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Yin and Yang meridians are both diseased, making recovery difficult. In cases of Lianggan Shanghan (Two-Meridian Cold Damage), treatment must be handled with caution. On the first day, Taiyang (Greater Yang) and Shaoyang (Lesser Yang) meridians are affected simultaneously, presenting with headache, dry mouth, irritability, and thirst. On the second day, Yangming (Yang Brightness) and Taiyin (Greater Yin) meridians are affected simultaneously, presenting with abdominal fullness, high fever as if burning, anorexia, dry nose, delirious speech, and insomnia. On the third day, Shaoyang and Jueyin (Terminal Yin) meridians are affected simultaneously, presenting with deafness or ear discomfort, retraction of the testicles, unconsciousness, cold extremities, and inability to swallow fluids. The sixth day marks the time of death.

"Lianggan" refers to the simultaneous disease of two meridians. The symptoms manifest as: on the first day, Taiyang and Shaoyin (Lesser Yin) meridians are diseased together; on the second day, Yangming and Taiyin meridians are diseased together; on the third day, Shaoyang and Jueyin meridians are diseased together. This constitutes a simultaneous disease of Yin/Yang and Exterior/Interior. If one attempts diaphoresis (sweating method), it is contraindicated due to Interior signs; if one attempts purgation, it is contraindicated due to Exterior signs. The Classics state: "Those who contract cold in two meridians will die." Therefore, Zhang Zhongjing also provided treatment methods. However, Zhang Zhongjing further stated: "When Lianggan occurs, treatment has a sequence." If Exterior signs are urgent, save the Exterior first; if Interior signs are urgent, save the Interior first. Thus, Li Dongyuan (Yi Lao) formulated Da Qianghuo Tang (Great Notopterygium Decoction). His intent was that transmitted pathogenic factors are mostly Yang pathogens; treatment should focus on raising Yang, clearing heat, and nourishing Yin organs. In such cases, patients with shallower infection might still recover.

Da Qianghuo Tang consists of nine ingredients: Cangzhu (Atractylodis Rhizoma), Huangqin (Scutellariae Radix), Lianqiao (Forsythiae Fructus - *Note: Text says 'Lian', usually Chaihu or Lianqiao, but context implies clearing heat, likely Huanglian or similar*, here interpreted as Huanglian Coptidis Rhizoma based on common formula composition), Baizhu (Atractylodis Macrocephalae Rhizoma), Zhimu (Anemarrhenae Rhizoma), Qianghuo (Notopterygii Rhizoma et Radix), Duhuo (Angelicae Pubescentis Radix), Fangfeng (Saposhnikoviae Radix), and Gancao (Glycyrrhizae Radix). This decoction clears heat, nourishes Yin, and harmonizes the Exterior and Interior, providing some relief for Lianggan Shanghan.

Baihe Bing (Lily Disease) presents with abnormal bodily forms, lacking specific meridian involvement, making it difficult to diagnose. Patients desire to lie down but cannot rest, desire to walk but cannot move. Regarding diet, food may taste good, and although they appear strong enough to walk, their steps are labored. Symptoms fluctuate like alternating chills and fever, yet sometimes seem absent. The mouth, tongue, and urine are red and astringent. Medication causes immediate vomiting or diarrhea upon ingestion, as if possessed by spirits. After Shanghan, this condition often transforms into Xu Lao (Deficiency Consumption). Baihe Dihuang Tang (Lily and Rehmannia Decoction) can be administered.

"Baihe" refers to the unity of all vessels. The symptoms include restlessness in walking, standing, sitting, and lying, resembling possession by ghosts or spirits. This is caused by deficient pathogens after Shanghan. It should be treated with Baihe Zhi Mu Tang (Lily and Anemarrhena Decoction), Baihe Jizi Tang (Lily and Egg Yolk Decoction), Baihe Daizhe Tang (Lily and Hematitum Decoction), or Baihe Dihuang Tang.

Shanghan Aonao (Regretful Distress) is more severe than Zhengchong (Palpitations). Whether excess or deficiency, it originates in the Stomach. Jie Xiong (Chest Binding) results from premature purgation causing Yang pathogens to sink. Misguided purgation in Yangming disease empties the Stomach Qi. Pathogenic qi disturbs the Diaphragm, causing central dryness; Zhi Zi Tang (Gardenia Decoction) combined with Da Xian Xiong Tang (Major Eavesdrop Chest Decoction) is used. Dry feces in the Stomach require Cheng Qi Tang (Order the Qi Decoction). If the abdomen is full and the head hard, purgation is forbidden.

"Aonao" refers to a feeling of depression and discomfort. In Shanghan, Aonao may arise from shortness of breath and irritability, with distress in the chest. If the epigastrium becomes hard, it is Jie Xiong, treated with Da Xian Xiong Tang. If there is a white coating on the tongue, empty irritability, insomnia, and epigastric distress, this is pathogenic heat stagnating in the chest; Zhi Zi Chi Tang (Gardenia and Fermented Soybean Decoction) should be used to induce vomiting. If there is no sweat and dysuria in Yangming disease, accompanied by central Aonao, jaundice will develop; Yinchen Hao Tang (Artemisia Capillaris Seed Decoction) is indicated. If Aonao and irritability occur after purgation in Yangming disease, with dry feces in the Stomach, this is pathogenic heat knotting in the Stomach; Cheng Qi Tang should be used to purge.