以汞粉转升成霜。一名水银霜。又名白灵砂。崔氏造霜法。用水银十两。配石硫黄十
两。各以一铛熬之。良久。汞熟硫溶。急倾入一铛。（稍缓即不相入）仍急搅之。良久。硫
成灰。水银不见。乃下伏龙肝末十两。盐末一两搅之。别以盐末铺铛底一分。入药在上。又
以盐末盖面一分。瓦盆覆之。盐土和泥涂缝。炭火 一伏时。先文后武。开盆刷下。凡一转
后。分旧土为四分。以一分和霜。入盐末二两。如前法飞之讫。又以土一分。盐末二两。和
飞如前。凡四转。土尽。更用新土。如此七转。乃成霜。用之。
气味辛温。有毒。畏荞麦秆灰硫黄。主治下痰涎。消积滞。利水。与轻粉同功。（濒湖）
轻粉粉霜。亦能洁净腑。去膀胱中垢腻。既毒而损齿。宜少用之。（洁古） 小儿燥渴。粉
霜一字。大儿半钱。莲化汤调下。冬月用莲肉。风热惊狂。神白丹。治伤寒积热。及风生惊
搐。或如狂病。药不效。粉霜一两。以白面六钱。和作饼子。炙熟同研。轻粉半两。铅白霜
二钱半。为末。滴水丸梧子大。每服十丸至十五丸。米饮下。
〔论〕濒湖所云粉霜。是从汞粉转升成霜者也。其述崔氏造霜法。乃即未成汞粉而造
成粉霜者也。寻绎制法。似与升水银成粉之法。化纯阴为燥烈者。犹有不同。而濒湖谓其与
轻粉同功。殊未细审也。试以方书疗滞下久积。全属五色脓血。或如烂鱼肠。并无大便。肠
中搅痛不可忍者。用粉霜轻粉朱砂 砂白丁香乳香巴豆诸味。是其以行积为功。却与轻粉并
用。即此一证。合之躁渴惊狂两方。便可推求其精义矣。
将汞粉通过升华工艺转化为霜状物。这种药物又名水银霜，还被称为白灵砂。崔氏制作霜剂的方法如下：取用水银十两、石硫黄十两，分别放入两个锅中加热熬制。经过较长时间后，待水银熟化、硫黄熔化，迅速将其倒入另一个锅中（若动作稍慢则两者无法融合）。随即快速搅拌，持续一段时间后，硫黄变成灰烬，水银也不见了踪迹。此时加入伏龙肝粉末十两、盐末一两并搅拌均匀。另外，在锅底铺上一层一分厚的盐末，将药物置于其上，再在药面上覆盖一层一分厚的盐末。用瓦盆盖住锅口，用盐和泥土混合的泥浆涂抹缝隙以防漏气。使用炭火煅烧一个时辰（约两小时），火候先文后武。开盆后将产物刷下。每完成一次转化过程，将旧的土分为四份，取其中一份与霜混合，加入盐末二两，按照之前的方法飞制（研磨过筛）完毕。再用一份土、二两盐末，按同样方法混合飞制。总共进行四次循环，直到旧土用完，再换用新土。如此反复七次，最终制成霜剂。
该药气味辛温，有毒。畏忌荞麦秆灰和硫黄。主要功效是祛除下焦痰涎，消除积滞，通利水道。其功效与轻粉相同。（李时珍《本草纲目》语）
轻粉和粉霜也能清洁脏腑，去除膀胱中的污垢腻滞。但因其有毒且会损伤牙齿，应当少量使用。（张元素《洁古家珍》语）
治疗小儿燥热口渴，用粉霜“一字”量，以大儿半钱量，用莲肉汤调服。冬季使用莲肉。治疗风热引起的惊狂症状，可用神白丹。此方主治伤寒积热，以及因风引发的惊厥抽搐，或表现为类似发狂的病证，若其他药物治疗无效，可使用此方。配方为：粉霜一两，白面六钱，混合做成饼状，烤熟后共同研成细末。再加入轻粉半两、铅白霜二钱半，一起研末，用滴水法制成梧桐子大小的丸药。每次服用十丸至十五丸，米饮送服。
〔论述〕李时珍所说的粉霜，是指从汞粉经升华制成的霜剂。他所描述的崔氏造霜法，实际上是在未制成汞粉之前直接制造粉霜的方法。仔细推敲其制作工艺，似乎与将水银升华为汞粉的方法不同，后者是将纯阴之质转化为燥烈之性。而李时珍认为它与轻粉功效相同，这显然没有经过细致审察。试举方书中治疗痢疾日久、积滞严重，排出物全为五色脓血，或如烂鱼肠状，并无正常大便，肠中绞痛难以忍受的案例来看，所用药物包括粉霜、轻粉、朱砂、砂仁、白丁香、乳香、巴豆等。这说明粉霜的功效在于行气破积。它常与轻粉配合使用。仅凭这一病例，结合上述治疗燥渴和惊狂的两个方剂，就可以推究出其精微义理了。
Mercury powder is converted into frost through sublimation. It is also known as Mercury Frost (Shuiyin Shuang) or White Spirit Cinnabar (Bai Lingsha). The method for preparing the frost by Master Cui is as follows: Take ten taels of Quicksilver (Shuiyin, 水银) and ten taels of Native Sulphur (Shi Liuhuang, 石硫黄), and heat them separately in two crucibles. After a considerable time, when the quicksilver is "cooked" and the sulphur has melted, quickly pour the mixture into another crucible (if delayed, they will not mix). Stir rapidly and continuously until the sulphur turns to ash and the quicksilver disappears. Then add ten taels of Fuli Longan Powder (Fulonggan Mo, 伏龙肝末 - calcined red clay) and one tael of Salt Powder (Yan Mo, 盐末), and stir well. Line the bottom of the crucible with a layer of salt powder one fen thick. Place the medicine on top, and cover the surface with another layer of salt powder one fen thick. Cover with a tile pot, seal the seams with mud made from salt and earth, and roast over charcoal fire for one shichen (approx. two hours), starting with gentle heat and increasing to strong heat. Open the pot and brush down the product. After each cycle, divide the old earth into four parts. Take one part, mix it with the frost, add two taels of salt powder, and process it by "flying" (levigation/sieving) as before. Repeat this with one part earth and two taels of salt powder. Perform this cycle four times until the old earth is exhausted, then use new earth. Repeat this process seven times in total to produce the frost.
It tastes pungent and is warm in nature; it is toxic. It is incompatible with Buckwheat Straw Ash (Qiaomai Gan Hui, 荞麦秆灰) and Sulphur (Liuhuang, 硫黄). Its main indications are to resolve phlegm-fluids in the lower jiao, eliminate stagnation, and promote urination. Its efficacy is similar to that of Calomel (Qingfen, 轻粉) [Li Shizhen].
Both Calomel (Qingfen, 轻粉) and Mercury Frost (Fenshuang, 粉霜) can cleanse the fu organs and remove turbid deposits in the bladder. However, due to their toxicity and potential to damage teeth, they should be used sparingly [Zhang Yuansu].
For pediatric dryness-thirst, administer one "yi zi" dose of Mercury Frost (Fenshuang, 粉霜) for infants, or half a qian for older children, mixed with Lotus Seed Decoction (Lianhua Tang, 莲化汤). In winter, use Lotus Root/Seed meat (Lianrou, 莲肉). For wind-heat induced mania and convulsions, use Shenbai Dan (Spirit White Pill, 神白丹). This formula treats accumulated heat from Cold Damage (Shanghan, 伤寒) and wind-induced convulsions or manic-like states, particularly when other medicines fail. The prescription consists of: Mercury Frost (Fenshuang, 粉霜) 1 liang, Wheat Flour (Baifan, 白面) 6 qian, mixed and baked into cakes, then ground together. Add Calomel (Qingfen, 轻粉) 0.5 liang and Lead White Frost (Qianbaishuang, 铅白霜) 2.5 qian, grind into powder, and make pills using water-drop method to the size of wutong seeds. Take 10-15 pills per dose, washed down with rice drink.
[Discussion] What Li Shizhen refers to as Mercury Frost (Fenshuang, 粉霜) is the frost produced by sublimating mercury powder. His description of Master Cui's method actually describes making the frost directly before it becomes mercury powder. Examining the preparation method, it seems distinct from the method of sublimating quicksilver into mercury powder, which transforms pure yin into a drying and acrid substance. Li Shizhen's claim that it shares the same efficacy as Calomel (Qingfen, 轻粉) lacks careful scrutiny. Consider cases in medical texts treating chronic dysentery with severe stagnation, where excrement is entirely five-colored pus and blood, or resembles rotten fish intestines, with no normal stool and unbearable intestinal cramping. The prescribed ingredients include Mercury Frost (Fenshuang, 粉霜), Calomel (Qingfen, 轻粉), Cinnabar (Zhusha, 朱砂), Amomum Fruit (Sharen, 砂仁), White Eugenia Flower (Baodingxiang, 白丁香), Frankincense (Ruxiang, 乳香), and Croton Seed (Badou, 巴豆). This demonstrates that its function is to move accumulation. Its concurrent use with Calomel (Qingfen, 轻粉) in this context, combined with the previous formulas for thirst and mania, allows one to deduce its precise therapeutic principles.