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Chao Yuanfang stated: Whenever a patient has just recovered from a pestilential toxic disease, the Spleen and Stomach remain deficient, and the Qi of grain and food has not yet recovered. If one engages in labor, reckless movement, or strains the body, and consumes pork, mutton, chicken, dog meat, raw fish slices, roasted meats, fried foods, fatty and greasy items, raw fruits, wheat-based foods, and other hard, astringent, and difficult-to-digest substances, these will stagnate and accumulate in the intestines and stomach. This leads to chest and diaphragm oppression, abdominal distension, and constipation, or severe vomiting and purging. If fever recurs and the disease relapses, it is incurable.

In the "Ping Re Lun" (Evaluation of Heat Treatise), the Yellow Emperor asked: There is a type of warm disease where the patient sweats but immediately becomes feverish again, the pulse is rapid and restless, does not diminish with sweating, and is accompanied by delirious speech and inability to eat. What is the name of this disease? Qibo replied: The disease is named Yin-Yang Jiao (Yin-Yang Intersection). Diseases characterized by intersection are fatal and untreatable. (This refers to the disorder of Yin and Yang, where Qi and Blood do not follow their proper courses, meridians become chaotic and erratic, causing the heat to persist incessantly, hence death.)

The disease known as Yin-Yang Yi (Yin-Yang Exchange) occurs when a man or woman, having just recovered from a pestilential disease but not yet fully restored, engages in sexual intercourse, thereby causing the disease to recur. This condition is called Yin-Yang Yi. When a man who has just recovered from illness but is not yet stable engages in coitus with a woman, causing her to fall ill, it is called Yang Yi; when a woman who has just recovered but is not yet stable engages in coitus with a man, causing him to fall ill, it is called Yin Yi. If two men or two women do not transmit the disease to each other, the term "Exchange" is used because Yin and Yang mutually influence each other, transferring the pathogenic toxin to the other person, akin to swapping or exchanging. Symptoms include fever, heavy head, stiffness and cramping of the four limbs, and lower abdominal pain; if these occur, it is a death case. If the disease progression is slow, death may still occur after months.

The Taiyang (Greater Yang) pulse is large; the Yangming (Yang Brightness) pulse is string-like and long; the Shaoyang (Lesser Yang) pulse is string-like and rapid; the Taiyin (Greater Yin) pulse is string-like and fine; the Shaoyin (Lesser Yin) pulse is deep; the Jueyin (Terminal Yin) pulse is slightly moderate. If the pulse shows deficiency and weakness in the Yang position and string-tightness in the Yin position, and is further exposed to warm Qi, it transforms into a plague/epidemic. In pestilential diseases, if the pulse is Hongda (Surging and Large), it is treatable; if the pulse is Hong (Surging) and Shu (Rapid), it is critical. If both Cun (Inch) positions are floating and large but weak upon pressure, tonification is indicated. If there is exterior excess heat combined with a Chen Se Xiao Xi (Deep, Choppy, Fine, and Small) pulse and cold feet, it is untreatable. In pestilential disease lasting four to five days, with body heat, abdominal fullness, and vomiting, if the pulse comes forth thin but strong, death occurs on the twelfth day. In pestilential disease lasting two to three days, with headache and abdominal fullness but normal diet, if the pulse is straight and rapid, death occurs on the eighth day. In pestilential disease lasting eight to nine days, with no head or body pain, red eyes, or color changes, but instead presenting with diarrhea, if the pulse is irregular (Die Die), non-pulsating upon pressure, occasionally large, and the epigastrium is firm, death occurs on the seventeenth day. In pestilential disease, if sweat does not appear, or if sweating does not reach the feet, it is a death case. In cases of Jue Ni (Cold Extremities), if spontaneous sweating occurs and the pulse is strong, rigid, and urgent, life is possible; if the pulse is deficient and soft, death ensues. In pestilential disease with diarrhea, if abdominal pain is severe, it is a death case.