大黄（黄芩为使。）
桔梗（节皮为使，畏白芨、龙胆、龙眼。）
甘遂（瓜蒂为使，恶远志，反甘草。）
天雄（远志为使，恶腐婢。）
芫花（决明为使，反甘草。）
泽漆（小豆为使，恶薯蓣。）
大戟（反甘草，畏菖蒲、芦草、鼠屎。）
钩吻（半夏为使，恶黄芩。）
藜芦（黄连为使，反细辛、芍药、五参、恶大黄。）
乌头、乌喙（莽草为使，反半夏、栝蒌、贝母、白蔹、白芨、恶藜芦。）
附子（地胆为使，恶蜈蚣，畏防风、甘草、黄 、人参、乌韭、黑豆。）
葶苈（榆皮为使，得酒良，恶僵蚕、石龙芮。）
半夏（射干为使，恶皂荚，畏雄黄、生姜、干姜、秦皮、龟甲，反乌头。）
虎掌（蜀漆为使，畏莽草。）
贯众（ 菌为使。）
蜀漆（栝蒌为使，恶贯众。）
恒山（畏玉札。）
牙子（芜荑为使，恶地榆、枣肌。）
白蔹（代赭为使，反乌头。）
白芨（紫石英为使，恶理石，畏李核、杏仁。）
茹（甘草为使，恶麦门冬。）
菌（得酒良，畏鸡子。）
荩草（畏鼠妇。）
夏枯草（土瓜为使。）
野狼毒（大豆为使，恶麦句姜。）
鬼臼（畏垣衣。）
茯苓、茯神（马 为使，恶白蔹，畏牡蒙、地榆、雄黄、秦胶、龟甲。）
柏实（牡蛎、桂、瓜子为使，恶菊花、羊蹄、诸石、面、曲。）
杜仲（畏蛇蜕、玄参。）
干漆（半夏为使，畏鸡子，今又忌油脂。）
蔓荆子（恶乌头、石膏。）
牡荆实（防风为使，恶石膏。）
五加皮（远志为使，畏蛇蜕、玄参。）
黄柏（恶干漆。）
辛荑（芎 为使，恶五石脂，畏菖蒲、蒲黄、黄连、石膏、黄环。）
酸枣仁（恶防己。）
槐子（天雄、景天为使。）
Rhubarb (Da Huang) (used with Scutellariae Radix [Huang Qin] as guiding drug.)
Platycodonis Radix (Jie Geng) (used with Pericarpium Citri Reticulatae Peel [Jie Pi] as guiding drug; averse to Bletillae Rhizoma [Bai Ji], Gentianae Radix [Long Dan], and Dimocarpus Longan [Long Yan].)
Kansui Radix (Gan Sui) (used with Momordicae Fructus [Gua Di] as guiding drug; dislikes Polygalae Radix [Yuan Zhi]; contrary to Glycyrrhizae Radix et Rhizoma [Gan Cao].)
Aconiti Lateralis Radix Preparata (Tian Xiong) (used with Polygalae Radix [Yuan Zhi] as guiding drug; dislikes Descurainiae Herba [Fu Bi].)
Genkwa Flos (Yuan Hua) (used with Cassiae Semen [Jue Ming] as guiding drug; contrary to Glycyrrhizae Radix et Rhizoma [Gan Cao].)
Euphorbiae Pekinensis Radix (Ze Qi) (used with Phaseoli Semen [Xiao Dou] as guiding drug; dislikes Dioscoreae Rhizoma [Shu Yu].)
Euphorbiae Pekinensis Radix (Da Ji) (contrary to Glycyrrhizae Radix et Rhizoma [Gan Cao]; averse to Acori Tatarinowii Rhizoma [Chang Pu], Arundo Rhizoma [Lu Cao], and Mus Stercus [Shu Shi].)
Gelsemii Ramulus et Folium (Gou Wen) (used with Pinelliae Rhizoma [Ban Xia] as guiding drug; dislikes Scutellariae Radix [Huang Qin].)
Veratri Radix (Li Lu) (used with Coptidis Rhizoma [Huang Lian] as guiding drug; contrary to Asari Radix et Rhizoma [Xi Xin], Paeoniae Radix Alba [Shao Yao], and the "Five Ginsengs" [Wu Shen]; dislikes Rhubarbi Radix et Rhizoma [Da Huang].)
Aconiti Radix (Wu Tou) and Aconiti Cornu (Wu Hui) (used with Illicii Anisi Staranis Herba [Mang Cao] as guiding drug; contrary to Pinelliae Rhizoma [Ban Xia], Trichosanthis Radix [Gua Lou], Fritillariae Cirrhosae Bulbus [Bei Mu], Ampelopsis Radix [Bai Lian], and Bletillae Rhizoma [Bai Ji]; dislikes Veratri Radix [Li Lu].)
Aconiti Lateralis Radix Preparata (Fu Zi) (used with Diplocardi Carapax [Di Dan] as guiding drug; dislikes Scolopendra [Wu Gong]; averse to Saposhnikoviae Radix [Fang Feng], Glycyrrhizae Radix et Rhizoma [Gan Cao], [missing character in original, likely Huang Qin or Huang Qi], Ginseng Radix et Rhizoma [Ren Shen], Ophiopogonis Japonici Bulbus [Wu Jiu], and Sojae Semen Nigrum [Hei Dou].)
Lepidii Fructus (Ting Li) (used with Ulmi Cortex [Yu Pi] as guiding drug; beneficial when taken with wine; dislikes Bombyx Batryticatus [Jiang Can] and Ranunculi Ternati Radix [Shi Long Rui].)
Pinelliae Rhizoma (Ban Xia) (used with Belamcandae Rhizoma [She Gan] as guiding drug; dislikes Gleditsiae Sinensis Spina [Zao Jia]; averse to Realgar [Xiong Huang], Zingiberis Recens Rhizoma [Sheng Jiang], Zingiberis Rhizoma [Gan Jiang], Fraxini Cortex [Qin Pi], and Testudinis et Chelonis Carapax et Plastrum [Gui Jia]; contrary to Aconiti Radix [Wu Tou].)
Typhonii Rhizoma (Hu Zhang) (used with Codonopsis Radix [Shu Qi] as guiding drug; averse to Illicii Anisi Staranis Herba [Mang Cao].)
Cyathulae Radix (Guan Zhong) (used with [missing character in original] as guiding drug.)
Codonopsis Radix (Shu Qi) (used with Trichosanthis Radix [Gua Lou] as guiding drug; dislikes Cyathulae Radix [Guan Zhong].)
Oldenlandiae Herba (Heng Shan) (averse to Yuzha [Yu Zha].)
Yazi (Ya Zi) (used with Myrobalani Fructus [Wu Yi] as guiding drug; dislikes Sanguisorbae Radix [Di Yu] and Ziziphi Spinosae Seed [Zao Ji].)
Ampelopsis Radix (Bai Lian) (used with Haematitum [Dai Zhe] as guiding drug; contrary to Aconiti Radix [Wu Tou].)
Bletillae Rhizoma (Bai Ji) (used with Flumen Calcitum [Zi Shi Ying] as guiding drug; dislikes Lizhi [Li Shi]; averse to Prunus Mume Seed [Li He] and Armeniacae Semen Amarum [Xing Ren].)
Ru (Ru) (used with Glycyrrhizae Radix et Rhizoma [Gan Cao] as guiding drug; dislikes Ophiopogonis Japonici Bulbus [Mai Men Dong].)
Jun (Jun) (beneficial when taken with wine; averse to Gallus Galli Ovum [Ji Zi].)
Jin Cao (Jin Cao) (averse to Porcellio [Shu Fu].)
Prunellae Spica (Xia Ku Cao) (used with Cucumis Melon Root Tu Gua [Tu Gua] as guiding drug.)
Wolf's Bane (Ye Lang Du) (used with Sojae Helpe [Da Dou] as guiding drug; dislikes Polygoni Multiflori Caulis [Mai Ju Jiang].)
Podophylli Fructus (Gui Jiu) (averse to Yuan Yi [Yuan Yi].)
Poria (Fu Ling) and Poria Cum Radix (Fu Shen) (used with [missing character in original, likely Ma Chi] as guiding drug; dislikes Ampelopsis Radix [Bai Lian]; averse to Mumeng [Mu Meng], Sanguisorbae Radix [Di Yu], Realgar [Xiong Huang], Qin Jiao [Qin Jiao], and Testudinis et Chelonis Carapax et Plastrum [Gui Jia].)
Platycladi Semen (Bai Shi) (used with Ostrea Concha [Mu Li], Cinnamomi Ramulus [Gui], and Cucurbitae Semen [Gua Zi] as guiding drugs; dislikes Chrysanthemi Flos [Ju Hua], Rumex Acetosella Radix [Yang Ti], various stones [Zhu Shi], flour [Mian], and yeast [Qu].)
Eucommiae Cortex (Du Zhong) (averse to Serpentinis Cutis [She Tui] and Scrophulariae Radix [Xuan Shen].)
Lac Resinae Siccata (Gan Xi) (used with Pinelliae Rhizoma [Ban Xia] as guiding drug; averse to Gallus Galli Ovum [Ji Zi]; currently also contraindicated with fatty oils.)
Viticis Fructus (Man Jing Zi) (dislikes Aconiti Radix [Wu Tou] and Gypsum Fibrosum [Shi Gao].)
Vitcis Fructus (Mu Jing Shi) (used with Saposhnikoviae Radix [Fang Feng] as guiding drug; dislikes Gypsum Fibrosum [Shi Gao].)
Acanthopanacis Cortex (Wu Jia Pi) (used with Polygalae Radix [Yuan Zhi] as guiding drug; averse to Serpentinis Cutis [She Tui] and Scrophulariae Radix [Xuan Shen].)
Phellodendri Cortex (Huang Bo) (dislikes Lac Resinae Siccata [Gan Xi].)
Magnoliae Flos (Xin Yi) (used with Ligustici Chuanxiong Rhizoma [Xiong Qiong] as guiding drug; dislikes Wushi Zhi [Wu Shi Zhi]; averse to Acori Tatarinowii Rhizoma [Chang Pu], Typhae Pollen [Pu Huang], Coptidis Rhizoma [Huang Lian], Gypsum Fibrosum [Shi Gao], and Huang Huan [Huang Huan].)
Ziziphi Spinosae Semen (Suan Zao Ren) (dislikes Stephaniae Tetrandrae Radix [Fang Ji].)
Sophorae Fructus (Huai Zi) (used with Aconiti Lateralis Radix Preparata [Tian Xiong] and Sedum Acre [Jing Tian] as guiding drugs.)