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Jue (Cold Extremities) refers to the coldness of the hands and feet, which is defined as the failure of Yin and Yang Qi to connect with each other. In cases where Yin deficiency leads to this disconnection, warming methods are used; in cases where Yang Qi sinks and becomes latent, failing to flow smoothly, purgative methods are employed. When pathogenic heat has entered but has not penetrated deeply, dispersing methods are applied. All these constitute Jue characterized by cold extremities. However, the meaning of "Jue" in *Neijing* (The Yellow Emperor's Inner Canon) differs: the three Yin meridians of the foot originate at the tips of the toes and converge below the sole of the foot. If Yang Qi is excessive while Yin Qi is deficient, Yang invades the Yin territory, resulting in Heat Jue (Heat Extremities), which necessarily begins from the soles of the feet; this is a disease of Yin deficiency, where the soles of the feet are often hot. If Yin Qi is dominant while Yang Qi is deficient, and Yang cannot overcome Yin, Cold Jue (Cold Extremities) occurs, starting at the five toes of the feet without extending to the knees. This coldness does not enter from the exterior but arises internally. Therefore, in syndromes of Yang deficiency, the four limbs are mostly not warm. Regarding the etiology of Cold Jue, it states that the individual, relying on their robust constitution, indulges in sexual activity during late autumn and winter when Yin is at its peak, depleting essence. With essence depleted below, cold qi rebels upward; due to the decline of Yang Qi, it fails to permeate and nourish the meridians, leading to cold hands and feet. Regarding the etiology of Heat Jue, it describes individuals engaging in intercourse after heavy drinking and eating. The qi of wine and grain contend with each other, exhausting true Yuan Qi. The Yin of the Spleen and Kidney is damaged internally, leaving Yuan Yang uncontrolled, resulting in hot hands and feet. Yin and Yang, interior and exterior, each have their respective functions. Yang governs the exterior and is warm; Yin governs the interior and is cold. The meridians of the interior and exterior circulate and connect at the four limbs. Thus, examples of major Yin and Yang Jue caused by damage from wine and sexual excess are presented at the beginning of the chapter. Subsequently, the pathological manifestations of the twelve meridians are narrated without mentioning hand-foot Jue or the causes of disease, because the two preceding examples allow for deduction. Therefore, Ye Tianshi stated: The Cold and Heat Jue mentioned in *Neijing* are deficiency syndromes caused by the rebellion of Yin and Yang Qi. Warming Yang for Cold Jue and nourishing Yin for Heat Jue perfectly aligns with Wang Bing’s (Wang Taipu) method of "strengthening the master of Water to control the glare of Sun, and benefiting the source of Fire to dissipate the shadows of Yin." Zhang Zhongjing, Liu Wansu (Hejian), and Hua Shuo (Andao) discussed hand-foot cold extremities caused by Cold Damage (Shanghan). Since the syndromes differ, the treatment methods also differ, which can be called clear discrimination. Other examples include: excessive mental fatigue causing Yang to flare up and internal exhaustion of Yin essence, accumulating until summer, resulting in Jian Jue (Frying Jue); severe anger injuring the Liver, causing sudden severance of form and Qi, with blood stagnating in the upper body, resulting in Bo Jue (Thinning Jue), also known as Qi Rebellion; pathology involving the Yangming and Shaoyin meridians results in Feng Jue (Wind Jue); exhaustion of all five collaterals, or being struck suddenly by evil spirits (Feishi Guiji), results in Shi Jue (Corpse Jue); evil blood rushing to the Heart results in Xue Jue (Blood Jue); confusion and stifling due to phlegm-dampness results in Tan Jue (Phlegm Jue); illness contracted due to drunkenness results in Zui Jue (Drunkenness Jue); illness contracted due to overeating results in Shi Jue (Food Jue). These are all cases of sudden collapse and fainting. Additionally, there are Bone Jue (characterized withered bones and painful nails), Corpse Jue (characterized by rigid body like a rafter), Yangming Jue (characterized by leakage and rigidity), Hui Jue (characterized by expulsion of roundworms), as well as Li Headache, Jue Heartache, Jue Lower Back Pain, Jue Hernia, Wei Jue (Flaccidity Jue), Bi Jue (Obstruction Jue), Hongjiao Jue (Charley Horse/Down's Ague Jue), etc. These are named Jue due to the presence of rebellious Qi. Students should study their treatments carefully and apply them accordingly.