治瘴病上热下寒。升降阴阳。及治痰气壅塞。上盛下虚。心火炎炽。肾水枯竭。及妇人血海久冷。
无子赤白带下。属虚寒者并治之。
黑锡（二两） 硫黄（二两） 肉桂（五钱） 沉香 附子（炮去皮脐）
故纸（炒） 小茴（炒） 木香 胡芦巴（酒浸炒） 肉蔻（面煨） 阳起石（研细水飞）
金铃子（蒸去皮核各二两）
上用新铁铫。如常法。结黑硫砂于地上。出火毒候冷研极细末。余药并末
同研。自朝至暮。以黑光为度。酒面糊丸。梧桐子大。阴干入布袋内。擦令光莹。每服三五十丸。盐汤下。
或枣汤。妇人艾叶汤下。瘴病上热下寒。是方硫黄之大热。能助真火。佐以黑铅之至阴。能治阴盛
格阳之病。木香能理诸气。肉蔻能下诸气。沉香能降诸气。加以故纸。小茴。胡芦巴。引阳
气入肾。肉桂能保肾。附子导热气下行入肾。若阳起石。能补肾添精。直高巅之上。引阳气下达肾经。
共为温补下元。镇固阳气与瘴病为宜也。
治瘴病上盛下虚。升降阴阳。及治伏暑泄泻如水。呕吐不止。
硝石（三两） 青皮（二两去穣）
五灵脂（二两去砂石） 陈皮（二两去白） 玄精石（二两研飞） 硫黄（二两为末）
同灵脂入锅内微火炒。用柳条搅。不可火大。再研极细末。上末醋糊为丸。豆大每服二十丸米饮下。
瘴病内伤生冷。外感暑气。气不升降。是方硝石性寒。佐以青陈皮。性疏快。硫黄大热。能助
真阳。佐以硝石玄精石之至阴。则伏阳格阴皆退。五灵脂能理气。共为通利三焦。升降阴阳之剂。瘴疾
挥霍变乱者。尤宜用之。
治疗瘴病表现为上热下寒。调节阴阳升降。以及治疗痰气壅塞。上实下虚。心火亢盛。肾水枯竭。以及妇人血海长期寒冷。导致不孕、赤白带下。属于虚寒证候的，一并治疗。
黑锡（二两） 硫黄（二两） 肉桂（五钱） 沉香 附子（炮制，去皮和脐）
补骨脂（炒） 小茴香（炒） 木香 葫芦巴（酒浸后炒） 肉豆蔻（面煨） 阳起石（研细，水飞法处理）
川楝子（蒸，去皮核，各二两）
以上药物用新的铁锅。按常规方法。在地面上炼制出黑色的硫化汞（黑硫砂）。去除火毒，待冷却后研磨成极细粉末。其余药物也制成粉末。
一起研磨。从早晨到傍晚。以呈现黑色光泽为度。用酒和面糊作为粘合剂制成丸药。大小如梧桐子。阴干后装入布袋内。摩擦使其光亮莹润。每次服用三五十丸。用盐汤送服。
或者用枣汤送服。妇人用艾叶汤送服。瘴病上热下寒，此方中硫黄的极大热性，能辅助真火。配合黑铅的至阴之性，能治疗阴盛格阳的病证。木香能调理诸气。肉豆蔻能降泄诸气。沉香能下降诸气。加上补骨脂、小茴香、葫芦巴，引导阳气进入肾脏。肉桂能固护肾脏。附子引导热性下行进入肾脏。至于阳起石，能补肾添精。直达头顶之上，引导阳气下达肾经。
共同起到温补下元的作用。镇固阳气，适合治疗瘴病。
治疗瘴病表现为上实下虚。调节阴阳升降。以及治疗伏暑引起的泄泻如水样。呕吐不止。
硝石（三两） 青皮（二两，去瓤）
五灵脂（二两，去砂石） 陈皮（二两，去白） 玄精石（二两，研细水飞） 硫黄（二两，制成粉末）
与五灵脂一同放入锅内，用微火炒。用柳条搅拌。不可火大。再次研磨成极细粉末。以上粉末用醋和面糊制成丸药。大小如豆类。每次服用二十丸，用米饮送服。
瘴病因内伤生冷食物，外感暑气。导致气机不升降。此方中硝石性寒，配合青皮和陈皮，性质疏快。硫黄大热，能辅助真阳。配合硝石和玄精石的至阴之性，则伏阳格阴都会消退。五灵脂能理气。共同起到通利三焦。调节阴阳升降的作用。瘴疾发病急骤、变化混乱的，尤其适宜使用。
Treats malarial disease presenting with heat above and cold below. Regulates the ascending and descending of Yin and Yang. Also treats phlegm-qi obstruction, excess above and deficiency below, blazing heart fire, and depletion of kidney water. It also treats women with long-standing coldness in the Blood Sea (Chong and Ren meridians), leading to infertility, red and white leukorrhea. All conditions belonging to deficiency-cold are treated together.
Heixi Dan (Black Tin Pill):
Black Tin (2 liang), Sulfur (2 liang), Rougui (Cinnamon Twig, 5 qian), Chenxiang (Aquilaria Wood), Fuzi (Aconite Root, processed, skin and lateral roots removed), Gubuzhi (Psoralea Fruit, stir-fried), Xiaohuixiang (Fennel Fruit, stir-fried), Muxiang (Aucklandia Root), Huluba (Trigonella Foenum-graecum Seed, soaked in wine and stir-fried), Roudoukou (Nutmeg, baked in flour), Yangqishi (Lecontite, finely ground and levigated via water flotation), Chuanliuzi (Sichuan Chinaberry Fruit, steamed, skin and seeds removed, each 2 liang).
Take a new iron pot. Process according to the usual method. Smelt black mercury sulfide on the ground. Remove the "fire toxicity" and wait for it to cool before grinding into an extremely fine powder. Grind the remaining herbs into powder as well.
Combine all powders. Grind continuously from morning until evening. The process is complete when a black luster appears. Use wine and wheat paste as binders to form pills, sized like *Morus alba* (mulberry) seeds. Dry them in the shade and store in cloth bags. Rub until smooth and glossy. Take 30–50 pills per dose, swallowed with salted water.
Alternatively, swallow with jujube decoction. For women, swallow with mugwort decoction.
Rationale: For malarial disease with heat above and cold below, the intense heat of Sulfur assists the True Fire. Assisted by the extreme yin nature of Black Tin, it treats diseases of Yin excess repelling Yang. Muxiang regulates Qi; Roudoukou descends Qi; Chenxiang lowers Qi. Combined with Gubuzhi, Xiaohuixiang, and Huluba, they guide Yang Qi into the Kidney. Rougui protects the Kidney. Fuzi guides heat downwards into the Kidney. Yangqishi tonifies the Kidney and replenishes essence, reaching the highest point of the head, guiding Yang Qi down to the Kidney meridian. Together, they warm and tonify the Lower Origin, stabilize and secure Yang Qi, making this formula suitable for malarial disease.
Zhaoyao Dan (Rescue Pill):
Treats malarial disease presenting with excess above and deficiency below. Regulates the ascending and descending of Yin and Yang. Also treats diarrhea resembling water caused by latent summerheat, and incessant vomiting.
Xiaoshi (Saltpeter/Niter, 3 liang), Qingpi (Green Tangerine Peel, 2 liang, pith removed), Wulingzhi (Trogopterus Dung, 2 liang, sand and stones removed), Chenpi (Dried Tangerine Peel, 2 liang, white pith removed), Xuanjingshi (Mirabilite/Natron, 2 liang, finely ground and levigated), Sulfur (2 liang, made into powder).
Mix with Wulingzhi and stir-fry in a pot over low heat. Stir with willow branches. Do not use high heat. Grind again into an extremely fine powder. Use vinegar and wheat paste to form pills, sized like beans. Take 20 pills per dose, swallowed with rice drink.
Rationale: Malarial disease caused by internal injury from raw/cold foods and external contraction of summerheat leads to failure of Qi to ascend and descend. Niter is cold in nature; assisted by Qingpi and Chenpi which have dispersing and regulating properties, and the great heat of Sulfur which assists True Yang, combined with the extreme yin nature of Niter and Xuanjingshi, latent Yang and repelled Yin both recede. Wulingzhi regulates Qi. Together, they unblock and benefit the San Jiao (Triple Burner) and regulate the ascending and descending of Yin and Yang. This formula is especially suitable for malarial disease that strikes suddenly and causes chaotic disturbances.