疹子出没常以六时为准，假如子后出午后即收，午后出子后即收，乃阳生阴成，阴生
阳成，造化自然之数也。凡此旋出旋收者轻，若一出连绵三四日不收者，乃阳毒太甚，宜大青汤或用荆芥牛蒡
子甘草元参石膏桔梗主之；若逡巡不出者，乃风寒外束，皮肤闭密也，宜荆防败毒散主之。
疹已出而复没者，乃风寒所逼而然。若不早治毒必内攻以致痒塌而死。急用升麻汤加
荆芥牛蒡子甘草热服，则疹必复出而安矣。
发热六七日以后，明是疹子却不见出，此必皮肤坚浓腠理闭密，或为风寒所袭，或曾有
吐泻，皆能伏也。急用托里散表之剂，如麻黄汤去杏仁加蝉蜕升麻，外用胡荽酒之类，如一
向未更衣者，必毒甚于内，伏而不出，《局方》凉膈散加牛蒡子主之。
疹子只怕不能得出，若出尽则毒便解，故治疹者于发热之时，当察时令寒暄酌而治之。
如时证大寒以桂枝葛根汤或麻黄汤发之，时证大热以升麻葛根汤或合人参白虎汤发之，
不寒不热以荆防败毒散发之。如尽一剂不出再作本汤服之，外用胡荽酒，又以苎麻蘸酒遍
身戛之，务令亟出。如三四作更不出，加腹中胀痛，气喘昏闷则死证也。
景岳曰∶按此万氏之法极得因时制宜之善，已尽发表之义矣。然发表之义亦最不易，
即如营卫不足而疹有不能出者，其证甚多，若徒知发之，而不知滋之，则营卫有弱者，非惟
不能发，而且恐穷其源矣。此其或在脾胃，或在血气，必得其神。庶乎有济如伤寒三表之
法，实亦有关于此。
疹毒出尽则邪气解散，正气自然和平。如发热烦闷，或呕吐，或泄泻，此毒邪壅遏尚未
出尽也。烦热者黄连解毒汤，呕泄者柴胡橘皮汤并外用胡荽酒及苎麻戛法如前，待疹子出
尽，则烦热自去，呕吐自止矣。
疹有既收而余毒未尽，至三日之外又复发出，或至五六次不已者，此因发热之时，不
避风寒，致令邪气郁于肌肉之间，留连不散，虽曾解散终属未畅耳，若兼杂证亦当随证治之。
疹子的出现与消退通常以十二时辰为准则。例如，若在子时之后出现，午后便消退；或在午后出现，子时后便消退，这是阳气生发、阴气成就，或阴气生发、阳气成就的自然造化规律。凡是这种随即出现随即消退的，病情较轻；如果一出疹就连绵三四天不消退，这是阳毒太盛，适宜使用大青汤，或者用荆芥、牛蒡子、甘草、玄参、石膏、桔梗为主组方治疗；如果疹子迟疑不出，这是风寒束缚体表，皮肤腠理致密所致，适宜用荆防败毒散主治。
疹子已经发出却又隐没回去的，是被风寒逼迫所致。如果不及时救治，毒邪必定内攻，导致皮疹塌陷而死。急需使用升麻汤加入荆芥、牛蒡子、甘草，趁热服用，那么疹子必定会再次发出而平安无事。
发热六七天以后，明明知道是出疹子却看不见出来，这一定是因为皮肤坚硬厚实、腠理致密，或者是被风寒侵袭，或者曾经有过呕吐腹泻，这些都能导致疹毒伏留。急需使用托里透表的方剂，如麻黄汤去掉杏仁，加入蝉蜕、升麻，外用胡荽酒之类擦拭；如果一直未解大便，说明体内毒邪甚重，伏留不出，可用《局方》中的凉膈散加入牛蒡子主治。
出疹子只怕不能透发出来，如果出透了，毒邪自然解除。所以治疗疹病的人，在发热的时候，应当观察时令气候的寒暖来斟酌施治。如果遇到时令证候大寒，用桂枝葛根汤或麻黄汤发散；遇到时令证候大热，用升麻葛根汤或合用人参白虎汤发散；不寒不热则用荆防败毒散发散。如果服完一剂药疹子仍不出，再煎本方服用，外用胡荽酒，又用苎麻蘸酒遍身擦刮，务必令其迅速透出。如果反复三四次仍不出，加上腹部胀痛、气喘昏闷，就是死证了。
张景岳说：按照万全（万氏）的方法，极得因时制宜的好处，已经尽到了发表的含义。然而“发表”这一义理也是最不容易掌握的，就像营卫不足而导致疹子不能透发的情况，证候很多，如果只知道发散，而不知道滋补，那么对于营卫虚弱的人，不仅不能发散，恐怕还会耗竭其本源。这种情况有的在脾胃，有的在血气，必须得其神妙之处，才可能有疗效，这也与伤寒论中三种表法有关联。
疹毒完全透出后，邪气自然解散，正气自然平和。如果出现发热烦闷，或者呕吐，或者泄泻，这是因为毒邪壅遏尚未完全透出。烦热的用黄连解毒汤，呕吐泄泻的用柴胡橘皮汤，并外用胡荽酒及苎麻擦刮的方法像前面所说的那样，等到疹子出尽，烦热自然去除，呕吐自然停止。
疹子虽然已经收没但余毒未尽，到了三天之外又再次发出，或者到五六次不停止的，这是因为在发热的时候，没有避开风寒，致使邪气郁结在肌肉之间，留连不散，虽然曾经解散过，终究属于不够通畅罢了，如果兼有其他杂证，也应当随证治疗。
The emergence and disappearance of rashes are usually regulated by the twelve two-hour periods (Shichen). For instance, if they appear after the Zi hour (11 PM–1 AM) and recede by Wu hour (11 AM–1 PM), or appear by Wu hour and recede after Zi hour, this represents the natural numerical order of creation where Yang generates Yin to complete it, or Yin generates Yang to complete it. Cases where rashes emerge and recede immediately are mild; however, if rashes persist continuously for three to four days without receding, it indicates excessive Yang toxicity, which should be treated with Daqing Tang (Great Blue Decoction) or a formula primarily composed of Jingjie (Schizonepetae Herba), Niubangzi (Arctii Fructus), Gancao (Glycyrrhizae Radix et Rhizoma), Xuanshen (Scrophulariae Radix), Shigao (Gypsum Fibrosum), and Jiegeng (Platycodonis Radix). If rashes hesitate to emerge, it is due to Wind-Cold binding the exterior and closing the skin pores tightly; this should be treated with Jingfang Baidu San (Schizonepeta and Saposhnikovia Powder to Overcome Toxicity).
If rashes have emerged but then disappear again, it is caused by being forced inward by Wind-Cold. If not treated promptly, the toxin will attack internally, leading to rash collapse and death. Urgently use Shengma Tang (Cimicifugae Decoction) added with Jingjie, Niubangzi, and Gancao, taken hot; then the rashes will surely re-emerge and the patient will be safe.
After six or seven days of fever, if it is clearly a case of rash eruption but no rash appears, this must be because the skin is thick and tough with closed pores, or due to an invasion of Wind-Cold, or previous vomiting and diarrhea, all of which can cause the toxin to lie latent. Urgently use formulas that support the interior and release the exterior, such as Mahuang Tang (Ephedra Decoction) with Xingren (Prunus Armeniacae Semen) removed and Chanui (Bombyx Batryticatus) and Shengma added. Externally apply Huisu Jiu (Coriander Wine). If there has been no bowel movement for some time, the internal toxin is severe and lying latent; treat with Liangge San (Cooling the Diaphragm Powder) from *Ju Fang* added with Niubangzi.
The only concern with rashes is whether they can be fully expressed; once fully expressed, the toxin is resolved. Therefore, when treating rashes during fever, one must observe the seasonal climate’s cold or heat to adjust treatment accordingly. In cases of severe cold season patterns, use Guizhi Gegen Tang (Cinnamon Twig and Pueraria Decoction) or Mahuang Tang to induce sweating; in cases of severe heat season patterns, use Shengma Gegen Tang or combine Ren Shen Baihu Tang (Ginseng White Tiger Decoction) to induce sweating; in neutral conditions, use Jingfang Baidu San to induce sweating. If one dose fails to produce rashes, administer another dose of the same decoction. Externally apply Huisu Jiu, and rub the whole body with Ramie root dipped in wine, ensuring rapid emergence. If after three or four attempts the rashes still do not emerge, accompanied by abdominal distension, pain, panting, and drowsiness, it is a fatal sign.
Zhang Jingyue stated: "According to Wan Quan’s method, it excellently adapts to the times and fully embodies the principle of releasing the exterior. However, the meaning of 'releasing the exterior' is also the most difficult to master. For example, when Ying and Wei deficiency prevents rash emergence, there are many such syndromes. If one only knows how to release but does not know how to nourish, those with weak Ying and Wei will not only fail to express the rash but may also exhaust their source. This may involve the Spleen and Stomach or Qi and Blood; one must grasp its subtlety to achieve efficacy. This is also related to the three methods of releasing the exterior in Cold Damage."
Once the rash toxin is fully expressed, the pathogenic qi dissipates, and the healthy qi naturally returns to harmony. If there is fever with restlessness, vomiting, or diarrhea, it indicates that the toxic pathogen is obstructed and has not yet fully emerged. For restlessness and heat, use Huanglian Jiedu Tang (Coptis Decoction to Resolve Toxin); for vomiting and diarrhea, use Chaihu Jupi Tang (Bupleurum and Tangerine Peel Decoction). Apply Huisu Jiu and the Ramie rubbing method externally as described previously. Once the rashes are fully expressed, the restlessness and heat will naturally subside, and vomiting will stop.
If rashes have receded but residual toxins remain, causing them to reappear after three days, or recurring five or six times without cessation, this is because exposure to Wind-Cold during the febrile stage allowed pathogenic qi to stagnate between the muscles, lingering without dispersing. Although previously dispersed, the resolution was incomplete. If complicated by other syndromes, treat according to the specific presentation.