阳毒热极失汗下，舌卷焦黑鼻煤烟，昏噤发狂如见鬼，咽疼唾血赤云斑。六七日前
尚可治，表里俱实黑奴丸，热盛解毒里实下，表实三黄石膏煎。
【注】阳毒，谓阳热至极之证也。失汗下，谓应汗不汗，应下不下，失其汗下之时也。热
毒炎炎不已，故舌卷焦黑，鼻内生煤烟也。热毒内攻乘心，故神昏噤栗，发狂如见鬼神，咽
疼唾血也。热毒外薄肌肤，故发赤色如锦云之斑也。六、七日前，谓日浅毒未深入，故
尚可治。表里俱实，谓有是证，无汗不大便者，宜黑奴丸两解之。无表里实证热盛者，宜
黄连解毒汤。兼燥渴者，合白虎汤清之。里实不便者，宜解毒承气汤下之，表实无汗者，
宜三黄石膏汤发之。
阴毒寒极色青黑，咽痛通身厥冷寒，重强身疼如被杖，腹中绞痛若石坚，或呕或利
或烦躁，或出冷汗温补先，无汗还阳退阴汗，
急灸气海及关元。
【注】阴毒，谓阴寒至极之证也。血脉受阴毒邪，故面色青黑也。阴毒内攻于里，故
咽痛腹中绞痛也。阴毒外攻于表，故厥冷通身，重强疼痛如被杖也，独阴无阳不化，故
阴凝腹若石之坚硬也。或呕吐、或下利，或烦躁、或冷汗出，皆阳虚不足或有之证，均以温补
为先，宜四逆汤倍加人参。若有是证，其人无汗，宜还阳散、退阴散，温而汗之，使
寒毒散而阳伸也。凡遇此证，俱宜急灸气海、关元二、三百壮，随服药饵，未有不生者也。
Yang Du (Toxic Heat Syndrome) arises when extreme heat fails to be resolved through sweating or purging. Symptoms include a curled, scorched-black tongue, nasal passages resembling coal smoke, coma with locked jaws, mania as if seeing ghosts, sore throat, hemoptysis, and red macules on the skin like cloud patterns. Within six to seven days of onset, it is still treatable. If both exterior and interior are excess, Heinu Wan (Black Slave Pill) is indicated. For excessive heat requiring detoxification combined with interior excess, purgatives are used. For exterior excess without sweat, Sanhuang Shigao Decoction (Three-Yellow Gypsum Decoction) is indicated.
[Note] Yang Du refers to a syndrome where yang-heat reaches its extreme. "Loss of sweating and purging" means that sweating or purging should have been performed but was not, missing the appropriate timing. The blazing heat toxin persists, causing the tongue to curl and turn black, and coal-smoke-like deposits in the nose. The heat toxin attacks inwardly affecting the Heart, leading to mental confusion, locked jaws with shivering, mania hallucinating spirits, sore throat, and spitting blood. The heat toxin presses outwardly on the skin, causing red rashes resembling brocade clouds. Six or seven days prior indicates a short duration where the toxin has not deeply penetrated, so treatment is still possible. "Excess in both exterior and interior" refers to presenting these symptoms with no sweat and constipation; Heinu Wan is suitable to resolve both aspects simultaneously. For cases without exterior-interior excess but with intense heat, Huanglian Jiedu Tang (Coptis Decoction for Detoxification) is indicated. If accompanied by dryness and thirst, combine with Baihu Tang (White Tiger Decoction) to clear heat. For interior excess with constipation, Jiedu Chengqi Tang (Detoxification Purgative Decoction) is used to purge. For exterior excess with no sweat, Sanhuang Shigao Tang (Three-Yellow Gypsum Decoction) is used to induce sweating.
Yin Du (Toxic Cold Syndrome) presents with cyanotic-black complexion, sore throat, generalized cold limbs and aversion to cold, heavy stiff body pain as if beaten by a club, and abdominal colic hard as stone. There may be vomiting, diarrhea, irritability, or cold sweat. In such cases, warming and tonifying must be prioritized. For those without sweat, Huan Yang San (Restore Yang Powder) and Tui Yin San (Push Away Yin Powder) are used to warm and induce sweating, dispersing cold toxin and extending yang. Urgently moxa Qihai (CV 6) and Guanyuan (CV 4).
[Note] Yin Du refers to a syndrome where yin-cold reaches its extreme. Blood vessels affected by yin-toxin cause the face to appear cyanotic and black. Yin-toxin attacking inward causes sore throat and abdominal colic. Yin-toxin attacking outward causes generalized cold limbs and heavy, stiff pain as if beaten. With only yin and no yang to transform, yin coagulates in the abdomen, making it hard as stone. Vomiting, diarrhea, irritability, or cold sweat are all signs of yang deficiency. Treatment should prioritize warming and tonifying, using Sini Tang (Frigid Extremities Decoction) with doubled Ren Shen (Ginseng Radix et Rhizoma). If these symptoms present with no sweat, Huan Yang San and Tui Yin San are indicated to warm and induce sweating, allowing the cold toxin to disperse and yang to recover. For any such case, urgently moxa Qihai (CV 6) and Guanyuan (CV 4) for two to three hundred moxibustion units, followed by herbal medicine, and recovery is assured.