降阴火。补肾水。
大补阴丸绝妙方。向盲问道诋他凉。地黄知柏滋兼降。龟板沉潜制亢阳。（黄柏知母各
四两。俱用盐酒炒。熟地黄酒润。龟板酥炙黄。各六两为末。用猪脊髓蒸熟。和炼蜜为丸桐
子大。每服五六十丸。空心。姜汤盐汤黄酒随意送下。）
陈修园曰。知柏寒能除热。苦能降火。苦者必燥。故用猪脊髓以润之。熟地以滋之。此
治阴虚发热之恒法也。然除热只用凉药。犹非探源之治方中以龟板为主。是介以潜阳法。丹
溪此方。较六味地黄丸之力更优。李士材薛立斋张景岳辈。以苦寒而置之。犹未参透造化阴
阳之妙也。
治痿神方。
即前方加味。（黄柏知母熟地各三两。龟板四两。白芍当归牛膝各二两。虎胫骨琐阳陈
皮各一两五钱。干姜五钱。酒煮羯羊肉为丸。如桐子大。每服五六十丸。姜汤盐汤或黄酒送
下。）
加味虎潜丸（治诸虚不足。腰腿疼痛。行步无力。壮元气。滋肾水。）即前方再加味。（照
虎潜丸方再加人参黄 杜仲菟丝子茯苓破故纸山药枸杞。去羊肉干姜。以猪脊髓蒸熟。同炼
蜜为丸。如桐子大。服法照前。）
陈修园曰。观此二方。可知苦寒之功用神妙。非薛立斋张景岳辈所可管窥。喻嘉言寓意
草。谓苦寒培生气。诚见道之言也。
能补诸虚百损五劳七伤。功效不能尽述。人制一料服之。可以延年一纪。其法须四人共
制一鹿。分而服之。逾年又共制之。四人共制四年。则每人得一全鹿。若一人独制一料。恐
久留变坏。药力不全矣。法用中鹿一只。宰好。将肚杂洗净。同鹿肉加酒煮熟。将肉横切。
焙干为末。取皮同杂。仍入原汤煮膏。和药末肉未加炼蜜为丸。其骨须酥炙为末。同入之。
（人参白术茯苓炙草当归川芎生地熟黄 天冬麦冬枸杞杜仲牛膝山药芡实菟丝子五味子琐阳
肉苁蓉破故纸巴戟肉葫芦巴川续断覆盆子楮实子秋石陈皮。各一斤。川椒小茴香沉香青盐各
半斤。法须精制诸药为未。候鹿胶成就。和捣为丸。梧桐子大。焙干。用生绢作小袋五十条。
每条约乘一斤。悬直透风处。用尽一袋。又取一袋。阴湿天须用火烘一二次为妙。每服八九
十丸。空心临卧姜汤盐汤送下。冬月酒下。）
陈修园曰。此方冠冕堂皇。富贵之家。无不喜好。修园不韵不注。明者自知然亦有不得
不言者。肥浓痰多之人。内蕴湿热者。体此丸。即犯膏粱无厌发痈疽之戒也。惟用瘦过于劳
苦。及自奉淡薄之人。或高年瘦弱。用此早晚两服以代点心。不无补益耳。○重可KT 法
降伏阴火。补益肾水。
大补阴丸是绝妙的方剂。那些盲目问道的人诋毁它性凉。方中地黄、知母、黄柏既能滋阴又能降火。龟板质地沉重，能潜镇制约亢盛的阳气。（黄柏、知母各四两，都用盐和酒炒制。熟地黄用黄酒润透。龟板用酥油炙至黄色。各六两研为细末。用猪脊髓蒸熟，与炼蜜混合制成梧桐子大小的药丸。每次服用五六十丸，空腹时，随意用姜汤、盐汤或黄酒送服。）
陈修园说：知母、黄柏性寒能清除热邪，味苦能降泄火势。但苦味药物必然燥烈，所以用猪脊髓来滋润它，用熟地黄来滋养它。这是治疗阴虚发热的常规法则。然而，如果除热只用凉药，还不是探究病源的治法。此方以龟板为主药，这是运用介类药材潜阳的方法。丹溪的此方，比六味地黄丸的功效更优越。李士材、薛立斋、张景岳等人，因为嫌其苦寒而将其摒弃，这还没有参透造化阴阳的奥妙。
治疗痿证的神效方剂。
即前方（大补阴丸）加味而成。（黄柏、知母、熟地黄各三两，龟板四两，白芍、当归、牛膝各二两，虎胫骨、琐阳、陈皮各一两五钱，干姜五钱。用酒煮羯羊肉制成药丸，如梧桐子大小。每次服用五六十丸，用姜汤、盐汤或黄酒送服。）
加味虎潜丸（治疗各种虚损不足，腰腿疼痛，行走无力，壮补元气，滋补肾水）。即前方再加味。（按照虎潜丸的配方，再加人参、黄芪、杜仲、菟丝子、茯苓、破故纸、山药、枸杞。去掉羊肉和干姜，用猪脊髓蒸熟，同炼蜜制成药丸，如梧桐子大小。服用方法照前。）
陈修园说：看这两个方子，可知苦寒药物的功用神妙，不是薛立斋、张景岳等人所能窥见的。喻嘉言在《寓意草》中说“苦寒能培补生气”，这确实是见识大道的言论。
能够补益各种虚损、百种损伤、五劳七伤，功效无法全部叙述。每人制作一料服用，可以延年十二岁。制作方法需要四人共同制作一只鹿，分而服用之。过了一年再共同制作。四人共同制作四年，则每人得到一只全鹿的药料。如果一人独自制作一料，恐怕久存会变质，药效就不完整了。方法是用中等大小的鹿一只，宰杀处理好，将内脏洗净，同鹿肉加酒煮熟。将肉横向切片，焙干研为细末。取鹿皮同内脏，仍放入原汤中煮成膏状，与药末、肉末混合，加入炼蜜制成药丸。鹿骨必须用酥油炙烤后研为细末，一同加入其中。（人参、白术、茯苓、炙甘草、当归、川芎、生地黄、熟地黄、天冬、麦冬、枸杞、杜仲、牛膝、山药、芡实、菟丝子、五味子、琐阳、肉苁蓉、破故纸、巴戟天、葫芦巴、川续断、覆盆子、楮实子、秋石、陈皮，各一斤。川椒、小茴香、沉香、青盐各半斤。方法需精制诸药为粉末，等候鹿胶制成，混合捣匀为丸，梧桐子大小，焙干。用生绢做成五十个小袋，每条约重一斤，悬挂在通风处。用完一袋，再取一袋。阴湿天气需用火烘烤一到两次为好。每次服用八九十丸，空腹及睡前用姜汤、盐汤送服。冬季用酒送服。）
陈修园说：此方冠冕堂皇，富贵人家没有不喜欢的。我陈修园不通韵致也不作注解，明白的人自然知道。但也有不得不说的话。肥腻厚味、痰多之人，体内蕴藏湿热者，服用此丸，就犯了“膏粱无厌发痈疽”的禁忌。只有用于过度劳累消瘦，以及生活清淡之人，或者年老体瘦弱者，早晚各服一次作为点心，倒是有补益作用。○重可镇怯法（注：原文“KT”推测为“镇怯”或类似含义的误植/简写，此处依语境意译，但实体提取保留原文词汇）
To subdue Yin fire. To tonify Kidney water.
Da Bu Yin Wan (Great Tonification of Yin Pill) is an exquisite formula. Those who ask the Way blindly slander it for being cold in nature. Rehmanniae Radix (Shu Di Huang), Anemarrhenae Rhizoma (Zhi Mu), and Phellodendri Cortex (Huang Bo) both nourish and descend. Testudinis Carapax et Plastrum (Gui Ban) is heavy and sinking, capable of subduing and restraining hyperactive Yang. (Phellodendri Cortex and Anemarrhenae Rhizoma, each 4 liang, stir-fried with salt and wine. Prepared Rehmanniae Radix moistened with yellow wine. Testudinis Carapax et Plastrum fried with suet until yellow. Each 6 liang, ground into powder. Steamed porcine spinal cord mixed with refined honey to form pills the size of tung tree seeds. Take 50-60 pills per dose, on an empty stomach, delivered with ginger soup, salt soup, or yellow wine as preferred.)
Chen Xiuyuan said: Anemarrhenae Rhizoma and Phellodendri Cortex are cold to clear heat and bitter to descend fire. However, bitter substances tend to be drying; therefore, porcine spinal cord is used to moisten it, and Prepared Rehmanniae Radix to nourish it. This is a standard method for treating fever due to Yin deficiency. Nevertheless, clearing heat using only cooling herbs is not a treatment that probes the root. This formula uses Testudinis Carapax et Plastrum as the chief herb, employing the method of using shellfish/shell materials to subdue Yang. Danxi’s Da Bu Yin Wan is superior in efficacy to Liu Wei Di Huang Wan (Six-Ingredient Pill with Rehmannia). Li Shicai, Xue Lizhai, Zhang Jingyue, and others discarded it because of its bitter-cold nature; they had not penetrated the subtleties of creation regarding Yin and Yang.
A miraculous formula for treating Wei syndrome (flaccidity syndrome).
This is the previous formula with added ingredients. (Phellodendri Cortex, Anemarrhenae Rhizoma, and Prepared Rehmanniae Radix, each 3 liang; Testudinis Carapax et Plastrum 4 liang; Paeoniae Radix Alba (Bai Shao), Angelicae Sinensis Radix (Dang Gui), and Achyranthis Bidentatae Radix (Niu Xi), each 2 liang; Tigris Ossis (Hu Jing Gu), Cynomorii Herba (Suo Yang), and Citri Reticulatae Pericarpium (Chen Pi), each 1.5 liang; Zingiberis Rhizoma (Gan Jiang) 5 qian. Wine-boiled male sheep meat is used to form pills the size of tung tree seeds. Take 50-60 pills per dose, delivered with ginger soup, salt soup, or yellow wine.)
Jia Wei Hu Qian Wan (Additive Tiger-Hiding Pill) (Treats various deficiencies and insufficiencies, pain in waist and legs, weakness in walking, strengthens Yuan Qi, and nourishes Kidney water). This is the previous formula with further additions. (Following the Hu Qian Wan formula, add Ginseng Radix (Ren Shen), Astragali Radix (Huang Qi), Eucommiae Cortex (Du Zhong), Cuscutae Semen (Tu Si Zi), Poria (Fu Ling), Psoraleae Fructus (Po Gu Zhi), Dioscoreae Rhizoma (Shan Yao), and Lycii Fructus (Gou Qi). Remove sheep meat and Zingiberis Rhizoma. Use steamed porcine spinal cord mixed with refined honey to form pills the size of tung tree seeds. Administration follows the previous method.)
Chen Xiuyuan said: Observing these two formulas reveals the miraculous efficacy of bitter-cold substances, which is beyond the comprehension of Xue Lizhai and Zhang Jingyue. Yu Jiayan, in *Yi Yi Cao* (Meaningful Grass), stated that "bitter-cold can cultivate vital Qi," which is indeed words from one who has seen the Dao.
It can tonify all types of deficiency, hundred injuries, Wu Lao (Five Labors), and Qi Shang (Seven Injuries); its effects cannot be fully described. If each person prepares one batch and takes it, one can extend life by twelve years. The method requires four people to jointly prepare one deer, dividing the medicine among themselves to take. After one year, they prepare another together. If four people prepare it together for four years, each person obtains the medicine of a whole deer. If one person prepares a batch alone, it may spoil over long storage, and the medicinal power will be incomplete. The method uses one medium-sized deer, slaughtered and cleaned. Wash the entrails well, then cook them with the deer meat and wine. Slice the meat horizontally, dry it by baking, and grind it into powder. Take the skin and entrails, return them to the original broth, and boil down to a paste. Mix this paste with the herbal powder and meat powder, adding refined honey to form pills. The bones must be fried with suet and ground into powder, then added together. (Ginseng Radix, Atractylodis Macrocephalae Rhizoma (Bai Zhu), Poria, Glycyrrhizae Radix et Rhizoma Praeparata (Zhi Cao), Angelicae Sinensis Radix, Chuanxiong Rhizoma (Chuan Xiong), Rehmanniae Radix (Sheng Di Huang), Prepared Rehmanniae Radix, Asparagi Radix (Tian Dong), Ophiopogonis Radix (Mai Dong), Lycii Fructus, Eucommiae Cortex, Achyranthis Bidentatae Radix, Dioscoreae Rhizoma, Euryales Semen (Qian Shi), Cuscutae Semen, Schisandrae Fructus (Wu Wei Zi), Cynomorii Herba, Cistanches Herba (Rou Cong Rong), Psoraleae Fructus, Morinda Officinalis Radix (Ba Ji Tian), Trigonospermae Semen (Hu Lu Ba), Cyathulae Radix (Chuan Xu Duan), Rubi Fructus (Fu Pen Zi), Torreya Seed (Chu Shi Zi), Urina Foenisecii (Qiu Shi), Citri Reticulatae Pericarpium, each 1 jin; Zanthoxyli Pericarpium (Chuan Jiao), Foeniculi Fructum (Xiao Hui Xiang), Aquilariae Lignum Resinatum (Chen Xiang), Natrii Chlorum (Qing Yan), each half jin. The method requires refining all herbs into powder, waiting for the deer glue to be ready, mixing and pounding into pills the size of tung tree seeds, drying them. Make fifty small bags of raw silk, each weighing about one jin. Hang them in a ventilated place. When one bag is finished, take another. On damp days, it is advisable to bake them once or twice with fire. Take 80-90 pills per dose, on an empty stomach and before bed, delivered with ginger soup or salt soup. In winter, deliver with wine.)
Chen Xiuyuan said: This formula is grand and majestic; wealthy families all favor it. I, Chen Xiuyuan, am not versed in elegance and do not annotate it; those who understand will know naturally. However, there are things I must say. For individuals who are obese, consume rich foods, have much phlegm, and harbor internal damp-heat, taking this pill violates the warning that "indulgence in rich food causes carbuncles and sores." It is only suitable for those who are emaciated due to overwork, live simply, or are elderly and frail. Taking it twice daily as a snack provides some benefit. ○ Heavy substances can calm fright (Note: Original text "KT" is interpreted contextually, likely referring to "Zhen Qie" or similar calming properties associated with heavy/mineral/shell substances).