五禁疮者，最恶症也。此痘一出，诸痘不能宣发成浆矣。─曰胃禁，二曰火禁，三
曰水禁，四曰风禁，五曰寒禁。胃禁者，因毒火炙热，不能发达于外，是以脾胃溃烂，
其外出之痘，在于唇口之间，而四五点相连，诸痘未浆，此痘先已黄熟，是热毒内
攻，胃已腐烂，诸痘不能成浆也。故凡唇口一见此痘，如见烦红气粗，热甚口臭异常
者，是其候也。不治。火禁者，因初发之际，身发寒热，就火温热太过，致使皮肤干
燥，又兼气虚不能拘逐，故毒停滞于皮肤之内，发泄不出，细看皮中觉有红色点子，无
头无脚，独于四肢或头面方广之处，见一二点者，则诸痘皆从此痘发泄为孽，隐隐不起
之痘，终不能快出者是也。宜外以水杨荆芥煎汤浴之。内用升麻和解散主之。则诸痘自
可起发矣。水禁者，有因初热之际，毒瓦斯方炽，误食生冷，则毒伏于皮肤之间，隐隐见
有红点，或于方广两胁，手足头面之际，发有水泡者是也。然冷气在内，故内必腹痛肚
胀，外必发热恶寒，宜以丁桂茯苓升麻大腹之类逐之。风禁者，因发热之初，失于避
风，是以肌表固密，痘不能出，皮肤麻木，不知痛痒，或皮毛干燥，肤痒欲搔，甚则狂
谵烦语者，此风与火相博也。治宜以干葛羌活蝉蜕之类逐之。寒禁者，发热之初，误经
冷水沐浴，或睡卧于铁漆之处，或衣被单薄，感冒寒气，是以寒凝肌表，痘毒不能宣
发，手足麻木，不知痛痒，或肢体冷痛，不能举动，更有独于受冷麻木冷痛之所，不出
痘子，惟在委曲避风之处，或头面发际之上，痘如隐疹者是也。宜内用川芎桂枝羌独
以逐之。外用重衣浓帛以温之。
五禁疮，是最为凶险的病症。一旦这种痘疹出现，其他痘疹就无法顺利透发并化脓成浆了。具体分为五种禁忌：一曰胃禁，二曰火禁，三曰水禁，四曰风禁，五曰寒禁。
所谓“胃禁”，是因为毒火炽盛灼热，导致痘毒不能向外透发，从而引起脾胃溃烂。表现为从口唇周围向外发出的几颗相连的痘疹，在其他痘疹尚未化浆时，这几颗痘疹已经先变黄成熟。这是热毒内攻，胃部（脾胃）已经腐烂，导致其他痘疹无法成浆。因此，凡是口唇间一见此类痘疹，若伴有烦躁面红、气粗、高热且口臭异常等症状，即为该证的征象。此症难以治愈。
所谓“火禁”，是指在痘疹初发之际，身体出现寒热症状，此时靠近火源取暖过度，致使皮肤干燥；加之患者气虚，无力驱除邪毒，导致毒邪停滞在皮肤内部，无法发泄出来。仔细观察皮肤中可见红色斑点，无头无脚，仅在四肢或头面部宽阔之处出现一两点。这样，其他痘疹都会因这几点痘疹而引发祸患，那些隐约不起、最终不能畅快透发的痘疹就是这种情况。适宜外用杨枝、荆芥煎汤沐浴，内服升麻和解散为主进行治疗，则其他痘疹自然可以起发透疹。
所谓“水禁”，是指痘疹初热之时，毒气正盛，误食生冷食物，导致毒邪潜伏在皮肤之间。隐约可见红点，或在两胁、手足、头面等宽阔之处，发出水泡。由于冷气在内，所以内部必然腹痛腹胀，外部必然发热恶寒。适宜用丁香、肉桂、茯苓、升麻、大腹皮等药物来驱逐邪气。
所谓“风禁”，是指在发热初期，未能避开风邪，导致肌表腠理固密，痘疹不能透出，皮肤麻木，不知痛痒，或者皮毛干燥，皮肤瘙痒想抓挠，严重时出现狂躁、谵语、烦躁胡言乱语，这是风邪与火邪相互搏结所致。治疗适宜用干葛根、羌活、蝉蜕等药物来驱逐风邪。
所谓“寒禁”，是指在发热初期，误用冷水沐浴，或睡卧在有铁漆气味（寒冷阴湿）的地方，或者衣被单薄，感冒寒气，导致寒邪凝滞于肌表，痘毒不能宣发透疹，出现手足麻木、不知痛痒，或者肢体冷痛、不能活动。更有甚者，只在受冷后麻木冷痛的部位不出痘子，而在弯曲避风之处，或头发生长发际之上，痘疹如同隐疹一样隐约可见。适宜内服川芎、桂枝、羌活、独活等药物来驱逐寒邪，外用厚衣重被来温煦身体。
Wu Jin Chuang (Five Prohibited Sores) is the most malignant condition. Once this type of pox appears, other pox cannot be properly excreted and transform into pus. It is categorized into five prohibitions: one is Wei Jin (Stomach Prohibition), two is Huo Jin (Fire Prohibition), three is Shui Jin (Water Prohibition), four is Feng Jin (Wind Prohibition), and five is Han Jin (Cold Prohibition).
Wei Jin (Stomach Prohibition) occurs when toxic fire is scorching hot, preventing the eruption of pox on the exterior, thereby causing ulceration of the Pi Wei (Spleen and Stomach). The manifestation involves a few connected pox erupting outward from between the lips and mouth. While other pox have not yet formed pus, these specific pox have already turned yellow and matured. This indicates that heat-toxin has attacked internally, causing rotting of the Wei Qi (Stomach Qi)/Pi Wei, preventing other pox from forming pus. Therefore, whenever such pox appear around the lips and mouth, accompanied by symptoms such as irritability, redness of the face, coarse breathing, high fever, and abnormal foul breath, it signifies this syndrome. This condition is incurable.
Huo Jin (Fire Prohibition) occurs during the initial eruption phase when the body exhibits chills and fever. Excessive warming near a fire source causes the skin to become dry. Additionally, due to Qi deficiency, the body lacks the strength to expel pathogens, causing toxins to stagnate within the skin without being excreted. Careful observation reveals red spots in the skin with no head or foot, appearing only as one or two spots on the limbs or broad areas of the head and face. Consequently, all other pox will suffer complications arising from these spots; the pox that remain faint, fail to rise, and do not erupt smoothly are indicative of this condition. Treatment should involve external bathing with a decoction of Yang Zhi (Poplar Twig) and Jing Jie (Schizonepeta), and internal administration of Sheng Ma He Jie San (Cimicifuga Harmonizing Powder) as the primary formula, allowing other pox to naturally rise and erupt.
Shui Jin (Water Prohibition) occurs when, at the onset of initial heat, the toxic qi is vigorous, but cold and raw foods are mistakenly consumed. This causes toxins to lie latent between the skin layers. Faint red spots may be seen, or blisters may erupt in broad areas such as the lateral hypochondrium, hands, feet, and head/face. Due to cold qi accumulating internally, there must be abdominal pain and distension internally, and fever with aversion to wind externally. Treatment should utilize drugs such as Ding Xiang (Clove), Rou Gui (Cinnamon Bark), Fu Ling (Poria), Sheng Ma (Cimicifuga), and Da Fu Pi (Areca Peel) to expel the pathogenic factors.
Feng Jin (Wind Prohibition) occurs when, at the beginning of fever, exposure to wind is neglected. This causes the muscle layer and interstices (Li Ji) to become tight and closed, preventing pox eruption. The skin becomes numb, lacking sensation of pain or itchiness, or the hair and skin become dry with an urge to scratch. In severe cases, mania, delirium, restlessness, and incoherent speech occur. This results from the struggle between Wind and Fire. Treatment should employ drugs such as Gan Ge Gen (Kudzu Root), Qiang Huo (Notopterygium), and Chan Tui (Cicada Slough) to expel Wind.
Han Jin (Cold Prohibition) occurs when, at the beginning of fever, cold water bathing is mistakenly used, or sleeping occurs in places associated with iron/lacquer (cold/damp environments), or clothing and bedding are too thin, leading to contraction of Cold qi. This causes Cold to coagulate in the muscle layer, preventing the dissemination and eruption of Pox Toxin. Symptoms include numbness of hands and feet, lack of pain/itch sensation, or cold pain in the limbs making movement difficult. Furthermore, pox may fail to erupt specifically in the areas affected by cold-induced numbness and pain, while appearing like hidden rashes in sheltered, wind-avoiding areas or along the hairline of the head. Internal treatment should use Chuan Xiong (Ligusticum), Gui Zhi (Cinnamon Twig), Qiang Huo (Notopterygium), and Du Huo (Angelica Pubescens) to expel Cold. External treatment should involve heavy clothing and thick blankets to warm the body.