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The blood and qi of the human body circulate in the Yang meridians during the day and in the Yin meridians at night. Starting from the Yin hour (3:00-5:00 AM) at dawn, the blood and qi flow from the Middle Jiao into the Lung Meridian of Hand-Taiyin; at the Mao hour (5:00-7:00 AM), they enter the Large Intestine Meridian of Hand-Yangming; at the Chen hour (7:00-9:00 AM), they enter the Stomach Meridian of Foot-Yangming; at the Si hour (9:00-11:00 AM), they enter the Spleen Meridian of Foot-Taiyin; at the Wu hour (11:00 AM-1:00 PM), they enter the Heart Meridian of Hand-Shaoyin; at the Wei hour (1:00-3:00 PM), they enter the Small Intestine Meridian of Hand-Taiyang; at the Shen hour (3:00-5:00 PM), they enter the Bladder Meridian of Foot-Taiyang; at the You hour (5:00-7:00 PM), they enter the Kidney Meridian of Foot-Shaoyin; at the Xu hour (7:00-9:00 PM), they enter the Pericardium Meridian of Hand-Jueyin; at the Hai hour (9:00-11:00 PM), they enter the Sanjiao Meridian of Hand-Shaoyang; at the Zi hour (11:00 PM-1:00 AM), they enter the Gallbladder Meridian of Foot-Shaoyang; and at the Chou hour (1:00-3:00 AM), they enter the Liver Meridian of Foot-Jueyin.

The circulation of blood and qi should be neither excessive nor insufficient. If the timing of Qi is missed or mishandled, inflammatory disasters will appear immediately. Furthermore, each hand and foot has three Yin and three Yang meridians. The three Yin meridians of the hands run from the Zang organs to the hands; the three Yang meridians of the hands run from the hands to the head; the three Yang meridians of the feet run from the head down to the feet; and the three Yin meridians of the feet run from the feet up into the abdomen, totaling twelve meridians.

There is another theory stating: On days of Zi, Wu, Mao, and You, Yin intersects with Yang, resulting in Qi deficiency, where pox lesions tend to attack aggressively; on days of Yin, Shen, Si, and Hai, Yang meets Yin, resulting in Blood deficiency, where pox lesions tend to peel off. On Chen days, Yang Qi moves downward, and Blood stagnates without advancing, so treating pox requires nourishing Blood; on Xu days, Yin Qi moves upward, and Qi stagnates and becomes insufficient, so treating pox requires tonifying Qi; on Chou and Wei days, Qi and Blood circulate evenly, making the prognosis for pox generally auspicious. This theory is established based on Yin and Yang. However, the deficiency and excess of Qi and Blood in the human body can be known at a glance. Since individual constitutions vary in Yin and Yang, how can one rigidly adhere to fixed times to generalize over diverse constitutions?

On the first and second days, fetal toxin emerges from the Kidneys, reaching the level of the bone marrow. On the second and third days, it transmits to the level of the Heart and blood vessels. On the third and fourth days, it transmits to the level of the Spleen and Stomach muscles. On the fourth and fifth days, it transmits to the level of the Liver and sinews. On the fifth and sixth days, it transmits to the exterior of the Lungs and skin/hair. By the seventh and eighth days, the pus gradually dries up, leading to recovery; otherwise, it may become inverted pox (Dao Ye) or form carbuncles and swellings.

The Liver corresponds to water blisters, which are blue-green and small; this is commonly known as chickenpox (Shui Dou). The Lungs correspond to purulent blisters, which are thick, turbid, white, and large; this is commonly known as smallpox (Dou Zi). The Heart corresponds to red spots [text missing], governing Blood; these are red and small, smaller than water blisters; this is commonly known as [missing character] zi. The Spleen corresponds to macules/rashes, which are pale yellow and smaller than [missing text]; this is commonly known as measles (Ma Zi).