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Yellow Emperor asked: The skin is divided into twelve regions. How do diseases manifest in these areas? Qibo replied: The skin is the domain of the meridians. When pathogenic factors invade the skin, the interstices (cou li) open. Once the interstices are open, pathogens enter the collaterals. When the collaterals are full, the pathogens flow into the main meridians; when the main meridians are full, the pathogens enter and reside in the zang-fu organs. Therefore, the skin has specific regional distributions. If left untreated (here "bu yu" is suspected to mean "not healing"), serious diseases may develop.

Yellow Emperor asked: I observe that the visible collaterals display varying colors—blue, yellow, red, white, and black differ from one another. What is the reason for this? Qibo answered: The main meridians have constant colors, whereas the colors of the collaterals are not fixed. Yellow Emperor asked: What are the constant colors of the meridians? Qibo said: The Heart corresponds to red, the Lung to white, the Liver to blue/green, the Spleen to yellow, and the Kidney to black. These all correspond to the colors of their respective meridians. Yellow Emperor asked: Do the colors of the yin and yang collaterals also correspond to the meridians? Qibo said: The color of the yin collaterals corresponds to the meridian, but the color of the yang collaterals changes without constancy, following the four seasons. Excess cold causes blood to coagulate and stagnate, resulting in a blue-black color; excess heat causes blood to become moist and lustrous, resulting in a yellow-red color. These are considered normal colors, indicating no disease. If all five colors appear simultaneously, it is termed a condition of alternating cold and heat.

Yellow Emperor asked: I have heard that wind is the beginning of all diseases. How should acupuncture be used to treat it? Qibo replied: Wind invading from the exterior causes chills, sweating, headache, heaviness of the body, and aversion to cold. Treatment should focus on Fengfu (DU16), regulating yin and yang. Deficiency patterns require tonification, while excess patterns require sedation. For severe wind causing neck and nape pain, puncture Fengfu (DU16). For severe wind causing sweating, moxa [missing character in text, contextually likely Xinhui or similar head point]; press the area with hand, instruct the patient to exhale, and there should be a palpable response. For aversion to wind due to wind pathogen, puncture the eyebrow ridge (i.e., Zanzhu BL2, needle 0.3 cun; if moxibustion, three moxa cones). For stiff neck (Shi Zhen) located between the transverse bones of the shoulder (i.e., Quepen LI15); for fractures limiting arm movement, align the arm straight with the elbow, and moxa Jizhong (DU9, also known as Bei Yangguan, needle 0.5 cun, moxa three cones); for collateral disorders where the hypochondrium pulls into the lower abdomen causing pain and distension, puncture [missing character, note says 'soft spaces beside the spine', likely referring to Huatuo Jiaji points]; for low back pain preventing turning or shaking, urgently pulling into the testicles, puncture the Ba Liao (Eight Holes) and the painful site; Ba Liao is located between the lumbar and sacral segments. For Shu Lu (scrofula with cold and heat), still puncture Han Fu; Han Fu is located at the Ying camp outside the lateral aspect of the knee joint.