六十难曰∶头心之病，有厥痛，有真痛，何谓也？然∶手三阳之脉，受风寒，伏留而不去
者，则名厥头痛；
入连在脑者，名真头痛。其五脏气相干，名厥心痛，
其痛甚，但在心，手足青者即名真心痛。其真心痛者，旦发夕死，夕发旦死。
六十一难曰∶经言望而知之谓之神，闻而知之谓之圣，问而知之谓之工，切脉而知之谓之巧，
何谓也？然∶望而知之者，望见其五色以知其病。
闻而知之者，闻其五音以别其病。
问而知之者，问其所欲五味，以知其病所起所在也。
切脉而知之者，诊其寸口，视其虚实，以知其病，病在何脏腑也。
经言以外知之曰圣，以内知之曰神，此之谓也。
六十二难曰∶脏井荥有五，腑独有六者，何谓也？然∶腑者阳也，三焦行于诸阳，故置一俞名曰
原。腑有六者，亦与三焦共一气也。
六十三难曰∶《十变》言，五脏六腑荥合，皆以井为始者，何也？然∶井者，东方春也，万
物之始生。诸 行喘息， 飞蠕动，当生之物，莫不以春生。故岁数始于春，日数始于甲，故以
井为始也。
六十四难曰∶《十变》又言，阴井木，阳井金；阴荥火，阳荥水；阴俞土，阳俞木，阴经金，阳经
火；阴合水，阳合土。阴阳皆不同，其意何也？
然∶是刚柔之事也。阴井乙木，阳井庚金。阳井庚，庚者，乙之刚也；阴井乙，乙者，庚之柔也。
乙为木，故言阴井木也；庚为金，故言阳井金也。余皆仿此。
第六十难说：头部和心脏的疾病，有厥痛，有真痛，这是什么意思呢？回答说：手三阳经脉，受到风寒侵袭，邪气潜伏停留而不消散的，就称为厥头痛；如果疼痛深入连及脑部的，称为真头痛。如果是五脏之气相互干扰引起的，称为厥心痛；如果疼痛非常剧烈，且疼痛集中在心脏部位，手足呈现青色的，就称为真心痛。那种真心痛的患者，早晨发病晚上就会死亡，晚上发病第二天早晨就会死亡。
第六十一难说：医经中说，通过观察就能知道病情叫做神，通过听声音就能知道病情叫做圣，通过询问就能知道病情叫做工，通过切脉就能知道病情叫做巧，这是什么意思呢？回答说：所谓望而知之，是观察病人的五色变化来了解他的疾病。所谓闻而知之，是听取病人的五音变化来辨别他的疾病。所谓问而知之，是询问病人对五味（酸苦甘辛咸）的欲望，从而知道疾病的起因和所在部位。所谓切脉而知之，是诊察寸口脉象，观察其虚实变化，从而知道疾病所在的具体脏腑。医经中说，从外部征象推断病情称为圣，从内部机理洞察病情称为神，说的就是这种情况。
第六十二难说：五脏的井穴、荥穴只有五个，而六腑独有六个，这是什么意思呢？回答说：六腑属阳，三焦运行于各条阳经之中，所以额外设置一个原穴，名叫原穴。六腑之所以有六个穴位（指五输穴加原穴），是因为它们与三焦共同属于一气。
第六十三难说：《十变》书中说，五脏六腑的荥穴和合穴，都以井穴作为开始，这是为什么呢？回答说：井穴对应东方春季，是万物开始生长的时节。凡是行走、喘息、飞翔、蠕动的生物，所有应当出生的事物，没有不是随着春天而生的。所以一年的岁数始于春季，一日的日干始于甲日，因此以井穴作为开始。
第六十四难说：《十变》书中又说，阴经的井穴属木，阳经的井穴属金；阴经的荥穴属火，阳经的荥穴属水；阴经的俞穴属土，阳经的俞穴属木；阴经的经穴属金，阳经的经穴属火；阴经的合穴属水，阳经的合穴属土。阴阳五行属性都不同，其中的用意是什么呢？回答说：这是刚柔相配的道理。阴井穴为乙木，阳井穴为庚金。阳井穴的庚金，庚是乙的刚；阴井穴的乙木，乙是庚的柔。乙属于木，所以说阴井属木；庚属于金，所以说阳井属金。其余穴位都仿照这个规律类推。
Difficulty 60 states: Diseases of the head and heart include Jue Tong (rebellious pain) and Zhen Tong (true pain). What is meant by this? The answer is: When the meridians of the three hands-yang are invaded by wind-cold, and the pathogenic factor lingers and does not dissipate, it is called Tou Wei Jue Tou Tong (Jue headache of the head). If the pain penetrates and connects to the brain, it is called Zhen Tou Tong (True headache). If the disorder arises from the mutual interference of the qi of the five zang organs, it is called Xin Wei Jue Xin Tong (Jue heartache). If the pain is severe, localized strictly in the heart, and accompanied by cyanosis of the hands and feet, it is called Zhen Xin Tong (True heartache). Patients with True heartache who develop symptoms in the morning will die by evening; those who develop symptoms in the evening will die by morning.
Difficulty 61 states: The classics say that diagnosing through observation is termed "Shen" (Divine), diagnosing through listening and smelling is termed "Sheng" (Sage), diagnosing through inquiry is termed "Gong" (Skilled), and diagnosing through pulse palpation is termed "Qiao" (Adroit). What is meant by this? The answer is: Diagnosing through observation involves observing the five complexions to identify the disease. Diagnosing through listening involves hearing the five vocal tones to distinguish the disease. Diagnosing through inquiry involves asking about the patient's cravings for the five flavors to determine the origin and location of the disease. Diagnosing through pulse palpation involves examining the Cun Kou (Radial Artery at the wrist) to assess excess or deficiency, thereby identifying the disease and its specific organ involvement. The classics state that inferring from external signs is "Sheng," while understanding internal mechanisms is "Shen." This is what is meant.
Difficulty 62 states: The Jing-Well and Ying-Spring points of the zang organs number five, but the fu organs have six. Why is this so? The answer is: The fu organs belong to Yang. The San Jiao (Triple Burner) circulates among all yang meridians; therefore, an additional Yuan-Source point is established. The reason there are six points for the fu organs is that they share one qi with the San Jiao.
Difficulty 63 states: The *Shi Bian* (Ten Transformations) states that the Ying-Spring and He-Sea points of the five zang and six fu organs all begin with the Jing-Well point. Why is this? The answer is: The Jing-Well point corresponds to the East and Spring, which is the beginning of the generation of all things. Whether creatures walk, breathe, fly, or crawl, all living beings emerge in spring. Therefore, the annual cycle begins with spring, and the sexagenary cycle of days begins with Jia. Thus, the Jing-Well point is considered the beginning.
Difficulty 64 states: The *Shi Bian* further states: Yin Jing-Well is Wood, Yang Jing-Well is Metal; Yin Ying-Spring is Fire, Yang Ying-Spring is Water; Yin Shu-Stream is Earth, Yang Shu-Stream is Wood; Yin Jing-River is Metal, Yang Jing-River is Fire; Yin He-Sea is Water, Yang He-Sea is Earth. The yin and yang elements differ. What is the rationale? The answer is: This concerns the relationship between Gang (Firm/Yang) and Rou (Soft/Yin). The Yin Jing-Well is Yi Wood, and the Yang Jing-Well is Geng Metal. Geng (Yang Metal) is the Gang aspect of Yi (Yin Wood); Yi is the Rou aspect of Geng. Since Yi belongs to Wood, the Yin Jing-Well is said to be Wood; since Geng belongs to Metal, the Yang Jing-Well is said to be Metal. The remaining points follow this pattern.