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Smallpox erupts from the interior to the exterior, and medication must be adjusted according to the stage of the disease. Generally speaking, after three days of fever, the rash should fully emerge; after another three days, the pustules begin to swell and rise; after another three days, the pus fills completely; and after another three days, the scabs contract and fall off. During the initial three days of fever, treatment should focus on supporting the interior and releasing the exterior (Tuo Li Jie Biao) to facilitate eruption. There are cases where Qi deficiency prevents eruption; in such instances, slight tonification of Qi is required, so that harmonized Qi leads to rapid eruption. However, astringent agents should not be used excessively in the early stage, lest the interstices (Cou Li) become closed, making eruption difficult. From the fourth to sixth day, the primary approach is cooling and detoxifying (Qing Liang Jie Du). Cooling prevents complications such as intestinal dryness due to blood heat, while detoxifying avoids dangers like toxin stagnation and black depression (Hei Xian). For patients presenting with Qi deficiency symptoms, cooling and detoxifying methods should be avoided to prevent diarrhea and internal retention of toxins. From the seventh to ninth day, the focus is on filling the pustules with pus. The treatment method should involve warming and tonifying Qi and Blood. When Qi and Blood circulate freely, the formation of pus becomes easy. If pus fails to form, it is necessarily due to weak Qi and depleted Blood, or stagnant Qi and sluggish Blood, combined with tight interstices. Thus, even if Essence and Qi are abundant, they cannot circulate smoothly, leading to this condition. External application of "Shuiyang Decoction" (Water Willow Soup) is appropriate, along with internal administration of herbs that promote blood circulation, nourish blood, move Qi, and tonify Qi. However, although warming and tonifying are suitable during the pus-filling stage to assist pus formation, if the underlying pathology originates from blood heat, and although the condition may have slightly improved with clearing and resolving, sudden heavy use of warming tonics like Ginseng (Renshen) may exacerbate blood heat, which is incorrect therapy. In such cases, only slight additions of cooling and detoxifying herbs to the pus-promoting formula can clear the blood heat trend, allowing the pustule sacs to fill with pus. However, excessive coldness will freeze the blood and cause toxin stagnation; therefore, one must stop when the disease is addressed and not exceed the proper limits. By the eleventh and twelfth days, the focus shifts to contraction and healing. Harmonizing Qi and Blood, tonifying the Spleen, and promoting water metabolism will naturally lead to scabbing. This describes the general rule. However, variations exist based on age and constitution, requiring detailed analysis of specific signs. One cannot rigidly apply a single method to infinite variations! When red spots appear, if the smallpox severity is mild, excessive external-releasing measures later should be avoided to prevent ulceration. If dry, red-purple rashes are encountered, urgent purgation and unblocking are necessary; otherwise, black depression will occur later. Within four to five days, eruption reaching the soles indicates completion. If not fully erupted, external-releasing herbs should be added to detoxifying formulas. Relying solely on cold-natured herbs causes delayed eruption. Between the seventh and eighth days, if toxins are not fully resolved, detoxifying herbs should be added to warming tonics. Bias towards warming tonics may intensify toxins, preventing pus formation. Between the eleventh and twelfth days, if pus is insufficient, strong tonification of Qi and Blood with slight residual detoxification is required; otherwise, abscesses and scars may result. Generally, when using cold herbs, avoid extreme cold; when using hot herbs, avoid extreme heat. Neither excess nor deficiency is desired. This is the essential principle and constant law. However, for releasing the exterior, warmth should not be far removed; for attacking the interior, coldness should not be far removed. Heat promotes circulation while cold causes stagnation; bitter flavors purge while sweet flavors moderate. These represent therapeutic flexibility and variable principles. The subtlety of adaptation lies in adjusting to circumstances. As stated in the *Classic* (*Jing*): "Nourish Yang in Spring and Summer, Nourish Yin in Autumn and Winter," adapting to seasonal temperature changes. It is also said: In Spring and Summer, Heaven's Qi dominates; treatment targets the Heart and Lungs, utilizing herbs like Scutellariae Radix (Huangqin), Coptidis Rhizoma (Huanglian), Schizonepetae Herba (Jingjie), and Saposhnikoviae Radix (Fangfeng). In Autumn and Winter, Earth's Qi dominates; treatment targets the Liver and Kidneys, utilizing herbs like Caryophylli Flos (Dingxiang), Cinnamomi Cortex (Guirou), Zingiberis Rhizoma (Shengjiang), and Aconiti Lateralis Radix Praeparata (Fuzi). While these guidelines are not absolute, they align with the intent of preserving Heavenly Harmony.