黄连 黄芩 山栀 黄柏 或加制大黄，蜜丸。
毒者，火邪亢极之谓。如上下积热，头目痛肿，口燥舌烂，二便秘结，发斑错语，及恶疮，消渴、疳蚀等症
者是。脉来大数，按而击指，非大苦大寒专精解毒，不足抑其悍烈。是方也，黄芩苦而枯，枯则轻浮，能泻火于
上。黄连苦而燥，燥则疏决，能泻火于中。黄柏、山栀苦而利，利则就湿，能泻火于下。再加大黄，蜜丸，上下
通治，救阴之策备矣。虽然，药寒到此可谓绝境，倘诊视不的，切勿轻投。古人以芩、连、柏为丸，曰三补丸。
黄柏一味，曰大补丸。名已不正，注方者添出许多蛇足，则言不顺矣。乃耳食之徒，认作补虚之补而司医事，吾
知病患，无所措其手足。
诗曰∶芩连栀柏黄，五味一般强，方虽名解毒，中病再休尝。
草龙胆 黄连 人参 麦冬 五味 柴胡 黄芩 栀仁 知母 天冬 甘草
过虑不决，睛痛水绿，此方主之。
肝主谋虑，胆主决断。过虑则火起于肝，故睛痛；不决则火起于胆，故膏绿。治胆火宜直折，故用芩、连、
柴胡、山栀、胆草；治肝火宜克制，故用天、麦门冬、参、草、五味、知母。
诗曰∶连胆由来苦，栀芩胡得甘，妙加生脉散，知母耐天炎
黄连（六两） 吴茱萸（一两，酒浸，同连炒） 加木香五钱治积滞热痢。
左目病，左胁作痛，此方主之。
左者何？肝位也。左金者何？谓金令直乘其位也。金何以得令？盖黄连泻去心火，肺不受困，则清肃之威左
行，而肝有所制耳。何用吴茱萸？以渠味辛气臊，臊则入肝，辛则疏利，是为反佐。加木香治痢何义？取其香温，
合前药能开发郁结，使气液宣通。经曰∶佐以所利，和以所宜，无病不克。
诗曰∶左金黄连吴茱萸，益元滑石粉甘草，补血黄 秦当归，一般六一铢两巧。
黄连、黄芩、山栀（栀子）、黄柏，或者加入制大黄，制成蜜丸。
所谓“毒”，是指火邪极度亢盛的状态。如上下的积热，导致头目疼痛肿胀，口燥舌部溃烂，大小便便秘不通，皮肤发斑且胡言乱语，以及恶疮、消渴病、疳蚀等病症，都属于此类。脉象来势盛大而数急，重按之下冲击手指，如果不是用大苦大寒的药物专门解毒，不足以抑制其猛烈之势。这个方剂中，黄芩味苦而性枯，枯则质地轻浮，能清泻上部的火邪；黄连味苦而性燥，燥则具有疏泄决断之力，能清泻中部的火邪；黄柏和山栀味苦而性利，利则趋向于湿润之地，能清泻下部的火邪。再加上大黄，制成蜜丸，上下通治，救阴的策略就完备了。虽然如此，药性寒凉到了极点，可以说是处于绝境，如果诊断不确切，千万不要轻易使用。古人将黄芩、黄连、黄柏制成丸剂，称为三补丸。单用黄柏一味，称为大补丸。名称已经不正确，注方的人又添出许多多余的内容，那么说法就不顺理成章了。于是那些道听途说的人，将其误认为是补虚的“补”药而从事医疗事务，我知道病患将会手足无措。
诗曰：黄芩、黄连、栀子、黄柏、大黄，五味药力一般强劲，方子虽然名叫解毒，但中病（病情缓解）之后不要再服用。
草龙胆、黄连、人参、麦冬、五味子、柴胡、黄芩、栀仁、知母、天冬、甘草。
思虑过度而不能决断，眼睛疼痛且眼眵呈绿色，此方主治。
肝主谋虑，胆主决断。思虑过度则火起于肝，所以眼睛疼痛；不能决断则火起于胆，所以眼眵变绿。治疗胆火宜直接折服，所以用黄芩、黄连、柴胡、山栀、龙胆草；治疗肝火宜克制，所以用天门冬、麦门冬、人参、甘草、五味子、知母。
诗曰：黄连、龙胆由来味苦，栀子、黄芩、柴胡得甘味之妙，巧妙加入生脉散，知母耐受天热之炎。
黄连（六两）、吴茱萸（一两，酒浸，与黄连同炒），加木香五钱可治疗积滞热痢。
左眼患病，左胁作痛，此方主治。
什么是“左”？这是肝的位置。“左金”是什么意思？是说金气命令直接乘袭其位置。金气为什么能得到命令？因为黄连泻去心火，肺不受困，则清肃的威严向左运行，从而制约肝气。为什么要用吴茱萸？因为它味辛气臊，臊味入肝，辛味能疏利，这是作为反佐药。加木香治疗痢疾有什么意义？取其香气温性，配合前面的药物能开发郁结，使气和津液宣通。经书说：用适宜的药物辅助，调和以适合病情，没有治不好的病。
诗曰：左金丸由黄连、吴茱萸组成，益元散由滑石粉、甘草组成，补血方由当归等组成，一般的六一散剂量巧妙搭配。
Rhizoma Coptidis (Huanglian), Radix Scutellariae (Huangqin), Fructus Gardeniae (Shanzhi), Cortex Phellodendri (Huangbai), or add processed Rhizoma Rhei (Zhi Dahuang), made into honeyed pills.
"Toxin" refers to the state where pathogenic fire is extremely hyperactive. Conditions such as accumulated heat in the upper and lower parts, causing pain and swelling of the head and eyes, dry mouth with ulcerated tongue, constipation of both stool and urine, skin macules accompanied by delirious speech, as well as malignant sores, Xiao Ke disease (wasting-thirst syndrome), and Gan Shi (infantile malnutrition with oral ulcers) fall into this category. The pulse is large and rapid, striking the fingers when pressed heavily. Without using strongly bitter and cold herbs specifically for detoxification, it is insufficient to suppress its fierce nature. In this formula, Huangqin is bitter and drying; being drying, it is light and floating, capable of draining fire from the upper jiao. Huanglian is bitter and desiccating; being desiccating, it has a dispersing and resolving action, capable of draining fire from the middle jiao. Huangbai and Shanzhi are bitter and promoting; being promoting, they tend towards dampness, capable of draining fire from the lower jiao. Adding Dahuang and making honeyed pills treats both upper and lower, completing the strategy to preserve Yin. Nevertheless, the medicinal properties are cold to the extreme, representing a desperate situation. If the diagnosis is not accurate, do not administer lightly. The ancients made pills from Huangqin, Huanglian, and Huangbai, called San Bu Wan (Three Tonifying Pills). Using only Huangbai alone is called Da Bu Wan (Great Tonifying Pill). The names are already incorrect; commentators added many superfluous elements, making the explanation illogical. Consequently, those who rely on hearsay mistake it for a "tonic" for deficiency and engage in medical practice. I know that patients will be at a loss.
Poem: Huangqin, Huanglian, Zhizi, Huangbai, Dahuang, five flavors generally strong; although the formula is named Detoxification, do not take it again after the illness is cured.
Radix Gentianae Longdancao (Caolongdan), Rhizoma Coptidis (Huanglian), Radix Ginseng (Renshen), Tuber Ophiopogonis (Maidong), Fructus Schisandrae (Wuweizi), Radix Bupleuri (Chaihu), Radix Scutellariae (Huangqin), Semen Gardeniae (Zhiren), Radix Anemarrhenae (Zhimu), Tuber Asparagi (Tian dong), Radix Glycyrrhizae (Gancao).
For excessive worry without decisiveness, eye pain, and greenish ocular discharge, this formula is indicated.
The Liver governs planning and deliberation; the Gallbladder governs decision-making. Excessive worry causes fire to arise in the Liver, hence eye pain; indecision causes fire to arise in the Gallbladder, hence greenish discharge. To treat Gallbladder fire, one should directly subdue it, thus using Huangqin, Huanglian, Chaihu, Zhizi, and Longdancao; to treat Liver fire, one should restrain it, thus using Tian Dong, Maidong, Renshen, Gancao, Wuweizi, and Zhimu.
Poem: Huanglian and Longdan have always been bitter; Zhizi, Huangqin, and Chaihu obtain sweetness; cleverly adding Sheng Mai San (Generate the Pulse Powder); Zhimu endures the summer heat.
Rhizoma Coptidis (Huanglian) (6 liang), Fructus Evodiae (Wuzhuyu) (1 liang, soaked in wine, stir-fried together with Huanglian), plus Radix Aucklandiae (Muxiang) 5 qian to treat dysentery due to stagnation and heat.
For left-eye disorders and pain in the left hypochondrium, this formula is indicated.
What is "Left"? It is the position of the Liver. What does "Zuo Jin" (Left Metal) mean? It means that the Metal command directly occupies its position. Why does Metal get the command? Because Huanglian drains Heart Fire, so the Lung is not constrained; then the clear and descending authority moves to the left, thereby restraining the Liver. Why use Wuzhuyu? Because its flavor is pungent and its odor is fishy/foul; the foul odor enters the Liver, and the pungency promotes free flow, serving as an adverse assistant (fan zuo). What is the meaning of adding Muxiang to treat dysentery? To utilize its aromatic and warm nature, combining with the previous herbs to open up stagnation and allow Qi and fluids to circulate freely. The Classics say: Assist with what is beneficial, harmonize with what is suitable, and no disease cannot be cured.
Poem: Zuo Jin Wan consists of Huanglian and Wuzhuyu; Yi Yuan San consists of Talcum (Huashi) and Gancao; Blood-tonifying formulas include Danggui; generally, the proportions of Liu Yi San (Six-to-One Powder) are skillfully matched.