吴球云∶紫河车即胞衣也。儿孕胎中，脐系于胞，胞系于母命门，受母之荫，父精母血
，相应
每每用此得效，用之女人尤妙。盖本其自出，各从其类也。若无子及多生女，并月水不调，
小产难产人服之，必主多子。危疾将绝者，一二服可更活一二日，其补阴之功极重，百发百
中，久服耳聪目明，须发乌黑，延年益寿，有夺造化之功，故名大造丸。用紫河车一具，男
用女胎，女用男胎，初生者，米泔洗净，新瓦焙干研末，或以淡酒蒸热捣晒研末，气力尤全
，且无火毒。败龟板年久者，童便浸三日，酥炙黄二两，或以童便浸过，石上磨净，蒸熟晒
研尤妙。黄柏去皮，盐酒浸炒一两半，杜仲去皮酥炙一两半，牛膝去苗酒浸晒一两二钱，肥
生地黄二两半，入砂仁六钱，白茯苓二两，绢袋盛，入瓦罐，酒煮七次，去茯苓、砂仁不用
，杵地黄为膏听用，天门冬去心，麦门冬去心，人参去芦，各一两二钱，夏月加五味子七钱
，各不犯铁器为末，同地黄膏入酒米糊丸如小大豆，每服八九十丸，空心盐汤下，冬月酒下
。女人去龟板，加当归二两，以乳煮糊为丸。男子遗精，女人带下，并加牡蛎粉一两。
世医用阳药滋补，非徒无益，为害非小。盖邪火只能动欲，不能生物。龟板、黄柏补阳
补阴
地黄凉血滋阴，得茯苓、砂仁同黄柏，则入少阴。白飞霞以此四味，为天一生水丸也。天门
冬，能保肺气，不令火炎，使肺气下行生水，然其性有降无升，得人参则鼓动元气，有升有
降，故同地黄为固本丸也。又麦门冬、人参、五味子三味，名生脉散，皆为肺经药，此方配
合之意，大抵以金水二脏，为生化之源，加河车以成大造之功故也。一人病弱，阳事败痿，
服此二料，身体顿异，连生四子。一妇年六十，已衰惫，服此寿至九十，犹强健。一人病后
不能作声，服此气壮声出，一人病痿足不任者半年，服此后能远行。
吴球说：紫河车就是胎盘。胎儿在母体子宫内孕育时，脐带连接着胎盘，胎盘连接着母亲的命门（肾间动气，生命之根），接受母亲荫庇，融合父亲的精气和母亲的血液，相互感应。因此常常使用此药而取得疗效，用于女性患者尤其奇妙。这是因为取用其原本所属之物，遵循同类相从的道理。对于无子嗣或只生女儿的女性，以及月经不调、有小产或难产经历的人服用，必定能多子多孙。危重疾病濒临死亡者，服用一两次可延续生命一两天，其补阴的功效极大，百发百中。长期服用可使耳聪目明，头发胡须乌黑，延年益寿，有夺天地造化之功，所以命名为大造丸。
配方：紫河车一具，男性选用女胎，女性选用男胎，必须是初生的。用米泔水洗净，在新瓦上焙干研成粉末；或者用淡酒蒸热后捣碎晒干再研成粉末，这样药力更加完整，且没有火毒。陈年败龟板，用童便浸泡三天，再用酥油炙至黄色，用量为二两；或者用童便浸泡过后，在石头上磨净，蒸熟晒干后研磨，效果尤其奇妙。黄柏去皮，用盐和酒浸泡后炒制，用量为一两半；杜仲去皮，用酥油炙制，用量为一两半；牛膝去苗，用酒浸泡后晒干，用量为一两二钱；肥厚的生地黄二两半，加入砂仁六钱，白茯苓二两，用绢袋装好，放入瓦罐中，用酒煮七次，去掉茯苓和砂仁不用，将地黄杵烂成膏备用。天门冬去心，麦门冬去心，人参去芦头，各一两二钱。夏季加五味子七钱。各药材均不接触铁器，研成粉末，同地黄膏一起，用酒和米糊制成如小豆大小的丸剂。每次服用八九十丸，空腹时用盐汤送服，冬季用酒送服。女性患者去掉龟板，加入当归二两，用乳汁煮糊为丸。男子遗精，女子带下病，均加入牡蛎粉一两。
世间的医生使用阳刚药物进行滋补，不仅没有益处，反而危害不小。因为邪火只能扰动情欲，不能化生万物。龟板、黄柏能补阳补阴（注：此处原文逻辑似有矛盾或特指阴阳双补之意，依原文直译），地黄凉血滋阴，得到茯苓、砂仁配合黄柏，则药力入少阴经。白飞霞认为这四味药组成了“天一生水丸”。天门冬能保护肺气，不让火势炎上，使肺气下行以生水，然而它的性质只有下降没有上升，得到人参则能鼓动元气，有升有降，所以与人参、地黄配合组成“固本丸”。另外，麦门冬、人参、五味子三味药，名为“生脉散”，都是肺经的药物。这个方子配伍的意图，大致是以金（肺）和水（肾）两脏作为生化之源，加上紫河车来成就大造之功。
曾有一人身体虚弱，阳痿不起，服用此方两料后，身体顿时好转，连生四个儿子。有一位六十岁的妇人，已经衰老疲惫，服用此方后活到九十岁，依然强健。有一人病后不能发声，服用此方后气壮声出。有一人患痿证，脚不能行走长达半年，服用此方后能够远行。
Wu Qiu stated: Ziheche (Placenta) is the placenta. When a fetus is conceived in the womb, the umbilical cord connects to the placenta, and the placenta connects to the Mingmen (Gate of Life, the root of vitality) of the mother, receiving the mother's protection, integrating the father's essence and the mother's blood, responding to each other. Therefore, using this substance often yields effective results, especially when used for women. This is because it utilizes its original source, following the principle that things of the same kind attract each other. It is beneficial for those without offspring or who have only given birth to daughters, as well as for women with irregular menstruation, history of spontaneous abortion, or difficult labor; taking it will surely lead to having many children. For critical patients on the verge of death, one or two doses can extend life by one or two days. Its efficacy in tonifying Yin is extremely significant, proving reliable in every instance. Long-term use leads to sharp hearing and clear vision, black hair and beard, longevity, and health, possessing the power to rival nature's creation, hence named Dazao Wan (Great Creation Pill).
Formula: One piece of Ziheche (Placenta); males should use a female fetus, females should use a male fetus, preferably from a newborn. Wash clean with rice water, dry on a new tile until crisp, and grind into powder; or steam with light wine until hot, pound, dry, and grind into powder. This preserves the medicinal strength fully and eliminates fire toxicity. Old Gui Ban (Testudinis Carapax et Plastrum), soaked in child's urine for three days, then fried with su (rendered animal fat) until yellow, 2 liang; or soak in child's urine, clean by grinding on a stone, steam until cooked, dry, and grind, which is particularly excellent. Huang Bo (Phellodendri Cortex), peeled, soaked in salt and wine, stir-fried, 1.5 liang. Duzhong (Eucommiae Cortex), peeled, fried with su, 1.5 liang. Niuxi (Achyranthis Bidentatae Radix), remove sprouts, soak in wine, dry, 1.2 qian. Fei Sheng Dihuang (Rehmanniae Radix), fleshy variety, 2.5 liang. Add Renshen (Ginseng Radix et Rhizoma) 6 qian, Baifuling (Poria) 2 liang. Place in a silk bag, put in a clay pot, boil in wine seven times. Remove Baifuling and Renshen, do not use them. Pound the Sheng Dihuang into a paste for later use. Tianmendong (Asparagi Radix), remove heart; Maidong (Ophiopogonis Radix), remove heart; Renshen (Ginseng Radix et Rhizoma), remove rhizome, each 1.2 liang. In summer, add Wuweizi (Schisandrae Fructus) 7 qian. Grind all herbs into powder without letting them touch iron vessels. Mix with the Dihuang paste, use wine and rice paste to make pills the size of small soybeans. Take 80-90 pills per dose, on an empty stomach with salt water decoction; in winter, take with wine. For women, remove Gui Ban (Testudinis Carapax et Plastrum), add Danggui (Angelicae Sinensis Radix) 2 liang, use milk to make the paste for pills. For men with spermatorrhea or women with leukorrhea, add Moli Fen (Ostreum Concha Powder) 1 liang.
Physicians of the world often use Yang-tonifying drugs for supplementation, which is not only useless but also harmful. Because pathogenic fire can only stimulate desire, not generate life. Gui Ban (Testudinis Carapax et Plastrum) and Huang Bo (Phellodendri Cortex) tonify both Yang and Yin; Sheng Dihuang (Rehmanniae Radix) cools blood and nourishes Yin. With the addition of Fuling (Poria) and Sharen (Amomi Fructus Rotundus) and Huang Bo (Phellodendri Cortex), the action enters the Shaoyin channel. Bai Feixia considered these four ingredients as forming the Tiansheng Yishui Wan (Heaven Generates Water Pill). Tianmendong (Asparagi Radix) protects Lung Qi, preventing fire from flaming upward, allowing Lung Qi to descend to generate Water. However, its nature is descending without ascending. With Renshen (Ginseng Radix et Rhizoma), it stirs up Yuan Qi (Primal Qi), achieving both ascending and descending actions. Thus, combined with Dihuang, it forms the Guben Wan (Root-Firming Pill). Additionally, Maidong (Ophiopogonis Radix), Renshen (Ginseng Radix et Rhizoma), and Wuweizi (Schisandrae Fructus) are known as Shengmai San (Generate Pulse Powder), all being herbs for the Lung channel. The intention behind this formula's combination is largely based on the Metal (Lung) and Water (Kidney) organs as the source of generation and transformation, adding Ziheche (Placenta) to achieve the Great Creation effect.
One case involved a man with weak constitution and impotence; after taking two doses of this formula, his body improved drastically, and he fathered four sons. A sixty-year-old woman, already frail and exhausted, took this formula and lived to ninety, remaining strong. Another patient lost his voice after illness; after taking this formula, his Qi strengthened and his voice returned. A third patient suffered from flaccidity syndrome, unable to walk for half a year; after taking this formula, he could travel long distances.