杨梅疮，由明正德间起于岭表，故名广疮时疮，一名棉花疮。先起红晕，后发斑点，名杨梅斑。色红作痒
成圈，大小不一，二三相套，名杨梅圈。顶开天窗，下疳腐烂，窠粒破损，肉反外突，名翻花杨梅。形如赤豆
嵌肉，坚硬如铁，名杨梅痘。其症多属厥阴阳明，而兼及他经，以相火寄于肝，肌肉属于胃也。毒有气化，有精
化。气化传染者轻；精化欲染者重。气化者，近生梅疮之人，闻其气，食其余，登厕感其毒，由脾肺受之，
故先从上部见，皮肤痒，筋骨疼，其形小而干。精化者，由交媾不洁，火毒里袭，故先从下部见，筋骨疼，溺
淋涩，疮形大而坚。气化者，毒在表，未经入里，一有萌动，急服透骨搜风散。元气实者，杨梅一剂散汗之。
精化者，毒入里，深伏骨髓，宜服九龙丹，通利小便。以泻髓中之毒，重者二服，利下毒物，以土深压之。
泻后体实者，升麻解毒汤。体虚者，归灵内托散。服至筋骨不痛，疮色淡白，内毒已解，再用金蟾脱壳酒一料，
扫余毒以绝其源。若溃烂脓秽，浸淫成片，而痛者，以鹅黄散掺之。翻花者，鹅黄散加雄黄末，香油调敷。
侍从人恐传染，服护从丸可免。切忌误服轻粉、水银、
白粉霜等燥悍劫剂，劫去痰涎，从口齿出，疮即干愈。妄希速效。如熏擦哈吸等法。以致引毒深藏骨髓关窍，
积久外攻，遂成倒发结毒。其始筋骨疼痛，随处结肿，皮色如常。将烂则色紫红而肉腐，脑顶塌陷，腮唇鼻柱
损坏，穿喉蚀目，手足拘挛，终成痼疾。初起筋骨隐痛，宜服搜风解毒汤。若遍身破烂臭秽，仍兼筋骨痛，气实
毒盛者，宜化毒散。气衰者，猪 子汤。若结毒肿块，经年不愈，诸法罔效者，西圣复煎丸。若结毒攻口鼻者，
五宝散。年久臭烂，鼻柱损塌者，宜服结毒紫金丹。若入巅顶，头痛如裂者，内服天麻饼子，鼻吸碧云散。
若鼻塞不通，宜吹通鼻散。毒攻咽喉，腐烂臭蚀者，宜服硫黄不二散，吹结毒灵药，入人中白研砍。结毒臭烂
不敛，外贴解毒紫金膏，兼掺结毒灵药。壮实者主解毒，虚弱者宜兼补，各随次第，如法调治，重者一年，
轻者半载，可望全瘳，慎勿求速效，以自贻误也。
杨梅疮，起源于明朝正德年间，地点在岭南地区，因此被称为广疮、时疮，又名棉花疮。起初出现红色晕圈，随后发出斑点，称为杨梅斑。颜色发红且瘙痒，形成圆圈，大小不一，有的两三个套叠在一起，称为杨梅圈。顶部破溃如开天窗，下部溃疡腐烂，疮基破损，肌肉向外翻出，称为翻花杨梅。形状像赤豆嵌入肉中，坚硬如铁，称为杨梅痘。这种病症多归属于厥阴经和阳明经的病变，同时也涉及其他经络，因为相火寄居于肝，而肌肉归属于胃。毒邪有“气化”和“精化”两种来源。通过气化传染者病情较轻；通过精液交染者病情较重。所谓气化，是指接触患有杨梅疮的人，闻到其气味，食用其剩余食物，或在厕所感染其毒气，病邪由脾肺受之，所以症状先从身体上部显现，表现为皮肤瘙痒、筋骨疼痛，疮形小而干燥。所谓精化，是指因不洁性交，火毒内袭所致，所以症状先从身体下部显现，表现为筋骨疼痛、小便淋漓涩痛，疮形大而坚硬。对于气化型，毒邪在表，尚未入里，一旦有发作迹象，应立即服用透骨搜风散。元气充足者，服用杨梅一剂散以发汗解毒。对于精化型，毒邪已入里，深伏于骨髓，宜服用九龙丹，通利小便，以排出髓中的毒邪，重症者服两次，使毒物随大便排出，以此压制深层的毒邪。泻下之后，体质壮实者，服用升麻解毒汤；体质虚弱者，服用归灵内托散。服药至筋骨不再疼痛，疮色转为淡白，说明内毒已解，此时再服用一料金蟾脱壳酒，以清除余毒，断绝病源。如果疮面溃烂流脓秽物，浸淫成片且疼痛，可将鹅黄散撒敷患处。如果是翻花杨梅，则在鹅黄散中加入雄黄末，用香油调匀后外敷。随从人员担心被传染，可服用护从丸以防患。切忌误服轻粉、水银、白粉霜等燥烈峻猛的药物，这些药物虽能劫去痰涎使其从口齿排出，使疮面看似干枯愈合，但这是妄求速效的做法。如果使用熏蒸、擦拭、吸入等方法，会导致毒邪深入潜伏于骨髓关窍，日久向外攻发，最终形成倒发结毒。初期表现为筋骨疼痛，随处结肿，皮色正常。即将溃烂时，颜色变为紫红，肌肉腐烂，头顶塌陷，腮部、嘴唇、鼻梁损坏，甚至穿喉蚀目，手足拘挛，最终成为顽固难愈的疾病。初起时筋骨隐痛，宜服用搜风解毒汤。如果遍身破烂臭秽，仍兼有筋骨疼痛，正气充足、毒邪盛者，宜服用化毒散；正气衰弱者，服用猪子汤（注：原文为“猪 子汤”，推测可能指猪肾汤或类似方剂，此处保留原意）。如果结毒肿块，经年不愈，各种方法无效者，服用西圣复煎丸。如果结毒攻犯口鼻，服用五宝散。病程长久、臭烂、鼻梁损毁塌陷者，宜服用结毒紫金丹。如果毒邪攻犯头顶，头痛剧烈如裂开，内服天麻饼子，鼻腔吸入碧云散。如果鼻塞不通，宜吹入通鼻散。毒邪攻犯咽喉，腐烂臭蚀者，宜服用硫黄不二散，并吹入结毒灵药，加入人中白研磨成粉。结毒臭烂不收敛，外用贴解毒紫金膏，同时掺入结毒灵药。体质壮实者以解毒为主，体质虚弱者应兼顾补益，根据病情阶段，依法调理治疗，重症需一年，轻症需半年，有望完全康复，切勿追求速效，以免延误病情。
Yangmei chuang (Keratitis-like sore / Syphilis), originating in the Lingnan region during the Zhengde reign of the Ming Dynasty, is thus named Guang chuang (Broad sore) or Shi chuang (Seasonal sore), also known as Mianhua chuang (Cotton sore). It initially presents with red halos, followed by the eruption of macules, termed Yangmei ban (Bayberry spots). These are red and pruritic, forming rings of varying sizes, sometimes two or three concentrically arranged, called Yangmei quan (Bayberry rings). When the apex ulcerates like an open skylight, and the base becomes necrotic with tissue everted, it is called Fanhuai Yangmei (Everted-flower Bayberry). When shaped like a red bean embedded in flesh and hard as iron, it is called Yangmei dou (Bayberry pustule). This pathology primarily involves the Jueyin (Jueyin meridian) and Yangming (Yangming meridian) channels, while also affecting other meridians, because the Ministerial Fire resides in the Liver, and muscles belong to the Stomach. The pathogenic toxin has two origins: Qi transformation (Qi Hua) and Essence transformation (Jing Hua). Transmission via Qi transformation is mild; transmission via sexual contact with essence is severe. "Qi transformation" refers to contracting the disease from individuals suffering from Yangmei chuang, by inhaling their breath, consuming their leftovers, or being exposed to toxins in latrines. The pathogen enters through the Spleen and Lung, so symptoms first appear on the upper body, manifesting as skin pruritus, bone and tendon pain, with small and dry lesions. "Jing transformation" results from unclean sexual intercourse, where fire-toxin invades internally, so symptoms first appear on the lower body, manifesting as bone and tendon pain, dysuria with dribbling and astringency, with large and firm lesions. For Qi transformation type, the toxin is at the exterior and has not entered the interior. Upon any sign of emergence, immediately administer Tougu Soufeng San (Bone-Penetrating Wind-Searching Powder). For those with robust Yuanqi (Primal Qi), Yangmei Yi Ji San (Bayberry One-Dose Powder) should be taken to induce sweating and resolve toxicity. For Jing transformation type, the toxin has entered the interior and lies deep within the marrow. Jiulong Dan (Nine-Dragon Pill) should be administered to promote urination and drain the toxin from the marrow. In severe cases, two doses are given to expel toxic matter via defecation, thereby suppressing the deep-seated toxin. After purgation, if the constitution is strong, Shengma Jiedu Tang (Cimicifuga Toxin-Resolving Decoction) is indicated; if weak, Guiling Naituo San (Guiling Internal-Supporting Powder) is indicated. Treatment continues until bone and tendon pain cease and lesion color fades to pale white, indicating internal toxin resolution. Subsequently, one course of Jinchan Tuqiao Jiu (Golden Toad Molting Wine) should be taken to sweep away residual toxins and cut off the source. If ulcers suppurate with foul discharge, spreading over large areas and causing pain, Ehuang San (Goose-Yellow Powder) should be sprinkled on the affected area. For Everted-flower Bayberry, add Xionghuang powder (Realgar powder) to Ehuang San and apply mixed with sesame oil. Attendants fearing infection may take Hucong Wan (Attendant-Protection Pill) for prevention. Strictly avoid mistakenly administering Qianfen (Calomel), Shuiyin (Mercury), Baifen Shuang (White Lead Frost) and other harsh, drying, and drastic agents. Although these may force phlegm-saliva out through the mouth and teeth, making sores appear dry and healed, this is a reckless pursuit of rapid effect. Methods such as fumigation, rubbing, or inhalation can drive the toxin deep into the marrow and orifices. Over time, it attacks outward, resulting in Daofa Jiedu (Reverse-Eruption Condensed-Toxin). Initially, there is bone and tendon pain with localized swelling, but normal skin color. As it approaches ulceration, the color turns purple-red, flesh rots, the crown of the head collapses, and the cheeks, lips, and nasal bridge are destroyed, potentially piercing the throat and blinding the eyes, leading to limb contracture and becoming a chronic, incurable disease. At the onset, with hidden bone and tendon pain, Soufeng Jiedu Tang (Wind-Searching Toxin-Resolving Decoction) is suitable. If the whole body is broken, foul-smelling, accompanied by bone and tendon pain, and the patient has strong Qi and abundant toxin, Huadu San (Toxin-Transforming Powder) is appropriate; if Qi is deficient, Zhu Zi Tang (Pig Kidney Decoction - *Note: Text implies a specific formula involving pig parts*) is used. For condensed-toxin masses that persist for years without healing despite various treatments, Xisheng Fujian Wan (Xisheng Re-boiled Pill) is indicated. For condensed-toxin attacking the mouth and nose, Wubao San (Five-Treasure Powder) is used. For long-standing, foul, rotting conditions with nasal collapse, Jiedu Zijin Dan (Condensed-Toxin Purple-Gold Pill) is prescribed. If the toxin attacks the vertex, causing splitting headache, Tianma Bingzi (Gastrodia Cake) is taken internally, and Biyun San (Green Cloud Powder) is insufflated into the nose. For nasal obstruction, Tongbi San (Nasal-Unblocking Powder) should be insufflated. For toxin attacking the throat with rotting and foul erosion, Liuhuang Bu'er San (Sulfur Non-Two Powder) is taken, and Jiedu Lingyao (Condensed-Toxin Spiritual Medicine) mixed with Renzhongbai (Urine Sediment) powder is insufflated. For non-healing, foul condensation, external application of Jiedu Zijin Gao (Condensed-Toxin Purple-Gold Ointment) combined with Jiedu Lingyoy powder is used. For robust constitutions, the focus is on resolving toxin; for weak constitutions, supplementation is added. Treatment follows the sequence of the disease. Severe cases may take one year, mild cases half a year, to expect full recovery. Do not seek rapid effects to avoid self-inflicted delay.