甘草(炙)二两 干姜三两 强人可四两 附子(生用,去皮,破八片)大者一枚
右三味,以水三升,煮取一升二合,去滓,分温再服,其脉即出者愈。
面色赤者,加葱九茎,腹中痛者,去葱加芍药二两。呕者,加生姜二两。咽痛者,去
芍药加桔梗一两。利止脉不出者,去桔梗加人参二两。病皆与方相应者,乃服之。
【方解】
论中扶阳抑阴之剂,中寒阳微不能外达,主以四逆;中外俱寒,阳气虚甚,主以附子
;阴盛于下,格阳于上,主以白通;阴盛于内,格阳于外,主以通脉。是则可知四逆
运行阳气者也,附子温补阳气者也,白通宣通上下之阳者也,通脉通达内外之阳者也
。今脉微欲绝;里寒外热,是肾中阴盛,格阳于外,故主之也。倍干姜,加甘草佐附
子,易名通脉四逆汤者,以其能大壮元阳,主持中外,共招外热返之于内。盖此时生
气已离,亡在俄顷,若以柔缓之甘草为君,何能疾呼外阳,故易以干姜,然必加甘草
与干姜等份者,恐涣漫之余,姜、附之猛,不能安养元气,所谓有制之师也。若面赤
者,加葱以通格上之阳。腹痛者,加芍药以和在里之阴。呕逆者,加生姜以止呕。咽
痛者,加桔梗以利咽。利止脉不出气少者,俱倍人参。以生元气而复脉也。
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少阴病,吐利,手足不逆冷,反发热者,不死,脉不至者,灸少阴七壮。
【注】
少阴吐利,法当逆冷,今不逆冷反发热者,是阳未衰,故曰不死。若脉不至,虽有外
热,恐是假热,须防阳脱,宜急灸少阴,速通其阳,则脉可复也。
【集注】
程知曰:前条通脉四逆汤是里寒外热,手足逆冷,而脉不至者也。此条用灸法是里寒
外热,手足不逆冷,而脉不至者也。少阴动脉,在足内踝。
喻昌曰:前条背恶寒之证,灸后用附子汤,阴寒内凝,非一灸所能胜也。此条手足反
热,祗是阴内阳外,故但灸本经,引之内入,不必更用温药也。
汪琥曰:经云,肾之原出于太溪,灸少阴七壮,当灸太溪。二穴在内踝后跟骨动脉陷
中。
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少阴病,吐利,手足逆冷,烦躁欲死者,吴茱萸汤主之。
【注】
名曰少阴病,主厥阴药者,以少阴、厥阴多合病,证同情异,而治别也。少阴有吐利
,厥阴亦有吐利;少阴有厥逆,厥阴亦有厥逆,少阴有烦躁,厥阴亦有烦躁,此合病
而证同者也。少阴之厥有微甚,厥阴之厥有寒热;少阴之烦躁则多躁,厥阴之烦躁则
多烦。盖少阴之病,多阴盛格阳,故主以四逆之姜、附,逐阴以回阳也;厥阴之病,
多阴盛郁阳,故主以吴茱萸之辛烈,迅散以通阳也,此情异而治别者也。今吐而不吐
蛔,手足厥冷,故以少阴病名之也。盖厥冷不过肘膝,多烦而躁欲死,故属厥阴病主
治也。所以不用四逆汤,而用吴茱萸汤也。
【集注】
程知曰:吐利,阴邪在里,上干脾胃也;厥冷,阳不温于四肢也;烦而躁,则阴盛之
极,至于阳气暴露扰乱不宁也,证至此,几濒危矣。非茱萸之辛温,无以降阴气之上
逆;非人参姜枣之甘温,无以培中土而制肾邪也。躁烦与烦躁亦有别,躁者阴躁,烦
者阳烦。躁烦者,言自躁而烦,是阴邪已外逼也;烦躁者,言自烦而躁,是阳气犹内
争也。其轻重浅深之别;学者宜详审之。
程应旄曰:温法原为阴寒而设,故真寒类多假热,凡阴盛格阳,阴证似阳等,皆少阴
蛊惑人耳目处,须从假处勘出真来,方不为之牵制。如吐利而见厥冷,是胃阳衰而肾
阴并入也。谁不知为寒者,顾反见烦躁欲死之证以诳之,是皆阳被阴拒而置身无地,
故有此像。吴茱萸汤挟木力以益火势,则土得温而水寒却矣。
[Tongmai Sini Decoction Formula]
Zhi Gancao (Prepared Licorice Root) 2 liang, Ganjiang (Dried Ginger) 3 liang (for robust individuals, may increase to 4 liang), Fuzi (Prepared Aconite Root Lateralis) 1 large piece (used raw, skin removed, broken into eight pieces).
The above three ingredients are decocted with 3 sheng of water until reduced to 1.2 sheng. The dregs are strained out, and the liquid is divided into two doses taken warm. If the pulse reappears after administration, the patient will recover.
If the face appears red, add 9 stalks of Congbai (Scallion White); if there is abdominal pain, remove the scallion and add Shaoyao (White Peony Root) 2 liang; if there is vomiting, add Shengjiang (Fresh Ginger) 2 liang; if there is sore throat, remove Shaoyao and add Jiegeng (Platycodon Root) 1 liang; if diarrhea stops but the pulse does not appear, remove Jiegeng and add Renshen (Ginseng Root) 2 liang. Administer only when the condition corresponds to the formula's indications.
[Formula Analysis]
Among the formulas discussed for supporting Yang and suppressing Yin: when internal cold causes Yang Qi to be weak and unable to reach the exterior, Sini Tang (Four Reversal Decoction) is the primary choice; when both interior and exterior are cold and Yang Qi is extremely deficient, Fuzi Tang (Aconite Decoction) is used; when Yin Cold is excessive in the lower jiao and repels Yang Qi to the upper jiao, Bitong Tang (White Connect Decoction) is used; when Yin Cold is excessive internally and repels Yang Qi to the exterior, Tongmai Sini Tang (Pulse-Connecting Four Reversal Decoction) is used. From this, it can be known that Sini Tang circulates Yang Qi, Fuzi Tang warms and tonifies Yang Qi, Bitong Tang unblocks Yang Qi between the upper and lower parts, and Tongmai Sini Tang connects Yang Qi between the interior and exterior. Currently, the pulse is faint and on the verge of disappearing, with internal cold and external heat. This indicates excessive Yin Cold in the Kidney repelling Yang Qi to the exterior; therefore, this formula is indicated. By doubling the amount of Ganjiang (Dried Ginger) and adding Gancao (Licorice Root) to assist Fuzi (Aconite Root), and renaming it Tongmai Sini Tang, it is because the formula greatly strengthens the Primordial Yang, governs the interior and exterior, and collectively attracts the external heat back into the interior. At this time, vital Qi has already dispersed, and death is imminent. If soft and slow-acting Gancao were used as the sovereign herb, how could it swiftly call back the external Yang? Therefore, Ganjiang is substituted as the sovereign herb. However, Gancao must be added in an equal proportion to Ganjiang, lest the fierce nature of Ganjiang and Fuzi fail to nourish the scattered Yuan Qi. This is what is meant by "an army with discipline." If the face is red, Congbai (Scallion White) is added to unblock the Yang repelled to the upper part; if there is abdominal pain, Shaoyao (White Peony Root) is added to harmonize the Yin within; if there is vomiting and counterflow qi, Shengjiang (Fresh Ginger) is added to stop vomiting; if there is a sore throat, Jiegeng (Platycodon Root) is added to benefit the throat. If diarrhea stops, the pulse does not appear, and Qi is deficient, Ren Shen (Ginseng Root) is doubled to generate primordial Qi and restore the pulse.
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In Shaoyin Disease, characterized by vomiting and diarrhea, if the hands and feet are not cold and instead there is fever, the prognosis is favorable (not fatal). If the pulse cannot be felt, moxibustion should be applied to the Shaoyin meridian seven times (seven moxa cones).
[Annotation]
Shaoyin Disease with vomiting and diarrhea typically presents with cold extremities. The fact that they are not cold and instead there is fever indicates that Yang Qi has not yet exhausted, hence it is stated that death will not occur. However, if the pulse is imperceptible, despite the presence of external heat, it may be false heat. One must guard against Yang collapse. Urgent moxibustion on the Shaoyin meridian is required to rapidly unblock its Yang Qi, so that the pulse may recover.
[Collected Annotations]
Cheng Zhi said: The previous clause regarding Tongmai Sini Tang describes internal cold with external heat, cold extremities, and an imperceptible pulse. This clause, using moxibustion, describes internal cold with external heat, non-cold extremities, and an imperceptible pulse. The arterial pulse of the Shaoyin meridian is located at the medial malleolus of the foot.
Yu Chang said: In the previous case of aversion to cold on the back, Fuzi Tang was used after moxibustion because Yin Cold coagulated internally, which one session of moxibustion could not overcome. In this case, the extremities are warm, indicating Yin inside and Yang outside; thus, only the home meridian is moxibusted to guide the Yang inward, without needing further warming herbs.
Wang Hu said: The classics state that the Source point of the Kidney is Taixi (KI3). Moxibustion on the Shaoyin meridian seven times should target Taixi. These points are located in the depression behind the medial malleolus where the posterior tibial artery beats.
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In Shaoyin Disease, characterized by vomiting and diarrhea, cold extremities, and severe restlessness bordering on death, Wuzhuyu Tang (Evodia Decoction) is the primary treatment.
[Annotation]
Although named Shaoyin Disease, the primary use of Jueyin disease medication is because Shaoyin and Jueyin often present as combined diseases. The symptoms are similar but the pathogenesis differs, leading to different treatments. Shaoyin Disease involves vomiting and diarrhea, as does Jueyin Disease; Shaoyin Disease involves cold extremities, as does Jueyin Disease; Shaoyin Disease involves irritability, as does Jueyin Disease. This represents combined disease with identical symptoms. However, Shaoyin cold extremities vary in severity, while Jueyin cold extremities vary in cold or heat nature; Shaoyin irritability tends toward physical restlessness (zao), while Jueyin irritability tends toward mental vexation (fan). Generally, Shaoyin disease involves Yin excess repelling Yang, treated with Sini Tang (Ginger and Aconite) to drive out Yin and return Yang. Jueyin disease involves Yin excess stifling Yang, treated with the pungent and fierce nature of Wuzhuyu (Evodia Fruit) to rapidly disperse and unblock Yang. This illustrates different pathogenesis requiring different treatments. Currently, there is vomiting without regurgitation of roundworms, and cold extremities, so it is named Shaoyin Disease. However, since the cold extremities do not extend beyond the elbows and knees, and there is significant vexation and restlessness bordering on death, it belongs to the domain of Jueyin Disease treatment. Therefore, Sini Tang is not used, but Wuzhuyu Tang is employed.
[Collected Annotations]
Cheng Zhi said: Vomiting and diarrhea indicate Yin pathogens in the interior affecting the Spleen and Stomach upward; cold extremities indicate Yang failing to warm the four limbs; irritability and restlessness indicate extreme Yin excess causing exposed Yang to become chaotic and unsettled. When the condition reaches this stage, it is nearly critical. Without the pungent-warm nature of Zhuyu (Evodia Fruit), the counterflow of Yin Qi cannot be descended; without the sweet-warm nature of Renshen (Ginseng Root), Shengjiang (Fresh Ginger), and Dazao (Jujube Fruit), the Middle Earth (Spleen/Stomach) cannot be fortified to control the Kidney pathogen. There is a distinction between Zao Fan (Restless Vexation) and Fan Zao (Vexatious Restlessness): Zao is Yin-induced restlessness, Fan is Yang-induced vexation. Zao Fan implies progressing from restlessness to vexation, indicating Yin pathogens forcing their way outward; Fan Zao implies progressing from vexation to restlessness, indicating Yang Qi still struggling internally. Scholars should carefully examine these differences in severity and depth.
Cheng Yingmao said: The warming method is originally established for Yin-Cold patterns; thus, true cold patterns often present with false heat. All cases of Yin excess repelling Yang or Yin patterns resembling Yang are traps set by Shaoyin disease to confuse the senses. One must discern the truth from the falsehood to avoid being constrained by them. For instance, vomiting and diarrhea accompanied by cold extremities indicate declining Stomach Yang and the merging of Kidney Yin. Who would not recognize this as a cold pattern? Yet, it deceptively presents with severe irritability and restlessness bordering on death. This occurs because Yang is rejected by Yin and has nowhere to reside, creating this appearance. Wuzhuyu Tang utilizes the power of Wood to augment Fire, thereby warming the Earth (Spleen/Stomach) and driving away the Water-Cold.