阳盛阴虚，则昼夜不得眠。盖夜以阴为主，阴气盛，则目闭而卧安。若阴为阳所胜，故终夜烦
扰而不得眠也。所谓阴虚则夜争者是也。汗出鼻干，不得卧，则邪在表也。若胃有燥屎与大热错语，
及大汗，胃中汁干而不得卧，则为邪在里也。胃不和则卧不得安，故宜散热和胃。若汗、吐、下后
虚烦不得眠，又从栀子豉汤以涌之。至于少阴病，热烦于内而不得眠，又宜扶阴散热。若瘥后不得
眠者，则热气与诸阳相并，阴气未复也。有汗下太过，阳气暴虚而不得眠者，若无热证，又宜姜
附汤以退阴复阳也。此又不可不知。
太阳病二三日，不能卧，但欲起，心下结，脉微弱者，此本有寒，今反下之，若利止，必结胸；
未止，三四日复下，必协热而利。结胸，理中丸。协热而利，白头翁汤。
少阴利下，咳而呕渴，心烦不得眠者，猪苓汤，此停水也；若二三日心烦不得眠，黄连阿胶汤。
病患小便不利，大便乍难乍易，时有微热，喘冒不能卧者，有燥屎也，大承气汤。
下之后复发汗，昼则烦躁不得眠，夜则安静，不呕不渴，无表里证，脉沉微，身无大热者，干
姜附子汤。
吐、下、汗后心中懊 ，虚烦不得眠，栀子豉汤。阳胜阴，则狂言乱梦，心烦乏气者，酸枣汤。
阴胜阳，则惊悸昏沉，大热干呕，呻吟错语，不得眠，犀角解毒汤。
中风，汗出，脉濡而弱，厥而且寒，躁不得眠，小建中汤；烦躁，竹叶石膏汤。
瘥后饮酒，烦恶干呕，口燥，呻吟错语，不得眠，犀角解毒汤。
阳热亢盛而阴液亏虚，会导致白天黑夜都无法入睡。因为夜晚以阴气为主，阴气旺盛时，眼睛闭合，睡眠安稳。如果阴气被阳热所克制，就会整夜烦躁不安而无法入睡。这就是所说的“阴虚则夜间争扰”的情况。如果有汗出、鼻干、无法躺卧的症状，说明邪气在体表。如果胃中有燥结的粪便并伴有高热和胡言乱语，以及大量出汗导致胃中津液枯竭而无法躺卧，这说明邪气在体内。胃气不和则睡眠不安稳，所以适宜用散热和胃的方法治疗。如果在发汗、催吐或泻下之后出现虚烦无法入睡，又应当使用栀子豉汤（Zhi Zi Chi Tang, Gardenia and Fermented Soybean Decoction）来涌吐郁热。至于少阴病，因内部热烦而无法入睡，又适宜采用扶正滋阴、清散热邪的方法。如果疾病初愈后无法入睡，是因为余热与诸阳之气相合并，阴气尚未恢复。如果有因发汗、泻下太过，导致阳气突然虚弱而无法入睡的情况，如果没有热证表现，又适宜使用姜附汤（Jiang Fu Tang, Ginger and Aconite Decoction）来退除阴寒、回复阳气。这些情况又是不可不知道的。
太阳病（Taiyang Disease, Exterior Syndrome of the Taiyang Channel）发病两三天，不能平卧，只想坐起，心下部痞塞胀满，脉象微弱的人，这是原本体内有寒，现在反而误用泻下法。如果腹泻停止，必定形成结胸（Jie Xiong, Chest Binding）；如果腹泻未止，再过三四天再次误用泻下法，必定导致协热利（Xie Re Li, Diarrhea with Accompanying Heat）。对于结胸，使用理中丸（Li Zhong Wan, Regulate the Middle Pill）；对于协热利，使用白头翁汤（Bai Tou Weng Tang, Pulsatilla Decoction）。
少阴病（Shaoyin Disease, Interior Cold-Heat Complex Syndrome of the Shaoyin Channel）出现下利，咳嗽且呕吐、口渴，心烦无法入睡的，使用猪苓汤（Zhu Ling Tang, Polyporus Decoction），这是水饮停聚所致；如果是发病两三天后心烦无法入睡，使用黄连阿胶汤（Huang Lian E Jiao Tang, Coptis and Donkey-Hide Gelatin Decoction）。
患者小便不利，大便时而困难时而容易，偶尔有轻微发热，气喘头昏无法躺卧的，是有燥屎内结，使用大承气汤（Da Cheng Qi Tang, Major Order the Qi Decoction）。
先泻下后又发汗，白天烦躁无法入睡，晚上却安静，没有呕吐也没有口渴，没有表证也没有里证，脉象沉微，身体没有大热的，使用干姜附子汤（Gan Jiang Fu Zi Tang, Dried Ginger and Aconite Decoction）。
经过催吐、泻下、发汗治疗后，心中懊恼（Ao Nao, Agitation and Discomfort），虚烦无法入睡的，使用栀子豉汤。阳胜阴衰，导致胡言乱语、多梦纷纭，心烦气短的，使用酸枣汤（Suan Zao Tang, Sour Jujube Seed Decoction）。
阴胜阳衰，导致惊悸昏沉，大热干呕，呻吟错语，无法入睡的，使用犀角解毒汤（Xi Jiao Jie Du Tang, Rhinoceros Horn Detoxification Decoction）。
中风（Zhong Feng, Wind Stroke/Attack），汗出，脉象濡弱，四肢厥冷且寒，躁动无法入睡的，使用小建中汤（Xiao Jian Zhong Tang, Minor Construct the Middle Decoction）；如果伴有烦躁，使用竹叶石膏汤（Zhu Ye Shi Gao Tang, Bamboo Leaf and Gypsum Decoction）。
Yang excess and Yin deficiency lead to insomnia throughout both day and night. Night is governed by Yin; when Yin Qi (Vital Energy) is abundant, the eyes close and sleep is peaceful. If Yin is overcome by Yang, there will be restlessness and insomnia all night long. This is what is meant by "Yin deficiency leads to nocturnal contention." With sweating, dry nose, and inability to lie down, the pathogenic factor is in the exterior. If there are dry feces in the stomach accompanied by high fever and delirious speech, along with profuse sweating causing depletion of gastric fluids leading to an inability to lie down, the pathogenic factor is in the interior. Disharmony of the Stomach results in restless sleep, so it is appropriate to use methods that clear heat and harmonize the Stomach. After sweating, vomiting, or purging, if deficiency-heat irritability and insomnia occur, one should employ Zhi Zi Chi Tang (Gardenia and Fermented Soybean Decoction) to induce vomiting and expel trapped heat. In cases of Shaoyin Disease (Interior Cold-Heat Complex Syndrome of the Shaoyin Channel) where internal heat irritability causes insomnia, it is appropriate to support Yin and clear heat. Following recovery from illness, if insomnia persists, it is because residual heat combines with various Yang energies while Yin has not yet recovered. If excessive sweating or purging causes a sudden deficiency of Yang leading to insomnia, and there are no signs of heat, Jiang Fu Tang (Ginger and Aconite Decoction) should be used to dispel Yin-cold and restore Yang. These points must not be overlooked.
In Taiyang Disease (Exterior Syndrome of the Taiyang Channel), if for two or three days the patient cannot lie down but wishes to sit up, has epigastric fullness, and a faint pulse, this indicates pre-existing cold within. If purgatives are incorrectly administered, and diarrhea stops, chest binding (Jie Xiong) will definitely form; if diarrhea does not stop and purgatives are administered again after three or four days, diarrhea with accompanying heat (Xie Re Li) will result. For chest binding, use Li Zhong Wan (Regulate the Middle Pill); for diarrhea with accompanying heat, use Bai Tou Weng Tang (Pulsatilla Decoction).
In Shaoyin Disease, if there is diarrhea, cough, vomiting, thirst, and irritability with insomnia, Zhu Ling Tang (Polyporus Decoction) is indicated, signifying water retention. If irritability and insomnia occur after two or three days, Huang Lian E Jiao Tang (Coptis and Donkey-Hide Gelatin Decoction) is indicated.
If a patient has difficulty urinating, irregular bowel movements (alternating between difficult and easy), occasional slight fever, wheezing, dizziness, and inability to lie down, there are dry feces, and Da Cheng Qi Tang (Major Order the Qi Decoction) should be used.
After purging followed by sweating, if the patient is irritable and insomniac during the day but quiet at night, without vomiting or thirst, lacking both exterior and interior syndromes, with a deep and faint pulse, and no significant body heat, Gan Jiang Fu Zi Tang (Dried Ginger and Aconite Decoction) is indicated.
After vomiting, purging, or sweating, if there is profound discomfort (Ao Nao), deficiency-heat irritability, and insomnia, Zhi Zi Chi Tang is indicated. When Yang overcomes Yin, resulting in delirious speech, chaotic dreams, irritability, and shortness of breath, Suan Zao Tang (Sour Jujube Seed Decoction) is indicated. When Yin overcomes Yang, resulting in palpitations, lethargy, severe heat, dry heaving, groaning, delirious speech, and insomnia, Xi Jiao Jie Du Tang (Rhino Horn Detoxification Decoction) is indicated.
In Wind Attack (Zhong Feng), with sweating, a soft and weak pulse, cold limbs, and restlessness with insomnia, Xiao Jian Zhong Tang (Minor Construct the Middle Decoction) is indicated; if accompanied by irritability, Zhu Ye Shi Gao Tang (Bamboo Leaf and Gypsum Decoction) is indicated.
Following recovery, if alcohol consumption leads to vexation, nausea, dry heaving, dry mouth, groaning, delirious speech, and insomnia, Xi Jiao Jie Du Tang is indicated.