大黄（黄芩为使）
桔梗（节皮为使，畏白芨、龙胆、龙眼）
甘遂（瓜蒂为使，恶远志，反甘草）
葶苈（榆皮为使，得酒良，恶僵蚕、石龙芮）
芫花（决明为使，反甘草）
泽漆（小豆为使，恶薯蓣）
大戟（反甘草）
钩吻（半夏为使，恶黄芩）
藜芦（黄连为使，反细辛、芍药、五参、恶大黄）
乌头乌喙（莽草为使，反半夏、栝蒌、贝母、白蔹、白芨，恶藜芦）
天雄（远志为使，恶腐婢）
附子（地胆为使，恶蜈蚣，畏防风、甘草、黄 、人参、乌韭、大豆）
贯众（ 菌为使）
半夏（射干为使，恶皂荚，畏雄黄、生姜、干姜、秦皮、龟甲，反乌头）
虎掌（蜀漆为使，畏莽草）
蜀漆（栝蒌为使，恶贯众）
恒山（畏玉札）
野狼牙（芜荑为使，恶秦艽、地榆）
白蔹（代赭为使，反乌头）
白芨（紫石英为使，恶理石、李核仁、杏仁）
菌（得酒良，畏鸡子）
茹（甘草为使，恶麦门冬）
荩草（畏鼠妇）
夏枯草（土瓜为使）
野狼毒（大豆为使，恶麦句姜）
鬼臼（畏垣衣）
茯苓、茯神（马 为使，畏牡蒙、地榆、雄黄、秦艽、龟甲、恶白蔹）
柏子仁（牡蒙、桂心、瓜子为使，畏菊花、羊蹄、诸石、面曲）
杜仲（恶蛇蜕、玄参）
干漆（半夏为使，畏鸡子）
蔓荆子（恶乌头、石膏）
牡荆实（防风为使，恶石膏）
五加皮（远志为使，畏蛇蜕、元参）
黄柏（恶干漆）
辛夷（芎 为使，恶五石脂，畏菖蒲、蒲黄、黄连、石膏、黄环）
酸枣仁（恶防己）
槐子（天雄、景天为使）
Da Huang (Rhei Radix et Rhizoma) (used with Huang Qin (Scutellariae Radix) as a guiding herb)
Jie Geng (Platycodonis Radix) (used with Jie Pi as a guiding herb; incompatible with Bai Ji (Bletillae Rhizoma), Long Dan (Gentianae Radix), and Long Yan)
Gan Sui (Euphorbiae Kansui Radix) (used with Gua Di as a guiding herb; adverse reaction with Yuan Zhi (Polygalae Radix); contrary to Gan Cao (Glycyrrhizae Radix et Rhizoma))
Ting Li (Semen Lepidii seu Descurainiae) (used with Yu Pi as a guiding herb; enhanced by wine processing; adverse reaction with Jiang Can (Bombyx Batryticatus) and Shi Long Rui (Ranunculi Ternati Herba))
Yuan Hua (Genkwa Flos) (used with Jue Ming Zi as a guiding herb; contrary to Gan Cao (Glycyrrhizae Radix et Rhizoma))
Ze Qi (Euphorbiae Pekinensis Herba) (used with Xiao Dou as a guiding herb; adverse reaction with Shu Yu (Dioscoreae Hypoglaucae Rhizoma))
Da Ji (Euphorbiae Pekinensis Radix) (contrary to Gan Cao (Glycyrrhizae Radix et Rhizoma))
Gou Wen (Gelsemii Ramulus et Folium) (used with Ban Xia (Pinelliae Rhizoma) as a guiding herb; adverse reaction with Huang Qin (Scutellariae Radix))
Li Lu (Veratri Radix) (used with Huang Lian (Coptidis Rhizoma) as a guiding herb; contrary to Xi Xin (Asari Radix et Rhizoma), Shao Yao (Paeoniae Radix), Wu Shen (the five types of Ginseng); adverse reaction with Da Huang (Rhei Radix et Rhizoma))
Wu Tou, Wu Hui (Aconiti Radix lateralis preparata / Aconiti Caulis) (used with Mang Cao as a guiding herb; contrary to Ban Xia (Pinelliae Rhizoma), Gua Lou (Trichosanthis Fructus), Bei Mu (Fritillariae Cirrhosae Bulbus), Bai Lian (Ampelopsis Radix), Bai Ji (Bletillae Rhizoma); adverse reaction with Li Lu (Veratri Radix))
Tian Xiong (Aconiti Radix lateralis preparata) (used with Yuan Zhi (Polygalae Radix) as a guiding herb; adverse reaction with Fu Bi)
Fu Zi (Aconiti Radix lateralis preparata) (used with Di Dan as a guiding herb; adverse reaction with Wu Gong (Centipeda); adverse with Fang Feng (Saposhnikoviae Radix), Gan Cao (Glycyrrhizae Radix et Rhizoma), Huang , Ren Shen (Ginseng Radix et Rhizoma), Wu Jiu, Da Dou (Sojae Semen Preparatum))
Guan Zhong (Cyathullae Rhizoma) (used with Jun as a guiding herb)
Ban Xia (Pinelliae Rhizoma) (used with She Gan (Belamcandae Rhizoma) as a guiding herb; adverse reaction with Zao Jiao (Gleditsiae Spina); adverse with Xiong Huang (Realgar), Sheng Jiang (Zingiberis Rhizoma Recens), Gan Jiang (Zingiberis Rhizoma), Qin Pi (Fraxini Cortex), Gui Jia (Testudinis et Carapacis Squama); contrary to Wu Tou (Aconiti Radix))
Hu Zhang (Aconiti Radix lateralis preparata) (used with Shu Qi as a guiding herb; adverse with Mang Cao)
Shu Qi (Radix Veratri Alti) (used with Gua Lou (Trichosanthis Fructus) as a guiding herb; adverse reaction with Guan Zhong (Cyathullae Rhizoma))
Heng Shan (Radix Veratri Alti) (adverse with Yu Zha)
Ye Lang Ya (Radix Allii Macrostemonis) (used with Wu Yi (Chloranthi Fructus) as a guiding herb; adverse reaction with Qin Jiao (Gentianae Macrophyllae Radix), Di Yu (Sanguisorbae Radix))
Bai Lian (Ampelopsis Radix) (used with Dai Zhe Shi (Haematitum) as a guiding herb; contrary to Wu Tou (Aconiti Radix))
Bai Ji (Bletillae Rhizoma) (used with Zi Shi Ying (Pyritum) as a guiding herb; adverse reaction with Li Shi, Li He Ren (Pruni Armeniacae Semen Amarum), Xing Ren (Armeniacae Semen Amarum))
Jun (enhanced by wine processing; adverse with Ji Zi (Galli Ovum))
Ru (used with Gan Cao (Glycyrrhizae Radix et Rhizoma) as a guiding herb; adverse reaction with Mai Men Dong (Ophiopogonis Radix))
Jin Cao (adverse with Shu Fu)
Xia Ku Cao (Prunellae Spica) (used with Tu Gua as a guiding herb)
Ye Lang Du (Radix Euphorbiae lathyris) (used with Da Dou (Sojae Semen Preparatum) as a guiding herb; adverse reaction with Mai Ju Jiang)
Gui Jiu (adverse with Yuan Yi)
Fu Ling, Fu Shen (Poria) (used with Ma as a guiding herb; adverse with Mu Meng, Di Yu (Sanguisorbae Radix), Xiong Huang (Realgar), Qin Jiao (Gentianae Macrophyllae Radix), Gui Jia (Testudinis et Carapacis Squama); adverse reaction with Bai Lian (Ampelopsis Radix))
Bai Zi Ren (Biotae Semen) (used with Mu Meng, Gui Xin (Cinnamomi Ramulus), Gua Zi as guiding herbs; adverse with Ju Hua (Chrysanthemi Flos), Yang Ti, Zhu Shi (various minerals), Mian Qu)
Du Zhong (Eucommiae Cortex) (adverse reaction with She Tui (Bovis Cornu desudatum), Xuan Shen (Scrophulariae Radix))
Gan Xi (Resina Taxodi) (used with Ban Xia (Pinelliae Rhizoma) as a guiding herb; adverse with Ji Zi (Galli Ovum))
Man Jing Zi (Viticis Semen) (adverse reaction with Wu Tou (Aconiti Radix), Shi Gao (Gypsum Fibrosum))
Mu Jing Shi (Viticis Fructus) (used with Fang Feng (Saposhnikoviae Radix) as a guiding herb; adverse reaction with Shi Gao (Gypsum Fibrosum))
Wu Jia Pi (Acanthopanacis Cortex) (used with Yuan Zhi (Polygalae Radix) as a guiding herb; adverse with She Tui (Bovis Cornu desudatum), Yuan Shen (Scrophulariae Radix))
Huang Bo (Phellodendri Cortex) (adverse reaction with Gan Xi (Resina Taxodi))
Xin Yi (Magnoliae Flos) (used with Xiong as a guiding herb; adverse reaction with Wu Shi Zhi; adverse with Chang Pu (Acori Tatarinowii Rhizoma), Pu Huang (Typhae Pollen), Huang Lian (Coptidis Rhizoma), Shi Gao (Gypsum Fibrosum), Huang Huan)
Suan Zao Ren (Ziziphi Spinosae Semen) (adverse reaction with Fang Ji (Stephaniae Tetrandrae Radix))
Huai Zi (Sophorae Japonicae Fructus) (used with Tian Xiong (Aconiti Radix lateralis preparata), Jing Tian as guiding herbs)