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All diseases have favorable (shun) and unfavorable (ni) prognoses. Abdominal distension, fever, and a large pulse constitute the first unfavorable condition; (Fever and a large pulse, compounded by abdominal distension, indicate that both exterior and interior pathogens are flourishing, thus constituting the first unfavorable condition.) Abdominal borborygmus with fullness, cold extremities accompanied by diarrhea, and a large pulse constitute the second unfavorable condition; (Abdominal borborygmus and fullness, cold extremities, and posterior discharge indicate a Yin syndrome. A large pulse is inappropriate for this presentation; the mismatch between pulse and symptoms constitutes the second unfavorable condition.) Epistaxis that does not stop, with a large pulse, constitutes the third unfavorable condition; (Epistaxis relates to Yin, while a large pulse relates to Yang. This represents excess Yang and deficiency of Yin, constituting the third unfavorable condition.) Coughing combined with hematuria, emaciation, and a small yet forceful pulse constitutes the fourth unfavorable condition; (Coughing, hematuria, and emaciation indicate that healthy Qi has declined. A small and rapid pulse indicates that pathogenic factors remain. The inability of pathogenic factors and healthy Qi to balance each other constitutes the fourth unfavorable condition.) Coughing, emaciation, fever, and a small and rapid pulse constitute the fifth unfavorable condition. (Emaciation and fever indicate the depletion of True Yin, leaving fire unquenched. A small, thin, and rapid pulse is a sign of flourishing pathogens and declining healthy Qi, constituting the fifth unfavorable condition.) In such cases, death will occur within fifteen days. (As solar terms change and time passes, Qi shifts. If the external pathogen is strong and the host Qi weak, resistance fails, hence death occurs within fifteen days.) Severe abdominal distension, cold extremities, emaciation, and severe diarrhea constitute the first unfavorable condition; (The following describes acute presentations of the five unfavorable conditions. Severe abdominal distension most fears deficiency of Middle Jiao Qi. If accompanied by cold extremities, emaciation, and severe diarrhea, it indicates the collapse of Spleen Yuan and the departure of Yang Qi, thus constituting the first unfavorable condition.) Abdominal distension with hematochezia, and a large pulse that intermittently ceases, constitute the second unfavorable condition; (Abdominal distension with hematochezia is a Yin disease. A large pulse that intermittently ceases indicates impending collapse of solitary Yang, thus constituting the second unfavorable condition.) Coughing, hematuria, loss of flesh and muscle, and a pulsating pulse (bo le) constitute the third unfavorable condition; (Coughing and hematuria indicate pathology in both Qi and Blood. Loss of flesh and muscle indicates deterioration of the Spleen. A pulsating pulse indicates the manifestation of the Zang organs' true pulse, signifying the loss of Stomach Qi, thus constituting the third unfavorable condition.) Hematemesis, chest fullness radiating to the back, and a small, rapid pulse constitute the fourth unfavorable condition; (Hematemesis and chest fullness radiating to the back indicate that Zang Qi connects to the back. A small, thin, and rapid pulse indicates severe depletion of True Yuan, thus constituting the fourth unfavorable condition.) Cough, vomiting, abdominal distension, and sputtering diarrhea (sun xie), with a pulse that is absent, constitute the fifth unfavorable condition. (Upper Jiao presents with cough and vomiting, Middle Jiao with distension, and Lower Jiao with sputtering diarrhea. Pathology in all three Jiaos with an absent pulse indicates the presence of pathogens but absence of healthy Qi, thus constituting the fifth unfavorable condition.) In such cases, death will occur in less than one shi (two hours). ("Less than one shi" means unable to complete a full day.) If physicians do not discern these signs, it is called "treating contrary to the disease" (ni zhi). (Forcing treatment on an incurable disease yields no benefit and only exacerbates harm, which is termed ni zhi.)