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Human Qi and Blood circulate in the Yang meridians during the day and in the Yin meridians at night. Starting from the Yin hour (03:00-05:00) at dawn, Qi and Blood flow from the Middle Jiao into the Lung Meridian of Hand-Taiyin; at the Mao hour (05:00-07:00), they flow into the Large Intestine Meridian of Hand-Yangming; at the Chen hour (07:00-09:00), into the Stomach Meridian of Foot-Yangming; at the Si hour (09:00-11:00), into the Spleen Meridian of Foot-Taiyin; at the Wu hour (11:00-13:00), into the Heart Meridian of Hand-Shaoyin; at the Wei hour (13:00-15:00), into the Small Intestine Meridian of Hand-Taiyang; at the Shen hour (15:00-17:00), into the Bladder Meridian of Foot-Taiyang; at the You hour (17:00-19:00), into the Kidney Meridian of Foot-Shaoyin; at the Xu hour (19:00-21:00), into the Pericardium Meridian of Hand-Jueyin; at the Hai hour (21:00-23:00), into the Sanjiao Meridian of Hand-Shaoyang; at the Zi hour (23:00-01:00), into the Gallbladder Meridian of Foot-Shaoyang; and at the Chou hour (01:00-03:00), into the Liver Meridian of Foot-Jueyin. The circulation of Qi and Blood should be neither excessive nor insufficient. If the timing of Qi is missed or imbalanced, disaster will appear immediately.

Furthermore, each hand and foot has three Yin and three Yang meridians. The three Yin meridians of the hands travel from the Zang organs to the hands; the three Yang meridians of the hands travel from the hands to the head; the three Yang meridians of the feet travel from the head down to the feet; and the three Yin meridians of the feet travel from the feet up into the abdomen, totaling twelve meridians.

There is another theory: On days corresponding to Zi, Wu, Mao, and You, Yin intersects with Yang, leading to a deficiency of Qi, causing variola (smallpox) lesions to tend to collapse (Dao Ye). On days corresponding to Yin, Shen, Si, and Hai, Yang converges with Yin, leading to a deficiency of Blood, causing variola lesions to tend to slough off. On Chen days, Yang Qi moves downward, while Blood stagnates and does not advance, requiring blood tonification for the lesions. On Xu days, Yin Qi moves upward, while Qi stagnates and becomes deficient, requiring Qi tonification for the lesions. On Chou and Wei days, both Qi and Blood circulate evenly, indicating a generally auspicious prognosis for the lesions. This theory is established based on the Yin and Yang of time and days. However, the deficiency and excess of human Qi and Blood can be known at a glance. Moreover, since individual constitutional Yin and Yang vary, how can one rigidly adhere to fixed times to generalize over diverse constitutions?

On the first and second days, fetal toxin emerges from the Kidneys, reaching the level of the bone marrow. On the second and third days, it transmits to the level of the Heart and blood vessels. On the third and fourth days, it transmits to the level of the Spleen, Stomach, and muscles. On the fourth and fifth days, it transmits to the level of the Liver and sinews. On the fifth and sixth days, it transmits to the exterior level of the Lungs and skin/hair. By the seventh and eighth days, the lesions become thickened and gradually dry out, leading to recovery. Otherwise, it may result in Dao Ye (inverted lesions) or form carbuncles and swellings.

The Liver corresponds to water blisters, which are greenish and small; this is commonly known as chickenpox (Shui Dou). The Lungs correspond to purulent blisters, which are turbid, white, and large; this is commonly known as variola (Dou Zi). The Heart corresponds to macules, governing blood, which are reddish and small, secondary to water blisters; this is commonly known as An Zi. The Spleen corresponds to papules/rash, which are pale yellow, followed by macules; this is commonly known as measles (Ma Zi).