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The Hand-Yangming Large Intestine Meridian has twenty acupoints. The meridian pathway starts from Shangyang (LI1), passes through Erjian (LI2) and Sanjian (LI3), reaches the Shu-stream points Hegu (LI4) and Yangxi (LI5), crosses Pianli (LI6) and Wenliu (LI7), descends to Xialian (LI8) and Shanglian (LI9), approaches Sanli (LI10), traverses the distance of Quchi (LI11), Zhouliao (LI12), and Wuli (LI13), ascends along Binao (LI14) and Jianyu (LI15) to Jugu (LI16), winds around Tianding (LI17) to Futu (LI18), He'liao (LI19) connects to the lips, and Yingxiang (LI20) is close to the nose.

Shangyang (LI1) is located on the medial side of the index finger; Erjian (LI2) is sought before the proximal interphalangeal joint; Sanjian (LI3) is located in the depression behind the joint; Hegu (LI4) is between the divergent bones of the tiger's mouth; Yangxi (LI5) is in the center of the wrist on the radial side; Pianli (LI6) is secured three cun distal to the wrist crease; Wenliu (LI7) is five cun distal to the wrist crease; Xialian (LI8) is seen five cun proximal to Quchi (LI11); Shanglian (LI9) is three cun proximal to Quchi (LI11); Sanli (LI10) is encountered two cun proximal to Quchi (LI11); Quchi (LI11) is at the end of the transverse cubital crease when the elbow is flexed; Zhouliao (LI12) is near the lateral margin of the large bone of the elbow; Wuli (LI13) is found in the center of the large tendon, moving inward three cun above the elbow; Binao (LI14) is measured seven cun above the elbow; Jianyu (LI15) is taken at the shoulder tip with the arm raised; Jugu (LI16) ascends from the tip of the shoulder; Tianding (LI17) is truly four cun lateral to the throat; Futu (LI18) is five cun lateral to Tiantu (CV22); He'liao (LI19) is five fen lateral to Shuigou (GV26); Yingxiang (LI20) is one cun superior to He'liao. The acupoints of the Large Intestine Meridian are clearly defined.

The Large Intestine governs Jin Ye (body fluids), hence it discusses diseases generated by Jin Ye (body fluids). The aforementioned two syndromes are self-diseases of this meridian; the subsequent syndromes may be diseases of this meridian or combined with other meridians. None of them mention Fu-organ diseases; examples are given to generalize the rest. Toothache occurs because the meridian enters the tooth gaps. Neck swelling occurs because the meridian ascends to the neck. Yellow eyes result from combined Taiyang (Greater Yang) and Shaoyang (Lesser Yang) meridian diseases. Dry mouth occurs because the meridian flanks the mouth. Rhinorrhea or epistaxis occurs because the meridian flanks the nasal cavity. The throat belongs to the Lung system, as Zang-Fu organs are connected. Jianyu (LI15) pain occurs because the meridian ascends to Jianyu (LI15). Inability to use the second finger (index finger) occurs because the meridian originates from the second finger. Excess patterns manifest as hot swelling, while deficiency patterns manifest as chills, distinguishing excess and deficiency by cold and heat.

The Large Intestine belongs to Metal, governs transformation, and serves as the official of transmission.
Ben Bing (Zang-Fu organ diseases):
Constipation, dysentery with bloody stool, tenesmus, carbuncles and hemorrhoids, rectal prolapse, borborygmus with pain. (The above syndromes, whether excess or deficiency, cold or heat, are all diseases of this Fu-organ, supplementing what was not prepared in the classic text.)
Biao Bing (Meridian diseases):
Toothache, sore throat (Hou Bi), neck swelling, dry mouth, (all same meridian); sensation of a lump in the throat, (the throat is not traversed by this meridian, but the meridian enters the Quepen area, follows the exterior of the Stomach meridian, and is close to the throat); rhinorrhea or epistaxis, yellow eyes, pain in the thumb and index finger, (all same meridian); fever due to retained food, (retained food inside, fever outside, thus considered a Biao disease); chills. (Same meridian.)