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Zhang Jiebin stated: There is a condition known as "Liang Gan Yu Han" (Two-Channel Cold Invasion), where the exterior and interior channels are simultaneously affected. On the first day, the Taiyang Channel (Greater Yang) and Shaoyin Channel (Lesser Yin) are both diseased in their respective exterior-interior relationship. Symptoms such as headache, fever, and aversion to cold indicate that the pathogen is at the exterior level; symptoms such as dry mouth and thirst indicate that the pathogen is at the interior level. On the second day, the Yangming Channel (Yang Brightness) and Taiyin Channel (Greater Yin) are both diseased. Symptoms such as body heat, eye pain, nasal dryness, and insomnia indicate that the pathogen is at the exterior level; symptoms such as abdominal fullness and loss of appetite indicate that the pathogen is at the interior level. On the third day, the Shaoyang Channel (Lesser Yang) and Jueyin Channel (Terminal Yin) are both diseased. Symptoms such as deafness, hypochondriac pain, alternating chills and fever, and vomiting indicate that the pathogen is at the exterior level; symptoms such as mental restlessness with fullness, retraction of the testicles, cold extremities, and inability to take in fluids or food indicate that the pathogen is at the interior level. In cases of Liang Gan, death may occur either after three days or six days because the Ying (Nutritive) and Wei (Defensive) Qi cease to circulate, the Zang-Fu organs become blocked, consciousness is lost, and the Stomach Qi is exhausted, leading inevitably to death. The strategy for rescue lies solely in distinguishing between urgency and slackness: one may release the exterior harmonize the interior, or tonify the root due to deficiency, ensuring that the Yuan Yang (Primordial Yang) does not collapse. Whether to treat the exterior or interior first must be judged according to clinical presentation; one should not rigidly adhere to specific formulas for treatment.

"Liang Gan" originally refers to the simultaneous disease of exterior and interior channels. Currently, there are cases where the Shaoyin Channel fails internally first, followed by the Taiyang Channel being affected externally; this corresponds to Liang Gan caused by indulgence in lust and desires. When the Taiyin Channel is injured internally, followed by repeated external contraction of pathogens into the Yangming Channel, this corresponds to Liang Gan caused by overexertion, labor, and irregular diet. When the Jueyin Channel experiences Qi rebellion within the Zang organs, and the Shaoyang Channel becomes diseased in the Fu organs, this corresponds to Liang Gan caused by imprudent emotional responses, physical fatigue damaging the sinews, and deterioration of the blood.

Zhang Jiebin further stated: "He Bing" (Combined Disease) refers to the simultaneous involvement of two or three Yang channels, representing the merging of pathological conditions. For instance, if initial symptoms include fever, aversion to cold, and headache, these are signs of Taiyang disease; if accompanied by insomnia, it constitutes a combination of Taiyang and Yangming diseases. If accompanied by vomiting and nausea, it constitutes a combination of Taiyang and Shaoyang diseases. If fever, insomnia, vomiting, and nausea all present together, it constitutes a combination of Yangming and Shaoyang diseases. If all three sets of symptoms are present, it is a Three-Yang Combined Disease. Since the pathological nature is similar, one must differentiate the pulse and syndromes to identify any rebellious patterns before applying appropriate therapeutic methods to correct the rebellion.

In the progression of Shanghan (Cold Damage) patterns, seven days constitute one period (Hou). Zhang Zhongjing stated: If Taiyang disease involving headache resolves spontaneously after seven days or more, it is because the pathogen has completed its course through the meridians. This aligns with the principle in the Neijing stating that on the seventh day, Taiyang disease declines, and headaches subside slightly. Yu Chang stated: "Guo Jing Bu Jie" (Pathogen Passing the Meridian Without Resolution) refers to conditions persisting beyond seven or eight days, up to thirteen days or more, where the illness exceeds one or two periods without resolving. However, when pathogens remain in the body for an extended time, they inevitably aggregate in the Three Yang channels, with Taiyang being most susceptible, followed by Shaoyang, and then Yangming. Once the pathogens reach the Three Yin channels, life and death can change in an instant, unlike the prolonged course observed in the Yang channels.