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Xu Zhongguang treated a patient in the stage of痘疹 (smallpox/variolae) swelling and rising, with darkened and withered lesions, accompanied by delirium. This indicated extreme hyperactivity of fire (excess heat). He treated him with Tuohuo Huisheng Dan (Fire-Retreating Life-Recovery Pill) and Wubi San (Peerless Powder), resulting in recovery.

He treated another patient with dense痘疹 (smallpox/variolae) filled with pus, white in color, suffering from lethargy and delirium. This was due to blood deficiency. He used Baoyuan Tang (Protective Qi Decoction) added with Danggui (Angelicae Sinensis Radix), Dihuang (Rehmanniae Radix), Chuanxiong (Ligustici Chuanxiong Rhizoma), Maidong (Ophiopogonis Radix), Fuling (Poria), and Suanzaoren (Ziziphi Spinosae Semen).

He treated another patient who experienced drowsiness after noon following痘疹 (smallpox/variolae), with a red face and delirium. This indicated fire arising from deficiency. He used Baoyuan Tang (Protective Qi Decoction) added with Danggui (Angelicae Sinensis Radix), Shaoyao (Paeoniae Radix Alba), and Huanglian (Coptidis Rhizoma).

Wan Mizhai treated the son of Hu Sanxi for痘疹 (smallpox/variolae). The patient frequently covered his face with his hands, curled his body downward, and repeatedly cried out, "I am afraid," as if seeing spirits. Wan said, "This is Ni Dou (reverse smallpox)." The Classics state: "When kidney qi fails, will is lost, and one sees ghosts in the eyes; this is a fatal condition that cannot be cured." Qian Yi (Qianshi) stated: "Kidney disease causes the body to crouch downward." Since this痘疹 (smallpox/variolae) originated from the kidney, it was incurable. It proved true.

He treated a woman in her twenties who had been feverish for five days without痘疹 (smallpox/variolae) erupting. She constantly rose to feel along the bed walls, was unconscious, and muttered incessantly. Wan said, "This is a fatal syndrome." It proved true.

Zhou Huang's son, aged thirteen, contracted痘疹 (smallpox/variolae) with fever. After five days, no痘疹 (smallpox/variolae) had erupted. He became manic and delirious, having already taken three doses of Baoyuan Tang (Protective Qi Decoction). Wan said, "This was a mistake; it violated the prohibition against 'reinforcing excess' (Shi Shi). In the initial stage of痘疹 (smallpox/variolae) fever, if there is fright, calm it; if thirsty, moisten it; if vomiting or diarrhea, harmonize it; if constipated, purge it; if heat is excessive, resolve it. If there are no other symptoms, medication is unnecessary. Now, this child has naturally robust yuan qi (original qi) and strong dietary habits, yet Baoyuan Tang (Protective Qi Decoction) was used to aid fire and become pathogenic, causing toxic vapors to stagnate and suppress, leading to mania. The heat is now severe. Urgent purgation is required. Administer Sanhuang Tang (Three-Yellow Decoction). Upon defecation, the mania ceased,痘疹 (smallpox/variolae) erupted, and by the seventeenth day, scabs formed. (The methods for treating痘疹 (smallpox/variolae) are contained entirely within these few sentences.)"

Wang Shaoxi's maid contracted痘疹 (smallpox/variolae) with fever and madness. Wan said, "The heat is extreme; it must be resolved quickly." He prepared Sanhuang Tang (Three-Yellow Decoction) for her to take. Upon defecation, the heat decreased, consciousness cleared,痘疹 (smallpox/variolae) erupted, and she recovered safely.

Xu's son, aged seventeen, developed痘疹 (smallpox/variolae). When the pustules were about to crust over, he suddenly became manic, spoke nonsense, danced, beat people, and cursed those he harbored grudges against in daily life. All lesions on his body burst open. Prayers and exorcisms were ineffective. Therefore, Anshen Wan (Calming the Spirit Pill) 100 pills were administered in two doses. After a long time, he regained consciousness. When asked about his behavior, he was confused and had no memory of it.