〔《活》〕病患身冷，脉沉细疾，烦躁而不饮水者，阴盛隔阳也，宜服霹雳散，须臾躁止得睡，汗出即瘥。
火焰散、丹砂丸并主之。（丹砂丸方见《活人书》。）
霹雳散 治阴盛隔阳，烦躁不饮水。
附子（一枚，炮熟取出，用冷灰挹，细研，入真腊茶二钱和匀。）
上为细末，分作二服，水二盏，煎至六分，临熟入蜜半匙，放温或冷服之，须臾躁止得睡，汗出即瘥。
〔海〕已寒丸 此丸不僭上，阳生于下，治阴症服四逆辈，胸中发躁而渴者，或数日大便秘，小便涩，亦服此丸。
上不躁，大小便自利。
肉桂 茯苓（各五钱） 良姜 乌头（炮。各七钱） 附子（炮） 干姜（炮） 芍药 茴香（炒。各一两）
上等分，为细末，糊为丸，如桐子大。温酒下，空心服五七十丸，八九十丸亦得，酒醋为糊俱可。
〔《本》〕破阴丹治阴中伏阳烦躁，六脉沉伏。（方论见阴毒。）
顷年乡人李信道得疾，六脉沉伏不见，深按至骨则若有力，头疼身温，烦躁，指末皆冷，胸中满，恶心。
更两医矣，皆不识，止用调气药。予诊之曰∶此阴中伏阳也，仲景法中无此证，世人患此者多。若用热药以助
之，则为阴所隔绝，不能导引真阳，反生客热；用冷药则所伏真火愈见消烁，非其治也。须用破散阴气，导达
真火之药，使火升水降，然后得汗而解矣。予授此药二百粒，作一服，冷盐汤下，不时烦躁狂热，手足躁扰，
其家大惊。予曰∶俗所谓换阳也。须臾稍定，略睡，身已中汗，自昏达旦方止，身凉而病除矣。
【《活人书》】患者身体发冷，脉象沉细且快速，烦躁但不想喝水的，是阴寒过盛格拒阳气所致，适宜服用霹雳散。不久后躁动停止并能入睡，出汗后病情即愈。
火焰散、丹砂丸也主治此证。（丹砂丸的方剂见载于《活人书》。）
附子（一枚，炮制成熟后取出，用冷灰覆盖吸去水分，细细研磨，加入真腊茶二钱混合均匀。）
以上药材研成细末，分作两次服用。用水两盏，煎煮至六分，临熟时加入半匙蜂蜜，放温或冷服。不久后躁动停止并能入睡，出汗后病情即愈。
【海藏】已寒丸：此丸药不会引起上部火热上冲，阳气生于下焦，治疗阴证服用四逆汤类方剂后，出现胸中烦躁且口渴者，或者数日大便秘结、小便涩滞不畅者，也服用此丸。
服药后上部不再烦躁，大小便自然通利。
肉桂、茯苓（各五钱）、良姜、乌头（炮制。各七钱）、附子（炮制）、干姜（炮制）、芍药、茴香（炒制。各一两）。
以上药材等分，研成细末，用面糊制成丸药，如梧桐子大小。用温酒送服，空腹服用五七十丸，服用八九十丸也可以，用酒醋调糊制作均可。
【《本草衍义》】破阴丹：治疗阴寒之中潜伏阳气导致的烦躁，六脉沉伏。（方论见“阴毒”条。）
近年同乡人李信道患病，六脉沉伏不见，深按至骨则感觉有力，头痛身温，烦躁，手指末端皆冷，胸中胀满，恶心。
经过两位医生诊治，都不认识此病，仅使用调理气机的药物。我诊察后说：这是阴中伏阳证，张仲景的法度中没有记载此证，世人患此病者很多。如果使用热药来助长它，就会被阴寒所格拒，不能引导真阳，反而产生客热；如果使用冷药，则被伏藏的真火会更加消减耗损，这不是正确的治法。必须使用破除消散阴气、引导通达真火的药物，使火升水降，然后才能通过出汗而解病。我给予此药二百粒，作为一次服用量，用冷盐汤送下。不时出现烦躁狂热，手足躁动扰攘，家属非常惊恐。我说：这就是世俗所说的“换阳”。不久后稍安定，略睡片刻，身上已经出汗，从黄昏到早晨才停止，身体变凉而疾病消除。
[From *Huoren Shu* (Book of Living Persons)] When a patient presents with cold limbs, a deep, fine, and rapid pulse, irritability without desire to drink, this is due to excess Yin repelling Yang. It is appropriate to administer Pili San (Thunderbolt Powder). After a short while, the restlessness ceases, sleep ensues, and recovery follows upon sweating.
Huoyan San (Flame Powder) and Dansha Wan (Cinnabar Pill) also treat this condition. (The formula for Dansha Wan is found in *Huoren Shu*.)
Pili San: Treats excess Yin repelling Yang, causing irritability and aversion to drinking.
Fuzi (Aconiti Lateralis Radix Praeparata, one piece, processed until cooked, removed, covered with cold ash to absorb moisture, finely ground), combined with Zhen Cha (Camelliae Sinensis Folium, two qian). Mix evenly.
Grind the above into a fine powder. Divide into two doses. Decoct with two cups of water until reduced to six-tenths. Just before completion, add half a spoonful of honey. Take warm or cold. After a short while, restlessness ceases, sleep ensues, and recovery follows upon sweating.
[Hai Zang] Yihan Wan: This pill does not cause hyperactivity of fire in the upper jiao; Yang Qi arises from the lower jiao. It treats Yin syndromes where, after administering Sini Tang-type formulas, the patient experiences chest irritability and thirst, or constipation and dysuria persisting for several days.
After administration, there is no irritability in the upper body, and bowel movements and urination become normal.
Rougui (Cinnamomi Cortex), Fuling (Poria), Liangjiang (Alpiniae Officinarum Rhizoma), Wutou (Aconiti Radix, processed), each seven qian; Fuzi (Aconiti Lateralis Radix Praeparata), Ganjiang (Zingiberis Rhizoma, processed), Shaoyao (Paeoniae Radix Alba), Huixiang (Foeniculi Fructus, stir-fried), each one liang.
Divide equally, grind into a fine powder, and bind with paste to form pills the size of paulownia seeds. Take with warm wine on an empty stomach, 50-70 pills, or up to 80-90 pills are acceptable. Paste made with wine or vinegar is also suitable.
[From *Bencao Yan Yi* (Supplement to Materia Medica)] Po Yin Dan: Treats irritability caused by latent Yang within Yin, with six pulses being deep and hidden. (The discussion of the formula is found under "Yin Du" [Yin Toxin].)
In recent years, my fellow townsman Li Xindao fell ill. His six pulses were deep and hidden, but felt forceful when pressed deeply to the bone. He had headache, warm body, irritability, cold fingertips, chest fullness, and nausea.
Two other physicians treated him but failed to recognize the condition, prescribing only qi-regulating herbs. I diagnosed it as "latent Yang within Yin." This syndrome is not recorded in Zhang Zhongjing's methods, yet many people suffer from it today. If hot herbs are used to assist it, they will be repelled by the Yin, failing to guide the True Yang, and instead generating exogenous heat. If cold herbs are used, the hidden True Fire will be further depleted. This is not the correct treatment. One must use herbs that break up and dissipate Yin Qi and guide and unblock the True Fire, allowing Fire to ascend and Water to descend, so that resolution occurs through sweating. I prescribed two hundred pills of this medicine as a single dose, taken with cold salted water. The patient experienced intermittent irritability, feverish sensation, and restless tossing of hands and feet, alarming his family. I said, "This is what laypeople call 'changing Yang'." After a short while, he stabilized slightly, slept briefly, and then sweated profusely. This continued from dusk until dawn, after which his body cooled and the illness was cured.