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The pulse of Taiyang disease (Disease of the Bladder and Small Intestine channels) resembles that of Shaoyin disease (Disease of the Kidney and Heart channels), and the symptoms of Shaoyin disease resemble those of Taiyang disease; hence it is termed "fan" (reversal/contrary), and the treatment must differ. Upon deep investigation into its principle, both present with a sunken pulse and fever. Because there is headache, it is diagnosed as Taiyang disease, where the pulse should be floating; however, the pulse is now not floating but sunken, caused by deficiency-cold in the interior persisting for a long time and the decline of healthy qi (Zheng Qi). Since there is body pain, it is appropriate to rescue the interior, strengthening the healthy qi internally to force the pathogenic factor outward; in this context, Ganjiang (Dried Ginger) and Sheng Fuzi (Raw Aconite Root) can also induce sweating to resolve the condition. If the interior were not deficient and cold, a floating pulse would appear, and it would strictly belong to the Mahuang Tang (Ephedra Decoction) syndrome of Taiyang disease. Both present with sunken pulse and fever, but because there is no headache, it is named Shaoyin disease, which should lack heat; however, here the cold pathogen is on the exterior, causing heat only due to skin constriction, while there is no heat in the interior. Therefore, Mahuang (Ephedra Herb) and Xixin (Asarum Root) are used to release the heat from the exterior, and Fuzi (Aconite Lateralis Radix Praeparata) is used to warm the Shaoyin meridians. If the cold pathogen were in the interior, there would certainly be no heat on the exterior, and symptoms such as vomiting, diarrhea, and cold limbs would appear, belonging strictly to the Si Ni Tang (Frigid Extremities Decoction) syndrome of true Shaoyin disease. From this perspective, the pathogenic factor on the exterior is shallow, so the "reversal" of fever is particularly mild; whereas the decline of healthy qi makes the "reversal" of the sunken pulse more significant. Thus, the Si Ni Tang formula is not less important than the Mahuang Fuzi Xixin Tang (Ephedra, Prepared Aconite, and Asarum Decoction). It can be seen that prepared Fuzi paired with Mahuang provides tonification within dispersion; raw Fuzi paired with Ganjiang provides dispersion within tonification. Although Taiyang and Shaoyin diseases both present with sunken pulse and fever, the presence or absence of headache distinguishes the pathology and medication, hence they are discussed together. If treated incorrectly, death is certain.

Yin and Yang Jue (cold extremities syndromes), if treated even slightly incorrectly, lead to immediate fatal outcomes. The so-called Yang Jue originates from the Qi level of the Three Yang channels after contracting cold pathogens, starting with headache, fever, and aversion to cold. It then transmits to the Blood level of the Three Yang channels, manifesting as cold extremities, intermittent warmth, dry and hard stools, delirium, thirst, tossing hands and feet, aversion to heat rather than cold, and a sunken, forceful pulse. This indicates a transmitted heat syndrome, termed Yang Jue. Yang extreme leading to Jue means Yang syndrome resembling Yin; although there is coldness externally, there is heat pathogen internally. This is because solidified stool was neglected to be purged, causing obstruction of Qi and blood, resulting in hands and feet alternating between cold and warm. Like fire refining gold, extreme heat causes gold to melt into water. Water freezing into ice can still bear weight. Mild Jue implies mild heat, treated with Si Ni San (Frigid Extremities Powder); deep Jue implies deep heat, treated with Da Cheng Qi Tang (Major Order the Qi Decoction). This refers to the principle that excess leads to harm, and control restores balance. If physicians do not recognize this and suspect Yin Jue, administering hot medicines would be like carrying firewood to put out a fire. The so-called Yin Jue occurs when the Blood level of the Three Yin channels directly contracts cold pathogens. Initially, there is no body heat or headache, only aversion to cold and cold extremities extending up to the arms and calves, with areas above elbows and knees remaining warm. Patients pull clothes over themselves, lie curled up, feel no thirst, and may have abdominal pain, vomiting, diarrhea, tremors, a face pale as if scraped by a knife, salivation, and a sunken, slow, and forceless pulse. This is a true Yin-cold syndrome directly affecting the Yin channels, not transmitting from Yang channels, termed Yin Jue. Mild cases are treated with Li Zhong Tang (Regulate the Middle Decoction), severe cases with Si Ni Tang for warming; errors must be avoided.