主治肾精不足，虚火炎上，腰膝痿软，骨热酸疼，足跟痛，小便淋秘或不禁，遗精梦泄，
水
熟地黄（八两） 山茱萸（四两） 白茯苓 干山药（各四两） 牡丹皮（三两） 泽
泻（二两）
上为末，炼蜜丸如桐子大，空心淡盐汤下。
柯韵伯曰∶肾虚不能藏精，坎宫之火无所附而妄行，下无以奉春生之令，上绝肺金之化
源。地黄禀甘寒之性，制熟味更浓，是精不足者补之以味也，用以大滋肾阴，填精补髓，壮
水之
静之
肾之
故
固封
借以
奉生
主治心血不足，神志不宁，津液枯竭，健忘，怔忡，大便不利，口舌生疮等症。
人参 酸枣仁 当归 生地黄 柏子仁 麦冬 天冬 远志 五味子 白茯苓 丹
参玄参 桔梗
上为末，炼蜜丸如椒目大，白汤下。
柯韵伯曰∶心者主火，而所以二者神也。神衰则火为患，故补心者必清其火而神始安。
补心
耳
之
以生心血，玄参之咸以补心血，
楫，远志为向导，和诸药入心而
生疮、大便不利之虞哉？
治心神昏乱，惊悸，怔忡，寤寐不安。
朱砂（另研） 黄连（各半两） 生地黄（三钱） 当归 甘草（各二钱）
上为细末，酒泡蒸饼丸如麻子大，朱砂为衣，每服三十丸，卧时津液下。
叶仲坚曰∶经曰∶神气舍心，精神毕具。又曰∶心者，生之本，神之舍也。且心为君主
之官
痴妄
以养
之；
安；
【六味地黄丸】
主治：肾精不足，虚火上炎，腰膝痿软无力，骨骼发热酸痛，足跟疼痛，小便淋漓涩痛或闭塞不通、或失禁，遗精及梦中泄精。
药物组成：熟地黄（八两）、山茱萸（四两）、白茯苓、干山药（各四两）、牡丹皮（三两）、泽泻（二两）。
制法与服法：将上述药材研为细末，用炼蜜制成如梧桐子大小的丸剂，空腹时用淡盐汤送服。
柯韵伯说：肾虚则不能固藏精气，肾中命门之火失去依附而妄行，向下无法顺应春生之气，向上断绝了肺金化源。地黄禀受甘寒之性，经过炮制后味道更加浓厚，这正是“精不足者，补之以味”的道理，用来大滋补肾阴，填补精髓，壮水之主以制阳光，使肾气宁静稳固，从而能够奉养生机。
【天王补心丹】
主治：心血不足，神志不宁，津液枯竭，健忘，心悸怔忡，大便不利，口舌生疮等症状。
药物组成：人参、酸枣仁、当归、生地黄、柏子仁、麦冬、天冬、远志、五味子、白茯苓、丹参、玄参、桔梗。
制法与服法：将上述药材研为细末，用炼蜜制成如胡椒籽大小的丸剂，用白开水送服。
柯韵伯说：心主火，而主宰精神的是神。神气衰弱则火邪为患，所以补益心脏必须清降其火，神志才能安宁。……（原文此处有缺漏）用以生养心血，玄参的咸味用以补益心血，……作为引导，调和诸药入心，难道还会有口舌生疮、大便不利的担忧吗？
【朱砂安神丸】
主治：心神昏乱，惊悸，怔忡，睡眠不安。
药物组成：朱砂（单独研磨）、黄连（各半两）、生地黄（三钱）、当归、甘草（各二钱）。
制法与服法：将药材研为极细粉末，用酒浸泡蒸饼制成如麻子大小的丸剂，以朱砂为衣，每次服用三十丸，临卧时以津液送服。
叶仲坚说：《内经》说：神气寄居在心，精神完备。又说：心是生命的根本，神的居所。且心是君主之官，……（原文此处有缺漏）以滋养……；……安宁；
[ Liuwei Dihuang Wan (Six-Ingredient Rehmannia Pill) ]
Indications: Insufficiency of Kidney Essence, deflection of deficient fire upward, flaccidity and weakness of the waist and knees, heat sensation in bones with soreness and pain, pain in the heels, dysuria or retention of urine, enuresis or incontinence, spermatorrhea, and nocturnal emission.
Ingredients: Shu Di Huang (Prepared Radix Rehmanniae, 8 liang), Shan Zhu Yu (Fructus Corni, 4 liang), Bai Fu Ling (Poria, 4 liang), Gan Shan Yao (Rhizoma Dioscoreae, 4 liang), Mu Dan Pi (Cortex Moutan, 3 liang), Ze Xie (Rhizoma Alismatis, 2 liang).
Preparation and Administration: Grind the above ingredients into fine powder, mix with refined honey to form pills the size of paulownia seeds. Take on an empty stomach with light salt water.
Ke Yunbo stated: When the Kidney is deficient, it cannot store Essence. The Fire of the Kan Palace (Kidney) has no attachment and wanders recklessly; downward it fails to support the command of Spring generation, and upward it severs the source of transformation for Metal (Lung). Di Huang possesses a sweet and cold nature; after being prepared, its flavor becomes richer. This embodies the principle that "for insufficiency of essence, tonify with flavor." It is used to greatly nourish Kidney Yin, fill and supplement marrow, strengthen Water to control Fire, calm the Kidney Qi, and thereby support vital functions.
[ Tianwang Buxin Dan (Heavenly Emperor Heart-Nourishing Pill) ]
Indications: Insufficiency of Heart Blood, restlessness of the Spirit, depletion of body fluids, forgetfulness, palpitations, constipation, and sores on the mouth and tongue.
Ingredients: Ren Shen (Radix Ginseng), Suan Zao Ren (Semen Ziziphi Spinosae), Dang Gui (Radix Angelicae Sinensis), Sheng Di Huang (Radix Rehmanniae Recens), Bai Zi Ren (Semen Platycladi), Mai Dong (Radix Ophiopogonis), Tian Dong (Rhizoma Asparagi), Yuan Zhi (Radix Polygalae), Wu Wei Zi (Fructus Schisandrae), Bai Fu Ling (Poria), Dan Shen (Radix Salviae Miltiorrhizae), Xuan Shen (Radix Scrophulariae), Jie Geng (Radix Platycodi).
Preparation and Administration: Grind the above ingredients into fine powder, mix with refined honey to form pills the size of pepper seeds. Take with plain boiled water.
Ke Yunbo stated: The Heart governs Fire, while the Spirit governs consciousness. When the Spirit declines, Fire becomes pathological. Therefore, to tonify the Heart, one must clear its Fire so that the Spirit may become tranquil. ... [Text missing] ... to generate Heart Blood, and the salty nature of Xuan Shen to supplement Heart Blood, ... acting as a guide, harmonizing the various herbs to enter the Heart. Would there still be concerns regarding sores on the mouth and tongue or constipation?
[ Zhusha Anshen Wan (Cinnabar Calming-the-Mind Pill) ]
Indications: Confusion of the Heart Spirit, fright and palpitations, severe palpitations, and insomnia.
Ingredients: Zhu Sha (Cinnabar, ground separately), Huang Lian (Rhizoma Coptidis, each half liang), Sheng Di Huang (Radix Rehmanniae Recens, 3 qian), Dang Gui (Radix Angelicae Sinensis), Gan Cao (Radix Glycyrrhizae, each 2 qian).
Preparation and Administration: Grind the ingredients into an extremely fine powder. Soak in wine, steam with steamed bread dough, and form pills the size of hemp seeds. Coat with Cinnabar. Take 30 pills per dose, swallowing with saliva before sleep.
Ye Zhongjian stated: The Classics say: "The Spirit resides in the Heart, and the Spirit and Mind are complete." It also says: "The Heart is the root of life and the residence of the Spirit." Moreover, the Heart is the Official of the Sovereign Lord, ... [Text missing] ... to nourish ... ; ... tranquility;