness, and thirst, drinking Ginger Soup while hot is an excellent method for arresting malaria. I often see patients consuming raw or cold foods during an attack; while the illness may seem to improve slightly, it often leads to Spleen deficiency and Stomach damage, becoming incurable. He also said: I frequently use 1 liang each of Renshen and Baizhu (Atractylodis Macrocephalae Rhizoma), along with 4 liang of Shengjiang, stewed and decocted for administration, which stops the malaria immediately. Using a large dose of Buzhong Yiqi Tang with stewed ginger is even more effective. Using Shengjiang alone is also effective. Alas, this method is extremely sound; why seek erratic prescriptions? Qingpi Yin (Clear the Spleen Drink) and Jiemie Yin (Arrest Malaria Drink) should absolutely not be taken lightly. Nourishing the righteous Qi naturally eliminates the pathogen; how could one risk life for the sake of a fleeting quick cure?
There are also symptoms resembling malaria. True malaria arises from external contraction of Wind-Cold, Summer-Heat, and Dampness, whereas malaria-like conditions arise from the decline of Zang-Fu organs and Qi-Blood. One type depends on the entry and exit of Ying and Wei (Defensive) Qi to determine onset and cessation; another depends on the conflict between Water and Fire to determine excess and deficiency. One focuses on the exterior, one on the interior; one attacks the pathogen, one supports the righteous Qi. There are Yang deficiency cases presenting with chills and fever resembling malaria, and Yin deficiency cases presenting similarly. Generally, malaria-like conditions are not true malaria; between these distinctions lie differences in pathogen vs. righteous Qi and deficiency vs. excess. A slight error in treatment can lead to life or death instantly; students of medicine must be particularly aware of this.