古有种痘之法，相传宋真宗时，峨嵋山神人所创，实具百发百中之功，洵为尽美尽善之术，推原其理，出痘
多感于得病之后，而种痘必施于无病之先，出痘或遭天地寒暑之不齐，而种痘必择天地融和之美候，内无他病之
夹杂，外复有善苗为引导，化险为夷，何乐不为。
或者曰∶痘为小儿一大病，当天行时，人人尚思远避，今无故取婴孩而与之以病，可乎，曰非也。譬如捕盗，
乘其羽翼未成，就而擒之，甚易耳；譬如去莠，乘其滋蔓未延，芟而除之，又甚易耳。小儿痘毒，其发由肾而肝、
而心、而肺、而脾，故痘之发毒，肾最重，脾最轻，即古用痘苗塞鼻孔法，亦必五脏传编，始能发热，缘鼻为肺
之外窍，苗塞鼻中，其气先传于肺，肺传心，心传脾，脾传肝，肝传肾，肾主骨，痘毒藏骨髓之内，感苗气而发其毒。
自骨髓尽达于筋，则肾脏之毒解矣。自筋尽达于肌肉，则肝脏之毒解矣。自肌肉尽达于血脉，则脾脏之毒解
矣。自血脉尽达于皮毛，则心脏之毒解矣。自皮毛尽达于颗粒，则肺脏之毒解矣。
苗气必历五脏层递而入，内毒亦必历五脏层递而出，此传送之次序也，今种牛痘法择于两臂中消烁清冷渊
二穴、上下交连之处，下苗种之，似与塞鼻孔之法有异，殊不知人身两臂，乃手少阳三焦经也，三焦者人身最关
要之腑，如天地之三元，总领五脏六腑，营卫经络，通内外左右上下之气，三焦通则内外左右上下皆通，得其关
要之处，引之直从皮毛血脉肌肉经络，同时直传而
入，纵有胎毒深藏于肾，亦自然同时引挈而出、如引路然，引诸坦途，则无颠踬之患，如引丝然，引其端绪，则
无棼乱之尤，此种痘所以免出痘之危险，更分别条列于后。
古代有种痘的方法，相传是在宋真宗时期，由峨眉山的神人创立的，确实具有百发百中的功效，实在是尽善尽美的技术。推究其原理，自然出痘多发生在患病之后，而种痘必须在未患病之前施行；自然出痘可能会遭遇天地寒暑变化的不均，而种痘必定选择天地气候融和的美好时机，体内没有其他疾病的夹杂，体外又有优良的痘苗作为引导，将危险转化为平安，有什么不乐意做的呢？
有人问：天花（痘）是小儿的一种大病，在时行疫病流行期间，人们尚且想要远远避开，现在无故让婴儿接触这种病，可以吗？回答说：不对。这就像捕捉盗贼，趁他羽翼未丰时就去擒拿，非常容易；又像去除杂草，趁它蔓延未广时去铲除，也非常容易。小儿的痘毒，其发作是由肾传至肝、再传至心、再传至肺、最后传至脾，所以痘毒发作时，肾最重，脾最轻。即如古代用痘苗塞鼻孔的方法，也必须经过五脏的传递，才能发热。因为鼻是肺的外窍，痘苗塞入鼻中，其气先传于肺，肺传心，心传脾，脾传肝，肝传肾。肾主骨，痘毒藏于骨髓之内，感受痘苗之气而激发其毒。从骨髓完全通达于筋，则肾脏的毒就解除了。从筋完全通达于肌肉，则肝脏的毒就解除了。从肌肉完全通达于血脉，则脾脏的毒就解除了。从血脉完全通达于皮毛，则心脏的毒就解除了。从皮毛完全通达于颗粒（痘疹），则肺脏的毒就解除了。
痘苗之气必须经历五脏层层递进地进入，体内的毒也必然经历五脏层层递进地排出，这就是传递的次序。如今种牛痘的方法选择在两臂中间消烁清冷渊二穴、上下交连之处下苗接种，似乎与塞鼻孔的方法有所不同，殊不知人身两臂，属于手少阳三焦经。三焦是人体最重要的腑，如同天地的三元，总领五脏六腑、营卫经络，贯通内外左右上下之气。三焦通畅，则内外左右上下都通畅。得其关键之处，引导痘苗直接从皮毛、血脉、肌肉、经络同时直接传入，即使有胎毒深藏在肾中，也会自然地同时被牵引而出，就像引路一样，引导走平坦的大道，就没有跌倒的危险；就像抽丝一样，引出它的头绪，就没有混乱的弊端。这就是种痘之所以能免除出痘危险的原因，更分别条列如下。
In ancient times, there was a method of variolation (smallpox inoculation), which is said to have been created by a divine person from Mount Emei during the reign of Emperor Zhenzong of Song. It truly possesses the efficacy of hitting the target every time and is indeed a perfect technique. Tracing its principle, natural smallpox often occurs after contracting the disease, whereas variolation must be performed before falling ill. Natural smallpox may be subject to the imbalance of heaven and earth's cold and heat, while variolation must select a favorable period when the climate of heaven and earth is harmonious. With no other diseases interfering internally and good vaccine material guiding externally, transforming danger into safety, why would one not do it?
Some might ask: Smallpox is a major disease for children. During an epidemic, people still try to avoid it at all costs. Now, without cause, exposing infants to this disease—is this acceptable? The answer is: No. It is like catching a thief; capturing him while his wings are not yet grown is very easy. It is also like removing weeds; eliminating them before they spread is also very easy. The poison of smallpox in children originates from the Kidney, then transmits to the Liver, Heart, Lung, and Spleen. Therefore, in the onset of smallpox poison, the Kidney is most severe, and the Spleen is lightest. Even in the ancient method of inserting vaccine material into the nasal cavity, fever can only occur after transmission through the five Zang organs. Since the nose is the external orifice of the Lung, the qi of the material inserted into the nose first transmits to the Lung, then to the Heart, then to the Spleen, then to the Liver, and finally to the Kidney. The Kidney governs the bones, and the smallpox poison hides within the bone marrow. Upon sensing the qi of the vaccine material, the poison is activated. When the poison extends completely from the bone marrow to the sinews, the poison of the Kidney is resolved. When it extends completely from the sinews to the muscles, the poison of the Liver is resolved. When it extends completely from the muscles to the blood vessels, the poison of the Spleen is resolved. When it extends completely from the blood vessels to the skin and hair, the poison of the Heart is resolved. When it extends completely from the skin and hair to the pustules, the poison of the Lung is resolved.
The qi of the vaccine material must enter layer by layer through the five Zang organs, and the internal poison must also exit layer by layer through the five Zang organs; this is the order of transmission. The modern method of cowpox vaccination selects the area between the two arms, specifically near the points Xiaoxiao (Lower Elimination) and Qinglengyuan (Clear Cold Abyss), where upper and lower parts connect, to administer the vaccine. This seems different from the nasal insertion method. However, it is unknown that the two arms belong to the Hand-Shaoyang Sanjiao Meridian (Triple Burner). The Sanjiao is the most crucial Fu organ in the human body, akin to the Three Primes of heaven and earth, commanding the five Zang and six Fu organs, Ying and Wei, meridians, and connecting the qi of the interior, exterior, left, right, upper, and lower. When the Sanjiao is unobstructed, the interior, exterior, left, right, upper, and lower are all unobstructed. By targeting this key point, the vaccine is guided to transmit directly and simultaneously from the skin, blood vessels, muscles, and meridians. Even if fetal poison is deeply hidden in the Kidney, it will naturally be drawn out simultaneously, just like being led on a path. Guiding along smooth roads eliminates the risk of stumbling; drawing out the thread's end eliminates chaos. This is why variolation avoids the dangers of natural smallpox. These points are listed separately below.