丹溪曰或问河间之言滞下似无挟虚挟寒者乎否乎予曰泄痢之病水谷或化或不化并无努责
惟觉
困倦若滞下则不然或脓或血或脓血相杂或肠垢或无糟粕或糟粕相混虽有痛不痛大痛之异然皆
里急后重逼迫恼人似乎皆热证实证也予近年涉历亦有大虚大寒者不可不知敢笔其略以备采览
予从叔年逾五十夏间患滞下病腹微痛所下褐色后重频并谷食大减时有微热察其脉皆弦而涩
似数而稍长却喜不甚浮大两手相等视其神气大减予曰此滞下忧虑所致心血亏脾气弱耳遂以参
术为君当归陈皮为臣川芎炒芍药茯苓为佐使时暄热甚加少黄连两月而安娄长官年三十余奉养
浓者夏秋间患滞下腹大痛有人教服单煮干姜与一帖则痛定少顷又作又与之定由是服干姜至三
斤八日视之左脉弦而稍大似数右脉弦而大稍减亦似数重取之似紧予曰此必醉饱后吃寒凉太过
而当作虚寒治之因其多服干姜遂教用四物汤去地黄加人参白术陈皮酒红花茯苓桃仁煎入生姜
汁饮之至一月而安金氏妇年近四十秋初尚热患滞下腹但隐痛夜重于书全不得睡食亦稍减口干
不饮已得治痢灵砂二帖矣予观之两手脉皆涩且不匀神思倦甚饮食全减因与四物汤倍加白术以
陈皮佐之与十数帖而安此三病者若因其逼迫而用峻剂岂不误人
按滞下之证古人多与泄泻同论至三因方始能另立条目盖实有不同夫病有从外感而得者须
分六
气之异外既受伤肠胃郁结遂成赤白等证当随其寒热温凉以调之有因脏气发动干犯肠胃而得者
须察其何脏相乘以平治之又有因饮食失节而得者则又审其何物所伤以消克之世之感此疾者其
因诚不越乎是三者但其受病之后肠胃拂郁脓血稠粘里急后重诸方虽有寒热虚实之论刘河间则
以为一出于热然考之内经似亦热多而寒少也我丹溪先生则以为亦有挟虚挟寒之证深戒学人须
宜识此世之局方不辨三因专用涩热之药其失甚矣至河间立说专用苦寒疏下之药则亦未甚为当
何则盖病有虚实治用先后若病气暴至元气壮实积滞胶固须宜下之病久气脱肠胃虚滑不禁者亦
宜温之涩之大抵治痢当从仲景河间之法可温则温可下则下或解表或利小便或待其自已刘河间
分别在表在里挟风挟热挟寒等证后之作者无越于斯但气血一条未尝表出立论其于芍药汤下有
曰行血则便自愈调气则后重除盖谓溲便脓血血之滞也故曰行血自愈奔迫后重气之实也故曰调
气
自除诚哉是言但脓血赤白亦有气病血病之分后重里急亦有气实血虚之异学人又不可不察详见
前论
丹溪说:有人问,河间先生关于“滞下”(痢疾)的论述中,似乎没有提到夹杂虚证和寒证的情况,是这样吗?我回答说:泄泻和痢疾这类疾病,饮食水谷有的能消化,有的不能消化,但都没有排便时努责用力的感觉,只是觉得困倦乏力。如果是滞下则不然,或者排出脓液,或者排出血液,或者脓血混杂,或者是肠垢,或者没有糟粕,或者糟粕混杂其中。虽然有疼痛和不疼痛、剧烈疼痛和轻微疼痛的不同,但都有里急后重(腹痛窘迫,时时欲便,肛门重坠,便出不爽)的症状,逼迫恼人,看起来似乎都是热证实证。我近年来经历的病例中,也有大虚大寒的情况,不可不知道。现简要记录以备参考。
我的从叔年过五十,夏天患滞下病,腹部微痛,排出的粪便呈褐色,里急后重频繁发作,食欲大大减退,有时有轻微发热。诊察他的脉象,都弦而涩,似数且稍长,但喜见不浮大,两手脉相等。观察他的神气,明显衰退。我说:这是滞下病由忧虑所致,心血亏虚,脾气虚弱。于是以人参、白术为君药,当归、陈皮为臣药,川芎、炒芍药、茯苓为佐使药。当时天气非常炎热,加少量黄连。两个月后痊愈。
娄长官三十多岁,平时生活优渥,夏秋之间患滞下病,腹部剧痛。有人教他单煮干姜服用一帖,则疼痛停止。过了一会儿又发作,再给他服用,疼痛又止。因此连续服用干姜达三斤。八天后诊察,左脉弦而稍大,似数;右脉弦而大,稍减,也似数。重按之感觉紧。我说:这一定是醉饱之后吃寒凉太过,应当作为虚寒证治疗。因为他已经多服了干姜,于是教他用四物汤去掉地黄,加入人参、白术、陈皮、酒红花、茯苓,煎煮时加入生姜汁饮用。一个月后痊愈。
金氏妇年近四十,初秋天气尚热时患滞下病,腹部只是隐隐作痛,夜间加重,完全无法入睡,饮食也稍微减少,口干但不想喝水。已经接受了治疗痢疾的灵砂二帖。我观察她,两手脉皆涩且不均匀,神思极度疲倦,饮食完全减少。于是给予四物汤,加倍使用白术,以陈皮佐助。服用十数帖后痊愈。这三种病症,如果因为患者感到逼迫难受而使用峻猛的药物,岂不误人?
按语:滞下的证候,古人多与泄泻一同论述,直到《三因方》才开始单独设立条目。大概确实有所不同。有的病是从外感得来的,必须区分六气的不同,外邪既已受伤,肠胃郁结,遂成赤白痢等证,应当根据寒热温凉来调治。有的是因脏气发动,干犯肠胃而得病的,必须考察是哪一脏相乘,以平定治疗。还有的是因饮食失节而得病的,则要审察是何种食物所伤,以消导克伐之法治疗。世人感染此疾,其原因确实不出这三者。但是患病之后,肠胃拂郁,脓血稠粘,里急后重,虽然各方虽有寒热虚实之论,刘河间则认为一律出于热证。然而考证《内经》,似乎也热多而寒少。我的丹溪先生则认为也有夹杂虚证和寒证的证候,深深告诫学人必须认识这一点。世间的局方不辨别三因,专门使用涩热药物,其失误很大。至于河间立说,专门使用苦寒疏下药物,也不甚恰当。为什么呢?因为病有虚实,治疗有先后。如果病气暴至,元气壮实,积滞胶固,应当使用下法;如果病久气脱,肠胃虚滑不禁,也应当使用温涩法。大体上治疗痢疾应当遵循张仲景、刘河间的方法,可温则温,可下则下,或解表,或利小便,或等待其自愈。刘河间分别在表在里、挟风、挟热、挟寒等证候之后,后来的作者没有超越这些。但关于气血的一条,未曾明确列出理论。他在芍药汤下说道:“行血则便脓自愈,调气则后重除。”大概是说排泄脓血,是血的凝滞,所以说行血则自愈;奔迫后重,是气的实证,所以说调气则自除。这话确实正确。但脓血赤白也有气病血病的分别,后重里急也有气实血虚的差异,学人又不可不仔细考察。详见前文论述。
Danxi said: Someone asked, "In Hejian's discussion on 'Zhixia' (Dysentery), it seems there is no mention of conditions complicated by deficiency and cold. Is this correct?" I replied: "For diseases such as diarrhea and dysentery, food and water may or may not be digested, yet there is no sensation of straining during defecation; one only feels fatigued and weak. However, for Zhixia, this is not the case. One may pass pus, blood, a mixture of pus and blood, intestinal mucus, feces without residue, or feces mixed with residue. Although there are differences in pain—some painful, some not, some severely painful, some mildly painful—all share the symptom of tenesmus (abdominal urgency with heavy sensation in the anus and unsatisfactory passage). This feeling is oppressive and distressing, appearing to be exclusively heat excess patterns. In my recent clinical experience, however, there have been cases of severe deficiency and cold that must be known. I record these briefly for reference."
My uncle, over fifty years old, suffered from Zhixia in summer. His abdomen was slightly painful, he passed brownish stools, experienced frequent tenesmus, his appetite decreased significantly, and he occasionally had a slight fever. His pulse was wiry and choppy in both hands, resembling rapidity and slightly long, but notably not floating or large. His spirit and qi were markedly diminished. I said, "This Zhixia is caused by worry, leading to heart blood deficiency and spleen qi weakness." Therefore, I used Ginseng Radix et Rhizoma (Renshen) and Atractylodis Macrocephalae Rhizoma (Baizhu) as sovereign herbs, Angelicae Sinensis Radix (Danggui) and Citri Reticulatae Pericarpium (Chenpi) as minister herbs, Ligusticum Chuanxiong Rhizoma (Chuanxiong), fried Paeoniae Radix Alba (Shaoyao), and Poria (Fuling) as assistant and envoy herbs. Given the intense summer heat, I added a small amount of Scutellariae Radix (Huanglian). He recovered after two months.
Official Lou, in his thirties, who lived luxuriously, suffered from Zhixia in late summer and autumn. His abdomen hurt severely. Someone advised him to boil dried ginger alone and take one dose, which stopped the pain. Shortly after, the pain returned; upon giving it again, the pain ceased. Consequently, he consumed three jin of dried ginger. Eight days later, examination showed his left pulse was wiry and slightly large, resembling rapidity; his right pulse was wiry and large, slightly reduced, also resembling rapidity. Deep pressure felt tight. I said, "This must be due to excessive intake of cold foods after drinking and eating heavily. It should be treated as a deficiency-cold pattern. Since he has already taken much dried ginger, I advise using Siwu Decoction (Four Substances Decoction) minus Rehmanniae Radix Preparata (Shudihuang), adding Ginseng Radix et Rhizoma (Renshen), Atractylodis Macrocephalae Rhizoma (Baizhu), Citri Reticulatae Pericarpium (Chenpi), Safflower (Honghua) prepared with wine, Poria (Fuling), and Peach Kernel (Taoren). Decoct with fresh ginger juice. He recovered after one month."
Madam Jin, nearly forty years old, contracted Zhixia in early autumn while it was still hot. Her abdomen had only dull pain, worse at night, preventing sleep entirely. Her diet decreased slightly. She complained of dry mouth but did not desire to drink. She had already taken two doses of Lingsha (a specific formula/powder for treating dysentery). Upon observation, her pulses in both hands were choppy and irregular. Her mental state was extremely fatigued, and she ate nothing. I prescribed Siwu Decoction (Four Substances Decoction) with doubled Atractylodis Macrocephalae Rhizoma (Baizhu), assisted by Citri Reticulatae Pericarpium (Chenpi). After taking more than ten doses, she recovered. If these three cases had been treated with harsh purgatives merely because of the patient's sense of oppression, it would have been a mistake.
Note: Ancient texts often discussed Zhixia together with loose stools/diarrhea. It was not until *San Yin Fang* (Treatise on the Causes and Manifestations of All Diseases) that it was established as a separate category, as there are indeed differences. Some diseases arise from external pathogens; one must distinguish the six climatic factors. Once the exterior is injured and the intestines and stomach become stagnant, red and white dysenteric stools form. Treatment should follow the principles of warming, cooling, etc. Some arise from internal organ dysfunction affecting the intestines and stomach; one must identify the affected zang-organ and treat accordingly. Others result from dietary indiscretion; one must identify the offending food and use resolving methods. The causes of this disease in the world generally fall into these three categories. However, once ill, the intestines and stomach are obstructed, pus and blood are thick and sticky, and tenesmus occurs. Although various formulas discuss cold, heat, deficiency, and excess, Liu Hejian argued that all stem from heat. Examining the *Neijing* (Inner Canon), it seems heat is more common than cold. My teacher, Danxi, believed there are also cases complicated by deficiency and cold, deeply warning students to recognize this. Local formularies (*Jufang*) fail to differentiate the three causes and exclusively use astringent and warming drugs, which is a great error. Conversely, Hejian’s theory relies solely on bitter-cold draining drugs, which is also not entirely appropriate. Why? Because diseases have deficiency and excess, and treatment has sequence. If pathogenic qi arrives suddenly and the primal qi is strong with stubborn stagnation, purging is indicated. If the disease is prolonged, qi is depleted, and the intestines and stomach are deficient and slippery, warming and astringing are indicated. Generally, treating dysentery should follow the methods of Zhang Zhongjing and Liu Hejian: warm if suitable, purge if suitable, release the exterior, promote urination, or wait for self-healing. Liu Hejian categorized syndromes by exterior/interior, wind, heat, and cold. Later authors did not exceed these categories. However, the distinction between qi and blood was not explicitly theorized. Under Shaoyao Tang (Peony Decoction), he stated: "Moving blood makes pus discharge heal; regulating qi eliminates tenesmus." This implies that bloody pus is due to blood stasis, hence moving blood heals it; tenesmus is due to qi excess/stagnation, hence regulating qi eliminates it. This is true. However, red and white pus/blood can be distinguished by qi or blood pathology, and tenesmus can be distinguished by qi excess or blood deficiency. Students must examine this carefully. See previous discussions for details.