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When the Ren Mai (Conception Vessel) is diseased, men develop internal accumulations known as the seven types of hernia (Qishen), and women suffer from leukorrhea (Dai Xia) and abdominal masses (Jia Ju). The pulse at the Cun Kou (Radial Artery) appears tight, fine, solid, and long, extending to the Guan position; this characterizes the Ren Mai. Patients often experience pain in the lower abdomen that wraps around the umbilicus and radiates downward to the Henggu area, with sharp cutting pain in the genital region. Additionally, if there is Qi rising in the abdomen, feeling like a finger pushing up against the heart, it causes stiffness and urgency, preventing flexion or extension of the body.

The Ren Mai is the sea of Yin meridians. It originates at Huiyin (CV1), ascends through Zhongji (CV3), and runs parallel with the Foot Jueyin Liver Meridian, Foot Taiyin Spleen Meridian, and Foot Shaoyin Kidney Meridian. It passes through Guanyuan (CV4), Shimen (CV5), and Qihai (CV6), meeting the Foot Shaoyang Gallbladder Meridian and Chong Mai (Penetrating Vessel) at Yinjiao (CV7). It continues through Jianli (CV11) and meets the Hand Taiyang Small Intestine Meridian, Hand Shaoyang Sanjiao Meridian, and Hand Yangming Large Intestine Meridian at Zhongwan (CV12). It then ascends to the throat, meeting the Yin Wei Mai (Yin Linking Vessel) at Tiantu (CV22) and Lianquan (CV23), finally terminating at Chengqi (ST1), located centrally below the eye. The origin of this vessel lies in True Yin (Zhen Yin), which corresponds to the "Earthly Dao" (referring to female reproductive physiology). However, for the Earthly Dao to be unobstructed, it must rely on the descent of Heavenly Qi. What is called Tian Gui (Heavenly Water/Gonadal Essence) is the primordial Qi of Heaven descending and transforming into essence to nourish the Earth, thereby generating True Yin. Once True Yin is sufficient, the Earthly Dao becomes patent. Consequently, the Chong Mai becomes vigorous, and menstruation occurs at regular intervals. If the Ren Mai is deficient and the Chong Mai declines, leading to the exhaustion of Tian Gui and obstruction of the Earthly Dao, the physical form deteriorates, resulting in infertility.

Although Yin resides internally and serves as the anchor for Yang, the fullness of True Yin depends on the sufficiency of Grain Spirit (Gu Shen, derived from food essence) and the arrival of specific age stages, after which the Heavenly Yuan (Primordial Qi) becomes firm. This is what is meant by "when Tian Gui arrives, the Earthly Dao begins to flow." Therefore, True Yin must rely on True Yang. Upon reaching forty years of age, Yin Qi naturally halves. This decline occurs because when Yang Qi reaches its peak and begins to wane, it is invaded by Yin pathogens. The invading Yin is exhausted Yin (Qiong Yin), not True Yin. Thus, although this manifests as a deficiency of True Yin, it is essentially a deficiency of True Yang.

In summary, diseases of the Ren Mai stem from a condition where Yin lacks Yang. Hence, men develop internal accumulations of the seven hernias, and women suffer from leukorrhea and abdominal masses; this is termed "Accumulated Yin" (Jie Yin). Regarding the pulse being tight, fine, solid, and long to the Guan position, this indicates an invasion by Yin Qi. Therefore, the symptoms include severe pain in the lower abdomen wrapping around the umbilicus to the genitals, and distress from abdominal Qi rushing upward to the heart, causing stiffness and inability to bend or straighten. Although these appear as symptoms of Yin deficiency, they are actually symptoms of Yang deficiency. For if True Yang existed within the Yin, True Yin would be abundant, harmonious, and self-content, connecting with the Three Yin and Three Yang meridians up to the space between the eyes, and no disease would occur.