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Whenever the exterior heat is excessive, the smallpox lesions will inevitably become dry and withered; if the exterior is too cold, the lesions will be frozen and unable to erupt. If internal heat is excessive, there will be constipation; if the interior is too cold, there will be diarrhea. If Qi stagnation is severe, abdominal distension, wheezing, and chest fullness will occur. If the heat-toxin is suppressed and cannot ascend and vent, it leads to abdominal distension and madness, with toxic vapors becoming rampant, affecting both the exterior and interior heavily, which infants and children cannot bear. Therefore, the key to treating smallpox lies in five aspects: securing the exterior, harmonizing the middle jiao, regulating Qi, penetrating the muscle layer to vent toxins, and resolving toxins. Securing the exterior prevents the hazards of dryness or freezing; harmonizing the middle jiao prevents the worries of constipation or diarrhea; keeping the interior Qi solid, blood and Qi vigorous internally, and the Spleen and Stomach strong helps aid maturation, naturally avoiding itching, collapse, or regression of the lesions. Regulating Qi prevents the excesses of stagnation, wheezing, and fullness; penetrating the muscle allows heat-toxins to extend and reach the exterior, preventing them from lingering inside; resolving toxins allows for distribution and elimination from both inside and outside, avoiding disasters from residual toxins spreading. By achieving these five points, the syndrome of blood-heat stagnation and obstruction need not be worried about. However, fire nature is urgent and should be resolved quickly, allowing no delay.

Regarding Lung smallpox eruption, it must be accompanied by Lung distension and wheezing, upward Qi rebellion with cough, heart vexation with epistaxis, chest fullness and rapid breathing, sneezing and throat bi, white lesion color, fine and round shape, skin like millet grains, forming blisters that are white and watery. If spots have not yet appeared but hair is withered and scorched, it is incurable. Regarding Spleen smallpox eruption, it must be accompanied by a stiff tongue root, abdominal distension and vomiting food, epigastric pain, heaviness of the body, frequent groaning and belching, aversion to cold with shivering, aversion to people, urgency and pain in the hypochondrium/epigastrium, difficulty moving the body, loose stools or sometimes constipation, heavy and swollen thighs and knees, or painful tongue root, yellowish lesion color, large and soft shape, alternating chills and fever, forming blisters that are yellow and foul-smelling. If spots are about to appear but lips first form crusts with much foul odor, it is incurable. Regarding Heart smallpox eruption, it must be accompanied by dry and painful throat, frequent palpitations and fright, excessive heat in palms, yellow eyes and deafness, heart pain with thirst and desire to drink, swelling of the chin making it difficult to turn the head towards the shoulder, hypochondriac pain and cheek swelling, red and stagnant crimson lesion color, sharp and fine shape, body heat like burning charcoal. Forming blisters that are sharp and purple; if spots are about to appear but drowsy heat and crimson macules occur, it is incurable. Regarding Liver smallpox eruption, it must be accompanied by bitter taste, yawning and frequent sighing, lower back pain preventing bending and straightening, heart and hypochondriac pain preventing turning sideways, sudden stuffiness and chest fullness, urinary incontinence or sometimes strangury, headache and chin pain, outer canthus pain, green lesion color, sharp and round shape, forming blisters that are white with green tint and contain much pus, hidden on both cheeks, difficult to rise and develop; if spots are about to appear but spirit is fatigued and muscles swollen, it is incurable. Regarding Kidney smallpox eruption, it must be accompanied by hunger without desire to eat, dry tongue and swollen throat, or coughing up blood, intestinal colic and heart pain, or pain in waist, abdomen, spine, and thighs, or frequent fear and heart palpitations feeling like hunger, black lesion color, forming blisters that are large and contain purple blood; if spots are about to appear mixed with rotting purple flesh swelling, hiccups, and inability to stand due to lower back pain, it is incurable.