治手足厥寒。脉细欲绝者。此方主之。
当归（三两） 桂枝（三两） 芍药（三两） 细辛（三两） 大枣（二十五枚） 甘
草（
上七味。以水八升。煮取三升。去滓。温服一升。日三服。当归四逆加吴茱萸生姜汤 治
手足厥寒脉细欲绝。其人内有久寒者。即前方加生姜（半斤） 吴茱萸（二升）上以水六升。
清酒六升。煮取五升。温分五服。
歌曰 三两辛归桂芍行。枣须廿五脉重生。甘通二两能回厥。寒入吴萸（二升。）姜（半
斤。）酒（六升。）烹。罗东逸曰。厥阴为三阴之尽。阴尽阳生。若受寒邪。则阴阳之气不相
顺接。故脉微而厥。然厥阴之脏。相火游行其间。经虽受寒。而脏不即寒。故先厥者后必发
热。所以伤寒初起。见其手足厥冷脉细欲绝者。不得遽认为寒而用姜、附也。此方取桂枝汤
君以当归者。厥阴主肝。肝为血室也。佐细辛。其味极辛。能达三阴。外温经而内温脏。通
草其性极通。善开关节。内通窍而外通荣。去生姜者。恐其过表也。倍大枣者。即建中加饴
之义。用二十五枚者。取五五之数也。肝之志苦急。肝之神欲散。辛甘并举。则志遂而神悦。
未有厥阴神志遂悦。
厥逆与太少不同治也。若其人内有久寒。非辛温之品不能兼治。则加吴萸、生姜之辛热。更
用酒煎。佐细辛。直通厥阴之脏。迅散内外之寒。是又救厥阴内外两伤于寒之法也。
治疗手足冰冷，脉象细微几乎摸不到的情况。此方主治。
当归（三两） 桂枝（三两） 芍药（三两） 细辛（三两） 大枣（二十五枚） 甘草（二两）
以上七味药，用水八升，煮取三升药液，去掉药渣。每次温服一升，每日服用三次。
当归四逆加吴茱萸生姜汤：治疗手足冰冷，脉象细微几乎摸不到，且患者体内有长期寒邪的情况。即在前方基础上加入生姜（半斤）、吴茱萸（二升）。以上药物用水六升、清酒六升，煮取五升药液，分五次温服。
歌诀云：三两细辛、当归、桂枝、芍药同用行气活血，大枣需用二十五枚以复脉重生，甘草通草各二两能回阳救厥，若寒邪深入则加吴茱萸（二升）、生姜（半斤），并用酒（六升）煎煮。
罗东逸说：厥阴经是三阴经的尽头，阴尽则阳生。如果受到寒邪侵袭，阴阳之气就不能顺利交接，所以会出现脉微和四肢厥冷。然而，厥阴脏（肝脏）中，相火（寄居于肝肾之间的命门之火）在其间游行。虽然经脉受了寒邪，但脏腑本身不会立即变寒。所以先出现厥冷的，后来必定会发热。因此，伤寒初起时，见到手足厥冷、脉象细微几乎摸不到的情况，不能立刻认定为纯寒证而使用干姜、附子等热药。此方以桂枝汤为基础，君药选用当归，因为厥阴主肝，肝为血之海（血室）。佐以细辛，其味道极辛，能通达三阴经，外温经脉而内温脏腑。通草其性质极通利，善于开通关节，内通窍道而外通营气。去掉生姜，是担心它发散太过而伤表。加倍使用大枣，就是建立中气加饴糖的意思。使用二十五枚大枣，是取“五五”之数。肝的志意害怕拘急，肝的神气喜欢疏散。辛味和甘味并用，则志意得以舒展而神气愉悦。没有哪里的厥阴神志能够舒展愉悦，而厥逆与太阳、少阳病的治疗方法是不同的。如果患者体内有长期寒邪，非辛温的药物不能兼治，那么就加入吴茱萸、生姜的辛热之性，再用酒煎煮，辅助细辛，直接通达厥阴之脏，迅速驱散内外的寒邪。这又是救治厥阴内外同时受寒的方法。
Treats coldness of the hands and feet, with a fine pulse that is nearly imperceptible. This formula is indicated for such cases.
Danggui (Radix Angelicae Sinensis) (3 liang), Guizhi (Ramulus Cinnamomi) (3 liang), Shaoyao (Radix Paeoniae Alba) (3 liang), Xixin (Herba Asari) (3 liang), Dazao (Fructus Jujubae) (25 pieces), Gancao (Radix Glycyrrhizae Preparata) (2 liang).
Take the above seven ingredients, add eight sheng of water, decoct to obtain three sheng of liquid, remove the dregs, and take one sheng warm each time, three times a day.
Danggui Sini Tang plus Wuzhuyu and Shengjiang Decoction: Treats coldness of the hands and feet, with a fine pulse that is nearly imperceptible, in patients who have chronic cold within the interior. Add Shengjiang (Fresh Rhizoma Zingiberis) (0.5 jin) and Wuzhuyu (Fructus Evodiae) (2 sheng) to the previous formula. Take the above ingredients, add six sheng of water and six sheng of clear wine, decoct to obtain five sheng of liquid, and divide into five warm doses.
Song says: Three liang each of Xixin, Danggui, Guizhi, and Shaoyang circulate; twenty-five Dazao are needed to revive the pulse. Two liang each of Gancao and Tongcao can reverse coldness; if cold penetrates deeply, add Wuzhuyu (2 sheng) and Shengjiang (0.5 jin), cooked with wine (6 sheng).
Luo Dongyi stated: Jueyin is the end of the three Yin meridians. When Yin reaches its extreme, Yang begins to generate. If invaded by cold pathogenic factors, the Qi of Yin and Yang fails to connect smoothly, resulting in a faint pulse and cold extremities. However, within the Jueyin organ (Liver), Ministerial Fire (Xianghuo) circulates. Although the meridians are affected by cold, the organs do not immediately become cold. Therefore, those who initially experience cold extremities will subsequently develop fever. Thus, at the onset of Cold Damage (Shanghan), when cold extremities and a fine, nearly imperceptible pulse are observed, one should not hastily diagnose it as pure cold and use hot herbs like Ganjiang (Dried Rhizoma Zingiberis) and Fuzi (Radix Aconiti Lateralis Preparata). This formula takes Guizhi Tang as the base, with Danggui as the sovereign herb, because Jueyin governs the Liver, and the Liver is the repository of blood. Assisted by Xixin, which has an extremely pungent flavor, it can penetrate the three Yin meridians, warming the exterior meridians and interior organs. Tongcao (Medulla Tetrapanacis) has an extremely unblocking nature, good at opening joints, connecting internal orifices and external Ying (Nutritive) Qi. Ginger is omitted to prevent excessive dispersal of the exterior. The amount of Dazao is doubled, following the principle of Jianzhong (Establishing the Middle) with Yitang (Maltose). Twenty-five pieces are used to symbolize the number "five times five." The will of the Liver fears tension, and the spirit of the Liver desires dispersion. Combining pungent and sweet flavors allows the will to be satisfied and the spirit to be joyful. There is no case where the spirit and will of Jueyin are satisfied and joyful, yet cold extremities persist; the treatment differs from that of Taiyang and Shaoyang. If the patient has chronic cold within, only pungent-warm substances can treat it concurrently. Therefore, add the pungent-hot Wuzhuyu and Shengjiang, and decoct with wine to assist Xixin in directly penetrating the Jueyin organ, rapidly scattering cold from both interior and exterior. This is another method for rescuing Jueyin from simultaneous cold invasion of the interior and exterior.