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In the *Ping Mai Fa* (Method of Assessing Pulse), if the pulse is tight in both yin and yang positions, accompanied by vomiting and diarrhea, yet the pulse remains tight and unresolved; if the pulse is slow, and after six or seven days there is a lack of appetite, this is termed "Late Onset" (Wan Fa). This is due to the retention of fluid-dampness, indicating that the pathogen has not yet been resolved. Cheng Wuji annotated that "Late Onset" refers to diseases that manifest later. My commentary states: In Volume 1 of *Waitai Miyao* (Prescriptions from the Imperial Cabinet), Zhang Wenzhong treats late-onset cold damage. Manifestations occurring from three months to one year after infection are called late onset. The formula uses Sheng Di Huang (Rehmanniae Radix), Zhi Zi (Gardeniae Fructus), Sheng Ma (Cimicifugae Rhizoma), Chai Hu (Bupleuri Radix), Shi Gao (Gypsum Fibrosum), and Wu Wei Zi (Schisandrae Fructus). If the head and face are red, remove Shi Gao and use Gan Ge Gen (Puerariae Lobatae Radix); if Sheng Di Huang is unavailable, use Chi Dou (Sojae Semen Praeparatum). Thus, "late onset" refers to the latest manifestation of cold damage. By inferring the intent, contracting cold-heat pathogens and manifesting symptoms half a year later is called late onset. For late onset at three months, the infection occurred before the Winter Solstice, regardless of whether it was seasonal qi or normal qi; for late onset at year-end, the infection occurred after the Summer Solstice, regardless of seasonal or normal qi. This is because cold-heat pathogens accumulate within and must manifest after half a year. Why is this so? From Autumn Equinox to Spring Equinox, regarding the cold of normal qi, the Winter Solstice serves as the boundary. Cold damage contracted before the Winter Solstice manifests its late onset peak by the end of March, approximately half a year after autumn. If cold damage is contracted after the Winter Solstice and manifests after May, it is termed heat disease, not late onset, because it involves a new contraction of pathogenic factors. Whenever cold-heat pathogens persist until after the two solstices (Winter/Summer) when Wood Qi becomes dominant, new contractions are most likely; with new contractions, the pathology bifurcates, thus it cannot be called late onset. From Spring Equinox to Autumn Equinox, regarding the cold of seasonal qi, the Summer Solstice serves as the boundary. Cold damage contracted before the Summer Solstice and manifesting in September is termed warm malaria, not late onset, due to concurrent new contraction. If cold damage is contracted after the Summer Solstice and manifests at year-end, it is called late onset, as it is separated by half a year. Regarding the heat of seasonal qi from Autumn Equinox to Spring Equinox, the Winter Solstice is the boundary. Heat contracted before the Winter Solstice manifests its late onset at the end of March, following the same method as normal qi; heat contracted after the Winter Solstice and manifesting at summer's end is termed warm-heat disease, not late onset, following the same method as normal qi. Regarding the heat of normal qi from Spring Equinox to Autumn Equinox, the Summer Solstice is also the boundary. Heat contracted before the Summer Solstice and manifesting in September is termed warm malaria, not late onset, following the same method as normal qi; heat contracted after the Summer Solstice and manifesting at year-end is called late onset, following the same method as normal qi. Therefore, "late onset" is distinguished from warm and heat diseases, and is contrasted with the immediate onset of seasonal and normal qi infections. Generally, infection after the Winter Solstice manifesting at year-end, and infection before the Summer Solstice manifesting in June, are considered immediate onsets. The character "Ji" (immediate) stands in direct opposition to "Wan" (late). If discussing only winter normal qi, it is unlikely to delay until the following year to manifest. *Ren Shu* (Book of Vitality) therefore changed it to three months to summer, likely missing the true meaning. The reason for such late onset is the accumulation of cold pathogens, which bind with body fluids, causing fluid retention into water-dampness, preventing the pathogen from dispersing. Pathogens that lie latent without manifesting are mostly due to fluid retention. *Waitai Miyao* Volume 4 records warm disease: Winter-warmth does not manifest immediately; in spring, it is suppressed by accumulated cold and cannot manifest; in summer, upon receiving heat, the spring cold resolves, and winter-warmth toxicity begins to emerge from the muscles. Rashes appear hidden like brocade patterns, accompanied by high fever, cough, chest oppression, and vomiting clear fluid. From this, we know that when winter-warmth is suppressed by spring cold, fluid retention occurs first. Thus, when it manifests in summer, vomiting of fluid must precede the appearance of rashes. This describes a case where seasonal qi contracted after the Winter Solstice manifests at summer's end, which is not classified as late onset. The formula used there includes Ma Huang (Ephedrae Herba), Xing Ren (Armeniacae Semen Amarum), Ge Gen (Puerariae Lobatae Radix), and Ju Pi (Citri Reticulatae Pericarpium), sharing the intent of resolving cold and water-dampness with the current formula. Furthermore, *Lu Yan Fang* (Verified Prescriptions) under the section on warm toxicity adds that if diarrhea has already occurred, Huang Lian Ju Pi Tang (Coptidis and Citri Reticulatae Decoction) should be taken. Thus, toxicity from retained water-dampness presents with both vomiting and diarrhea, treated similarly to late onset. It would be acceptable to classify the two types of warm toxicity in *Waitai Miyao* and *Lu Yan Fang* as warm variants of late onset.