凡好嫖者，恋坛酣战，自觉马口间如针戳之痛，此毒瓦斯已起也。未几而生鱼口
矣，未几而生疳疮矣，又未几而遍身生疮矣，黄脓泛滥，臭腐不堪。世人皆以为毒
盛，多用败毒之药，孰知日败毒而毒愈盛，疮愈多而不易愈。往往有腐烂者，日用
败毒之剂，其疮不能收口。须知此症于泄精之时，泄精则元气亏损，故毒乘虚而入。
若元气大旺，毒难深入，即有传染，不过轻微之毒，可一泄而愈。今遍身无非毒疮，
明是大虚而毒深中也，不补虚以泻毒，乌能奏功乎。倘止服败毒之药，无异于以石
投水矣。方用二生汤∶
生黄 （三两） 土茯苓（三两） 生甘草（三钱） 水煎服。连服四剂而疮渐红活，
再服四剂而尽干燥，又服四剂全愈。
此方之妙，全不去解毒，止用黄 以补气，气旺而邪自难留，得生甘草之化毒，
得土茯苓之引毒，毒去而正自无亏，气生而血又能养，此治法之巧，而无如世人之
未识也，可胜叹息云。
人有龟头忽生疳疮，服败毒之药，毒尽从大小便出。倘大肠燥结，则败毒之药
不能径走大肠，势必尽趋小便，而小便口细，毒难罄泄，于是毒不留于肠中而反单
结于外势。毒盛必发，安能不腐烂哉，往往龟头烂落，连龟身亦烂尽矣。世人多以
外药敷之，虽外药亦不可少，然不先消其火毒，而遽用外药以止遏，不啻如石之压
卵也，故必先用汤治之。方名散毒神丹∶
黄柏（三钱） 茯苓（一两） 生甘草（三钱） 炒栀子（三钱） 肉桂（一钱） 水煎服。
连服四剂，则火毒自从小便而出，疼痛少止。然后用生势丹敷之。
炒黄柏（三两） 儿茶（一两） 冰片（三分） 生甘草（一两） 大黄（三钱） 乳香（一钱）
没药（一钱） 麝香（三钱） 丹砂（一钱，不 ） 各为绝细末，和匀渗之，渗上即止痛，逢湿
即渗末，不数日脓尽血干，肉筋再长，一月全愈，但不能再长龟头也。愈后须补气血，用
十全大补汤，连服一月或两月，则外势仍能伸缩，尚可种子。否则多服败毒之药，又用泄
火之剂，无论命门寒冷，而外势亦且冰冷，安得阳和之骤复哉。此先后治法之各异，实有次序也。
人有疳疮初发，鱼口将生，苟不急治，必遍身生疮，迁延岁月，腐烂身体，多
不可救，故必须早治为妙。然早治之法，世人多以五虎散败毒，虽毒亦能往下泄，
而损伤元气正不少也，未为得法。设或败毒之药少减，又恐有留毒之患，亦未为治
法之妙。盖毒瓦斯之入，因元气之虚也。因虚而感毒，又败毒而重虚，毋论毒尽不泄，
已犯虚虚之戒，况只败毒，毒更难散也。治之法宜于补中攻泄，则毒既尽出而正又
无亏。方用早夺汤∶
人参（一两） 生黄 （一两） 茯苓（一两） 当归（一两） 远志（三钱） 生甘草（三钱）
金银花（一两） 大黄（一两） 石膏（一两） 柴胡（二钱） 白术（一两） 天花粉（三钱）
水煎服。一剂而大泻恶物，臭秽不堪，急掘土埋之。再服二剂，而臭物恶秽无留于肠胃矣。后
可减去大黄、石膏，加土茯苓二两，同前药再煎服四剂，则一身上下与头面之间，必有隐
隐疮影现于皮肤之内。再服二剂，疮影亦渐消矣。再二剂，永不生矣。
此方用大黄以泄毒，用石膏以清毒，用甘草、金银花以化毒，用柴胡、天花粉
以散毒，非多助之以大补气血之药，妙在用参、 、归、术之类自获全胜。此等之
方，余实亲视而亲验者也。倘病患阴虚阳燥，方中可加熟地数两，或加玄参一两亦可，
余品不可乱加也。
人有遍身生杨梅之疮，因误服轻粉，一时收敛，以图目前遮饰，岂知藏毒于内，
必至外溃，未几而毒发于鼻，自觉一股臭气冲鼻而出，第二日鼻色变黑，不闻香臭
矣。此等症见，断须急治，否则鼻柱自倾，一至腐烂，便不可救。虽急治而用些小
之剂，亦正无益，毒瓦斯已盛，非杯水可济也。况杨梅结毒，不结于他处，而结于鼻
中，其毒更胜，此毒不在他脏而在肺经也。肺气，清气也。毒瓦斯非清气可比，毒瓦斯
在肺则清气尽为毒瓦斯矣。肺气出于鼻而藏于肾，肾感毒瓦斯移之于肺，以散于皮肤，
则毒瓦斯可以外出。今用轻粉收敛，则毒发皮肤者尽还肺中，肺又归还于肾，而肾不
受，乃上冲于鼻，而鼻孔细小，安得遽泄，自然毒瓦斯尽结于鼻，而鼻乃独受其祸矣。
治法必须多药以解其毒，以肺经不能直治，必隔一隔二以治之也。方用护鼻散∶
玄参（三两） 麦冬（二两） 生甘草（一两） 生丹砂末（三钱） 桔梗（五钱） 金银花（三两）
天花粉（三钱） 水煎，调丹砂末服。一剂而鼻知香臭矣。连服四剂，鼻黑之色去，不必忧鼻梁
之烂落矣。更用全鼻散∶
玄参（一两） 生甘草（三钱） 金银花（一两） 当归（一两） 麦冬（五钱） 人参（三钱）
生丹砂末（一钱） 水煎服。十剂而一身之毒尽出，可保无虞。
前方过于勇猛，所以救其急。后方近于和平，所以补其虚，而丹砂前后皆用者，
以轻粉之毒，非丹砂不能去。轻粉乃水银所烧，而丹砂乃水银之母，子见母自然相
逢不肯相离，丹砂出而轻粉亦出，此世人之所未知耳。倘鼻柱已倾，肉腐不堪，将
前护鼻散救之，虽鼻不重长，而性命可援，亦不致死亡也。
人有生杨梅疮，遍体皆烂，疼痛非常，人以为毒瓦斯之在皮肤也，谁知是血虚而
毒结于皮肤耳。夫杨梅之疮，发于骨髓之中，毒在骨难于医疗，毒在皮肤，似易于
施治矣。然毒未出于皮肤，其毒蕴藏，泻骨中之毒，可从下而外泄。毒已出于皮肤，
其毒开张，敛肌中之毒，不可由表而入。攻得其法则易泄散，未得其法则转横也。
故治之法补其血，泻其毒，引之而尽从小便而出，始得其治法耳。方用二苓化毒汤∶
白茯苓（一两） 土茯苓（二两） 金银花（二两） 当归（一两） 紫草（三钱） 生甘草（二钱）
水酒各半煎服。十剂全愈，并无回毒也。
此方视之平淡无奇，而实有异功者，补以泻之也。杨梅本生于肾之虚，肾虚则
血虚矣。不补虚以治疮，反泻毒以耗血，此世人治梅疮所以多不效。
附∶梅昆璧治杨梅疮水药方
金银花 防风 归尾 紫花地丁 川萆 川牛膝 甘草稍 金蝉蜕 羌活
威灵仙 连翘 赤芍 白鲜皮 何首乌（以上各一钱） 土茯苓（一两）
疮在头上，加荆芥、白芷各八分。疮在下部，加木瓜、木通各五分。疮在
头上下部，荆芥、白芷、木瓜、木通并用。
上水煎服十剂，日服一剂。先将鲜猪肉淡煮汤，服药后即以淡肉汤一碗压
之，令泻下恶物，每出大便，即在空地上挖一土坑，泻入坑内，即将泥土掩
盖好，恐其毒瓦斯传人，为害非浅。
Those who frequent prostitutes, indulging in sexual intercourse, feel a pain in the urethral orifice as if pricked by needles; this indicates that the *mei du* (syphilitic toxin) has arisen. Soon thereafter, *yu kou* (chancre of the penis) will appear; soon after, *gan chuang* (ulcerative lesions) will develop; and shortly after that, sores will erupt all over the body, with yellow pus flooding and an unbearable foul rot. The world assumes the toxin is excessive and frequently employs herbs to purge toxins (*bai du*). Little do they know that daily purging only exacerbates the toxin, causing more sores that are difficult to heal. Often, those with ulcerated lesions use purging agents daily, yet the sores fail to close. One must understand that during ejaculation, seminal loss depletes *yuan qi* (primordial qi), allowing the toxin to enter through the deficiency. If *yuan qi* were robust, the toxin would struggle to penetrate deeply; even if contracted, it would be merely mild and could be resolved through a single discharge. Now, since the entire body is covered with toxic sores, it clearly indicates severe deficiency with deep-seated toxin. Without tonifying deficiency to drain the toxin, how can efficacy be achieved? Merely taking purging herbs is like throwing stones into water—futile. The prescription used is Er Sheng Tang:
Sheng Huang Qi (Raw Astragali Radix, 3 liang), Tu Fu Ling (Smilax Glabrae Rhizoma, 3 liang), Sheng Gan Cao (Raw Glycyrrhizae Radix et Rhizoma, 3 qian). Decoct in water and take orally. After four doses, the sores gradually become red and vibrant; after another four doses, they dry completely; after four more doses, full recovery occurs.
The brilliance of this formula lies not in directly detoxifying, but in using Huang Qi to tonify qi. When qi is robust, pathogenic factors cannot linger. With Sheng Gan Cao transforming the toxin and Tu Fu Ling guiding the toxin outward, the toxin leaves while the righteous qi remains intact; as qi generates, blood nourishes. This demonstrates the ingenuity of this treatment method, which unfortunately escapes the recognition of most people—a matter for sighing.
In cases where a chancre suddenly appears on the glans penis, and purging herbs cause the toxin to exit via urination and defecation: if the large intestine is dry and constipated, the purging herbs cannot travel directly through the large intestine and will instead divert entirely to the small intestine. Since the urethra is narrow, the toxin cannot be fully expelled. Consequently, the toxin does not remain in the intestines but concentrates externally on the genitalia. As the toxin becomes excessive, eruption is inevitable, leading to necrosis. Often, the glans sloughs off, and the entire penis rots away. People often apply external medications. While external applications are necessary, applying them abruptly to suppress symptoms without first clearing fire-toxin is like pressing an egg with a stone—ineffective. Therefore, internal decoction therapy must precede external treatment. The prescription is named San Du Shen Dan:
Huang Bo (Phellodendri Cortex, 3 qian), Fu Ling (Poria, 1 liang), Sheng Gan Cao (Raw Glycyrrhizae Radix et Rhizoma, 3 qian), Chao Zhi Zi (Fried Gardeniae Fructus, 3 qian), Rou Gui (Cinnamomi Cortex, 1 qian). Decoct in water and take orally.
After four doses, fire-toxin exits naturally via urine, and pain subsides slightly. Then apply Sheng Shi Dan externally.
Chao Huang Bo (Fried Phellodendri Cortex, 3 liang), Er Cha (Catechu, 1 liang), Bing Pian (Borneolum Syntheticum, 3 fen), Sheng Gan Cao (Raw Glycyrrhizae Radix et Rhizoma, 1 liang), Da Huang (Rhei Radix et Rhizoma, 3 qian), Ru Xiang (Olibanum, 1 qian), Mo Yao (Myrrha, 1 qian), She Xiang (Moschus, 3 qian), Dan Sha (Cinnabaris, 1 qian, not ground). Grind each into an ultra-fine powder, mix evenly, and sprinkle on the lesion. Pain stops immediately upon application; reapply when wet. Within a few days, pus dries, blood ceases, and muscle/tissue regenerates, achieving full recovery in one month. However, the glans will not regrow. Post-recovery, tonify qi and blood using Shi Quan Da Bu Tang (Ten Significant Tonifying Decoction) for one to two months. This allows the external genitalia to regain elasticity and fertility. Otherwise, excessive use of purging and heat-clearing herbs leads to coldness of the Ming Men (Gate of Life) and the genitalia, preventing the rapid return of Yang harmony. These sequential treatments follow a strict order.
When *gan chuang* initially appears and *yu kou* is about to form, urgent treatment is essential. Delay leads to systemic sores, chronic progression, bodily rot, and often untreatable outcomes. Early treatment is crucial. However, the common early approach using Wu Hu San (Five Tiger Powder) to purge toxins drains the toxin downward but severely damages *yuan qi*, which is suboptimal. Reducing the purging dose risks leaving residual toxin, which is also imperfect. Toxin invasion occurs due to *yuan qi* deficiency. Contracting toxin due to deficiency, then purging further weakens the body, violating the principle of "not making deficiency worse" (*xu xu*). Moreover, mere purging fails to disperse the toxin. The treatment should combine tonification with aggressive drainage, ensuring toxin expulsion while preserving righteous qi. The prescription is Zao Duo Tang:
Ren Shen (Ginseng Radix, 1 liang), Sheng Huang Qi (Raw Astragali Radix, 1 liang), Fu Ling (Poria, 1 liang), Dang Gui (Angelicae Sinensis Radix, 1 liang), Yuan Zhi (Polygalae Radix, 3 qian), Sheng Gan Cao (Raw Glycyrrhizae Radix et Rhizoma, 3 qian), Jin Yin Hua (Lonicerae Japonicae Flos, 1 liang), Da Huang (Rhei Radix et Rhizoma, 1 liang), Shi Gao (Gypsum Fibrosum, 1 liang), Chai Hu (Bupleuri Radix, 2 qian), Bai Zhu (Atractylodis Macrocephalae Rhizoma, 1 liang), Tian Hua Fen (Trichosanthis Radix, 3 qian). Decoct in water and take orally.
One dose causes massive evacuation of foul matter, which must be buried immediately. Two more doses clear all foul residue from the intestines. Subsequently, reduce Da Huang and Shi Gao, add Tu Fu Ling (2 liang), and continue decocting with the previous herbs for four doses. At this stage, faint outlines of sores may appear under the skin of the body and face. Two more doses gradually eliminate these outlines. Two additional doses prevent recurrence.
This formula uses Da Huang to drain toxin, Shi Gao to clear toxin, Gan Cao and Jin Yin Hua to transform toxin, and Chai Hu and Tian Hua Fen to disperse toxin. Its brilliance lies in supporting these actions with significant qi- and blood-tonifying herbs like Ren Shen, Huang Qi, Dang Gui, and Bai Zhu, ensuring victory. I have personally verified such formulas. For patients with yin deficiency and yang dryness, add Shu Di Huang (Rehmanniae Radix Praeparata, several liang) or Xuan Shen (Scrophulariae Radix, 1 liang); other ingredients should not be altered arbitrarily.
Some patients with systemic syphilis mistakenly take Qing Fen (Calomel), causing temporary contraction for cosmetic concealment. This traps the toxin internally, leading to eventual rupture. Soon, toxin erupts in the nose, accompanied by a foul odor. By the second day, the nose turns black, and smell is lost. Such symptoms require urgent treatment; otherwise, the nasal bridge collapses, and necrosis becomes incurable. Minor prescriptions are useless against such intense toxin. Syphilitic toxin concentrating in the nose is particularly severe, affecting the Lung Meridian rather than other organs. Lung qi is clear and pure; toxin is not. When toxin resides in the lungs, clear qi is corrupted. Lung qi emerges from the nose and is rooted in the Kidney. If the Kidney contracts toxin and transfers it to the lungs to dissipate through the skin, the toxin exits. However, Qing Fen’s astringent property forces skin-dissipated toxin back into the lungs, which then returns it to the Kidneys. The Kidneys reject it, forcing it upward to the nose. Due to the narrow nostrils, the toxin cannot escape easily, accumulating in the nose and causing disaster.
Treatment requires multiple herbs to resolve toxin. Since the Lung Meridian cannot be treated directly, indirect methods (treating related meridians) are used. The prescription is Hu Bi San:
Xuan Shen (Scrophulariae Radix, 3 liang), Mai Dong (Ophiopogonis Radix, 2 liang), Sheng Gan Cao (Raw Glycyrrhizae Radix et Rhizoma, 1 liang), Sheng Dan Sha (Ground Cinnabaris, 3 qian), Jie Geng (Platycodonis Radix, 5 qian), Jin Yin Hua (Lonicerae Japonicae Flos, 3 liang), Tian Hua Fen (Trichosanthis Radix, 3 qian). Decoct in water, mix with Dan Sha powder, and take orally. One dose restores olfaction. Four doses remove nasal blackening, preventing bridge collapse. Follow with Quan Bi San:
Xuan Shen (Scrophulariae Radix, 1 liang), Sheng Gan Cao (Raw Glycyrrhizae Radix et Rhizoma, 3 qian), Jin Yin Hua (Lonicerae Japonicae Flos, 1 liang), Dang Gui (Angelicae Sinensis Radix, 1 liang), Mai Dong (Ophiopogonis Radix, 5 qian), Ren Shen (Ginseng Radix, 3 qian), Sheng Dan Sha (Ground Cinnabaris, 1 qian). Decoct in water and take orally. Ten doses expel all systemic toxin, ensuring safety.
The former formula is potent for emergency rescue; the latter is milder to tonify deficiency. Dan Sha is used in both because it specifically counteracts Qing Fen toxicity. Qing Fen is calcined mercury; Dan Sha is the "mother" of mercury. Like a child meeting its mother, they bind together; expelling Dan Sha expels Qing Fen. This mechanism is unknown to most. If the nasal bridge has collapsed and tissue is rotten, Hu Bi San can save life, though the nose will not regrow.
Syphilis presenting with widespread ulceration and severe pain is often attributed to surface toxin. In reality, it stems from blood deficiency with toxin stagnating in the skin. Syphilitic sores originate in the bone marrow; toxin in bone is hard to treat, while toxin in skin seems easier. However, if toxin has not yet emerged to the skin, it is contained; draining bone toxin allows outward release. If toxin has emerged, it expands; attempting to draw intramuscular toxin inward via the exterior is incorrect. Correct attack leads to easy dispersion; incorrect attack causes worsening. Thus, treatment must tonify blood, drain toxin, and guide it out via urine. The prescription is Er Ling Hua Du Tang:
Bai Fu Ling (White Poria, 1 liang), Tu Fu Ling (Smilax Glabrae Rhizoma, 2 liang), Jin Yin Hua (Lonicerae Japonicae Flos, 2 liang), Dang Gui (Angelicae Sinensis Radix, 1 liang), Zi Cao (Arnebiae Radix seu Lithospermi Radix, 3 qian), Sheng Gan Cao (Raw Glycyrrhizae Radix et Rhizoma, 2 qian). Decoct in half water, half wine, and take orally. Ten doses yield full recovery without relapse.
This formula appears simple but works by tonifying to drain. Syphilis arises from Kidney deficiency, which leads to blood deficiency. Treating sores by purging toxin consumes blood, explaining why many treatments fail.
Appendix: Mei Kunbi’s Water Prescription for Syphilis
Jin Yin Hua (Lonicerae Japonicae Flos), Fang Feng (Saposhnikoviae Radix), Gui Wei (Angelicae Sinensis Radix Caudex), Zi Hua Di Ding (Violae Herba), Chuan Bi Xie (Dioscoreae Hypoglaucae Rhizoma), Chuan Niu Xi (Cyathulae Radix), Gan Cao Shao (Glycyrrhizae Radix et Rhizoma Apical Part), Jin Chan Tui (Cryptotympanae Periostracum), Qiang Huo (Notopterygii Rhizoma seu Radix), Wei Ling Xian (Clematidis Radix et Rhizoma), Lian Qiao (Forsythiae Fructus), Chi Shao (Paeoniae Radix Rubra), Bai Xian Pi (Dictamni Cortex), He Shou Wu (Polygoni Multiflori Radix) [each 1 qian], Tu Fu Ling (Smilax Glabrae Rhizoma, 1 liang).
For sores on the head, add Jing Jie (Schizonepetae Spica) and Bai Zhi (Angelicae Dahuricae Radix), 8 fen each. For sores on the lower body, add Mu Gua (Chaenomelis Fructus) and Mu Tong (Akebiae Caulis), 5 fen each. For sores on both upper and lower body, use all four.
Decoct in water, take ten doses, one per day. First, boil fresh pork in light broth. Immediately after taking the medicine, drink one bowl of this light meat broth to induce evacuation of foul matter. Upon defecation, dig a pit in open ground, dispose of waste, and cover with soil to prevent toxin transmission.