疟病者。由夏伤于暑。客于肤里。致肌腠虚隙。至秋又寒湿乘之。动前暑热，邪正相搏。阴阳交争。会遇有
时。更相胜负。阳胜则发热。阴胜则发寒。阴阳互胜。则发寒热。热则烦躁闷乱。寒则噤栗战悚。阴阳会遇。交
争已过。邪正相离。则寒热俱歇。若邪动气至。又复发作。故疟休作有时也。其发晏者。邪正会过迟也。其发朝
者。邪正会遇早也。其间日发者，邪气入深而行瘥迟。不能日作。故间日乃发也。今叙方于后。
桃仁汤
治小儿发疟不止。
桃仁（汤浸去皮尖并双仁者麸炒黄一两） 鳖甲（一两酥炙黄去裙） 桂心（半两） 黄芩（半两） 川升
麻（半两） 赤茯苓（去黑皮半两）
上为粗散。每服一钱。水一小盏。煎至五分。去滓温服。无时。
灵豆膏
治如前。大蒜一枚。去皮研。巴豆三升。去皮心。同湿纸裹煨熟。一处研为膏。丸麻子大。每服二三五丸。
醋汤送下。吐泻即瘥。后用藿香汤补之。
藿香汤
藿香（去土） 肉豆蔻（面裹煨） 甘草（各一分）
上为细末。每服半钱，水一盏。煎至七分温服。连服三服。无时。
朱衣使者 治如前。
砒（半两细研） 绿豆末（一分） 黑豆末（一分）
上同研匀细。滴水丸黍米大。辰砂为衣。间日发者。于好日夜临卧时。冷醋水送下二丸。频日发者。只于当
日夜服如上法。儿极小者与一丸。端午日合佳。
又方 治如前。以生鹿角为细末。发已前。乳汁调服一字。
又方 治如前。以鸡 中黄皮炒极燥为末。乳汁服之。男雄女雌。
又方 治如前。以蛇蜕皮一两。取每条长五寸以上者。烧灰存性。研细末。每服一钱。新水调下。未发前
服。三岁上半钱。以下者一字。
又方 治如前。以黄丹二分。蜜水和之与服。如冷者以酒和。冷服。
万金丹
治痰盛挟积。发疟久不瘥。
阿魏（一钱汤化去砂石和面作饼煨熟锉细炒干） 朱砂（一分研水飞） 砒霜（一钱用醋半盏慢火上熬醋尽）
丁香（半两） 巴豆（七个去皮膜油尽取霜） 木香（半两） 相思子（十四个）
上为细末。炼蜜和丸黍米大。未发前新水下一二粒。一岁加一粒。至十岁上止十粒。绝早服。忌热物一时辰。
知母丸
治疟疾热甚者。
知母（一两微炒） 鳖甲（一两酥炙焦去裙 ） 川大黄（一两细锉，微炒） 朱砂（一钱水飞研） 赤茯苓
（去黑皮一两） 川芒硝（半两） 川升麻（半两） 龙脑（一钱研）
上为末。拌匀细。炼蜜丸黍米大。每服五七丸。生姜汤送下。得利即愈。量大小加减。
小儿温疟 灸两乳下一指三壮。壮如小麦大。
恒山汤
治小儿疟疾。
恒山（一两锉） 小麦（三合） 淡竹叶（切一升）
上为粗末。水煎去滓。腊中儿服一蚬壳。半月者二蚬壳。盈月者半小合。以意增之。
乌梅丸
治疟疾寒甚者。
乌梅肉（一两焙干） 母丁香（半两） 桂心（半两） 当归（去须洗焙半两） 干漆（半两炒烟出尽）
上为细末。入研细麝香末半钱拌匀。炼蜜和丸黍米大。每服十丸，粥饮下。
茶清散
治诸疟疾。
人言（一两） 黑豆（一升） 河水（四升）
上同煮至水尽。炒干为末。每服一字或半钱。热多者腊茶清调下。寒多者草茶清调下。间日者于发夜临卧
服。频日者但临卧。忌热物一时辰。此方宜斟酌。
鬼见愁 治乳奶婴小患疟。无计可治。服此的验神应。
代赭石（用丁头五粒火 醋淬十次研极细） 朱砂（透明块子半钱水飞） 砒霜（皂子大）
上三味。用湿纸七重同裹。慢火内煨至纸干。取出顿地上出火
毒。次入脑麝各半字。金箔五片同研。共为细末。每一字。于发日早以麻油一滴。调药敷鼻尖上。立止。
草果子汤
治脾寒发疟。草果子三个。甘草五寸。大枣七个。并锉碎。分三服。水一盏。煎至半盏。放温服。更量大小
加减。
疟病，是由于夏季感受暑邪，邪气潜伏于肌肤腠理之间，导致肌表腠理空虚疏松。到了秋季，寒湿之邪乘虚而入，引动体内潜伏的暑热，邪气与正气相互搏结。此时阴阳之气发生交争，且这种交争有一定的时间规律，双方交替胜负。当阳气胜时则出现发热；阴气胜时则出现发冷；阴阳交替胜负，则表现为寒热往来。发热时伴有烦躁、胸闷、神志昏乱；发冷时则牙齿打颤、身体战栗。当阴阳之气交会完毕，交争停止，邪气与正气分离，寒热症状就会暂时休止。如果邪气再次发动，正气随之响应，疟疾又会复发，所以疟疾的特点是发作和休止都有定时。发作时间较晚的，是因为邪正交会的时间推迟了；发作时间较早的，是因为邪正交会的时间提前了。如果是隔日发作一次，是因为邪气深入体内，运行迟缓，不能每日发作，所以要隔一天才发作。以下叙述治疗方剂：
桃仁汤
治疗小儿疟疾发作不止。
桃仁（用汤浸泡，去皮尖及双仁部分，麸炒至黄色，一两） 鳖甲（一两，用酥炙黄，去除裙边） 桂心（半两） 黄芩（半两） 川升麻（半两） 赤茯苓（去除黑皮，半两）
以上药物研成粗散。每次服用一钱，用水一小盏，煎煮至五分，去渣后温服，不拘时候。
灵豆膏
治疗方法同上。大蒜一枚，去皮后研磨；巴豆三升，去皮去心。两者用湿纸包裹，煨熟后，一起研磨成膏状。制成如麻子大小的丸药。每次服用二至五丸，用醋汤送下。服药后出现呕吐或腹泻症状即痊愈。之后再用藿香汤进行调理补益。
藿香汤
藿香（去除泥土） 肉豆蔻（用面粉包裹煨熟） 甘草（各一分）
以上药物研成细末。每次服用半钱，用水一盏，煎煮至七分，温服。连续服用三次，不拘时候。
朱衣使者
治疗方法同上。
砒（半两，细细研磨） 绿豆末（一分） 黑豆末（一分）
以上药物共同研磨均匀细腻。滴入水制成如黍米大小的丸药。外用辰砂作为衣层。如果是隔日发作的疟疾，在好日子的夜晚临睡前，用冷醋水送服两丸。如果是每日发作的疟疾，只需在当天的夜晚按上述方法服用。婴儿极小的只给一丸。最好在端午节配制。
又一方
治疗方法同上。将生鹿角研成细末。在疟疾发作前，用乳汁调服“一字”量。
又一方
治疗方法同上。取鸡肫中的黄皮，炒至极干燥后研成细末，用乳汁送服。雄鸡用公鸡，雌鸡用母鸡。
又一方
治疗方法同上。取蛇蜕皮一两，选取每条长度在五寸以上的，烧成灰但保留药性（存性），研成细末。每次服用一钱，用新汲水调服。在疟疾发作前服用。三岁儿童服用半钱，三岁以下的服用“一字”量。
又一方
治疗方法同上。取黄丹二分，用蜂蜜调和后服用。如果患儿体质偏寒，用酒调和，冷服。
万金丹
治疗痰湿盛且夹杂积滞，导致疟疾久治不愈。
阿魏（一钱，用汤化开，去除砂石，和面做成饼，煨熟后切碎炒干） 朱砂（一分，用水飞法研磨） 砒霜（一钱，用半盏醋在慢火上熬制，直到醋完全蒸发） 丁香（半两） 巴豆（七个，去皮膜，榨尽油后取霜） 木香（半两） 相思子（十四个）
以上药物研成细末，用炼蜜调和，制成如黍米大小的丸药。在疟疾发作前，用新水送服一至二粒。一岁的患儿加一粒，直到十岁以上为止，最多十粒。要在绝早时分服用。服药后一个时辰内忌食热物。
知母丸
治疗疟疾热势严重的。
知母（一两，微炒） 鳖甲（一两，用酥炙焦，去除裙边） 川大黄（一两，细锉，微炒） 朱砂（一钱，水飞研磨） 赤茯苓（去除黑皮，一两） 川芒硝（半两） 川升麻（半两） 龙脑（一钱，研磨）
以上药物研成粉末，拌匀。用炼蜜调和，制成如黍米大小的丸药。每次服用五至七丸，用生姜汤送下。服药后大便通畅即痊愈。根据患儿年龄大小增减剂量。
恒山汤
治疗小儿疟疾。
恒山（一两，锉碎） 小麦（三合） 淡竹叶（切段，一升）
以上药物研成粗末。用水煎煮，去渣。腊月出生（冬季）的婴儿服用一蚬壳的量；半月大的婴儿服用两蚬壳的量；满月以上的婴儿服用半小合的量。根据情况酌情增加。
乌梅丸
治疗疟疾寒势严重的。
乌梅肉（一两，焙干） 母丁香（半两） 桂心（半两） 当归（去除须根，洗净焙干，半两） 干漆（半两，炒至烟尽）
以上药物研成细末，加入研磨细的麝香末半钱，拌匀。用炼蜜调和，制成如黍米大小的丸药。每次服用十丸，用粥饮送下。
茶清散
治疗各种疟疾。
人言（即砒霜，一两） 黑豆（一升） 河水（四升）
以上药物共同煮至水干，炒干后研成细末。每次服用“一字”或半钱。热象多者，用腊茶清调服；寒象多者，用草茶清调服。隔日发作的，在发作那天的夜晚临睡前服用；每日发作的，仅在临睡前服用。忌食热物一个时辰。此方宜斟酌使用。
鬼见愁
治疗乳儿婴幼儿患疟疾，无计可施时，服用此方确实有效且神奇。
代赭石（用五个铁钉头，火红后淬入醋中，重复十次，研磨至极细） 朱砂（透明块状，半钱，水飞法处理） 砒霜（皂子大小）
以上三味药，用七层湿纸包裹，放入慢火中煨至纸干。取出后顿在地上以消除火毒。然后加入冰片、麝香各“一字”量，金箔五片，共同研磨成细末。每次取“一字”量，在发作日的早晨，用一滴麻油调药敷在鼻尖上，立即止住。
草果子汤
治疗脾寒引起的疟疾。草果子三个，甘草五寸，大枣七个。全部锉碎。分三次服用。用水一盏，煎煮至半盏，放温后服用。再根据患儿大小增减剂量。
Malaria disease is caused by summerheat injury in summer, where pathogenic factors lodge in the skin and muscle layers, causing the interstices of the muscles and pores to become deficient and loose. In autumn, cold-dampness takes advantage of this deficiency to invade, stirring up the latent summerheat, leading to a struggle between pathogenic factors and healthy qi. The yin and yang energies contend with each other, meeting at specific times and alternating in victory and defeat. When yang prevails, fever occurs; when yin prevails, chills occur; when yin and yang alternate in prevailing, alternating chills and fever manifest. Fever is accompanied by restlessness, chest tightness, and mental confusion; chills are accompanied by clenched teeth, trembling, and shivering. When the encounter between yin and yang concludes and the contention ceases, the pathogenic factors separate from the healthy qi, and both chills and fever subside temporarily. If the pathogenic factors move again and the healthy qi responds, malaria will recur; thus, malaria is characterized by regular intervals of attack and remission. Attacks occurring later indicate a delayed encounter between pathogenic factors and healthy qi; attacks occurring earlier indicate an early encounter. Intermittent attacks (occurring every other day) occur because the pathogenic factors have penetrated deeply and move slowly, unable to attack daily, hence appearing only every other day. The following prescriptions are described:
Taoren Tang (Peach Kernel Decoction)
Treats persistent malaria in children.
Taoren (Peach Kernel, *Prunus persica* seed), soaked in water, peeled, removed of tips and double kernels, stir-fried with bran until yellow, 1 liang; Biejia (Soft-shelled Turtle Shell, *Trionyx sinensis* carapace), 1 liang, stir-fried with butter until yellow, remove skirt edges; Guixin (Cinnamon Twig Heart, *Cinnamomum cassia* inner bark), 0.5 liang; Huangqin (Scutellaria Root, *Scutellaria baicalensis* root), 0.5 liang; Chuan Shengma (Cimicifuga Rhizome, *Cimicifuga foetida* rhizome), 0.5 liang; Chi Fuling (Red Poria, *Poria cocos* sclerotium with red skin), black skin removed, 0.5 liang.
Grind the above into coarse powder. Take 1 qian per dose, decoct with one small cup of water until reduced to 0.5 cup, strain, and take warm. Administer at any time.
Lingdou Gao (Spirit Bean Paste)
Treatment as above. One clove of garlic, peeled and ground; 3 sheng of Badou (Croton Seed, *Croton tiglium* seed), peeled and cored. Wrap together in wet paper and bake/roast until cooked. Grind together into a paste. Form pills the size of hemp seeds. Take 2-5 pills per dose, delivered with vinegar water. Recovery follows vomiting or diarrhea. Subsequently, use Huoxiang Tang (Agastache Decoction) for supplementation.
Huoxiang Tang (Agastache Decoction)
Huoxiang (Patchouli Herb, *Pogostemon cablin* herb), free of soil; Roudoukou (Nutmeg Seed, *Myristica fragrans* seed), wrapped in flour and baked; Gancao (Licorice Root, *Glycyrrhiza uralensis* root), each 1 fen.
Grind the above into fine powder. Take 0.5 qian per dose, decoct with one cup of water until reduced to 0.7 cup, take warm. Take three doses consecutively. Administer at any time.
Zhu Yi Shi Zhe (The Red-Cloaked Messenger)
Treatment as above. Pi (Arsenic Trioxide, *As2O3*), 0.5 liang, finely ground; Ludou Mo (Mung Bean Powder, *Vigna radiata* seed powder), 1 fen; Heidou Mo (Black Soybean Powder, *Glycine max* seed powder), 1 fen.
Grind the above uniformly and finely. Add drops of water to form pills the size of millet grains. Coat with Zhusha (Cinnabar, *HgS*). For intermittent malaria, take two pills on a clear night before sleep, delivered with cold vinegar water. For frequent daily attacks, take once on the day of attack before sleep as above. For very young infants, give one pill. It is best to prepare this on the Dragon Boat Festival (Duanwu).
Another Prescription
Treatment as above. Grind fresh Deer Antler (*Cervus nippon* cornu) into fine powder. Before the onset of malaria, take one "yi zi" amount mixed with milk.
Another Prescription
Treatment as above. Roast the yellow membrane inside the chicken gizzard (*Proventriculus galli domesticus*) until extremely dry, grind into powder, and deliver with milk. Use male roosters for boys and female hens for girls.
Another Prescription
Treatment as above. Take 1 liang of Snake Slough (*Bungarus multicinctus* integument), selecting pieces longer than five cun. Burn to ash but retain medicinal properties, grind into fine powder. Take 1 qian per dose, delivered with newly drawn water. Take before the onset of malaria. For three-year-olds, take half a qian; for younger children, take one "yi zi" amount.
Another Prescription
Treatment as above. Take 2 fen of Huangdan (Minium, *Pb3O4*), mix with honey, and take. If the patient has cold constitution, mix with wine and take cold.
Wanjin Dan (Ten-Thousand-Gold Pill)
Treats malaria prolonged due to excessive phlegm and accumulation.
Awei (Asafoetida Resin, *Ferula assa-foetida* gum resin), 1 qian, dissolved in water, filtered to remove sand, mixed with flour to make a cake, baked, chopped, and stir-fried dry; Zhusha (Cinnabar, *HgS*), 1 fen, washed with water (water-flotation method); Pishuang (Arsenic Trioxide, *As2O3*), 1 qian, boiled with half a cup of vinegar over slow fire until vinegar is exhausted; Dingxiang (Clove, *Syzygium aromaticum* flower bud), 0.5 liang; Badou (Croton Seed, *Croton tiglium* seed), seven kernels, peeled, membranes removed, oil pressed out to take the dregs/paste; Muxiang (Aucklandia Root, *Aucklandia lappa* root), 0.5 liang; Xiangsi Zi (Abrus Precatorius Seed, *Abrus precatorius* seed), fourteen kernels.
Grind the above into fine powder. Mix with refined honey to form pills the size of millet grains. Take 1-2 pills before the onset of malaria, delivered with new water. Add one pill per year of age, up to ten years old, maximum ten pills. Take at dawn. Avoid hot food for one shichen (two hours).
Zhimu Wan (Anemarrhena Pill)
Treats severe heat in malaria.
Zhimu (Anemarrhena Rhizome, *Anemarrhena asphodeloides* rhizome), 1 liang, slightly stir-fried; Biejia (Soft-shelled Turtle Shell, *Trionyx sinensis* carapace), 1 liang, stir-fried with butter until scorched, remove skirt edges; Chuan Dahuang (Rhubarb Root, *Rheum palmatum* root), 1 liang, finely cut, slightly stir-fried; Zhusha (Cinnabar, *HgS*), 1 qian, water-flotation ground; Chi Fuling (Red Poria, *Poria cocos* sclerotium), black skin removed, 1 liang; Chuan Mangxiao (Mirabilite, *Na2SO4·10H2O*), 0.5 liang; Chuan Shengma (Cimicifuga Rhizome, *Cimicifuga foetida* rhizome), 0.5 liang; Longnao (Borneol, *C10H18O*), 1 qian, ground.
Grind the above into powder, mix well. Mix with refined honey to form pills the size of millet grains. Take 5-7 pills per dose, delivered with ginger water. Recovery follows bowel movement. Adjust dosage according to age and size.
Pediatric Warm Malaria
Moxibustion on three points located one finger-width below both nipples. Three moxa cones per point, cone size like a wheat grain.
Hengshan Tang (Dichroa Root Decoction)
Treats pediatric malaria.
Hengshan (Dichroa Root, *Dichroa febrifuga* root), 1 liang, cut; Xiaomai (Wheat Grain, *Triticum aestivum* grain), 3 he; Danzhuye (Bamboo Leaf, *Phyllostachys nigra* leaf), cut, 1 sheng.
Grind the above into coarse powder. Decoct in water, strain. Infants born in the twelfth lunar month take one clam shell measure; those half a month old take two clam shells; those full month old take half a small cup. Increase according to need.
Wumei Wan (Dark Plum Pill)
Treats severe chills in malaria.
Wumei Rou (Dark Plum Flesh, *Prunus mume* fruit pulp), 1 liang, baked dry; Mu Dingxiang (Mother Clove, *Syzygium aromaticum* flower bud), 0.5 liang; Guixin (Cinnamon Twig Heart, *Cinnamomum cassia* inner bark), 0.5 liang; Danggui (Angelica Sinensis Root, *Angelica sinensis* root), remove roots, wash, bake, 0.5 liang; Ganqi (Dry Lacquer, *Rhus verniciflua* resin), 0.5 liang, stir-fry until smoke ceases.
Grind the above into fine powder. Add 0.5 qian of finely ground Shexiang (Musk, *Moschus moschiferus* secretion), mix well. Mix with refined honey to form pills the size of millet grains. Take ten pills per dose, delivered with porridge drink.
Cha Qing San (Tea Liquor Powder)
Treats various types of malaria.
Renyan (Arsenic Trioxide, *As2O3*), 1 liang; Heidou (Black Soybean, *Glycine max* seed), 1 sheng; Heshui (River Water), 4 sheng.
Boil the above together until water is gone, stir-fry dry, and grind into powder. Take one "yi zi" or half a qian per dose. For cases with more heat, mix with Lacha Qing (Winter Tea Liquor, *Camellia sinensis* infusion); for cases with more cold, mix with Caocha Qing (Wild Tea Liquor, *Camellia sinensis* infusion). For intermittent malaria, take on the night of the attack before sleep; for frequent daily attacks, take only before sleep. Avoid hot food for one shichen. This prescription should be used with discretion.
Gui Jian Chou (Ghost's Sorrow)
Treats malaria in nursing infants where no other treatment works. This formula is effective and miraculous.
Daizheshi (Hematite, *Fe2O3*), use five iron nail heads, heat red, quench in vinegar ten times, grind extremely fine; Zhusha (Cinnabar, *HgS*), transparent lump, 0.5 qian, water-flotation processed; Pishuang (Arsenic Trioxide, *As2O3*), size of a soap bean.
Wrap the above three ingredients in seven layers of wet paper. Bake slowly over low fire until paper is dry. Remove and place on the ground to eliminate fire toxicity. Then add Naobing (Borneol, *C10H18O*) and Shexiang (Musk, *Moschus moschiferus* secretion), each one "yi zi" amount, and five sheets of Jinbo (Gold Foil, *Au*), grind together into fine powder. Take one "yi zi" amount. On the morning of the attack, mix with one drop of Mayou (Sesame Oil, *Sesamum indicum* seed oil) and apply to the tip of the nose. Cessation is immediate.
Caoguozzi Tang (Tsaoko Cardamom Decoction)
Treats spleen-cold induced malaria. Three Caoguozis (Tsaoko Cardamom Fruit, *Alpinia oxyphylla* fruit), five cun of Gancao (Licorice Root, *Glycyrrhiza uralensis* root), seven Dazao (Jujube Fruit, *Ziziphus jujuba* fruit). All cut into pieces. Divide into three doses. Decoct with one cup of water until reduced to half a cup. Take warm. Adjust dosage according to age and size.